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List of works by Clifton E Barry

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

scientific article published on 9 March 2018

5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins

scientific article published on 30 October 2007

A Convergent Synthesis of Chiral Diaminopimelic Acid Derived Substrates for Mycobacterial l,d-Transpeptidases

A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosis ⬇️

scientific journal article

A comparative lipidomics platform for chemotaxonomic analysis of Mycobacterium tuberculosis

scientific article

A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

scientific article

A genome-wide sequence-independent comparative analysis of insertion–deletion polymorphisms in multiple Mycobacterium tuberculosis strains

scientific article published on 15 September 2005

A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response

scientific article published in Nature

A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis

scientific article

A low-carb diet for a high-octane pathogen

scientific article published on 01 June 2005

A medicinal chemists' guide to the unique difficulties of lead optimization for tuberculosis

scientific article

A novel F(420) -dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents

scientific article published on 28 December 2012

A point mutation in the mma3 gene is responsible for impaired methoxymycolic acid production in Mycobacterium bovis BCG strains obtained after 1927

scientific journal article

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

scientific article (publication date: 22 June 2000)

A sterilizing tuberculosis treatment regimen is associated with faster clearance of bacteria in cavitary lesions in marmosets

scientific article published on 4 May 2015

Age and the epidemiology and pathogenesis of tuberculosis

scientific article published in The Lancet

AhpC, oxidative stress and drug resistance in Mycobacterium tuberculosis.

scientific article

Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization

scientific article published on 22 October 2015

Analysis of the Lipids of Mycobacterium tuberculosis

scientific article published on 01 January 2001

Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery

scientific article

Antimycobacterial natural products: synthesis and preliminary biological evaluation of the oxazole-containing alkaloid texaline

Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain

scientific journal article

Association of antigen-stimulated release of tumor necrosis factor-alpha in whole blood with response to chemotherapy in patients with pulmonary multidrug-resistant tuberculosis

scientific article

Association of lipoarabinomannan with high density lipoprotein in blood: implications for diagnostics

scientific article published on 16 March 2013

BacA, an ABC transporter involved in maintenance of chronic murine infections with Mycobacterium tuberculosis

scientific article

Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli

scientific journal article

Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis

scientific article

C4-Phenylthio β-lactams: Effect of the chirality of the β-lactam ring on antimicrobial activity

scientific article published on 20 August 2019

C4-alkylthiols with activity against Moraxella catarrhalis and Mycobacterium tuberculosis

scientific article published on October 2011

Cell Wall: Physical Structure and Permeability

Cell wall structure of a mutant of Mycobacterium smegmatis defective in the biosynthesis of mycolic acids.

scientific article

Changes in inflammatory protein and lipid mediator profiles persist after antitubercular treatment of pulmonary and extrapulmonary tuberculosis: A prospective cohort study

scientific article published on 18 June 2019

Chasing Koch's chimera.

scientific article published on April 2013

ChemInform Abstract: A Medicinal Chemists′ Guide to the Unique Difficulties of Lead Optimization for Tuberculosis

Clifton E. Barry, III: TB's strategic opponent. Interviewed by Amy Maxmen

scientific article published in March 2009

Combinatorial lead optimization of [1,2]-diamines based on ethambutol as potential antituberculosis preclinical candidates

scientific article published in March 2003

Comment on: Identification of antimicrobial activity among FDA-approved drugs for combating Mycobacterium abscessus and Mycobacterium chelonae

scientific article published on 7 October 2011

Comparative Evaluation of Sloppy Molecular Beacon and Dual-Labeled Probe Melting Temperature Assays to Identify Mutations in Mycobacterium tuberculosis Resulting in Rifampin, Fluoroquinolone and Aminoglycoside Resistance

scientific article

Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.

scientific article published in June 1996

Confronting the scientific obstacles to global control of tuberculosis

scientific article published on April 2008

Construction of Fluorescent Analogs to Follow the Uptake and Distribution of Cobalamin (Vitamin B12) in Bacteria, Worms, and Plants

scientific article published on 17 May 2018

Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance

scientific article

Corrections to Structure−Activity Relationships of Antitubercular Nitroimidazoles. 2. Determinants of Aerobic Activity and Quantitative Structure−Activity Relationships

article published in 2009

Corrigendum to “Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization” [Bioorg. Med. Chem. 23 (2015) 7240–7250]

scholarly article by Candice Soares de Melo et al published January 2016 in Bioorganic & Medicinal Chemistry

DNA microarrays: translational tools for understanding the biology of Mycobacterium tuberculosis.

scientific article

Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals

scientific article published on October 2009

Desacetyluvaricin from Uvaria accuminata, Configuration of Uvaricin at C-36

scientific article published on 01 July 1985

Design of a nucleoside inhibitor of biotin protein ligase from Mycobacterium tuberculosis

scholarly article published 2011

Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents

scientific article published on October 2006

Detection of stealthy small amphiphilic biomarkers.

scientific article published on 28 May 2014

Development of a selective activity-based probe for adenylating enzymes: profiling MbtA Involved in siderophore biosynthesis from Mycobacterium tuberculosis

scientific article

Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis

scientific article published on September 2004

Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.

scientific article

Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action

scientific article

Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria ⬇️

scientific article published on July 3, 1995

Diversity in the Chlamydia trachomatis histone homologue Hc2.

scientific article published on September 1993

DnaE2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosis

scientific article

Drug sensitivity and environmental adaptation of mycobacterial cell wall components.

scientific article published on July 1996

Dynamic exometabolome analysis reveals active metabolic pathways in non-replicating mycobacteria.

scientific article published on 16 September 2015

Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients

scientific article

ESI-MS Assay of M. tuberculosis Cell Wall Antigen 85 Enzymes Permits Substrate Profiling and Design of a Mechanism-Based Inhibitor

scientific article published on 09 August 2011

Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.

scientific article

Efficacy and safety of metronidazole for pulmonary multidrug-resistant tuberculosis

scientific article published on 03 June 2013

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

scientific article

Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis

scientific article

Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression

scientific article

Evaluation of the diagnostic utility of a whole-blood interferon-gamma assay for determining the risk of exposure to Mycobacterium tuberculosis in Bacille Calmette-Guerin (BCG)-vaccinated individuals

scientific article published on 4 March 2008

Expansion of the mycobacterial "PUPylome"

scientific article

Exploring alternative biomaterials for diagnosis of pulmonary tuberculosis in HIV-negative patients by use of the GeneXpert MTB/RIF assay

scientific article published on 09 October 2013

Expression, production and release of the Eis protein by Mycobacterium tuberculosis during infection of macrophages and its effect on cytokine secretion

scientific journal article

Extensively drug-resistant tuberculosis in South Korea: risk factors and treatment outcomes among patients at a tertiary referral hospital

scientific article published in January 2008

Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum

scientific article published on 4 December 2017

Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the β' subunit of RNA polymerase

scientific article published on 26 February 2014

Frequency of adverse reactions to first- and second-line anti-tuberculosis chemotherapy in a Korean cohort

scientific article published on 08 May 2012

Fumarate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis.

scientific article

Functional role of methylation of G518 of the 16S rRNA 530 loop by GidB in Mycobacterium tuberculosis

scientific article published on 07 October 2013

Genetic diversity of Mycobacterium tuberculosis isolates from a tertiary care tuberculosis hospital in South Korea

scientific article

Genotypic susceptibility testing of Mycobacterium tuberculosis isolates for amikacin and kanamycin resistance by use of a rapid sloppy molecular beacon-based assay identifies more cases of low-level drug resistance than phenotypic Lowenstein-Jensen t

scholarly article by Soumitesh Chakravorty et al published January 2015 in Journal of Clinical Microbiology

Getting the iron out

scientific article published on 01 August 2005

Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses

scientific article

High-sensitivity MALDI-MRM-MS imaging of moxifloxacin distribution in tuberculosis-infected rabbit lungs and granulomatous lesions

scientific article

Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives

scientific article published on May 2015

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

scientific article published on 25 June 2014

Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway

scientific article published in November 2005

Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis

scientific journal article

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

scientific journal article

Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis

scientific article (publication date: 2013)

Impact of diabetes and smoking on mortality in tuberculosis

scientific article

Improved rapid molecular diagnosis of multidrug-resistant tuberculosis using a new reverse hybridization assay, REBA MTB-MDR.

scientific article

In Vivo Phenotypic Dominance in Mouse Mixed Infections withMycobacterium tuberculosisClinical Isolates

scientific article published on 07 July 2005

Infection dynamics and response to chemotherapy in a rabbit model of tuberculosis using [¹⁸F]2-fluoro-deoxy-D-glucose positron emission tomography and computed tomography

scientific article

Infectious disease. More than just bugs in spit.

scientific article

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site

scientific article published on 08 January 2021

Inhibition of CorA-Dependent Magnesium Homeostasis Is Cidal in Mycobacterium tuberculosis

scientific article published on 23 September 2019

Inhibition of Mycobacterium tuberculosis AhpD, an element of the peroxiredoxin defense against oxidative stress

scientific article

Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid.

scientific article published on June 1998

Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosis

scientific article published on December 2008

Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine

scientific article

Investigation and conformational analysis of fluorinated nucleoside antibiotics targeting siderophore biosynthesis

scientific article

Is the mycobacterial cell wall a hopeless drug target for latent tuberculosis?

scholarly article by Helena I. Boshoff & Clifton E Barry published June 2006 in Drug discovery today. Disease mechanisms

Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis.

scientific article published in November 2000

Lessons from Seven Decades of Antituberculosis Drug Discovery

article by Clifton E Barry published 22 March 2011 in Current Topics in Medicinal Chemistry

Lessons from seven decades of antituberculosis drug discovery.

scientific article published on January 2011

Linezolid for XDR-TB--Final Study Outcomes.

scientific article

Linezolid for treatment of chronic extensively drug-resistant tuberculosis

scientific article

Linezolid resistance in patients with drug-resistant TB and treatment failure in South Africa

scientific article published on 01 August 2019

Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in Mycobacterium tuberculosis

scientific article published on 9 January 2012

Long-acting formulations for the treatment of latent tuberculous infection: opportunities and challenges.

scientific article published in February 2018

Major Global Killer Tamed by Hydrogen

scientific article

Mathematical Model of Oxygen Transport in Tuberculosis Granulomas

scientific article published on 8 August 2015

Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis

scientific article

Mechanisms of isoniazid resistance in Mycobacterium tuberculosis

scientific article published on 01 January 1998

Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis

scientific article

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

scientific article

Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo

scientific article

Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques

scientific article

Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms

scientific article published on 07 June 2013

Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline

scientific article published on 09 September 2019

Molecular degree of perturbation of plasma inflammatory markers associated with tuberculosis reveals distinct disease profiles between Indian and Chinese populations.

scientific article

Molecular insights into the binding of coenzyme F420 to the conserved protein Rv1155 from Mycobacterium tuberculosis

scientific article

Mutations in extensively drug-resistant Mycobacterium tuberculosis that do not code for known drug-resistance mechanisms.

scientific article

Mutations in gidB confer low-level streptomycin resistance in Mycobacterium tuberculosis

scientific article

Mycobacterium leprae is naturally resistant to PA-824

scientific article

Mycobacterium smegmatis: an absurd model for tuberculosis?

scholarly article by Clifton E Barry published October 2001 in Trends in Microbiology

Mycobacterium tuberculosis growth at the cavity surface: a microenvironment with failed immunity

scientific article

Mycobacterium tuberculosis in the post-genomic age.

scientific article

Mycobacterium tuberculosis inhibits maturation of human monocyte-derived dendritic cells in vitro

scientific article published on 9 July 2003

Mycolic Acid/Cyclopropane Fatty Acid/Fatty Acid Biosynthesis and Health Relations

article

Mycolic acids as diagnostic markers for tuberculosis case detection in humans and drug efficacy in mice

scientific article (publication date: 2012)

Mycolic acids: structure, biosynthesis and physiological functions

scientific article

Neutrophils are the predominant infected phagocytic cells in the airways of patients with active pulmonary TB.

scientific article

Next-generation therapeutics

Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii

scientific article published on 13 March 2013

Non-transpeptidase binding arylthioether β-lactams active against Mycobacterium tuberculosis and Moraxella catarrhalis

scientific article published on 12 December 2014

Novel Route to 5-Position Vinyl Derivatives of Thiolactomycin: Olefination versus Deformylation

Novel route to 5-position vinyl derivatives of thiolactomycin: Olefination vs. deformylation

scientific article

Nucleoid condensation in Escherichia coli that express a chlamydial histone homolog.

scientific article published on April 1992

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release

scientific article

PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis

scientific article published on 01 March 2020

PET/CT imaging correlates with treatment outcome in patients with multidrug-resistant tuberculosis.

scientific article published on December 2014

PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis.

scientific article

Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis

scientific article

Pathology of Tuberculosis in the Human Lung

scholarly article published 17 September 2010

Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening

scientific article

Pharmacokinetic evaluation of the penetration of antituberculosis agents in rabbit pulmonary lesions

scientific article published on 10 October 2011

Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis

scientific article

Phenoxazinone synthase: enzymatic catalysis of an aminophenol oxidative cascade

scientific article published in 1988

Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development

scientific article published on 31 October 2019

Polymorphisms associated with resistance and cross-resistance to aminoglycosides and capreomycin in Mycobacterium tuberculosis isolates from South Korean Patients with drug-resistant tuberculosis

scientific article

Predictors of pulmonary tuberculosis treatment outcomes in South Korea: a prospective cohort study, 2005-2012

scientific article

Prevalence of and risk factors for resistance to second-line drugs in people with multidrug-resistant tuberculosis in eight countries: a prospective cohort study

scientific article

Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis

scientific article

Prospects for new antitubercular drugs

scientific article published in October 2004

Proteasomal protein degradation in Mycobacteria is dependent upon a prokaryotic ubiquitin-like protein

scientific article

Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis

scientific article

Quantification of small molecule organic acids from Mycobacterium tuberculosis culture supernatant using ion exclusion liquid chromatography/mass spectrometry

scientific article published in January 2006

Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

scientific article published on 10 February 2020

Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens

scientific article published on 24 June 2013

Rapid detection of Mycobacterium tuberculosis biomarkers in a sandwich immunoassay format using a waveguide-based optical biosensor.

scientific article

Rapid detection of fluoroquinolone-resistant and heteroresistant Mycobacterium tuberculosis by use of sloppy molecular beacons and dual melting-temperature codes in a real-time PCR assay

scientific article

Rapid, high-throughput detection of rifampin resistance and heteroresistance in Mycobacterium tuberculosis by use of sloppy molecular beacon melting temperature coding

scientific article

Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis

scientific article published in January 2006

Reagent precoated targets for rapid in-tissue derivatization of the anti-tuberculosis drug isoniazid followed by MALDI imaging mass spectrometry

scientific article

Real-Time Investigation of Tuberculosis Transmission: Developing the Respiratory Aerosol Sampling Chamber (RASC)

scientific article

Respiratory flexibility in response to inhibition of cytochrome C oxidase in Mycobacterium tuberculosis

scientific article

Rhabdomyolysis in a patient treated with linezolid for extensively drug-resistant tuberculosis

scientific article

Rv2607 from Mycobacterium tuberculosis is a pyridoxine 5'-phosphate oxidase with unusual substrate specificity

scientific article

SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis

scientific article published on 17 January 2012

SYNTHESIS AND SPECTROSCOPIC DIFFERENTIATION OF 2- AND 4-ALKOXYTHIOTETRONIC ACIDS.

scientific article

Sensititre MYCOTB MIC plate for testing Mycobacterium tuberculosis susceptibility to first- and second-line drugs

scientific article published on 07 October 2013

Setting Our Sights on Infectious Diseases

scientific article published on 06 December 2019

Some Nigerian anti-tuberculosis ethnomedicines: a preliminary efficacy assessment

scientific article

Spectrum of latent tuberculosis — existing tests cannot resolve the underlying phenotypes: author's reply

scientific article published in 2010

Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific

scientific article published on 30 August 2018

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824

scientific article

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824.

scientific article

Structure-Activity Relationships of Pyrazolo[1,5-<i>a</i>]pyrimidin-7(4<i>H</i>)-ones as Antitubercular Agents

scientific article published on 06 January 2021

Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli

scientific article

Structure-activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis

scientific article published on 03 September 2013

Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles

scientific article published on March 2009

Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships

scientific article published on March 2009

Structure-activity relationships of antitubercular nitroimidazoles. 3. Exploration of the linker and lipophilic tail of ((s)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824).

scientific article

Structure-activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling

scientific article

Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles

scientific article published on 14 November 2011

Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis

scientific article

Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.

scientific article published on 7 March 2008

Synthesis of labeled meropenem for the analysis of M. tuberculosis transpeptidases

scientific article published on January 2010

TB drug development: immunology at the table

scientific article

Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode

scientific article published on 27 September 2019

Targeting the formation of the cell wall core of M. tuberculosis

scientific article published on June 2007

The 16-kDa alpha-crystallin (Acr) protein of Mycobacterium tuberculosis is required for growth in macrophages

scientific journal article

The Death of the "Three Ms".

scientific article published on 16 November 2015

The W-Beijing lineage of Mycobacterium tuberculosis overproduces triglycerides and has the DosR dormancy regulon constitutively upregulated

scientific article published on 19 January 2007

The association between sterilizing activity and drug distribution into tuberculosis lesions

scientific article published on 7 September 2015

The biosynthesis of mycolic acids in Mycobacterium tuberculosis. Enzymatic methyl(ene) transfer to acyl carrier protein bound meromycolic acid in vitro

scientific journal article

The chemical biology of new drugs in the development for tuberculosis

scientific article

The development of new chemotherapeutics for multidrug-resistant tuberculosis

article

The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824

scientific article

The effect of oxygenated mycolic acid composition on cell wall function and macrophage growth in Mycobacterium tuberculosis

scientific journal article

The genetics and biochemistry of isoniazid resistance in mycobacterium tuberculosis.

scientific article published in May 2000

The mechanism of action of PA-824: Novel insights from transcriptional profiling

scientific article

The ongoing challenge of latent tuberculosis

scientific article

The present state of the tuberculosis drug development pipeline

article

The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis

scientific journal article

The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis

scientific journal article

The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice

scientific journal article

The role of chemical biology in tuberculosis drug discovery and diagnosis.

scientific article

The specificity of methyl transferases involved in trans mycolic acid biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.

scientific article published in June 2001

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

scientific article (publication date: December 2009)

The stringent response of Mycobacterium tuberculosis is required for long-term survival

scientific journal article

The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions

scientific article

The three RelE homologs of Mycobacterium tuberculosis have individual, drug-specific effects on bacterial antibiotic tolerance

scientific article

The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action

scientific article published on 9 July 2004

Timing is everything for compassionate use of delamanid

scientific article published on 01 March 2015

Top down characterization of secreted proteins from Mycobacterium tuberculosis by electron capture dissociation mass spectrometry

scientific article published on 01 March 2003

Transmission of Mycobacterium tuberculosis from patients who are nucleic acid amplification test- negative.

scientific article

Treatment of Tuberculosis.

scientific article published in November 2015

Tuberculosis

scientific article published on 13 September 2015

Tuberculosis - metabolism and respiration in the absence of growth

scientific article

Tuberculosis drugs' distribution and emergence of resistance in patient's lung lesions: A mechanistic model and tool for regimen and dose optimization

scientific article published on 02 April 2019

Tuberculosis – strategies towards anti-infectives for a chronic disease

Tuberculosis: Drug discovery goes au naturel

scientific article

Tuberculosis: what we don't know can, and does, hurt us.

scientific article

Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates

scientific article (publication date: June 2008)

Understanding latent tuberculosis: the key to improved diagnostic and novel treatment strategies

scientific article

Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis

scientific article (publication date: 26 December 2003)

Unorthodox approach to the development of a new antituberculosis therapy

scientific article published on June 2009

Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis

scientific article

Utility of the REBA MTB-Rifa® assay for rapid detection of rifampicin resistant Mycobacterium tuberculosis

scientific article

Virulence and Persistence Mechanisms of Mycobacterium tuberculosis

scholarly article published 18 September 2017

Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli

scientific article

Within patient microevolution of Mycobacterium tuberculosis correlates with heterogeneous responses to treatment

scientific article

‘Imagination is more important than knowledge’

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