List of works - Jonathan Harris

An androgen receptor mutation in the MDA-MB-453 cell line model of molecular apocrine breast cancer compromises receptor activity

scientific article

Characterization of ENU-induced Mutations in Red Blood Cell Structural Proteins

scientific article

Characterization of the retinoid orphan-related receptor-alpha coactivator binding interface: a structural basis for ligand-independent transcription

scientific article published in May 2002

Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1

scientific article published on 04 April 2019

Decreased androgen receptor levels and receptor function in breast cancer contribute to the failure of response to medroxyprogesterone acetate.

scientific article

Decreased expression of the glutathione S-transferases alpha and pi genes in human renal cell carcinoma

scientific article published on 01 December 1990

Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics

scientific article

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition.

scientific article published on 18 May 2015

Epitope map for a growth hormone receptor agonist monoclonal antibody, MAb 263.

scientific article

Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors

scientific article published on 19 February 2016

Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype.

scientific article published on 21 October 2009

Hormone status selects for spontaneous somatic androgen receptor variants that demonstrate specific ligand and cofactor dependent activities in autochthonous prostate cancer.

scientific article

Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits

scientific article

Improving the Selectivity of Engineered Protease Inhibitors: Optimizing the P2 Prime Residue Using a Versatile Cyclic Peptide Library

scientific article published on 22 September 2015

Inhibitory GH receptor extracellular domain monoclonal antibodies: three-dimensional epitope mapping

scientific article published on 11 October 2011

Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs

scientific article published on 14 June 2017

Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network

scientific article (publication date: 27 April 2011)

Mechanism-based selection of a potent kallikrein-related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI-1

scientific article published on 01 September 2013

Molecular and structural basis of androgen receptor responses to dihydrotestosterone, medroxyprogesterone acetate and Δ(4)-tibolone.

scientific article published on 14 November 2013

Mutation of the androgen receptor causes oncogenic transformation of the prostate

scientific article

Natural and engineered plasmin inhibitors: applications and design strategies.

scientific article published on 11 January 2012

Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14.

scientific article

PSA/KLK3 AREI promoter polymorphism alters androgen receptor binding and is associated with prostate cancer susceptibility.

scientific article published on 6 December 2006

Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment

scientific article

Plasmin substrate binding site cooperativity guides the design of potent peptide aldehyde inhibitors.

scientific article

Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif

scientific article published in PLoS ONE

Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin- Using Oriented Peptide Library Screening

scientific article

Proteases and proteomics: cutting to the core of human skin pathologies

scientific article published on 13 April 2014

Proteases: common culprits in human skin disorders

scientific article published on 28 December 2013

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.

scientific article

Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum

scientific article published on 30 September 2016

Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells

scientific article published on 30 April 2012

Structural and functional consequences of glutamine tract variation in the androgen receptor.

scientific article

Structure-function analysis of the Rev-erbA and RVR ligand-binding domains reveals a large hydrophobic surface that mediates corepressor binding and a ligand cavity occupied by side chains

scientific article published on 01 May 2000

Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target

scientific article published on 01 April 1999

Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold

scientific article published on 19 July 2016

Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4.

scientific article

The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine

scientific journal article

The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment

scientific article

The isolation and characterization of the major glutathione S-transferase from the squid Loligo vulgaris

scientific article published on 01 January 1991

The temperature activated HtrA protease from pathogen Chlamydia trachomatis acts as both a chaperone and protease at 37 degrees C.

scientific article published on 26 June 2007

Whole-genome landscape of pancreatic neuroendocrine tumours.

scientific article published on 15 February 2017

List of works by Jonathan Harris

An androgen receptor mutation in the MDA-MB-453 cell line model of molecular apocrine breast cancer compromises receptor activity

Characterization of ENU-induced Mutations in Red Blood Cell Structural Proteins

Characterization of the retinoid orphan-related receptor-alpha coactivator binding interface: a structural basis for ligand-independent transcription

Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1

Decreased androgen receptor levels and receptor function in breast cancer contribute to the failure of response to medroxyprogesterone acetate.

Decreased expression of the glutathione S-transferases alpha and pi genes in human renal cell carcinoma

Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition.

Epitope map for a growth hormone receptor agonist monoclonal antibody, MAb 263.

Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors

Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype.

Hormone status selects for spontaneous somatic androgen receptor variants that demonstrate specific ligand and cofactor dependent activities in autochthonous prostate cancer.

Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits

Improving the Selectivity of Engineered Protease Inhibitors: Optimizing the P2 Prime Residue Using a Versatile Cyclic Peptide Library

Inhibitory GH receptor extracellular domain monoclonal antibodies: three-dimensional epitope mapping

Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs

Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network

Mechanism-based selection of a potent kallikrein-related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI-1

Molecular and structural basis of androgen receptor responses to dihydrotestosterone, medroxyprogesterone acetate and Δ(4)-tibolone.

Mutation of the androgen receptor causes oncogenic transformation of the prostate

Natural and engineered plasmin inhibitors: applications and design strategies.

Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14.

PSA/KLK3 AREI promoter polymorphism alters androgen receptor binding and is associated with prostate cancer susceptibility.

Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment

Plasmin substrate binding site cooperativity guides the design of potent peptide aldehyde inhibitors.

Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif

Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin- Using Oriented Peptide Library Screening

Proteases and proteomics: cutting to the core of human skin pathologies

Proteases: common culprits in human skin disorders

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.

Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum

Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells

Structural and functional consequences of glutamine tract variation in the androgen receptor.

Structure-function analysis of the Rev-erbA and RVR ligand-binding domains reveals a large hydrophobic surface that mediates corepressor binding and a ligand cavity occupied by side chains

Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target

Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold

Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4.

The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine

The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment

The isolation and characterization of the major glutathione S-transferase from the squid Loligo vulgaris

The temperature activated HtrA protease from pathogen Chlamydia trachomatis acts as both a chaperone and protease at 37 degrees C.

Whole-genome landscape of pancreatic neuroendocrine tumours.