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List of works by Sharyn D. Baker

A Metabolomics Approach for Predicting OATP1B-Type Transporter-Mediated Drug–Drug Interaction Liabilities

scientific article published in 2022

A Phase I study of the oral antimetabolite, CS-682, administered once daily 5 days per week in patients with refractory solid tumor malignancies

scientific article published on 01 November 2006

A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML

scientific article published on 16 May 2019

A liquid chromatography/tandem mass spectrometry assay to quantitate MS-275 in human plasma.

scientific article published on 12 September 2006

A method for determination of dimethyl benzoylphenyl urea (BPU) in human plasma by using LC/UV.

scientific article

A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias

scientific article

A phase 1 study of the CXCR4 antagonist plerixafor in combination with high-dose cytarabine and etoposide in children with relapsed or refractory acute leukemias or myelodysplastic syndrome: A Pediatric Oncology Experimental Therapeutics Investigato

scientific article published on 14 April 2017

A phase I and pharmacologic study of DMP 840 administered by 24-hour infusion

scientific article

A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors

scientific article

A phase I evaluation of multitargeted antifolate (MTA, LY231514), administered every 21 days, utilizing the modified continual reassessment method for dose escalation.

scientific article

A phosphotyrosine switch regulates organic cation transporters ⬇️

scientific article published on 16 March 2016

A rapid and sensitive method for determination of dimethyl benzoylphenyl urea in human plasma by using LC/MS/MS.

scientific article published in November 2003

A rapid and sensitive method for determination of sorafenib in human plasma using a liquid chromatography/tandem mass spectrometry assay

scientific article published on 23 June 2006

ABCC4 Is a Determinant of Cytarabine-Induced Cytotoxicity and Myelosuppression.

scientific article published on 04 February 2016

Activated pregnenolone X-receptor is a target for ketoconazole and its analogs.

scientific article published on April 2007

Activity of the Multikinase Inhibitor Sorafenib in Combination With Cytarabine in Acute Myeloid Leukemia ⬇️

scientific article published on April 12, 2011

Alternative formulations of sorafenib for use in children ⬇️

scientific article published on June 20, 2013

An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors.

scientific article published in December 2004

Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients.

scientific article published on 29 March 2007

Binding of gefitinib, an inhibitor of epidermal growth factor receptor-tyrosine kinase, to plasma proteins and blood cells: in vitro and in cancer patients

scientific article published in July 2006

CREBBP mutations in relapsed acute lymphoblastic leukaemia

scientific article

CYP3A phenotyping approach to predict systemic exposure to EGFR tyrosine kinase inhibitors

scientific article published on 01 December 2006

Castration-dependent pharmacokinetics of docetaxel in patients with prostate cancer

scientific article

Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1).

scientific article published on 18 December 2013

Cerebrospinal fluid pharmacokinetics and penetration of continuous infusion topotecan in children with central nervous system tumors

scientific article published in January 1996

Characterization of Topotecan-Mediated Redistribution of DNA Topoisomerase I by Digital Imaging Microscopy ⬇️

scientific article published on June 15, 1998

Clinical pharmacodynamics of continuous infusion topotecan in children: systemic exposure predicts hematologic toxicity

scientific article published on 01 September 1994

Clinical pharmacokinetics of docetaxel : recent developments

scientific article

Clinical pharmacokinetics of unbound docetaxel: role of polysorbate 80 and serum proteins

scientific article published in October 2003

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

scientific article published in Nature Communications

Clinical significance of in vivo cytarabine-induced gene expression signature in AML.

scientific article published on 14 September 2015

Comparative pharmacokinetics of weekly and every-three-weeks docetaxel.

scientific article

Comparison of antitumor effects of multitargeted tyrosine kinase inhibitors in acute myelogenous leukemia

scientific article

Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models

scientific article

Contribution of ABCC4-mediated gastric transport to the absorption and efficacy of dasatinib

scientific article published on 21 June 2013

Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide

scientific article published on 22 January 2013

Corrigendum to "Quantification of 5-azacytidine in plasma by electrospray tandem mass spectrometry coupled with high-performance liquid chromatography" [J. Chromatogr. B 813(1) (2004) 81-88]

scientific article published on 25 March 2016

Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia

scientific article published on 17 September 2013

Design, synthesis and evaluation of anti-CD123 antibody drug conjugates

scientific article published on 17 September 2016

Determination of the docetaxel vehicle, polysorbate 80, in patient samples by liquid chromatography-tandem mass spectrometry

scientific article published in June 2002

Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes.

scientific article published in June 2007

Differentiation therapy in poor risk myeloid malignancies: Results of a dose finding study of the combination bryostatin-1 and GM-CSF.

scientific article

Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia.

scientific article

Disposition of polyoxyethylated excipients in humans: implications for drug safety and formulation approaches

scientific article published on 01 November 2003

Distribution of paclitaxel in plasma and cerebrospinal fluid

scientific article published in June 2003

Docetaxel metabolism is not altered by imatinib: findings from an early phase study in metastatic breast cancer ⬇️

scientific article published on February 25, 2011

Dose banding as an alternative to body surface area-based dosing of chemotherapeutic agents

scientific article

Ductal access for prevention and therapy of mammary tumors

scientific article published in January 2006

E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia

scientific article

Effect of ABCC2 (MRP2) transport function on erythromycin metabolism

scientific article published on 30 March 2011

Effect of common CYP3A4 and CYP3A5 variants on the pharmacokinetics of the cytochrome P450 3A phenotyping probe midazolam in cancer patients

scientific article published in October 2005

Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan

scientific article published in November 2005

Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia

scientific article

Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia.

scientific article

Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia

scientific article published in May 1996

Evaluation of alternate size descriptors for dose calculation of anticancer drugs in the obese

scientific article

Evaluation of artemisinins for the treatment of acute myeloid leukemia.

scientific article published on 28 April 2016

Factors affecting cytochrome P-450 3A activity in cancer patients.

scientific article published in December 2004

Factors affecting pharmacokinetic variability following doxorubicin and docetaxel-based therapy.

scientific article

Germline polymorphisms in EGFR and survival in patients with lung cancer receiving gefitinib

scientific article published on 22 August 2007

Gilteritinib Inhibits Glutamine Uptake and Utilization in <i>FLT3</i>-ITD-Positive AML

scientific article published on 13 September 2021

Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b.

scientific article published on 7 May 2015

High-dose topotecan with granulocyte-colony stimulating factor in fluoropyrimidine-refractory colorectal cancer: a phase II and pharmacodynamic study.

scientific article

Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia.

scientific article published on 11 December 2017

Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.

scientific article published on 8 July 2017

Identification of predictive markers of cytarabine response in AML by integrative analysis of gene-expression profiles with multiple phenotypes.

scientific article

In vitro and in vivo clinical pharmacology of dimethyl benzoylphenylurea, a novel oral tubulin-interactive agent

scientific article published in December 2005

Influence of CYP3A4 inhibition on the steady-state pharmacokinetics of imatinib

scientific article

Influence of OATP1B1 Function on the Disposition of Sorafenib-β-D-Glucuronide

scientific article

Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel

scientific article

Influence of smoking on the pharmacokinetics and toxicity profiles of taxane therapy

scientific article published on 29 May 2012

Influence of solute carriers on the pharmacokinetics of CYP3A4 probes.

scientific article published on 28 May 2008

Inherited variation in OATP1B1 is associated with treatment outcome in acute myeloid leukemia.

scientific article published on 10 December 2015

Inhibition of OATP1B1 by tyrosine kinase inhibitors: in vitro-in vivo correlations.

scientific article published on 07 January 2014

Inhibition of OCTN2-mediated transport of carnitine by etoposide

scientific article

Integrating Clinical Pharmacology Concepts in Individualized Therapy With Tyrosine Kinase Inhibitors

scientific article published on March 1, 2013

Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators

scientific article published on 09 September 2021

Intentional Modulation of Ibrutinib Pharmacokinetics through CYP3A Inhibition

scientific article published on 09 November 2021

Interaction of imatinib with human organic ion carriers

scientific article

Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters

scientific article published on 22 September 2009

Marginal increase of sunitinib exposure by grapefruit juice

scientific article

Modulation of erlotinib pharmacokinetics in mice by a novel cytochrome P450 3A4 inhibitor, BAS 100.

scientific article published on 6 May 2008

Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death

scientific article

OATP1B1 Polymorphism as a Determinant of Erythromycin Disposition ⬇️

scientific article published on September 19, 2012

OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues

scientific article published on 16 February 2017

Ontogeny and sorafenib metabolism

scientific article

Oral sodium phenylbutyrate in patients with recurrent malignant gliomas: a dose escalation and pharmacologic study

scientific article published on April 2005

Paclitaxel repackaged in an albumin-stabilized nanoparticle: handy or just a dandy?

scientific article published on 01 November 2005

Palmar-plantar erythrodysesthesia syndrome following treatment with high-dose methotrexate or high-dose cytarabine

scientific article published on 11 May 2017

Panobinostat enhances cytarabine and daunorubicin sensitivities in AML cells through suppressing the expression of BRCA1, CHK1, and Rad51

scientific article (publication date: 2013)

Pharmacodynamic-guided modified continuous reassessment method-based, dose-finding study of rapamycin in adult patients with solid tumors

scientific article published on September 2008

Pharmacogenetic pathway analysis of docetaxel elimination.

scientific article

Pharmacogenetics of ABCG2 and adverse reactions to gefitinib

scientific article published on 01 December 2006

Pharmacokinetic and safety study of weekly irinotecan and oral capecitabine in patients with advanced solid cancers

scientific article published on 30 December 2006

Pharmacokinetic considerations for new targeted therapies.

scientific article published on 17 December 2008

Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase

scientific article published on 01 December 1996

Pharmacokinetics and toxicity of weekly docetaxel in older patients

scientific article published on October 2006

Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies.

scientific article published on 25 April 2005

Pharmacology of fluorinated pyrimidines: eniluracil

scientific article

Phase I and clinical pharmacology study of bevacizumab, sorafenib, and low-dose cyclophosphamide in children and young adults with refractory/recurrent solid tumors.

scientific article published on 8 November 2012

Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors

scientific article published on 12 April 2007

Phase I and pharmacokinetic study of irofulven, a novel mushroom-derived cytotoxin, administered for five consecutive days every four weeks in patients with advanced solid malignancies.

scientific article

Phase I and pharmacokinetic study of novel L-nucleoside analog troxacitabine given as a 30-minute infusion every 21 days

scientific article

Phase I and pharmacokinetic study of pemetrexed administered every 3 weeks to advanced cancer patients with normal and impaired renal function

scientific article

Phase I and pharmacokinetic study of the water-soluble dolastatin 15 analog LU103793 in patients with advanced solid malignancies

scientific article published on 01 August 1998

Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia

scientific article

Phase I study of ON 01910.Na, a novel modulator of the Polo-like kinase 1 pathway, in adult patients with solid tumors.

scientific article published on 27 October 2008

Phase I study of continuous weekly dosing of dimethylamino benzoylphenylurea (BPU) in patients with solid tumours.

scientific article published on 3 November 2006

Phase I trial of bortezomib in combination with docetaxel in patients with advanced solid tumors

scientific article

Phase I trial of paclitaxel and etoposide for recurrent ovarian carcinoma: a Gynecologic Oncology Group Study

scientific article published on 01 December 2000

Phase I trial, pharmacokinetics, and pharmacodynamics of vandetanib and dasatinib in children with newly diagnosed diffuse intrinsic pontine glioma

scientific article published on 27 March 2013

Phase II evaluation of docetaxel plus exisulind in patients with androgen independent prostate carcinoma.

scientific article published in August 2006

Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia

scientific article published in February 2002

Phase II trial of docetaxel with rapid androgen cycling for progressive noncastrate prostate cancer

scientific article

Phase II, randomized, placebo-controlled trial of neoadjuvant celecoxib in men with clinically localized prostate cancer: evaluation of drug-specific biomarkers

scientific article

Population pharmacokinetic model for docetaxel in patients with varying degrees of liver function: incorporating cytochrome P4503A activity measurements

scientific article

Population pharmacokinetic model for topotecan derived from phase I clinical trials

scientific article published on 01 June 2000

Population pharmacokinetic-pharmacodynamic model of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid in cancer patients.

scientific article published in April 2008

Population pharmacokinetics of troxacitabine, a novel dioxolane nucleoside analogue

scientific article published on 01 April 2006

Predicting vinorelbine disposition and toxicity: does BSA provide more than a "bad statistical association"?

scientific article published on 01 May 2006

Prospective evaluation of the pharmacokinetics and toxicity profile of docetaxel in the elderly.

scientific article

Quantification of 5-azacytidine in plasma by electrospray tandem mass spectrometry coupled with high-performance liquid chromatography.

scientific article published in December 2004

Quantification of sunitinib in human plasma by high-performance liquid chromatography-tandem mass spectrometry.

scientific article published on 12 September 2008

Quantitation of sorafenib and its active metabolite sorafenib N-oxide in human plasma by liquid chromatography-tandem mass spectrometry

scientific article

Role of equilibrative nucleoside transporter 1 (ENT1) in the disposition of cytarabine in mice

scientific article published on 02 December 2019

Sequences of topotecan and cisplatin: phase I, pharmacologic, and in vitro studies to examine sequence dependence

scientific article

Should anticancer drug doses be adjusted in the obese patient?

scientific article published on 01 March 1995

Sorafenib metabolism, transport, and enterohepatic recycling: physiologically based modeling and simulation in mice.

scientific article published on 6 April 2016

Specific method for determination of OSI-774 and its metabolite OSI-420 in human plasma by using liquid chromatography-tandem mass spectrometry

scientific article published in August 2003

Stability of sunitinib in oral suspension.

scientific article published on 24 June 2008

Temozolomide in patients with advanced cancer: phase I and pharmacokinetic study

scientific article

The genomic landscape of hypodiploid acute lymphoblastic leukemia

scientific article published on 20 January 2013

Total and active rabbit antithymocyte globulin (rATG;Thymoglobulin) pharmacokinetics in pediatric patients undergoing unrelated donor bone marrow transplantation

scientific article published on February 2009

Transcriptome profiling of patient derived xenograft models established from pediatric acute myeloid leukemia patients confirm maintenance of FLT3-ITD mutation

scientific article published on June 2016

Troxacitabine in patients with refractory leukemia

scientific article published in August 2002

Troxacitabine, an L-stereoisomeric nucleoside analog, on a five-times-daily schedule: a phase I and pharmacokinetic study in patients with advanced solid malignancies

scientific article

Tumor targeting by conjugation of DHA to paclitaxel

scientific article published in July 2001

Two drug interaction studies evaluating the pharmacokinetics and toxicity of pemetrexed when coadministered with aspirin or Ibuprofen in patients with advanced cancer

scientific article (publication date: 15 January 2006)

Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate ABT-751, ABT-751 glucuronide, and ABT-751 sulfate in human plasma for clinical pharmacology studies

scientific article published on 09 June 2006

Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate dimethyl benzoylphenylurea (BPU) and its five metabolites in human plasma and urine for clinical pharmacology studies.

scientific article

Validation and implementation of a method for determination of bryostatin 1 in human plasma by using liquid chromatography/tandem mass spectrometry.

scientific article published in February 2005

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