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List of works by Douglas L. Mann

A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway

scholarly article

Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor.

scientific article published on 21 July 2003

Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia

scientific article

Adaptive and maladptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading

scientific article

Advanced Heart Failure and Transplant Cardiology: A Subspecialty Is Born

scientific article published on 01 March 2009

Advanced Heart Failure and Transplant Cardiology: A Subspecialty is Born

scientific article published on 01 March 2009

An overview of tumor necrosis factor alpha and the failing human heart.

scientific article

Angiotensin II as an inflammatory mediator: evolving concepts in the role of the renin angiotensin system in the failing heart

scientific article published in January 2002

Angiotensin II induces tumor necrosis factor biosynthesis in the adult mammalian heart through a protein kinase C-dependent pathway

scientific article

Angiotensin-receptor blockade in acute myocardial infarction--a matter of dose

scientific article published on 10 November 2003

Anti-angiotensin therapy: new perspectives

scientific article

Antiinflammatory therapy in myocarditis

scientific article

Apoptosis and the heart: a decade of progress

scientific article

Aspirin Does Not Increase Heart Failure Events in Heart Failure Patients: From the WARCEF Trial

scientific article published in August 2017

Association between mortality and implantable cardioverter-defibrillators by aetiology of heart failure: a propensity-matched analysis of the WARCEF trial

Association of quality of life with anticoagulant control in patients with heart failure: the Warfarin and Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) trial

scientific article

Autoimmunity, immunoglobulin adsorption and dilated cardiomyopathy: has the time come for randomized clinical trials?∗∗∗Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessa

scientific article published on 01 July 2001

Beneficial effects of the CorCap cardiac support device: five-year results from the Acorn Trial

scientific article published on 16 July 2011

Benefit of warfarin compared with aspirin in patients with heart failure in sinus rhythm: a subgroup analysis of WARCEF, a randomized controlled trial

scientific article

Biomarkers of inflammation in heart failure

scientific article published on July 2010

Bleeding Risk and Antithrombotic Strategy in Patients With Sinus Rhythm and Heart Failure With Reduced Ejection Fraction Treated With Warfarin or Aspirin

scientific article

CD14-deficient mice are protected against lipopolysaccharide-induced cardiac inflammation and left ventricular dysfunction.

scientific article

CHA2 DS2 -VASc score and adverse outcomes in patients with heart failure with reduced ejection fraction and sinus rhythm

scientific article published on 21 July 2016

CHA2DS2-VASC SCORE AND ADVERSE EVENTS IN PATIENTS WITH HEART FAILURE AND SINUS RHYTHM

Can valsartan reduce the occurrence of atrial fibrillation in heart failure patients?

scientific article published in October 2005

Cardiac Disease in Cancer Patients: An Overview

scientific article published on 01 September 2010

Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression.

scientific article

Cardiac remodeling as therapeutic target: treating heart failure with Cardiac Support Devices

scientific article published in June 2005

Cardiac remodelling and myocardial recovery: lost in translation?

scientific article published on August 2010

Cardiorenal rescue study in acute decompensated heart failure: rationale and design of CARRESS-HF, for the Heart Failure Clinical Research Network

scientific article

Cardiovascular phenotype in HFpEF patients with or without diabetes: a RELAX trial ancillary study

scientific article

Cellular remodeling in heart failure disrupts K(ATP) channel-dependent stress tolerance

scientific article

Circulating Interleukin-6 in Severe Heart Failure

article

Circulating levels of tumor necrosis factor correlate with indexes of depressed heart rate variability: a study in patients with mild-to-moderate heart failure

scientific article published in March 2003

Circulating p53-responsive microRNAs as predictive biomarkers in heart failure after acute myocardial infarction: the long and arduous road from scientific discovery to clinical utility

scientific article published on July 2013

Clinical and Echocardiographic Factors Associated With New-Onset Atrial Fibrillation in Heart Failure – Subanalysis of the WARCEF Trial –

Clinical applications of miRNAs in cardiac remodeling and heart failure

scientific article published on September 2010

Clinical evaluation of the CorCap Cardiac Support Device in patients with dilated cardiomyopathy

scientific article published in October 2007

Cognitive Decline Over Time in Patients With Systolic Heart Failure: Insights From WARCEF

scientific article published on 01 December 2019

Cognitive function in ambulatory patients with systolic heart failure: insights from the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial

scientific article

Colchicine and the failing heart: a "FINER" anti-inflammatory agent?

scientific article published on April 2014

Communication in the heart: the role of the innate immune system in coordinating cellular responses to ischemic injury

scientific article

Comparable performance of the Kansas City Cardiomyopathy Questionnaire in patients with heart failure with preserved and reduced ejection fraction

scientific article

Comparison of outcomes of white versus black patients hospitalized with heart failure and preserved ejection fraction

scientific article published in October 2004

Comparison of patients with heart failure and preserved left ventricular ejection fraction among those with versus without diabetes mellitus

scientific article

Contemporary medical options for treating patients with heart failure

scientific article

Coronary collaterals predict improved survival and allograft function in patients with coronary allograft vasculopathy

scientific article published on 24 May 2013

Cross-regulation between the renin-angiotensin system and inflammatory mediators in cardiac hypertrophy and failure

scientific article published in August 2004

Cyclooxygenase-2 inhibitor treatment improves left ventricular function and mortality in a murine model of doxorubicin-induced heart failure

scientific article published on 15 March 2004

Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support

scientific article published on 15 January 2014

Designs for mechanical circulatory support device studies

scientific article published on February 2007

Desmin mediates TNF-alpha-induced aggregate formation and intercalated disk reorganization in heart failure.

scientific article published on June 2008

Determinants of Myocardial Recovery in Myocarditis

scientific article published on 01 September 2005

Diabetic cardiomyopathy: bench to bedside

scientific article

Differential Expression of Heat Shock Proteins in Normal and Failing Human Hearts

scientific article published on 01 April 1998

Digoxin treatment in heart failure--unveiling risk by cluster analysis of DIG data

scientific article

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

scientific article

Doppler and two-dimensional echocardiographic diagnosis of Björk-Shiley prosthetic valve malfunction: Importance of interventricular septal motion and the timing of onset of valve flow

scientific article published on 01 October 1986

Downregulation of connexin40 and increased prevalence of atrial arrhythmias in transgenic mice with cardiac-restricted overexpression of tumor necrosis factor

article

Duality of innate stress responses in cardiac injury, repair, and remodeling

scientific article published in October 2004

Dysferlin mediates the cytoprotective effects of TRAF2 following myocardial ischemia reperfusion injury

scientific article published on 26 February 2014

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial

scientific article published on March 2013

Effect of the soluble TNF-antagonist etanercept on tumor necrosis factor bioactivity and stability

scientific article published on September 2008

Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study

scientific article published on 14 April 2015

Effects of age on ventricular performance during graded supine exercise

scientific article published on 01 January 1986

Effects of phosphodiesterase type 5 inhibition on systemic and pulmonary hemodynamics and ventricular function in patients with severe symptomatic aortic stenosis

scientific article

Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial

scientific article

Elevated circulating levels of serum tumor necrosis factor-alpha in patients with hemodynamically significant pressure and volume overload

scientific article published on 01 July 2000

Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation

scientific article published on January 2014

Endothelin Antagonism and the Failing Heart: an Unfilled Promise, an Unmet Need, or an Unanswered Question?

scholarly article by Douglas L. Mann published in September 2002

Epidemiology and natural history of recovery of left ventricular function in recent onset dilated cardiomyopathies

scientific article published on December 2013

Exercise training and skeletal muscle inflammation in chronic heart failure

scientific article published on 01 September 2003

Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy

scientific article published on January 2008

Expression of proinflammatory cytokines in the failing human heart: comparison of recent-onset and end-stage congestive heart failure

article

Extracellular matrix remodeling following myocardial injury.

scientific article

Failure of benefit and early hazard of bucindolol for Class IV heart failure

scientific article published in August 2003

Functional relation between infarct thickness and regional systolic function in the acutely and subacutely infarcted canine left ventricle

scientific article published on 01 August 1989

Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock

scientific article published on 01 March 2005

Getting pumped about heart failure

scientific article published on June 2014

Guidelines are Merely Guidelines

scientific article published on 01 March 2011

Guidelines, performance measures, and the practice of medicine: mind the gap.

scientific article

Heart Failure Guidelines, Performance Measures, and the Practice of Medicine

scientific article published on December 14, 2010

Heart Failure Severity and Quality of Warfarin Anticoagulation Control (From the WARCEF Trial)

Heart failure 2008: an update for clinicians

scientific article published on 01 May 2008

Hepcidin in anemia of chronic heart failure

scientific article

Heterogeneous effects of tissue inhibitors of matrix metalloproteinases on cardiac fibroblasts

scientific article published in February 2005

Highlights of the 2006 Scientific Sessions of the Heart Failure Society of America

scientific article published on 22 January 2007

How to build an integrated biobank: the Washington University Translational Cardiovascular Biobank & Repository experience

scientific article published on 18 April 2013

Hypogonadism in male patients with cancer

scientific article published in June 2006

Immunomodulatory role of non-neuronal cholinergic signaling in myocardial injury

scientific article published on 04 June 2019

Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study

scientific article published in June 2008

Improving outcomes in heart failure: It's not unusual beyond usual care.

scientific article

In Vivo Expression of Proinflammatory Mediators in the Adult Heart after Endotoxin Administration: The Role of Toll‐Like Receptor–4

scientific article published on 23 April 2001

In search of new therapeutic targets and strategies for heart failure: recent advances in basic science

scientific article

Increased myocardial gene expression of tumor necrosis factor-alpha and nitric oxide synthase-2: a potential mechanism for depressed myocardial function in hibernating myocardium in humans

scientific article

Infectious complications in patients with left ventricular assist device: etiology and outcomes in the continuous-flow era.

scientific article published in October 2010

Inflammation and treatment response to sertraline in patients with coronary heart disease and comorbid major depression

scientific article

Inflammatory mediators and the failing heart: a translational approach

scientific article

Inflammatory mediators and the failing heart: past, present, and the foreseeable future

scientific article

Inhibition of PPAR-α activity in mice with cardiac-restricted expression of tumor necrosis factor: potential role of TGF-β/Smad3

scientific article published on 10 November 2006

Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways

scientific article

Interleukin-6 and viral myocarditis: the Yin-Yang of cardiac innate immune responses.

scientific article

Is It Time for a New Taxonomy for Heart Failure?

scientific article published on 14 July 2016

Is myocardial recovery possible and how do you measure it?

scientific article published on June 2012

Left Ventricular Ejection Fraction and Risk of Stroke and Cardiac Events in Heart Failure: Data From the Warfarin Versus Aspirin in Reduced Ejection Fraction Trial

scientific article

Left atrial volume and cardiovascular outcomes in systolic heart failure: effect of antithrombotic treatment

Left ventricular size and shape: determinants of mechanical signal transduction pathways

scientific article

Letter by Taylor et al regarding article, "Hydralazine and isosorbide dinitrate in heart failure: historical perspectives, mechanisms, and future directions".

scientific article published in December 2011

Load-dependent and -independent regulation of proinflammatory cytokine and cytokine receptor gene expression in the adult mammalian heart

scientific article

Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial

scientific article published on December 2013

Mechanisms and models in heart failure: the biomechanical model and beyond

scientific article

Mechanisms of idiopathic dilated cardiomyopathies

MicroRNAs and the Failing Heart

scientific article published on 01 June 2007

Mitochondrial tolerance to stress impaired in failing heart

scientific article published in September 2003

Mitral valve repair in heart failure: five-year follow-up from the mitral valve replacement stratum of the Acorn randomized trial

scientific article published on 26 January 2011

Mitral valve surgery in heart failure: insights from the Acorn Clinical Trial

scientific article published on 31 July 2006

Modulation of left ventricular dilation remodeling with epicardial restraint devices in postmyocardial infarction heart failure

scientific article published on December 2009

Molecular imaging and the failing heart: through the looking glass

scientific article

Myocardial Expression Levels of Micro-Ribonucleic Acids in Patients With Left Ventricular Assist Devices

scientific article published on 01 November 2011

Myocardial Proinflammatory Cytokine Expression and Left Ventricular Remodeling in Patients With Chronic Mitral Regurgitation

article

Myocardial recovery and the failing heart: myth, magic, or molecular target?

scientific article

NHLBI's program for VAD therapy for moderately advanced heart failure: the REVIVE-IT pilot trial

scientific article

Natural variability of circulating levels of cytokines and cytokine receptors in patients with heart failure: implications for clinical trials

article

Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes

scientific article published on 25 January 2008

New insights into mechanisms of action of carvedilol treatment in chronic heart failure patients--a matter of time for contractility

scientific article published on 22 December 2011

New predictive models of heart failure mortality using time-series measurements and ensemble models

scientific article

New therapeutics for chronic heart failure

scientific article

Normalization of cardiac structure and function after regression of cardiac hypertrophy

article

Nuclear factor-kappaB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction.

scientific article published on 15 December 2003

Oxidative stress promotes ligand-independent and enhanced ligand-dependent tumor necrosis factor receptor signaling

scientific article

Pharmacogenomics and the failing heart are we waiting for godot?

scientific article published on 23 June 2008

Plasma matrix metalloproteinase and inhibitor profiles in patients with heart failure

scientific article published on 01 December 2002

Positioning of inflammatory biomarkers in the heart failure landscape

scientific article published on 11 May 2013

Preclinical and clinical assessment of the safety and potential efficacy of thalidomide in heart failure

scientific article published in October 2002

Prediction of Mode of Death in Heart Failure

article

Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia

scientific article

Prognostic significance of biomarkers in predicting outcome in patients with coronary artery disease and left ventricular dysfunction: results of the biomarker substudy of the Surgical Treatment for Ischemic Heart Failure trials

scientific article

Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)

scientific article published on 01 April 1996

Pseudoseptic inflammatory knee effusion caused by phagocytosis of sickled erythrocytes after fracture into the knee joint

scientific article published on 01 February 1995

Pulse pressure and prognosis in patients with heart failure with reduced ejection fraction

scientific article published on 23 February 2019

Quality of anticoagulation control in preventing adverse events in patients with heart failure in sinus rhythm: Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction trial substudy

scientific article published on 7 April 2015

Rationale and study design of the increase of vagal tone in heart failure study: INOVATE-HF.

scientific article published in June 2012

Rationale, design and organisation of an efficacy and safety study of oxypurinol added to standard therapy in patients with NYHA class III - IV congestive heart failure

scientific article published in November 2004

Rationale, design, and methods for a pivotal randomized clinical trial for the assessment of a cardiac support device in patients with New York health association class III-IV heart failure

scientific article published in June 2004

Reappraising the role of inflammation in heart failure

scientific article published on 22 January 2020

Recent insights into the role of tumor necrosis factor in the failing heart.

scientific article

Recognition of self-DNA drives cardiac inflammation: why broken hearts fail

scientific article

Recurrent stroke in the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial

scientific article

Relation of tissue Doppler-derived myocardial velocities to serum levels and myocardial gene expression of tumor necrosis factor-alpha and inducible nitric oxide synthase in patients with ischemic cardiomyopathy having coronary artery bypass graftin

scientific article published in October 2002

Relationship of functional recovery to scar contraction after myocardial infarction in the canine left ventricle

scientific article published on 01 April 1989

Resting Heart Rate and Ischemic Stroke in Patients with Heart Failure

scientific article

Restoring public trust in scientific research by reducing conflicts of interest

scientific article published on 01 October 2019

Results of the Randomized Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction Trial (RAAM-PEF)

scientific article published on 31 May 2011

Review of side-effect profile of combination ezetimibe and statin therapy in randomized clinical trials

scientific article

Role of innate and adaptive immune mechanisms in cardiac injury and repair

scientific article

Role of microRNAs in cardiac remodeling and heart failure

scientific article published on April 2011

Role of the innate immune system in acute viral myocarditis

scientific article

Serum biomarkers in severe refractory cardiogenic shock

scientific article

Signaling pathways involved in left ventricular remodeling: Summation

scientific article published on 01 December 2002

Single- versus dual-chamber sensor-driven pacing: Comparison of cardiac outputs

article

Soluble tumor necrosis factor receptors and heart failure risk in older adults: Health, Aging, and Body Composition (Health ABC) Study

scientific article published on 09 December 2013

Speckle strain echocardiography predicts outcome in patients with heart failure with both depressed and preserved left ventricular ejection fraction

scientific article published on 10 May 2014

Spectrum of pleiotropic effects of statins in heart failure

scientific article published on April 2008

Sphingosine 1-phosphate as a therapeutic target in heart failure: more questions than answers

scientific article published on 25 April 2012

Sphingosine Mediates the Immediate Negative Inotropic Effects of Tumor Necrosis Factor-α in the Adult Mammalian Cardiac Myocyte

scientific article published in Journal of Biological Chemistry

Statement Regarding the Pre and Post Market Assessment of Durable, Implantable Ventricular Assist Devices in the United States

article

Statement Regarding the Pre and Post Market Assessment of Durable, Implantable Ventricular Assist Devices in the United States: Executive Summary

article

Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States

scientific article

Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States

article

Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States: executive summary

scientific article

Stress-activated cytokines and the heart: from adaptation to maladaptation

scientific article

Stroke in heart failure in sinus rhythm: the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction trial

scientific article

Sustained benefits of the CorCap Cardiac Support Device on left ventricular remodeling: three year follow-up results from the Acorn clinical trial

scientific article

THE ROLE OF CYTOKINES IN THE FAILING HUMAN HEART

scientific article published on 01 November 1998

TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways

scientific article published in September 2007

TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle

scientific article

TNFalpha decreases alphaMHC expression by a NO mediated pathway: role of E-box transcription factors for cardiomyocyte specific gene regulation

scientific article published in February 2002

Targeted Overexpression of Noncleavable and Secreted Forms of Tumor Necrosis Factor Provokes Disparate Cardiac Phenotypes

scientific article published on 29 December 2003

Targeted anticytokine therapy and the failing heart

scientific article

Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL).

scientific article published on 15 March 2004

Targeted cancer therapeutics: the heartbreak of success

scientific article published on 01 August 2006

Targeted overexpression of transmembrane tumor necrosis factor provokes a concentric cardiac hypertrophic phenotype

scientific article published on 11 August 2003

The Emerging Role of Small Non-coding RNAs in the Failing Heart: Big Hopes for Small Molecules

scientific article published on 01 April 2011

The Heart Failure Society of America in 2020: a vision for the future

scientific article published on February 2012

The Heartmate Risk Score predicts morbidity and mortality in unselected left ventricular assist device recipients and risk stratifies INTERMACS class 1 patients

scientific article published on 11 March 2015

The Seattle Heart Failure Model: prediction of survival in heart failure

scientific article published on 13 March 2006

The adverse impact of diabetes mellitus on left ventricular remodeling and function in patients with severe aortic stenosis

scientific article

The cytoprotective effects of tumor necrosis factor are conveyed through tumor necrosis factor receptor-associated factor 2 in the heart

scientific article

The development of myocardial fibrosis in transgenic mice with targeted overexpression of tumor necrosis factor requires mast cell-fibroblast interactions

scientific article published on 24 October 2011

The emerging role of innate immunity in the heart and vascular system: for whom the cell tolls

scientific article published on April 2011

The emerging role of microRNAs in cardiac remodeling and heart failure

scientific article

The emerging role of statins in the treatment of heart failure

scientific article published on 20 December 2005

The first prognostic model for stroke and death in patients with systolic heart failure

scientific article published on 5 November 2015

The fractional shortening-velocity ratio: validation of a new echocardiographic Doppler method for identifying patients with significant aortic stenosis

scientific article published in June 1990

The metabolic syndrome and mortality in an ethnically diverse heart failure population

scientific article published on 27 May 2008

The relationship of the erythrocyte sedimentation rate to inflammatory cytokines and survival in patients with chronic heart failure treated with angiotensin-converting enzyme inhibitors

scientific article published on 01 August 2000

The role of innate immune responses in the heart in health and disease

scientific article published on January 2004

The vagus nerve and autonomic imbalance in heart failure: past, present, and future

scientific article published on March 2011

Therapeutic targeting of innate immunity in the failing heart

scientific article

Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury

scientific article published on 15 September 2006

Transforming growth factor-beta receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor

scientific article

Translational medicine: mitigating risks for investigators

scientific article published on May 1, 2013

Treatment of heart failure beyond practice guidelines. Role of cardiac remodeling

scientific article published on 05 September 2008

Tumor Necrosis Factor-α Is Persistently Expressed in Cardiac Allografts in the Absence of Histological or Clinical Evidence of Rejection

article

Tumor necrosis factor receptor-associated factor 2 mediates mitochondrial autophagy

scientific article

Tumor necrosis factor receptor-associated factor 2 signaling provokes adverse cardiac remodeling in the adult mammalian heart

scientific article published on 14 March 2013

Tumor necrosis factor-alpha and myocardial remodeling in progression of heart failure: a current perspective

scientific article

Tumor necrosis factor-induced signal transduction and left ventricular remodeling

scientific article

Update: shortness of breath

scientific article published in April 2014

Urinary Proteomics and Outcomes in Heart Failure With Preserved Ejection Fraction

scientific article published in 2024

Use of biomarkers in the management of heart failure: are we there yet?

scientific article published in March 2003

Vagal nerve stimulation for heart failure: new pieces to the puzzle?

scientific article published in February 2015

Warfarin and Aspirin in Patients with Heart Failure and Sinus Rhythm

scientific article published on 02 May 2012

Xanthine oxidase inhibition for hyperuricemic heart failure patients: design and rationale of the EXACT-HF study

scientific article published on July 2013