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List of works by Hans Vasen

8q23.3 and 11q23.1 as modifying loci influencing the risk for CRC in Lynch syndrome.

scientific article published on 14 December 2011

A cell-free assay for the functional analysis of variants of the mismatch repair protein MLH1.

scientific article published in March 2010

A cost-effectiveness analysis of colorectal screening of hereditary nonpolyposis colorectal carcinoma gene carriers

scientific article published on 01 May 1998

A cost‐effectiveness analysis of colorectal screening for hereditary nonpolyposis colorectal carcinoma gene carriers

article

A genome wide linkage search for breast cancer susceptibility genes

scientific article published on July 2006

A hundred years of Lynch syndrome research (1913-2013).

scientific article published in June 2013

A nation-wide study comparing sporadic and familial adenomatous polyposis-related desmoid-type fibromatoses.

scientific article

A new deletion polymorphism at D5S71 raises the linkage information on adenomatous polyposis coli: implications for presymptomatic diagnosis.

scientific article published in February 1991

A new hereditary colorectal cancer network in the Middle East and eastern mediterranean countries to improve care for high-risk families

scientific article

A pooled analysis of the outcome of prospective colonoscopic surveillance for familial colorectal cancer

scientific article published on 29 August 2013

A procedure for the detection of linkage with high density SNP arrays in a large pedigree with colorectal cancer

scientific article published on 12 January 2007

A prospective study on predictive factors linked to the presence of BRCA1 and BRCA2 mutations in breast cancer patients

scientific article published on 01 July 2005

A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis

scientific article

A thirty-year follow-up surveillance study for neoplasia of a dutch ulcerative colitis cohort

scientific article published on 28 November 2013

APC mutation in the alternatively spliced region of exon 9 associated with late onset familial adenomatous polyposis.

scientific article

APC mutations are associated with increased bone mineral density in patients with familial adenomatous polyposis

scientific article published on 18 June 2010

AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study

scientific article published on July 2007

Addition of a 161-SNP polygenic risk score to family history-based risk prediction: impact on clinical management in non-BRCA1/2 breast cancer families

scientific article published on 11 June 2019

Age at diagnosis as an indicator of eligibility for BRCA1 DNA testing in familial breast cancer

scientific article published on 01 May 1995

An Evidence-Based Review on Surveillance for Lynch Syndrome

article

An Overview of the Lynch Syndrome (Hereditary Non-polyposis Colorectal Cancer)

An alternative to prophylactic colectomy for colon cancer prevention in HNPCC syndrome.

scientific article published in October 2005

Analysis of MUTYH Genotypes and Colorectal Phenotypes in Patients With MUTYH-Associated Polyposis

scientific article published on 30 October 2008

Application of a Serum Protein Signature for Pancreatic Cancer to Separate Cases from Controls in a Pancreatic Surveillance Cohort.

scientific article

Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome

scientific article published on 08 January 2020

Attitudes toward genetic testing in childhood and reproductive decision-making for familial adenomatous polyposis.

scientific article

Author reply

BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients

scientific article

Bannayan-Riley-Ruvalcaba syndrome: further delineation of the phenotype and management of PTEN mutation-positive cases.

scientific article published on January 2003

Benefit of Surveillance for Pancreatic Cancer in High-Risk Individuals: Outcome of Long-Term Prospective Follow-Up Studies From Three European Expert Centers

scientific article published on 25 April 2016

Body mass index increases risk of colorectal adenomas in men with Lynch syndrome: the GEOLynch cohort study

scientific article published on 23 August 2010

Body weight and risk of breast cancer in BRCA1/2 mutation carriers ⬇️

scientific article published on August 21, 2010

CHEK2 1100delC Is a Susceptibility Allele for HNPCC-Related Colorectal Cancer

scientific article published on 01 August 2008

CM-Score: a validated scoring system to predict CDKN2A germline mutations in melanoma families from Northern Europe

scientific article published on 16 April 2018

Can the identification of high risk groups increase the effectiveness of colon cancer screening programmes?

scientific article

Cancer Risks for PMS2-Associated Lynch Syndrome

scientific article published on 30 August 2018

Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database

scientific article published on 9 December 2015

Cancer occurrence during follow-up of the CAPP2 study -aspirin use for up to four years significantly reduces Lynch syndrome cancers for up to several years after completion of therapy.

scientific article published on 25 May 2010

Cancer risk and genotype-phenotype correlations in PTEN hamartoma tumor syndrome

scientific article published in March 2014

Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

scientific article published on 28 July 2017

Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis.

scientific article

Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance

scientific article

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

scientific article published on 24 July 2019

Cancer risks in BRCA2 families: estimates for sites other than breast and ovary.

scientific article published in September 2005

Cancer: Lynch syndrome--how should colorectal cancer be managed?

scientific article published in April 2011

Characteristics of Lynch syndrome associated ovarian cancer

scientific article published on 05 June 2018

Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma. International Collaborative Group on HNPCC.

scientific article published in July 1998

Characterization of Familial Non-BRCA1/2 Breast Tumors by Loss of Heterozygosity and Immunophenotyping

scientific article published on 01 March 2006

Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.

scientific article published on 25 September 2008

Clinical Findings with Implications for Genetic Testing in Families with Clustering of Colorectal Cancer

article by Juul T. Wijnen et al published 20 August 1998 in The New England Journal of Medicine

Clinical Utility Gene Card for: Familial adenomatous polyposis (FAP) and attenuated FAP (AFAP)--update 2014.

scientific article published on 24 September 2014

Clinical and histologic characteristics of malignant melanoma in families with a germline mutation in CDKN2A.

scientific article published on 12 May 2011

Clinical evidence for an association between familial adenomatous polyposis and type II diabetes

scientific article

Clinical heterogeneity of familial colorectal cancer and its influence on screening protocols.

scientific article

Clinical heterogeneity of hereditary breast cancer and its impact on screening protocols: The dutch experience on 24 families under surveillance

scientific article published on 01 January 1993

Clinical management of hereditary colorectal cancer syndromes

scientific article published on 13 January 2015

Clinical utility gene card for: familial adenomatous polyposis (FAP) and attenuated FAP (AFAP).

scientific article published on 2 February 2011

Close linkage of a highly polymorphic marker (D5S37) to familial adenomatous polyposis (FAP) and confirmation of FAP localization on chromosome 5q21-q22.

scientific article

Colectomy and ileorectal anastomosis is still an option for selected patients with familial adenomatous polyposis

scientific article

Colonoscopy in Lynch syndrome: the need for a new quality score.

scientific article

Colorectal cancer and family history.

scientific article

Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report

scientific article published on 10 October 2017

Colorectal cancer risk in HNPCC families: Development during lifetime and in successive generations

article

Colorectal cancer risk in HNPCC families: development during lifetime and in successive generations. National Collaborative Group on HNPCC

scientific article published on 01 July 1997

Colorectal cancer risk variants at 8q23.3 and 11q23.1 are associated with disease phenotype in APC mutation carriers.

scientific article

Colorectal cancer risk variants on 11q23 and 15q13 are associated with unexplained adenomatous polyposis

scientific article

Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas

scientific article published on 15 June 2009

Colorectal surveillance in Lynch syndrome families.

scientific article published on June 2013

Combined analysis of three lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers

scientific article published on 11 October 2012

Comprehensive genetic analysis of seven large families with mismatch repair proficient colorectal cancer

article

Consequences of CT colonography in stenosing colorectal cancer

scientific article published on 25 October 2016

Consequences of testing for mismatch repair deficiency of colorectal cancer in clinical practice

scientific article published on 21 November 2017

Constitutional mismatch repair deficiency as a differential diagnosis of neurofibromatosis type 1: consensus guidelines for testing a child without malignancy

scientific article published on 10 November 2018

Constitutional or biallelic? Settling on a name for a recessively inherited cancer susceptibility syndrome.

scientific article

Conventional and tissue microarray immunohistochemical expression analysis of mismatch repair in hereditary colorectal tumors

scientific article published on February 2003

Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

scientific article published on 20 July 2020

Correction: Dietary Supplement Use and Colorectal Adenoma Risk in Individuals with Lynch Syndrome: The GEOLynch Cohort Study.

scientific article

Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): a review of the literature.

scientific article published on 24 October 2006

Correspondence re: A. Müller et al., Exclusion of breast cancer as an integral tumor of hereditary nonpolyposis colorectal cancer. Cancer Res., 62: 1014-1019, 2002

scientific article published on 01 March 2003

Cost-utility analysis of genetic screening in families of patients with germline MUTYH mutations

scientific article

Cumulative risk of developing polyps or malignancy at the ileal pouch—anal anastomosis in patients with familial adenomatous polyposis

scientific article published on 01 May 1999

Decision analysis in the management of duodenal adenomatosis in familial adenomatous polyposis.

scientific article

Decision analysis in the surgical treatment of colorectal cancer due to a mismatch repair gene defect

scientific article published on December 2003

Declining detection rates for APC and biallelic MUTYH variants in polyposis patients, implications for DNA testing policy

scientific article published on 16 September 2019

Decrease in mortality in Lynch syndrome families because of surveillance.

scientific article published in March 2006

Desmoid tumors in a dutch cohort of patients with familial adenomatous polyposis

scientific article

Desmoid tumors in patients with familial adenomatous polyposis

scientific article published in July 2002

Detection of pancreatic cancer using serum protein profiling.

scientific article

Diagnosis of Constitutional Mismatch Repair-Deficiency Syndrome Based on Microsatellite Instability and Lymphocyte Tolerance to Methylating Agents

scientific article published on 24 June 2015

Diagnostic approach and management of Lynch syndrome (hereditary nonpolyposis colorectal carcinoma): a guide for clinicians

scientific article published on July 2006

Diagnostic criteria for constitutional mismatch repair deficiency syndrome: suggestions of the European consortium 'care for CMMRD' (C4CMMRD).

scientific article published on 15 April 2014

Diagnostic value of targeted next-generation sequencing in patients with suspected pancreatic or periampullary cancer.

scientific article published on 3 August 2017

Diet quality and colorectal tumor risk in persons with Lynch syndrome

scientific article published on 15 September 2020

Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome: the GEOLynch cohort study

scientific article published on 12 June 2014

Dietary Supplement Use and Colorectal Adenoma Risk in Individuals with Lynch Syndrome: The GEOLynch Cohort Study

scientific article

Dietary patterns and colorectal adenomas in Lynch syndrome: the GEOLynch cohort study

scientific article published on 17 December 2012

Dilatation of the main pancreatic duct as first manifestation of small pancreatic ductal adenocarcinomas detected in a hereditary pancreatic cancer surveillance program

scientific article published on 22 March 2019

Dilemmas in the management of screen-detected lesions in patients at high risk for pancreatic cancer

scientific article published on 12 July 2016

Disease expression in juvenile polyposis syndrome: a retrospective survey on a cohort of 221 European patients and comparison with a literature-derived cohort of 473 SMAD4/BMPR1A pathogenic variant carriers

scientific article published on 13 May 2020

Do lifestyle factors influence colorectal cancer risk in Lynch syndrome?

scientific article published on June 2013

Double balloon endoscopy for detection of small-bowel adenomas in familial adenomatous polyposis after pancreaticoduodenectomy according to Whipple

scientific article published on 20 August 2008

Duodenal adenomatosis in familial adenomatous polyposis

scientific article published on 01 January 1995

Duodenal adenomatosis in familial adenomatous polyposis.

scientific article published on March 2004

Duodenal adenomatosis in familial adenomatous polyposis.

scientific article published in May 2004

Duodenal surveillance improves the prognosis after duodenal cancer in familial adenomatous polyposis

scientific article

EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer

scientific article (publication date: 2003)

Early detection of breast and ovarian cancer in families with BRCA mutations.

scientific article published on 11 January 2005

Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome

scientific article

Effectiveness and causes for failure of surveillance of CDKN2A-mutated melanoma families.

scientific article

Efficacy of early diagnosis and treatment in women with a family history of breast cancer. European Familial Breast Cancer Collaborative Group.

scientific article published on October 1999

Endometrial Cancer in Four Sisters: Report of a Kindred with Presumed Cancer Family Syndrome

scientific article published on 01 August 1994

Endoscopic full thickness resection for early colon cancer in Lynch syndrome.

scientific article published in July 2019

Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort

scientific article published on 20 October 2009

Environmental factors and colorectal tumor risk in individuals with hereditary nonpolyposis colorectal cancer.

scientific article published in June 2007

Equivalent Helicobacter pylori infection rates in Lynch syndrome mutation carriers with and without a first-degree relative with gastric cancer

scientific article published on 4 February 2016

Erratum to: A new hereditary colorectal cancer network in the Middle East and eastern Mediterranean countries to improve care for high-risk families.

scientific article

Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium

scientific article

Evaluation of management of desmoid tumours associated with familial adenomatous polyposis in Dutch patients.

scientific article

Evidence for accelerated colorectal adenoma–carcinoma progression inMUTYH-associated polyposis?

scientific article published on 16 August 2011

Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia

scientific article published on 25 July 2017

Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia.

scientific article published on 12 October 2017

Exome sequencing of germline DNA from non-BRCA1/2 familial breast cancer cases selected on the basis of aCGH tumor profiling

scientific article

Expanded extracolonic tumor spectrum in MUTYH-associated polyposis

scientific article

Experience of discharge from colonoscopy of mutation negative HNPCC family members.

scientific article published in May 2003

Extending the p16-Leiden tumour spectrum by respiratory tract tumours

scientific article

Extracolonic Manifestations of Familial Adenomatous Polyposis: Desmoid Tumours, and Upper Gastrointestinal Adenomas and Carcinomas ⬇️

scientific article published on January 1, 1998

Extracolonic cancer risk in Dutch patients with APC (adenomatous polyposis coli)-associated polyposis

scientific article published on 10 May 2017

Extracolonic cancer risk in patients with serrated polyposis syndrome and their first-degree relatives

scientific article published in December 2013

Familial Pancreatic Cancer: To Screen or not to Screen?

scientific article published on 17 December 2015

Familial adenomatous polyposis and its clinical surveillance.

scientific article published on April 1993

Familial adenomatous polyposis: from bedside to bench and vice versa. A tribute to the somatic cell geneticist P. Meera Khan.

scientific article

Familial and hereditary non-polyposis colorectal cancer: issues relevant for surgical practice

scientific article published on 01 January 1998

Familial endometrial cancer in female carriers of MSH6 germline mutations

scientific article (publication date: October 1999)

Family history, surgery, and APC mutation are risk factors for desmoid tumors in familial adenomatous polyposis: an international cohort study.

scientific article

Female fertility after colorectal surgery for familial adenomatous polyposis: a nationwide cross-sectional study

scientific article published in August 2010

From gene to disease; MutYH-associated polyposis coli (MAP)

scientific article published in December 2005

From gene to disease; from DNA 'mismatch' repair genes to hereditary non-polyposis colorectal carcinoma

scientific article published in April 2001

Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing.

scientific article published in August 1999

Genetic analysis of a breast-ovarian cancer family, with 7 cases of colorectal cancer linked toBRCA1, fails to support a role forBRCA1 in colorectal tumorigenesis

scientific article published on 01 December 2000

Genetic counseling in hereditary nonpolyposis colorectal cancer

scientific article published on 01 January 1996

Genetic testing in familial melanoma: uptake and implications.

scientific article published in August 2008

Genetic variant in the telomerase gene modifies cancer risk in Lynch syndrome

scientific article published on 5 September 2012

Genome-wide copy neutral LOH is infrequent in familial and sporadic microsatellite unstable carcinomas.

scientific article published on 15 April 2008

Genome-wide linkage scan in Dutch hereditary non-BRCA1/2 breast cancer families identifies 9q21-22 as a putative breast cancer susceptibility locus

scientific article published in November 2008

Genome-wide scanning for linkage in 56 Dutch breast cancer families selected for a minimal probability of being due to BRCA1 or BRCA2.

scientific article published on 17 June 2005

Genotype predicting phenotype in familial adenomatous polyposis: a practical application to the choice of surgery

scientific article

Genotype-phenotype correlations as a guide in the management of familial adenomatous polyposis.

scientific article published in March 2007

Genotype-phenotype correlations for pancreatic cancer risk in Dutch melanoma families with pathogenic CDKN2A variants

scientific article published on 01 June 2020

Genotype-phenotype correlations in 19 Dutch cases with APC gene deletions and a literature review.

scientific article published on 13 June 2007

Germ line mutations of mismatch repair genes in hereditary nonpolyposis colorectal cancer patients with small bowel cancer: International Society for Gastrointestinal Hereditary Tumours Collaborative Study

scientific article published in June 2006

Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis.

scientific article published in May 2007

Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli.

scientific article

Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer

scientific article

Guidelines for surveillance of individuals with constitutional mismatch repair-deficiency proposed by the European Consortium “Care for CMMR-D” (C4CMMR-D)

scientific article published on 20 February 2014

Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer).

scientific article published on 27 February 2007

Guidelines for the clinical management of familial adenomatous polyposis (FAP).

scientific article published on 14 January 2008

Health benefits and cost-effectiveness of primary genetic screening for Lynch syndrome in the general population.

scientific article

Health, life, and disability insurance and hereditary nonpolyposis colorectal cancer.

scientific article published in March 1998

Height and Colorectal and Endometrial Cancer Risk for Persons with Lynch Syndrome

scientific article published on 17 August 2020

Hereditary Colorectal Cancer

Hereditary Nonpolyposis Colorectal Cancer

scientific article published on 01 August 1994

Hereditary cancer registries improve the care of patients with a genetic predisposition to cancer: contributions from the Dutch Lynch syndrome registry

scientific article published on 14 March 2016

Hereditary medullary thyroid carcinoma

scientific article published on 01 January 1995

Hereditary nonpolyposis colorectal cancer: results of long-term surveillance in 50 families

scientific article published on 01 July 1995

Heterozygous mutations in PMS2 cause hereditary nonpolyposis colorectal carcinoma (Lynch syndrome).

scientific article published in February 2006

High Growth Rate of Pancreatic Ductal Adenocarcinoma inCDKN2A-p16-LeidenMutation Carriers

scientific article published on 10 July 2018

High detection rate of adenomas in familial colorectal cancer ⬇️

scientific article published on September 9, 2010

High frequency of copy-neutral LOH inMUTYH-associated polyposis carcinomas

scientific article published in September 2008

High risk of endometrial cancer in colorectal cancer kindred is pathognomonic for MMR-mutation carriers

scientific article published on 8 October 2008

High-resolution melting (HRM) re-analysis of a polyposis patients cohort reveals previously undetected heterozygous and mosaic APC gene mutations.

scientific article published on June 2015

History of the International Collaborative Group on Hereditary Non Polyposis Colorectal Cancer

scientific article published in January 2003

Identification and management of Lynch syndrome in the Middle East and North African countries: outcome of a survey in 12 countries

scientific article published on 24 October 2020

Identification of HNPCC by molecular analysis of colorectal and endometrial tumors.

scientific article

Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: results ofa pilot study

scientific article published on 16 June 2016

Identification of patients with (atypical) MUTYH-associated polyposis by KRAS2 c.34G > T prescreening followed by MUTYH hotspot analysis in formalin-fixed paraffin-embedded tissue.

scientific article published in January 2008

Ileorectal anastomosis is appropriate for a subset of patients with familial adenomatous polyposis

scientific article published on 01 December 2000

Improved overall survival after contralateral risk-reducing mastectomy in BRCA1/2 mutation carriers with a history of unilateral breast cancer: a prospective analysis

scientific article published on 8 July 2014

Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database

scientific article published on 3 June 2016

Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

scientific article published on 6 July 2017

Inclusion of malignant fibrous histiocytoma in the tumour spectrum associated with hereditary non-polyposis colorectal cancer

article

Increased MUTYH mutation frequency among Dutch families with breast cancer and colorectal cancer

scientific article published on 27 February 2010

Increased Risk of Cancer Other Than Melanoma in CDKN2A Founder Mutation (p16-Leiden)-Positive Melanoma Families

scientific article published on 01 November 2008

Increased colorectal cancer incidence in obligate carriers of heterozygous mutations in MUTYH.

scientific article published on 23 April 2009

Increased prevalence of Barrett's esophagus in patients with MUTYH-associated polyposis (MAP)

scientific article published on 01 April 2020

Increased prevalence of colonic adenomas in patients with acromegaly.

scientific article published in September 1994

Increased risk of colorectal neoplasia in asymptomatic liver-transplant recipients.

scientific article

Infiltration of Lynch Colorectal Cancers by Activated Immune Cells Associates with Early Staging of the Primary Tumor and Absence of Lymph Node Metastases

scientific article published on 18 January 2012

Inflammatory potential of the diet and colorectal tumor risk in persons with Lynch syndrome

scientific article

Informing one's family about genetic testing for hereditary non-polyposis colorectal cancer (HNPCC): a retrospective exploratory study

scientific article published in January 2005

Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers

scientific article published on 16 September 2019

Interval cancers in hereditary non-polyposis colorectal cancer (Lynch syndrome)

scientific article published on 01 May 1995

Is a colorectal neoplasm diagnosis a trigger to change dietary and other lifestyle habits for persons with Lynch syndrome? A prospective cohort study

scientific article published on 08 August 2020

Is breast cancer part of the tumor spectrum of hereditary nonpolyposis colorectal cancer?

scientific article published on June 2001

Is colorectal surveillance indicated in patients with PTEN mutations?

scientific article

Is surveillance of the small bowel indicated for Lynch syndrome families?

scientific article

Kluwer Academic Publishers: Familial Cancer

announcement of journal

Known susceptibility SNPs for sporadic prostate cancer show a similar association with “hereditary” prostate cancer

scientific article published on 05 January 2015

Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report

scientific article published on 28 February 2019

Limited resection of pancreatic cancer in high-risk patients can result in a second primary: Table 1

scientific article published on 02 April 2015

Long Term Follow-up of HNPCC Gene Mutation Carriers: Compliance with Screening and Satisfaction with Counseling and Screening Procedures

article

Long-term compliance with endoscopic surveillance for familial adenomatous polyposis

scientific article

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

scientific article published on 27 October 2011

Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

article

Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer.

scientific article published on 24 May 2013

Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans. ⬇️

scientific article

Low frequency of POLD1 and POLE exonuclease domain variants in patients with multiple colorectal polyps

scientific article published on 02 March 2019

Lynch syndrome caused by germline PMS2 mutations: delineating the cancer risk

scientific article published on 15 December 2014

MSH2 genomic deletions are a frequent cause of HNPCC

article

MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families.

scientific article

MUTYH-associated polyposis (MAP)

scientific article

MUTYH-associated polyposis carcinomas frequently lose HLA class I expression - a common event amongst DNA-repair-deficient colorectal cancers

scientific article published in September 2009

Magnetic resonance imaging surveillance detects early-stage pancreatic cancer in carriers of a p16-Leiden mutation

scientific article published in December 2010

Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16

scientific article published in February 1996

Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium

scientific article published on 31 October 2019

Massive gastric polyposis associated with a germline SMAD4 gene mutation

scientific article

Meat consumption and meat preparation in relation to colorectal adenomas among sporadic and HNPCC family patients in The Netherlands

scientific article published on 01 November 2002

Meat consumption and preparation, and genetic susceptibility in relation to colorectal adenomas

scientific article published on 01 March 1997

Microsatellite instability, immunohistochemistry, and additional PMS2 staining in suspected hereditary nonpolyposis colorectal cancer

scientific article published in February 2004

Molecular analysis of the APC gene in 105 Dutch kindreds with familial adenomatous polyposis: 67 germline mutations identified by DGGE, PTT, and southern analysis

article

Molecular analysis of the APC gene in 105 Dutch kindreds with familial adenomatous polyposis: 67 germline mutations identified by DGGE, PTT, and southern analysis

scientific article published on 01 January 1997

Molecular characterization of the spectrum of genomic deletions in the mismatch repair genesMSH2,MLH1,MSH6, andPMS2 responsible for hereditary nonpolyposis colorectal cancer (HNPCC)

article

Molecular genetic tests as a guide to surgical management of familial adenomatous polyposis

scientific article published on 01 August 1996

Molecular genetic tests in surgical management of familial adenomatous polyposis

scientific article published on 01 April 1998

Multiple endocrine neoplasia syndrome type 2: The value of screening and central registration

scientific article published on 01 November 1987

Multiple endocrine neoplasia syndromes

scientific article published on 01 January 1984

Mutation and association analyses of the candidate genes ESR1, ESR2, MAX, PCNA, and KAT2A in patients with unexplained MSH2-deficient tumors

article

Mutations associated with HNPCC predisposition -- Update of ICG-HNPCC/INSiGHT mutation database

scientific article

Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer

scientific article published in October 1997

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.

scientific article published in June 1999

No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies

scientific article published on 29 July 2018

No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in and : A Prospective Lynch Syndrome Database Study

scientific article

No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas

scientific article published in November 2000

Non-allelic heterogeneity of familial adenomatous polyposis.

scientific article

Nonpolypoid colorectal neoplasms: a challenge in endoscopic surveillance of patients with Lynch syndrome.

scientific article published on 25 February 2013

Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study

scientific article published on 17 August 2015

Occurrence of thyroid carcinoma in Dutch patients with familial adenomatous polyposis. An epidemiological study and report of new cases

scientific article published on 01 September 1998

One to 2-year surveillance intervals reduce risk of colorectal cancer in families with Lynch syndrome

scientific article published on 2 March 2010

Optimizing the timing of colorectal surgery in patients with familial adenomatous polyposis in clinical practice

scientific article published on 01 June 2019

Outcome of ovarian cancer after breast cancer in BRCA1 and BRCA2 mutation carriers

scientific article published on 18 October 2016

Ovarian cancer in Lynch syndrome; a systematic review.

scientific article

Ovarian metastases of colorectal and duodenal cancer in familial adenomatous polyposis

scientific article published in December 2012

Pancreatic cancer-associated gene polymorphisms in a nation-wide cohort of p16-Leiden germline mutation carriers; a case-control study

scientific article published on 26 June 2015

Pancreatic carcinoma in carriers of a specific 19 base pair deletion of CDKN2A/p16 (p16-leiden).

scientific article published on September 2003

Pheochromocytoma in multiple endocrine neoplasia type 2: European study

scientific article published on 01 October 1995

Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers

scientific article published on 13 August 2009

Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumours from HNPCC patients

article

Preface

Prevalence of adenomas among young individuals at average risk for colorectal cancer.

scientific article

Prevalence of small-bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

scientific article published on 10 September 2014

Progress in Genetic Testing, Classification, and Identification of Lynch Syndrome

scientific article published on 01 April 2005

Prospective results of surveillance colonoscopy in dominant familial colorectal cancer with and without Lynch syndrome

scientific article published in June 2006

Prospective risk of cancer and the influence of tobacco use in carriers of the p16-Leiden germline variant

scientific article

Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

scientific article published on 4 January 2018

Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition.

scientific article

Psychological distress and quality of life following positive fecal occult blood testing in colorectal cancer screening

scientific article published on 31 March 2020

Psychological distress and quality of life of partners of individuals with familial adenomatous polyposis.

scientific article

Psychological distress and use of psychosocial support in familial adenomatous polyposis.

scientific article published in March 2010

Psychosocial issues in genetic testing for familial adenomatous polyposis: a review of the literature.

scientific article published on August 2008

Quality colonoscopy and risk of interval cancer in Lynch syndrome

scientific article published on 16 July 2013

Quality of colonoscopy in Lynch syndrome

scientific article published on 24 October 2014

Quality of life after surgery for colon cancer in patients with Lynch syndrome: partial versus subtotal colectomy

scientific article

Quality of life after total colectomy with ileorectal anastomosis or proctocolectomy and ileal pouch-anal anastomosis for familial adenomatous polyposis

scientific article

Quantification of sequence exchange events between PMS2 and PMS2CL provides a basis for improved mutation scanning of Lynch syndrome patients

scientific article published in May 2010

Randomized Comparison of Surveillance Intervals in Familial Colorectal Cancer

scientific article published on 2 November 2015

Rapid detection of BRCA1 mutations by the protein truncation test

scientific article published on 01 June 1995

Rapid detection of translation-terminating mutations at the adenomatous polyposis coli (APC) gene by direct protein truncation test.

scientific article

Recommendations for the management of women with an increased genetic risk of gynaecological cancer

scientific article published in December 2002

Recommendations to improve identification of hereditary and familial colorectal cancer in Europe.

scientific article published on 18 September 2009

Rectal Cancer Risk in Hereditary Nonpolyposis Colorectal Cancer After Abdominal Colectomy

scientific article published on 01 February 1997

Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer ⬇️

scientific article

Refinement of screening for familial pancreatic cancer.

scientific article

Reply

Reply

Reply to V. Bonadona et al ⬇️

scientific article published on June 10, 2013

Reply to Win and Jenkins

scientific article published on 18 April 2013

Review article: The Lynch syndrome (hereditary nonpolyposis colorectal cancer).

scientific article published on December 2007

Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability ⬇️

scientific article

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts

scientific article published on 13 February 2013

Risk and epidemiological time trends of gastric cancer in Lynch syndrome carriers in the Netherlands

scientific article published on 10 November 2009

Risk of colorectal and endometrial cancer for carriers of mutations of the hMLH1 and hMSH2 gene: correction for ascertainment

scientific article

Risk of developing adenomas and carcinomas in the ileal pouch in patients with familial adenomatous polyposis

scientific article published on 10 October 2008

Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion ofp16 (p16-Leiden)

scientific article published on 01 September 2000

Risk of multiple pancreatic cancers in CDKN2A-p16-Leiden mutation carriers

scientific article published on 16 May 2018

Risk reducing mastectomy: outcomes in 10 European centres.

scientific article published on 7 November 2008

Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

scientific article published on 01 December 2020

Risks of Lynch syndrome cancers for MSH6 mutation carriers

scientific article

Risks of less common cancers in proven mutation carriers with lynch syndrome

scientific article published on 22 October 2012

Safety of endoscopic mucosal resection (EMR) of large non-pedunculated colorectal adenomas in the elderly.

scientific article published on 8 September 2017

Screening behavior of individuals at high risk for colorectal cancer

scientific article published on 01 February 2005

Screening for BRCA2 mutations in 81 Dutch breast-ovarian cancer families

scientific article published on January 2000

Screening for hereditary non-polyposis colorectal cancer: A study of 22 kindreds in The Netherlands

scientific article published on 01 March 1989

Screening for prostate cancer in Dutch hereditary prostate cancer families

scientific article published in February 2008

Screening for the multiple endocrine neoplasia syndrome type I. A study of 11 kindreds in The Netherlands

scientific article published on 01 December 1989

Screening in breast cancer families: is it useful?

scientific article published on June 1994

Screening of Individuals at High Risk for Pancreatic Cancer

scientific article published on 19 March 2019

Screening of families predisposed to cancer development in The Netherlands.

scientific article published in March 1990

Serum peptide signatures for pancreatic cancer based on mass spectrometry: a comparison to CA19-9 levels and routine imaging techniques.

scientific article

Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis

scientific article

Skin self-examination of persons from families with familial atypical multiple mole melanoma (FAMMM).

scientific article published on 20 November 2008

Small-bowel cancer in Lynch syndrome: is it time for surveillance?

scientific article published on September 2008

Smoking increases the risk for colorectal adenomas in patients with Lynch syndrome

scientific article published on 4 November 2011

Somatic APC mosaicism: an underestimated cause of polyposis coli.

scientific article published on 29 June 2007

Surgical management for advanced duodenal adenomatosis and duodenal cancer in Dutch patients with familial adenomatous polyposis: A nationwide retrospective cohort study

scientific article published on 21 January 2012

Surveillance colonoscopy practice in Lynch syndrome in the Netherlands: A nationwide survey.

scientific article published in September 2007

Surveillance for Hereditary Nonpolyposis Colorectal Cancer

scientific article published on 01 December 2002

Surveillance for familial melanoma: recommendations from a national centre of expertise

scientific article published on 01 May 2019

Surveillance for familial pancreatic cancer.

scientific article published on January 2003

Surveillance for hereditary cancer: does the benefit outweigh the psychological burden?--A systematic review.

scientific article published on 25 February 2012

Surveillance in hereditary nonpolyposis colorectal cancer

scientific article published on 01 January 1993

Surveillance of Second-Degree Relatives from Melanoma Families with a CDKN2A Germline Mutation

scientific article published on 29 July 2013

Survival after adjuvant 5-FU treatment for stage III colon cancer in hereditary nonpolyposis colorectal cancer.

scientific article published in April 2004

Survival analysis of endometrial carcinoma associated with hereditary nonpolyposis colorectal cancer

scientific article published on 01 November 2002

Survival in prospectively ascertained familial breast cancer: Analysis of a series stratified by tumour characteristics,BRCAmutations and oophorectomy

article

Survival in women with MMR mutations and ovarian cancer: a multicentre study in Lynch syndrome kindreds

scientific article published on 26 July 2009

Survival of MUTYH-associated polyposis patients with colorectal cancer and matched control colorectal cancer patients

scientific article

Survival of Patients with Ovarian Cancer due to a Mismatch Repair Defect

scientific article published on 01 January 2005

Suspected HNPCC and Amsterdam criteria II: evaluation of mutation detection rate, an international collaborative study

scientific article published in March 2002

Suspected hereditary nonpolyposis colorectal cancer

scientific article published on 01 June 1999

TGFBR1*6A may contribute to hereditary colorectal cancer

scientific article published in May 2005

Targeted next-generation sequencing of FNA-derived DNA in pancreatic cancer

scientific article published on 26 September 2016

Targeted prostate cancer screening in BRCA1 and BRCA2 mutation carriers: results from the initial screening round of the IMPACT study

scientific article

The "unnatural" history of colorectal cancer in Lynch syndrome: lessons from colonoscopy surveillance

scientific article published on 19 July 2020

The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype

scientific article

The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families

scientific article published on 01 December 2003

The International Collaborative Group on HNPCC

scientific article published on 01 July 1994

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

scientific article published on 01 May 1991

The Natural Course of Multiple Endocrine Neoplasia Type iib

scientific article published on 01 June 1992

The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer.

scientific article published in August 2001

The clinical phenotype of hereditary versus sporadic prostate cancer: HPC definition revisited

scientific article published on 14 March 2016

The effect of genotypes and parent of origin on cancer risk and age of cancer development in PMS2 mutation carriers

scientific article published on 25 June 2015

The epidemiology of endometrial cancer in hereditary nonpolyposis colorectal cancer

scientific article published on 01 July 1994

The establishment of a polyposis register.

scientific article

The familial dysplastic nevus syndrome. Natural history and the impact of screening on prognosis. A study of nine families in the Netherlands

scientific article published in February 1989

The frequency of a positive family history for colorectal cancer: a population-based study in the Netherlands

scientific article published on 01 November 2006

The importance of a large sample cohort for studies on modifier genes influencing disease severity in FAP patients

scientific article published on 29 December 2013

The importance of a well-structured pancreatic screening program for familial and hereditary pancreatic cancer

scientific article published on 4 December 2017

The majority of 22 Dutch high-risk breast cancer families are due to either BRCA1 or BRCA2

scientific article published on 01 January 1996

The natural history of a combined defect in MSH6 and MUTYH in a HNPCC family

scientific article published on 01 January 2007

The outcome of endometrial carcinoma surveillance by ultrasound scan in women at risk of hereditary nonpolyposis colorectal carcinoma and familial colorectal carcinoma

scientific article published on 01 March 2002

The protocol for a european double-blind trial of aspirin and resistant starch in familial adenomatous polyposis: The capp study

scientific article published on 01 July 1995

The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer.

scientific article published in June 1994

The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome.

scientific article published on July 2008

The role of mismatch repair gene defects in the development of adenomas in patients with HNPCC

scientific article published on 01 January 2004

The role of the prostate cancer gene 3 urine test in addition to serum prostate-specific antigen level in prostate cancer screening among breast cancer, early-onset gene mutation carriers

scientific article published on 5 March 2015

The tumour spectrum in hereditary non-polyposis colorectal cancer: A study of 24 kindreds in the netherlands

scientific article published on 01 July 1990

The value of screening and central registration of families with familial adenomatous polyposis. A study of 82 families in The Netherlands.

scientific article published in March 1990

Three germline mutations in the TP53 gene

scientific article published on 01 January 1997

Thyroid C-cell hyperplasia and micronodules in close relatives of MEN-2A patients: pitfalls in early diagnosis and reevaluation of criteria for surgery

scientific article published on 01 January 1987

Thyroid carcinoma as first manifestation of familial adenomatous polyposis.

scientific article published on September 1996

Transanal minimally invasive surgery (TAMIS) versus endoscopic submucosal dissection (ESD) for resection of non-pedunculated rectal lesions (TRIASSIC study): study protocol of a European multicenter randomised controlled trial

scientific article published on 13 July 2020

Transsphenoidal microsurgery as primary treatment in 25 acromegalic patients: results and follow-up ⬇️

scientific article published on February 1, 1988

Treatment of mesenteric desmoid tumours with the anti-oestrogenic agent toremifene: case histories and an overview of the literature.

scientific article

Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

scientific article

Urologists' and GPs' knowledge of hereditary prostate cancer is suboptimal for prostate cancer counseling: a nation-wide survey in The Netherlands

scientific article

Value-based healthcare in Lynch syndrome

scientific article published in June 2013

Variation in mutation spectrum partly explains regional differences in the breast cancer risk of female BRCA mutation carriers in the Netherlands

scientific article

Variation in precursor lesions of pancreatic cancer among high-risk groups

scientific article published on 21 November 2012

What is hereditary nonpolyposis colorectal cancer (HNPCC).

scientific article published on July 1994

What is the appropriate screening protocol in Lynch syndrome?

scientific article published on 7 July 2006

When should endoscopic screening in familial adenomatous polyposis be started?

scientific article published on 01 April 2000

Whole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients.

scientific article

Whole exome sequencing suggests much of non-BRCA1/BRCA2 familial breast cancer is due to moderate and low penetrance susceptibility alleles

scientific article

Worldwide survey among polyposis registries of surgical management of severe duodenal adenomatosis in familial adenomatous polyposis.

scientific article published in June 2003

[Characterisation of families with hereditary prostate cancer in the Netherlands]

scientific article published on 01 October 2002

[Desmoid tumour as indication of familial adenomatous polyposis].

scientific article

[Familial gastric cancer: diagnosis, treatment and periodic surveillance].

scientific article published on 01 January 2011

[Frequency of duodenal adenomas in patients with familial adenomatous polyposis].

scientific article published on 01 September 2001

[From gene to disease; the APC gene and familial adenomatous polyposis coli]

scientific article published on 01 October 2000

[Genetics of colorectal cancer. I. Non-polyposis and polyposis forms of hereditary colorectal cancer]

scientific article published on 01 June 1999

[Genetics of colorectal cancer. II. Hereditary background of sporadic and familial colorectal cancer]

scientific article published on 01 June 1999

[Hemolytic anemia associated with severe liver insufficiency as an initial symptom of Wilson's disease]

scientific article published on 01 November 1982

[Hereditary mutations in the p53 tumor suppressor gene; significance for clinical practice. National Work Group Hereditary Mamma Carcinoma]

scientific article published on 01 June 1996

[Hereditary prostate carcinoma. National Work Group Hereditary Urological tumors. Foundation Tracing Hereditary Tumors]

scientific article published on 01 May 1996

[Indications for surgery of incidentally detected adrenal gland tumors]

scientific article published on 01 May 1984

[Intraocular tumor metastases]

scientific article published on 01 June 1982

[Periodic colonoscopic examinations of persons with a positive family history for colorectal cancer. Work Group 'Hereditary non-polyposis- colon-rectum cancers']

scientific article published on 01 June 1999

[Periodic examination of families with hereditary nonpolyposis colorectal carcinoma in The Netherlands: a study of 41 families]

scientific article published on 01 January 1994

[Periodical screening of families with a hereditary predisposition for breast carcinoma]

scientific article published on 01 November 1993

[The doctor and the yellow girl]

scientific article published on 01 October 1988

[The value of screening and the national registration of hereditary tumors]

scientific article

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