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List of works by Christian Pike

17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain

scientific article

APOE genotype affects metabolic and Alzheimer-related outcomes induced by Western diet in female EFAD mice

scientific article published on 03 December 2018

Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice

scientific article

Age-related changes in neuroactive steroid levels in 3xTg-AD mice.

scientific article published on 2 November 2012

Age-related changes in serum and brain levels of androgens in male Brown Norway rats

scientific article published in November 2009

Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures

scientific article published in August 1991

All-D-enantiomers of beta-amyloid exhibit similar biological properties to all-L-beta-amyloids.

scientific article published in March 1997

Alzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactions

scientific article

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

scientific article

Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro ⬇️

scientific article published on October 13, 1995

Androgen cell signaling pathways involved in neuroprotective actions.

scientific article published on 22 November 2007

Androgen regulation of beta-amyloid protein and the risk of Alzheimer's disease.

scientific article published on 7 July 2007

Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection

scientific journal article

Androgens modulate beta-amyloid levels in male rat brain.

scientific article published in November 2003

Androgens modulate neuronal vulnerability to kainate lesion

scientific article published in January 2003

Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease.

scientific article published in December 2006

Androgens selectively protect against apoptosis in hippocampal neurones

scientific article

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

scientific article published on September 1993

Caspase activation contributes to astrogliosis

scientific article published in March 2012

Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles

scientific article

Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen.

scientific article published on 29 November 2005

Deconvolution of the confounding variations for reverse transcription quantitative real-time polymerase chain reaction by separate analysis of biological replicate data

scientific article

Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function

scientific article

Differential effects of synthetic progestagens on neuron survival and estrogen neuroprotection in cultured neurons.

scientific article published on 11 January 2014

Effects of aging, high-fat diet, and testosterone treatment on neural and metabolic outcomes in male brown Norway rats

scientific article published on 22 September 2018

Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus

scientific article published in December 2001

Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease.

scientific article

Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death.

scientific article

Evaluation of the effects of testosterone and luteinizing hormone on regulation of β-amyloid in male 3xTg-AD mice ⬇️

scientific article published on May 14, 2012

Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion ⬇️

scientific article published on May 9, 2003

Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection.

scientific article published on 8 March 2007

Gender, sex steroid hormones, and Alzheimer's disease.

scientific article

Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans

scientific article published in Scientific Reports

Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors

scientific article

Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease

scientific article

Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease

scientific article published in 2015

Microglial transcription profiles in mouse and human are driven by APOE4 and sex

scientific article published on 05 October 2021

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

scientific article published in April 1993

Neuroprotective properties of selective estrogen receptor agonists in cultured neurons.

scientific article

Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice.

scientific article

Obesity and sex interact in the regulation of Alzheimer's disease

scientific article published on 17 December 2015

Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice.

scientific article

Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones

scientific article published on January 2009

Progesterone blocks estrogen neuroprotection from kainate in middle-aged female rats

scientific article published on 07 September 2008

Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-β.

scientific article

Progestins inhibit the neuroprotective effects of estrogen in rat hippocampus.

scientific article published on 21 June 2006

Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats.

scientific article

Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice

scientific article published on 14 February 2008

Sex and the development of Alzheimer's disease.

scientific article published on January 2017

Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure

scientific article

Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease

scientific article

TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity

scholarly article by V Alexandra Moser et al published 5 November 2018 in Journal of Neuroinflammation

TSPO ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice

scientific article published on 18 June 2018

Testosterone attenuates β-amyloid toxicity in cultured hippocampal neurons ⬇️

scientific article published on November 16, 2001

Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways ⬇️

scientific article published on August 31, 2010

The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties

scientific article

The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity

scientific article published on April 2015

The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection.

scientific article published in June 2005

beta-Amyloid increases enzyme activity and protein levels of glutamine synthetase in cultured astrocytes

scientific article

beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology

scientific article published on September 1, 1992

β‐Amyloid Neurotoxicity In Vitro: Evidence of Oxidative Stress but Not Protection by Antioxidants ⬇️

scientific article published on October 1, 1997

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