List of works - Alex Horsley

A novel method for infant multiple breath washout: First report in clinical practice

scientific article published on 18 June 2019

A very breathless woman

scientific article published in the British Medical Journal

Accurate lung volume measurements in vitro using a novel inert gas washout method suitable for infants

scientific article published in December 2015

An immunocytochemical assay to detect human CFTR expression following gene transfer

scientific article

Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation

scientific article (published 2016-01-20)

Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation

scientific article

Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation

scientific article (publication date: 7 December 2011)

Aspergillosis and the role of mucins in cystic fibrosis

scientific article

Assessing arthritis in the context of cystic fibrosis

scientific article published on 05 March 2019

Author's response: heterogeneity of change in LCI in patients with cystic fibrosis following antibiotic treatment

scientific article published on 05 September 2013

Book review: Hodson and Geddes’ Cystic Fibrosis

scientific article published in March 2016

Burkholderia latens infection in cystic fibrosis

scientific article published on 02 February 2011

Can early Burkholderia cepacia complex infection in cystic fibrosis be eradicated with antibiotic therapy?

scientific article

Challenge for a new era-importance of ensuring accuracy of genotype in cystic fibrosis registries

scientific article published on 8 April 2016

Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation

scientific article

Chapter 1 Genetics and pathophysiology

article

Chapter 5 Management of respiratory exacerbations

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Closed circuit rebreathing to achieve inert gas wash-in for multiple breath wash-out

scientific article

Comment on Comparison of lung clearance index determined by washout of N2 and SF6 in infants and preschool children with cystic fibrosis

scientific article published on 02 March 2019

Commentaries on Viewpoint: Using the same cut-off for sulfur hexafluoride and nitrogen multiple-breath washout may not be appropriate

scientific article published in December 2015

Consensus statement for inert gas washout measurement using multiple- and single- breath tests.

scientific article published on 8 February 2013

Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI.

scientific article

Discordance between clinical, physiological, and radiological measures in cystic fibrosis

scientific article

ERS International Congress, Madrid, 2019: highlights from the Paediatric Assembly

scientific article published on 01 April 2020

Effect of intermittent inspiratory leaks on measurement of lung clearance index using nitrogen and sulfur hexafluoride

scientific article published on 19 October 2018

Effects of cystic fibrosis lung disease on gas mixing indices derived from alveolar slope analysis

scientific article published on 25 June 2008

Effects of ivacaftor in patients with cystic fibrosis who carry the G551D mutation and have severe lung disease

scientific article published in July 2014

Efficacy and complications of small-bore, wire-guided chest drains

scientific article published in December 2006

Enhanced photoacoustic gas analyser response time and impact on accuracy at fast ventilation rates during multiple breath washout

scientific article

Evaluation of the impact of alveolar nitrogen excretion on indices derived from multiple breath nitrogen washout

scientific article

Feasibility and challenges of using multiple breath washout in COPD

scientific article published on 10 July 2018

Gout and hyperuricaemia in adults with cystic fibrosis

scientific article published in July 2011

Handheld computers in medicine: the way forward. ⬇️

scientific article published on July 2005

Implications of fatherhood in cystic fibrosis

scientific article published on 16 March 2019

Itraconazole and inhaled fluticasone causing hypothalamic-pituitary-adrenal axis suppression in adults with cystic fibrosis

scientific article published on 28 December 2012

Longitudinal Assessment of Children with Mild Cystic Fibrosis Using Hyperpolarized Gas Lung Magnetic Resonance Imaging and Lung Clearance Index.

scientific article published on 29 June 2017

Lung clearance index in adults with non-cystic fibrosis bronchiectasis.

scientific article

Lung clearance index in cystic fibrosis subjects treated for pulmonary exacerbations

scientific article published on 9 July 2015

Lung clearance index in detection of post-transplant bronchiolitis obliterans syndrome

scientific article published on 15 October 2019

Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in

scientific article published on 25 February 2020

Lung clearance index in the assessment of airways disease

scientific article published on 25 February 2009

Lung clearance index is a repeatable and sensitive indicator of radiological changes in bronchiectasis

scientific article

Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis

scientific article published on 03 August 2007

Modelling structural determinants of ventilation heterogeneity: A perturbative approach

scientific article published in PLoS ONE

Modelling structural determinants of ventilation heterogeneity: a perturbative approach

Orkambi in patients with severe disease - Bumps in the road to CFTR modulation

scientific article published on 19 April 2017

Patterns of regional lung physiology in cystic fibrosis using ventilation magnetic resonance imaging and multiple-breath washout

scholarly article by Laurie J. Smith et al published 25 October 2018 in European Respiratory Journal

Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis

scientific article

Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement

scientific article published on 01 March 2018

Putting lung function and physiology into perspective: cystic fibrosis in adults

scientific article published on 15 September 2014

Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis

scientific article published on 12 December 2013

Reply: lung clearance index in primary ciliary dyskinesia and bronchiectasis

scientific article published in May 2014

Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study

scientific article published in 2023

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

scientific article published in 2023

Simultaneous sulfur hexafluoride and nitrogen multiple-breath washout (MBW) to examine inherent differences in MBW outcomes

scientific article published on 01 October 2019

Supine posture changes lung volumes and increases ventilation heterogeneity in cystic fibrosis.

scientific article published on 27 November 2017

Sweat chloride is not a useful marker of clinical response to Ivacaftor.

scientific article published on 20 November 2013

The assessment of short and long term changes in lung function in CF using 129Xe MRI

scientific article published on 06 July 2020

Using social media to improve communication with people with cystic fibrosis

scientific article

VX-659-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

article

Ventilation heterogeneity and the benefits and challenges of multiple breath washout testing in patients with cystic fibrosis.

scientific article published on 23 September 2015

Ventilation heterogeneity in children with well controlled asthma with normal spirometry indicates residual airways disease.

scientific article

What is the importance of classifying Aspergillus disease in cystic fibrosis patients?

scientific article published on 29 May 2014

List of works by Alex Horsley

A novel method for infant multiple breath washout: First report in clinical practice

A very breathless woman

Accurate lung volume measurements in vitro using a novel inert gas washout method suitable for infants

An immunocytochemical assay to detect human CFTR expression following gene transfer

Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation

Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation

Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation

Aspergillosis and the role of mucins in cystic fibrosis

Assessing arthritis in the context of cystic fibrosis

Author's response: heterogeneity of change in LCI in patients with cystic fibrosis following antibiotic treatment

Book review: Hodson and Geddes’ Cystic Fibrosis

Burkholderia latens infection in cystic fibrosis

Can early Burkholderia cepacia complex infection in cystic fibrosis be eradicated with antibiotic therapy?

Challenge for a new era-importance of ensuring accuracy of genotype in cystic fibrosis registries

Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation

Chapter 1 Genetics and pathophysiology

Chapter 5 Management of respiratory exacerbations

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Closed circuit rebreathing to achieve inert gas wash-in for multiple breath wash-out

Comment on Comparison of lung clearance index determined by washout of N2 and SF6 in infants and preschool children with cystic fibrosis

Commentaries on Viewpoint: Using the same cut-off for sulfur hexafluoride and nitrogen multiple-breath washout may not be appropriate

Consensus statement for inert gas washout measurement using multiple- and single- breath tests.

Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI.

Discordance between clinical, physiological, and radiological measures in cystic fibrosis

ERS International Congress, Madrid, 2019: highlights from the Paediatric Assembly

Effect of intermittent inspiratory leaks on measurement of lung clearance index using nitrogen and sulfur hexafluoride

Effects of cystic fibrosis lung disease on gas mixing indices derived from alveolar slope analysis

Effects of ivacaftor in patients with cystic fibrosis who carry the G551D mutation and have severe lung disease

Efficacy and complications of small-bore, wire-guided chest drains

Enhanced photoacoustic gas analyser response time and impact on accuracy at fast ventilation rates during multiple breath washout

Evaluation of the impact of alveolar nitrogen excretion on indices derived from multiple breath nitrogen washout

Feasibility and challenges of using multiple breath washout in COPD

Gout and hyperuricaemia in adults with cystic fibrosis

Handheld computers in medicine: the way forward. ⬇️

Implications of fatherhood in cystic fibrosis

Itraconazole and inhaled fluticasone causing hypothalamic-pituitary-adrenal axis suppression in adults with cystic fibrosis

Longitudinal Assessment of Children with Mild Cystic Fibrosis Using Hyperpolarized Gas Lung Magnetic Resonance Imaging and Lung Clearance Index.

Lung clearance index in adults with non-cystic fibrosis bronchiectasis.

Lung clearance index in cystic fibrosis subjects treated for pulmonary exacerbations

Lung clearance index in detection of post-transplant bronchiolitis obliterans syndrome

Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in

Lung clearance index in the assessment of airways disease

Lung clearance index is a repeatable and sensitive indicator of radiological changes in bronchiectasis

Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis

Modelling structural determinants of ventilation heterogeneity: A perturbative approach

Modelling structural determinants of ventilation heterogeneity: a perturbative approach

Orkambi in patients with severe disease - Bumps in the road to CFTR modulation

Patterns of regional lung physiology in cystic fibrosis using ventilation magnetic resonance imaging and multiple-breath washout

Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis

Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement

Putting lung function and physiology into perspective: cystic fibrosis in adults

Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis

Reply: lung clearance index in primary ciliary dyskinesia and bronchiectasis

Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Simultaneous sulfur hexafluoride and nitrogen multiple-breath washout (MBW) to examine inherent differences in MBW outcomes

Supine posture changes lung volumes and increases ventilation heterogeneity in cystic fibrosis.

Sweat chloride is not a useful marker of clinical response to Ivacaftor.

The assessment of short and long term changes in lung function in CF using 129Xe MRI

Using social media to improve communication with people with cystic fibrosis

VX-659-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

Ventilation heterogeneity and the benefits and challenges of multiple breath washout testing in patients with cystic fibrosis.

Ventilation heterogeneity in children with well controlled asthma with normal spirometry indicates residual airways disease.

What is the importance of classifying Aspergillus disease in cystic fibrosis patients?