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List of works by Martin Biel

A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation

scientific article published on 19 August 2020

A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa.

scientific article published on 10 December 2010

A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase

scientific journal article

A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.

scientific article published on 14 August 2014

A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network

scientific article published on 03 February 2014

AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments

scientific article published on 28 July 2016

AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects

scientific article published on 24 May 2017

AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye.

scientific article published on 31 August 2017

Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures.

scientific article published on 2 May 2019

Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2

scientific article

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

article

Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy

scientific article published on 12 November 2018

Advancing Gene Therapy for PDE6A Retinitis Pigmentosa

scientific article published on 01 January 2019

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

scientific article published on 16 March 2020

An arginine residue in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels

scientific article published on 10 January 2005

An olfactory subsystem that detects carbon disulfide and mediates food-related social learning

scientific article published on 15 July 2010

Antisense Oligonucleotide- and CRISPR-Cas9-Mediated Rescue of mRNA Splicing for a Deep Intronic CLRN1 Mutation

scientific article published on 31 July 2020

Auditory event-related signals in mouse ERG recordings

scientific article published on 13 November 2013

Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model.

scientific article published on January 2012

CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration

scientific article published in March 2012

CNGA3: A Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity

scientific article published on 01 August 2011

Calmodulin is a functional regulator of Cav1.4 L-type Ca2+ channels

scientific article

Cardiac HCN channels: structure, function, and modulation

scientific article

Cellular zinc levels are modulated by TRPML1-TMEM163 interaction.

scientific article

Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction

scientific article published on 27 December 2012

Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes

scientific article

Chemo- and thermosensory responsiveness of Grueneberg ganglion neurons relies on cyclic guanosine monophosphate signaling elements

scientific article published on 31 August 2011

Complex regulation of voltage-dependent activation and inactivation properties of retinal voltage-gated Cav1.4 L-type Ca2+ channels by Ca2+-binding protein 4 (CaBP4).

scientific article published on 30 August 2012

Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology.

scientific article published on 10 December 2015

Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation

scientific article

Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium.

scholarly article

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif

scientific article published on 9 September 2015

Cyclic nucleotide-gated channels

scientific article published on January 2009

Cyclic nucleotide-regulated cation channels

scientific article published on 02 December 2008

Design and Development of AAV-based Gene Supplementation Therapies for Achromatopsia and Retinitis Pigmentosa.

scientific article published in January 2018

Detection of cGMP in the degenerating retina

scientific article published in January 2013

Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response

scientific article published on May 2016

Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial

scientific article published on 01 September 2018

Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine

scientific article published on 29 January 2007

Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice

scientific article published in January 2017

Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes

scientific article published in January 2003

Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa

scientific article published in January 2017

Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

scientific article

Efficient Stochastic Programming in Julia

scientific article published in 2022

Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice

scientific article published on June 2015

Endolysosomal Cation Channels and Cancer-A Link with Great Potential.

scientific article published on 5 January 2018

Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency.

scientific article published on 11 May 2017

Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency

scientific article

Enigmatic rhodopsin mutation creates an exceptionally strong splice acceptor site

scientific article published on 01 January 2020

Exploring HCN channels as novel drug targets ⬇️

scientific article published on November 18, 2011

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

scientific article

From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease.

scientific article

Function and dysfunction of CNG channels: insights from channelopathies and mouse models

scientific article published on June 2007

Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina

scientific article published in February 2004

Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Towards Treating Human PDE6A-Retinitis Pigmentosa

scientific article

Gene replacement therapy for retinal CNG channelopathies

scientific article published on 17 July 2013

Gene therapy approaches to restore retinal cGMP channel function.

scientific article

Gene therapy for achromatopsia.

scientific article published on 17 January 2017

Gene therapy restores missing cone-mediated vision in the CNGA3-/- mouse model of achromatopsia

scientific article published in January 2012

Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

scientific article published on January 2014

Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

scientific article

Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43).

scientific article published on 7 December 2017

Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa

scientific article

Grating Acuity at Different Luminances in Wild-Type Mice and in Mice Lacking Rod or Cone Function

scientific article published on 01 January 2005

Grueneberg ganglion neurons are finely tuned cold sensors

scientific article published in June 2010

HCN channels: new roles in sinoatrial node function

scientific article

HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure

scientific article published on 25 January 2016

HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path

scientific article published on 10 July 2010

HCN3 contributes to the ventricular action potential waveform in the murine heart

scientific article

HCN3 ion channels: roles in sensory neuronal excitability and pain

scientific article published on 27 July 2019

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress

scientific article published on 17 April 2018

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

scientific article (publication date: 21 August 2014)

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients.

scientific article

Hyperpolarization-activated cation channels: from genes to function

scientific article

Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration

scientific article

Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments

scientific article published in May 2015

Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1

scientific journal article

Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3.

scientific article published in April 2005

In Vitro Evaluation of AAV Vectors for Retinal Gene Therapy

article

In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors

scientific article (publication date: 2016)

In vivo analysis of cone survival in mice

scientific article

International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels

scientific article

International Union of Pharmacology. XLII. Compendium of voltage-gated ion channels: cyclic nucleotide-modulated channels

scientific article published on December 2003

Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes

scientific article published on 19 October 2019

Investigation of the immunogenicity of different types of aggregates of a murine monoclonal antibody in mice

scientific article published on 15 August 2014

Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency

scientific article published on 4 October 2012

KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury

scientific article

Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping

scientific journal article

Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia

scientific article published on 5 January 2016

Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study

scientific article published on 04 June 2013

Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells

scientific article published on 21 March 2022

MicroRNA-365 regulates human cardiac action potential duration

scientific article

Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4

scientific article (publication date: 5 September 2003)

Morphological characterization of the retina of the CNGA3(-/-)Rho(-/-) mutant mouse lacking functional cones and rods

scientific article

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

scientific article published on 26 October 2013

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

scientific article published in January 2017

NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa

scientific article published on 22 January 2014

Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1

scientific article published on 06 April 2020

Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders

scientific article published on 22 February 2021

Odorant-evoked electrical responses in Grueneberg ganglion neurons rely on cGMP-associated signaling proteins

scientific article published on 4 February 2013

Optimized Subretinal Injection Technique for Gene Therapy Approaches

article

Optimized technique for subretinal injections in mice

scientific article

Optogenetic Control of Neural Circuits in the Mongolian Gerbil.

scientific article

POLO.Jl: Policy-based optimization algorithms in Julia

scientific article published on 02 August 2019

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes

scientific article

Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb

scientific article

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.

scientific article

Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors

scientific article published on 24 June 2014

Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors

scientific article published on 30 March 2016

Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice

scientific article published on December 2009

Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice.

scientific article published on 22 December 2010

Photopharmacological control of bipolar cells restores visual function in blind mice

scientific article published on 5 June 2017

Physiological roles of cGMP-gated channels: lessons from mouse models and human channelopathies.

scientific article

Planar patch clamp approach to characterize ionic currents from intact lysosomes

scientific article published on 7 December 2010

Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons

scientific article published on 31 July 2017

Quantification of the sixth DNA base hydroxymethylcytosine in the brain

scientific article published in July 2010

Quantifying macromolecular interactions in living cells using FRET two-hybrid assays

scientific article published on 10 November 2016

Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels

scientific article

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

scientific article published on 02 July 2021

Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP

scientific article

Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization

scientific article published on 13 January 2016

Residual photosensitivity in mice lacking both rod opsin and cone photoreceptor cyclic nucleotide gated channel 3 alpha subunit.

scientific article

Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function

scientific article

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy

scientific article published on 7 March 2018

Retinal gene delivery by adeno-associated virus (AAV) vectors: Strategies and applications

scientific article

Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype.

scientific article published on 17 July 2015

Rod and cone contributions to horizontal cell light responses in the mouse retina.

scientific article published in July 2008

Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibition

scientific article

Role of TRPML and two-pore channels in endolysosomal cation homeostasis

scientific article published on 19 April 2012

Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels

scientific article (publication date: 31 October 2003)

Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial

scientific article published on 30 April 2020

Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

scientific article published on 27 November 2018

Sick sinus syndrome in HCN1-deficient mice.

scientific article

Small Molecules for Early Endosome-Specific Patch Clamping.

scientific article published in July 2017

Structural and functional phenotyping in the cone-specific photoreceptor function loss 1 (cpfl1) mouse mutant - a model of cone dystrophies

scientific article

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

scientific article published in August 2017

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates.

scientific article published in November 2017

Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain

scholarly article

Synaptic plasticity in CNGA3(-/-) mice: cone bipolar cells react on the missing cone input and form ectopic synapses with rods.

scientific article

Systematic Studies on Stabilization of AAV Vector Formulations by Lyophilization

scientific article published in 2022

TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

article

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity

scientific article published on 13 July 2020

TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms

scientific article published on 18 September 2017

The Role of HCN Channels in Ventricular Repolarization ⬇️

scientific article published on November 1, 2011

The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the <i>Cnga3</i>-Deficient Mouse Model of Achromatopsia

scientific article published on 23 December 2020

The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel

scientific article

The cyclic nucleotide-gated ion channel CNGA3 contributes to coolness-induced responses of Grueneberg ganglion neurons

scientific article published on 18 February 2010

The enhancement of HCN channel instantaneous current facilitated by slow deactivation is regulated by intracellular chloride concentration.

scientific article published on 20 May 2006

The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.

scientific article published on January 2011

The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart

scientific article

The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides

scientific journal article

The protein interaction networks of mucolipins and two-pore channels

scientific article published on 02 November 2018

The retinitis pigmentosa mutation c.3444+1G>A in CNGB1 results in skipping of exon 32

scientific article

The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.

scientific article published on 30 August 2017

The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores

scientific journal article

Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates

scientific article published in 2010

Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells.

scientific article published on 20 January 2017

Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function.

scientific article

Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).

scientific article published on 4 February 2013

Vision tests in the mouse: Functional phenotyping with electroretinography

scientific article published in January 2009

Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia

scientific article published on 8 April 2015

cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function

scientific article published on September 2013

cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice

scientific article

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