List of works - Taifo Mahmud

3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis

scientific article published on 29 April 2019

A Highly Promiscuous ß-Ketoacyl-ACP Synthase (KAS) III-like Protein Is Involved in Pactamycin Biosynthesis

scientific article published on 6 January 2017

A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway.

scientific article published in February 2005

A comparative analysis of the sugar phosphate cyclase superfamily involved in primary and secondary metabolism

scientific article

A homologue of the Mycobacterium tuberculosis PapA5 protein, rif-orf20, is an acetyltransferase involved in the biosynthesis of antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.

scientific article published in May 2005

A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria

scientific article published on 25 June 2002

A novel type of geosmin biosynthesis in myxobacteria

scientific article published in June 2005

A unique mechanism for methyl ester formation via an amide intermediate found in myxobacteria

scientific article

Alternative epimerization in C(7)N-aminocyclitol biosynthesis is catalyzed by ValD, a large protein of the vicinal oxygen chelate superfamily.

scientific article

Analysis of genome sequences from plant pathogenic Rhodococcus reveals genetic novelties in virulence loci

scientific article

Angucyclinones from an Indonesian Streptomyces sp.

scientific article

Anti-malarial activities of acylated bruceolide derivatives

scientific article published on 01 March 1998

Antibacterial Potential of Secondary Metabolites from Indonesian Marine Bacterial Symbionts

scientific article published on 29 June 2020

Apoptolidins A and C activate AMPK in metabolically sensitive cell types and are mechanistically distinct from oligomycin A.

scientific article published on 12 December 2014

Armeniaspirol Antibiotic Biosynthesis: Chlorination and Oxidative Dechlorination Steps Affording Spiro[4.4]non-8-ene

scientific article published on 15 February 2019

Asymmetric Synthesis and Biological Activities of Pactamycin-Inspired Aminocyclopentitols

scientific article published on 10 January 2018

Biosynthesis and Metabolic Engineering of Pseudo-oligosaccharides

scientific article published on 30 August 2018

Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds

scientific article published on 21 December 2006

Biosynthesis of the Nuclear Factor of Activated T Cells Inhibitor NFAT-133 in Streptomyces pactum

scientific article published on 07 December 2020

Biosynthesis of the cyclitol moiety of pyralomicin 1a in Nonomuraea spiralis MI178-34F18.

scientific article

Biosynthesis of the validamycins: identification of intermediates in the biosynthesis of validamycin A by Streptomyces hygroscopicus var. limoneus.

scientific article published in March 2001

Biosynthesis of unusual aminocyclitol-containing natural products.

scientific article published on 28 July 2007

Biosynthetic Studies on the α-Glucosidase Inhibitor Acarbose inActinoplanessp.: 2-epi-5-epi-Valiolone Is the Direct Precursor of the Valienamine Moiety

scientific article published in 2002

Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419. ⬇️

scientific article

Biosynthetic studies and genetic engineering of pactamycin analogs with improved selectivity toward malarial parasites.

scientific article published in April 2011

Biosynthetic studies on the alpha-glucosidase inhibitor acarbose: the chemical synthesis of dTDP-4-amino-4,6-dideoxy-alpha-D-glucose.

scientific article published in February 2002

Biosynthetic studies on the alpha-glucosidase inhibitor acarbose: the chemical synthesis of isotopically labeled 2-epi-5-epi-valiolone analogs.

scientific article published in September 2003

Biotransformations of anthranilic acid and phthalimide to potent antihyperlipidemic alkaloids by the marine-derived fungus Scedosporium apiospermum F41-1

scientific article published in 2021

Catalytic analysis of the validamycin glycosyltransferase (ValG) and enzymatic production of 4''-epi-validamycin A

scientific article published on 19 June 2008

Characterization of the early stage aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic acid: the RifN protein specifically converts kanosamine into kanosamine 6-phosphate.

scientific article

Comparative metabolomic analysis of an alternative biosynthetic pathway to pseudosugars in Actinosynnema mirum DSM 43827

scientific article published on 12 August 2013

Complete genome sequence of the myxobacterium Sorangium cellulosum

scientific article

Correction to Limazepines A-F, Pyrrolo[1,4]benzodiazepine Antibiotics from an Indonesian Micrococcus sp.

scientific article published on 23 December 2015

Correction to Structure of a Sedoheptulose 7-Phosphate Cyclase: ValA from Streptomyces hygroscopicus.

scientific article published on 27 June 2014

De novo synthesis of a sunscreen compound in vertebrates

scientific article

Deciphering pactamycin biosynthesis and engineered production of new pactamycin analogues.

scientific article

Distinct Substrate Specificity and Catalytic Activity of the Pseudoglycosyltransferase VldE.

scientific article

Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087. ⬇️

scientific article

Evolution and Distribution of C7-Cyclitol Synthases in Prokaryotes and Eukaryotes.

scientific article

Evolutionary divergence of sedoheptulose 7-phosphate cyclases leads to several distinct cyclic products.

scientific article

Exophilone, a Tetrahydrocarbazol-1-one Analogue with Anti-Pulmonary Fibrosis Activity from the Deep-Sea Fungus Exophiala oligosperma MCCC 3A01264

scientific article published on 11 July 2022

Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A.

scientific article

Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis 5008 ⬇️

scientific article

Genetic insights into pyralomicin biosynthesis in Nonomuraea spiralis IMC A-0156. ⬇️

scientific article

Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838.

scientific article

Genetically engineered production of 1,1'-bis-valienamine and validienamycin in Streptomyces hygroscopicus and their conversion to valienamine. ⬇️

scientific article published on 27 September 2008

Genome features and secondary metabolite potential of the marine symbiont Streptomyces sp. RS2

scientific article published on 20 May 2023

Global and pathway-specific transcriptional regulations of pactamycin biosynthesis in Streptomyces pactum ⬇️

scientific article published on 01 October 2018

Glycosylation of acyl carrier protein-bound polyketides during pactamycin biosynthesis

scientific article published on 15 July 2019

Identification of Elaiophylin Skeletal Variants from the Indonesian Streptomyces sp. ICBB 9297.

scientific article published on 28 October 2015

Identification of asm19 as an acyltransferase attaching the biologically essential ester side chain of ansamitocins using N-desmethyl-4,5-desepoxymaytansinol, not maytansinol, as its substrate

scientific article published in June 2002

Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699.

scientific article published on August 2005

Indonesian medicinal plants. VII. Seven new clerodane-type diterpenoids, peronemins A2, A3, B1, B2, B3, C1, and D1, from the leaves of Peronema canescens (Verbenaceae).

scientific article published on May 1994

Indonesian medicinal plants. VIII. Chemical structures of three new triterpenoids, bruceajavanin A, dihydrobruceajavanin A, and bruceajavanin B, and a new alkaloidal glycoside, bruceacanthinoside, from the stems of Brucea javanica (Simaroubaceae). ⬇️

scientific article published on July 1994

Indonesian medicinal plants. XVII. Characterization of quassinoids from the stems of Quassia indica. ⬇️

scientific article published on November 1996

Interkingdom Genetic Mix-and-Match To Produce Novel Sunscreens

scientific article published on 07 November 2019

Interrogating the Tailoring Steps of Pactamycin Biosynthesis and Accessing New Pactamycin Analogues.

scientific article published on 15 June 2016

Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.

scientific article published in March 2003

Isolation and stereospecific synthesis of indole alkaloids with lipid-lowering effects from the marine-derived fungus Colletotrichum gloeosporioides BB4

scientific article published in 2023

Limazepines A-F, pyrrolo[1,4]benzodiazepine Antibiotics from an Indonesian Micrococcus sp.

scientific article

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

scientific article published on 9 December 2024

Marine natural products. XXXVI. Biologically active polyacetylenes, adociacetylenes A, B, C, and D, from an Okinawan Marine sponge of Adocia sp ⬇️

scientific article published on 01 April 1996

Markerless mutations in the myxothiazol biosynthetic gene cluster: a delicate megasynthetase with a superfluous nonribosomal peptide synthetase domain.

scientific article published in October 2003

Mechanistic Insights into Validoxylamine A 7'-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

scientific article

Melithiazol biosynthesis: further insights into myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl transferases.

scientific article published in October 2003

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Modification of rifamycin polyketide backbone leads to improved drug activity against rifampicin-resistant Mycobacterium tuberculosis.

scientific article published on July 2014

Modified phenazines from an Indonesian Streptomyces sp. ⬇️

scientific article

Mutasynthesis of fluorinated pactamycin analogues and their antimalarial activity

scientific article published on 22 March 2013

Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B.

scientific article published in November 2007

Nonribosomal Peptide Biosynthesis: Point Mutations and Module Skipping Lead to Chemical Diversity

scientific article published on 01 March 2006

Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells

scientific article

Novel Violet Pigment, Nostocine A, an Extracellular Metabolite from Cyanobacterium Nostoc spongiaeforme

scientific article published on 31 March 2009

Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis

scientific article

Occurrence and non-detectability of maytansinoids in individual plants of the genera Maytenus and Putterlickia

scientific article published in February 2003

Phomaligols F–I, polyoxygenated cyclohexenone derivatives from marine-derived fungus Aspergillus flavus BB1

scientific article published in 2021

Potential Antidiabetic Fumiquinazoline Alkaloids from the Marine-Derived Fungus Scedosporium apiospermum F41-1

scientific article published on 04 March 2020

Progress in aminocyclitol biosynthesis

scientific article published on 25 March 2009

Pseudoglycosyltransferase Catalyzes Nonglycosidic C–N Coupling in Validamycin A Biosynthesis ⬇️

scientific article published on July 18, 2011

Rearranged and unrearranged angucyclinones from Indonesian Streptomyces spp. ⬇️

scientific article

Shared Biosynthesis of the Saliniketals and Rifamycins in Salinispora arenicola is Controlled by the sare1259-Encoded Cytochrome P450 ⬇️

scientific article published on September 15, 2010

Structure Characterization and Biological Activity of 2-Arylbenzofurans from an Indonesian Plant, Sesbania grandiflora (L.) Pers

scientific article published on 30 December 2019

Structure of a Sedoheptulose 7-Phosphate Cyclase: ValA from Streptomyces hygroscopicus ⬇️

scientific article

Succinylated Apoptolidins from Amycolatopsis sp. ICBB 8242.

scientific article published on 6 May 2015

Synthesis of 5-epi-[6-(2)H(2)]valiolone and stereospecifically monodeuterated 5-epi-valiolones: exploring the steric course of 5-epi-valiolone dehydratase in validamycin A biosynthesis.

scientific article published in July 2001

Taxol and its related taxoids from the needles of Taxus sumatrana. ⬇️

scientific article published on February 1995

The C7N aminocyclitol family of natural products.

scientific article

The biosynthesis of acarbose and validamycin.

scientific article

The secondary metabolite pactamycin with potential for pharmaceutical applications: biosynthesis and regulation

scientific article published on 25 April 2019

The sedoheptulose 7-phosphate cyclases and their emerging roles in biology and ecology

scientific article published on 12 May 2017

The α-ketoglutarate/Fe(II)-dependent dioxygenase VldW is responsible for the formation of validamycin B.

scientific article

Total Synthesis of (±)-Isoperbergins and Correction of the Chemical Structure of Perbergin

scientific article published on 2 September 2016

Transcriptional regulation and increased production of asukamycin in engineered Streptomyces nodosus subsp. asukaensis strains.

scientific article published on 5 May 2012

ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A.

scientific article

l-Phenylalanine Alters the Privileged Secondary Metabolite Production in the Marine-Derived Fungus Trichoderma erinaceum F1-1

scientific article published on 30 December 2019

l-Tryptophan Induces a Marine-Derived Fusarium sp. to Produce Indole Alkaloids with Activity against the Zika Virus

scientific article published on 12 November 2020

β-Carboline Alkaloids From the Deep-Sea Fungus Trichoderma sp. MCCC 3A01244 as a New Type of Anti-pulmonary Fibrosis Agent That Inhibits TGF-β/Smad Signaling Pathway

scientific article published on 28 July 2022

List of works by Taifo Mahmud

3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis

A Highly Promiscuous ß-Ketoacyl-ACP Synthase (KAS) III-like Protein Is Involved in Pactamycin Biosynthesis

A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway.

A comparative analysis of the sugar phosphate cyclase superfamily involved in primary and secondary metabolism

A homologue of the Mycobacterium tuberculosis PapA5 protein, rif-orf20, is an acetyltransferase involved in the biosynthesis of antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.

A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria

A novel type of geosmin biosynthesis in myxobacteria

A unique mechanism for methyl ester formation via an amide intermediate found in myxobacteria

Alternative epimerization in C(7)N-aminocyclitol biosynthesis is catalyzed by ValD, a large protein of the vicinal oxygen chelate superfamily.

Analysis of genome sequences from plant pathogenic Rhodococcus reveals genetic novelties in virulence loci

Angucyclinones from an Indonesian Streptomyces sp.

Anti-malarial activities of acylated bruceolide derivatives

Antibacterial Potential of Secondary Metabolites from Indonesian Marine Bacterial Symbionts

Apoptolidins A and C activate AMPK in metabolically sensitive cell types and are mechanistically distinct from oligomycin A.

Armeniaspirol Antibiotic Biosynthesis: Chlorination and Oxidative Dechlorination Steps Affording Spiro[4.4]non-8-ene

Asymmetric Synthesis and Biological Activities of Pactamycin-Inspired Aminocyclopentitols

Biosynthesis and Metabolic Engineering of Pseudo-oligosaccharides

Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds

Biosynthesis of the Nuclear Factor of Activated T Cells Inhibitor NFAT-133 in Streptomyces pactum

Biosynthesis of the cyclitol moiety of pyralomicin 1a in Nonomuraea spiralis MI178-34F18.

Biosynthesis of the validamycins: identification of intermediates in the biosynthesis of validamycin A by Streptomyces hygroscopicus var. limoneus.

Biosynthesis of unusual aminocyclitol-containing natural products.

Biosynthetic Studies on the α-Glucosidase Inhibitor Acarbose inActinoplanessp.: 2-epi-5-epi-Valiolone Is the Direct Precursor of the Valienamine Moiety

Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419. ⬇️

Biosynthetic studies and genetic engineering of pactamycin analogs with improved selectivity toward malarial parasites.

Biosynthetic studies on the alpha-glucosidase inhibitor acarbose: the chemical synthesis of dTDP-4-amino-4,6-dideoxy-alpha-D-glucose.

Biosynthetic studies on the alpha-glucosidase inhibitor acarbose: the chemical synthesis of isotopically labeled 2-epi-5-epi-valiolone analogs.

Biotransformations of anthranilic acid and phthalimide to potent antihyperlipidemic alkaloids by the marine-derived fungus Scedosporium apiospermum F41-1

Catalytic analysis of the validamycin glycosyltransferase (ValG) and enzymatic production of 4''-epi-validamycin A

Characterization of the early stage aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic acid: the RifN protein specifically converts kanosamine into kanosamine 6-phosphate.

Comparative metabolomic analysis of an alternative biosynthetic pathway to pseudosugars in Actinosynnema mirum DSM 43827

Complete genome sequence of the myxobacterium Sorangium cellulosum

Correction to Limazepines A-F, Pyrrolo[1,4]benzodiazepine Antibiotics from an Indonesian Micrococcus sp.

Correction to Structure of a Sedoheptulose 7-Phosphate Cyclase: ValA from Streptomyces hygroscopicus.

De novo synthesis of a sunscreen compound in vertebrates

Deciphering pactamycin biosynthesis and engineered production of new pactamycin analogues.

Distinct Substrate Specificity and Catalytic Activity of the Pseudoglycosyltransferase VldE.

Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087. ⬇️

Evolution and Distribution of C7-Cyclitol Synthases in Prokaryotes and Eukaryotes.

Evolutionary divergence of sedoheptulose 7-phosphate cyclases leads to several distinct cyclic products.

Exophilone, a Tetrahydrocarbazol-1-one Analogue with Anti-Pulmonary Fibrosis Activity from the Deep-Sea Fungus Exophiala oligosperma MCCC 3A01264

Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A.

Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis 5008 ⬇️

Genetic insights into pyralomicin biosynthesis in Nonomuraea spiralis IMC A-0156. ⬇️

Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838.

Genetically engineered production of 1,1'-bis-valienamine and validienamycin in Streptomyces hygroscopicus and their conversion to valienamine. ⬇️

Genome features and secondary metabolite potential of the marine symbiont Streptomyces sp. RS2

Global and pathway-specific transcriptional regulations of pactamycin biosynthesis in Streptomyces pactum ⬇️

Glycosylation of acyl carrier protein-bound polyketides during pactamycin biosynthesis

Identification of Elaiophylin Skeletal Variants from the Indonesian Streptomyces sp. ICBB 9297.

Identification of asm19 as an acyltransferase attaching the biologically essential ester side chain of ansamitocins using N-desmethyl-4,5-desepoxymaytansinol, not maytansinol, as its substrate

Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699.

Indonesian medicinal plants. VII. Seven new clerodane-type diterpenoids, peronemins A2, A3, B1, B2, B3, C1, and D1, from the leaves of Peronema canescens (Verbenaceae).

Indonesian medicinal plants. VIII. Chemical structures of three new triterpenoids, bruceajavanin A, dihydrobruceajavanin A, and bruceajavanin B, and a new alkaloidal glycoside, bruceacanthinoside, from the stems of Brucea javanica (Simaroubaceae). ⬇️

Indonesian medicinal plants. XVII. Characterization of quassinoids from the stems of Quassia indica. ⬇️

Interkingdom Genetic Mix-and-Match To Produce Novel Sunscreens

Interrogating the Tailoring Steps of Pactamycin Biosynthesis and Accessing New Pactamycin Analogues.

Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.

Isolation and stereospecific synthesis of indole alkaloids with lipid-lowering effects from the marine-derived fungus Colletotrichum gloeosporioides BB4

Limazepines A-F, pyrrolo[1,4]benzodiazepine Antibiotics from an Indonesian Micrococcus sp.

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Marine natural products. XXXVI. Biologically active polyacetylenes, adociacetylenes A, B, C, and D, from an Okinawan Marine sponge of Adocia sp ⬇️

Markerless mutations in the myxothiazol biosynthetic gene cluster: a delicate megasynthetase with a superfluous nonribosomal peptide synthetase domain.

Mechanistic Insights into Validoxylamine A 7'-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

Melithiazol biosynthesis: further insights into myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl transferases.

Minimum Information about a Biosynthetic Gene cluster.

Modification of rifamycin polyketide backbone leads to improved drug activity against rifampicin-resistant Mycobacterium tuberculosis.

Modified phenazines from an Indonesian Streptomyces sp. ⬇️

Mutasynthesis of fluorinated pactamycin analogues and their antimalarial activity

Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B.

Nonribosomal Peptide Biosynthesis: Point Mutations and Module Skipping Lead to Chemical Diversity

Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells

Novel Violet Pigment, Nostocine A, an Extracellular Metabolite from Cyanobacterium Nostoc spongiaeforme

Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis

Occurrence and non-detectability of maytansinoids in individual plants of the genera Maytenus and Putterlickia

Phomaligols F–I, polyoxygenated cyclohexenone derivatives from marine-derived fungus Aspergillus flavus BB1

Potential Antidiabetic Fumiquinazoline Alkaloids from the Marine-Derived Fungus Scedosporium apiospermum F41-1

Progress in aminocyclitol biosynthesis

Pseudoglycosyltransferase Catalyzes Nonglycosidic C–N Coupling in Validamycin A Biosynthesis ⬇️