List of works - Paul J Barton

A 5' duplication of the alpha-cardiac actin gene in BALB/c mice is associated with abnormal levels of alpha-cardiac and alpha-skeletal actin mRNAs in adult cardiac tissue.

scientific article published on October 1986

A gene expression profile of the myocardial response to clenbuterol.

scientific article published on 13 March 2009

A gene-centric strategy for identifying disease-causing rare variants in dilated cardiomyopathy

article

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy

scientific article

A quantitative gene expression profile of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) in the myocardium of patients with deteriorating heart failure requiring left ventricular assist device support.

scientific article published in December 2006

A skeletal muscle-specific enhancer regulated by factors binding to E and CArG boxes is present in the promoter of the mouse myosin light-chain 1A gene

scientific article

AMP deaminase 1 gene polymorphism and heart disease-a genetic association that highlights new treatment

scientific article

ATP-binding cassette subfamily B member 1 polymorphisms do not determine cyclosporin exposure, acute rejection or nephrotoxicity after heart transplantation.

scientific article published in January 2010

Advances in induced pluripotent stem cells, genomics, biomarkers, and antiplatelet therapy highlights of the year in JCTR 2013.

scientific article

An intrinsic timer that controls cell-cycle withdrawal in cultured cardiac myocytes

scientific article published on 01 December 1999

Analysis of Cardiac Myocyte Biology in Transgenic Mice: A Protocol for Preparation of Neonatal Mouse Cardiac Myocyte Cultures

article

Assignment of the human cardiac/slow skeletal muscle troponin C gene (TNNC1) between D3S3118 and GCT4B10 on the short arm of chromosome 3 by somatic cell hybrid analysis

scientific article

Assignment of the human fast skeletal muscle troponin C gene (TNNC2) between D20S721 and GCT10F11 on chromosome 20 by somatic cell hybrid analysis ⬇️

scientific article published on September 1, 1997

Association of Titin-Truncating Genetic Variants With Life-threatening Cardiac Arrhythmias in Patients With Dilated Cardiomyopathy and Implanted Defibrillators

scientific article published on 05 June 2019

Author Correction: WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

scientific article published on 09 September 2019

C34T AMP deaminase 1 gene mutation protects cardiac function in donors.

scientific article published in May 2004

Calcineurin splicing variant calcineurin Aβ1 improves cardiac function after myocardial infarction without inducing hypertrophy.

scientific article

CardioClassifier: disease- and gene-specific computational decision support for clinical genome interpretation.

scientific article published on 25 January 2018

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

scientific article published on 01 February 2022

Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy

scientific article published on 01 July 2003

Changes in sarcomeric and non-sarcomeric cytoskeletal proteins and focal adhesion molecules during clinical myocardial recovery after left ventricular assist device support.

scientific article published in March 2007

Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals

scientific article published on 27 May 2020

Choice of cell-delivery route for skeletal myoblast transplantation for treating post-infarction chronic heart failure in rat.

scientific article

Chronic treatment with clenbuterol modulates endothelial progenitor cells and circulating factors in a murine model of cardiomyopathy.

scientific article

Clinical, molecular, and genomic changes in response to a left ventricular assist device

scientific article

Close physical linkage of human troponin genes: organization, sequence, and expression of the locus encoding cardiac troponin I and slow skeletal troponin T

scientific article (publication date: April 1999)

Contemporary Insights Into the Genetics of Hypertrophic Cardiomyopathy: Toward a New Era in Clinical Testing?

scientific article published on 18 April 2020

Cyclin-dependent kinase inhibitor expression in human heart failure. A comparison with fetal development.

scientific article published in April 1999

Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes.

scientific article published on 11 January 2017

Detection of myosin gene expression in the developing heart using probes derived by polymerase chain reaction

scientific article published on 01 January 1991

Determination of the 5' exon structure of the human cardiac alpha-myosin heavy chain gene

scientific article (publication date: 30 September 1991)

Development of a Comprehensive Sequencing Assay for Inherited Cardiac Condition Genes

scientific article published on 17 February 2016

Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro

scientific article published in April 1987

Developmental regulation of myosin gene expression in mouse cardiac muscle

scientific article

Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development ⬇️

scientific article published on November 15, 1992

Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model.

scientific article published on 16 April 2007

Effect of ABCB1 genotype on pre- and post-cardiac transplantation plasma lipid concentrations

scientific article published on 29 March 2011

Effect of AMP-deaminase 3 knock-out in mice on enzyme activity in heart and other organs

scientific journal article

Effect of adenosine monophosphate deaminase-1 C34T allele on the requirement for donor inotropic support and on the incidence of early graft dysfunction after cardiac transplantation.

scientific article

Efficiency of a high-titer retroviral vector for gene transfer into skeletal myoblasts.

scientific article

Elevated expression of Nkx-2.5 in developing myocardial conduction cells.

scientific article published in July 2001

Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy

scientific article published on 28 March 2008

Elevated tumor necrosis factor-alpha and interleukin-6 in myocardium and serum of malfunctioning donor hearts

scientific article published on 01 November 2000

Expression of RGS3, RGS4 and Gi alpha 2 in acutely failing donor hearts and end-stage heart failure

scientific article published in June 2001

Expression of extracellular matrix genes during myocardial recovery from heart failure after left ventricular assist device support

scientific article published in February 2009

Expression of homeobox genes Msx-1 (Hox-7) and Msx-2 (Hox-8) during cardiac development in the chick

scientific article published on 01 July 1993

Expression of human membrane skeleton protein genes for protein 4.1 and betaIISigma2-spectrin assayed by real-time RT-PCR.

scientific article

Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy.

scientific article published on 13 June 2013

FineSplice, enhanced splice junction detection and quantification: a novel pipeline based on the assessment of diverse RNA-Seq alignment solutions.

scientific article published on 25 February 2014

Gene expression during cardiac development

scientific article published on January 1, 1992

Gene therapy--the state of play.

scientific article

Genetic Etiology for Alcohol-Induced Cardiac Toxicity.

scientific article

Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy

scientific article published on 16 April 2019

Genetic association studies: personalized medicine in cardiac transplantation

scientific article published on 01 February 2006

Genetic modifiers to the PLN L39X mutation in a patient with DCM and sustained ventricular tachycardia?

scientific article

Genomic Organisation, Alternative Splicing and Polymorphisms of the Human Cardiac Troponin T Gene ⬇️

scientific article published on June 1, 1998

Heterogeneic nature of adult cardiac side population cells.

scientific article

Histiocytoid cardiomyopathy and microphthalmia with linear skin defects syndrome: phenotypes linked by truncating variants in NDUFB11.

scientific article published on January 2017

Hyperubiquitination of proteins in dilated cardiomyopathy

scientific article (publication date: February 2003)

Identification of a new target of miR-16, Vacuolar Protein Sorting 4a.

scientific article

Identification of cis-acting DNA elements required for expression of the human cardiac troponin I gene promoter

scientific article published on 01 January 2000

Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure

scientific article published in July 2003

Increased toll-like receptor 4 in the myocardium of patients requiring left ventricular assist devices

scientific article published in February 2004

Influence of glutathione-S-transferase (GST) inhibition on lung epithelial cell injury: role of oxidative stress and metabolism.

scientific article published on 10 April 2015

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

scientific article

Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross

scientific article published in Nature

Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients

scientific article published in April 2015

Isolation and characterization of the human cardiac troponin I gene (TNNI3)

scientific article

Left ventricular assist device-induced molecular changes in the failing myocardium.

scientific article published on May 2008

Localization of the acetylcholine receptor gamma subunit gene to human chromosome 2q32----qter.

scientific article

Localization of the fast skeletal muscle troponin I gene (TNNI2) to 11p15.5: genes for troponin I and T are organized in pairs

scientific article published on 01 November 1997

Mapping transcriptional start sites and in silico DNA footprinting

scientific article published in January 2007

Molecular cloning of human cardiac troponin T isoforms: expression in developing and failing heart.

scientific article published in October 1995

Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy

scientific article published on 28 November 2006

Myocardial dysfunction in donor hearts. A possible etiology

scientific article published on 01 May 1999

Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalized after recovery: potential implications for local creatine synthesis

scientific article

Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapy.

scientific article

Myosin light chain gene expression in developing and denervated fetal muscle in the mouse

scientific article published on 01 December 1989

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.

scientific article published on 14 September 2017

Non-coding region variants upstream of MEF2C cause severe developmental disorder through three distinct loss-of-function mechanisms

scientific article published on 21 May 2021

Nuclear factor NF-kappa B in myocardium: developmental expression of subunits and activation by interleukin-1 beta in cardiac myocytes in vitro

scientific article published in August 1998

Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice.

scientific article published on 17 April 2009

Phenotype and Clinical Outcomes of Titin Cardiomyopathy.

scientific article published in October 2017

Phenotypic Expression and Outcomes in Individuals With Rare Genetic Variants of Hypertrophic Cardiomyopathy

scientific article published on 01 September 2021

Phenylephrine requires the TATA box to activate transcription of GLUT1 in neonatal rat cardiac myocytes.

scientific article published on April 2005

Possible regulatory roles of promoter g-quadruplexes in cardiac function-related genes - human TnIc as a model.

scientific article

Quantitative approaches to variant classification increase the yield and precision of genetic testing in Mendelian diseases: the case of hypertrophic cardiomyopathy

scientific article published on 29 January 2019

Quantitative myocardial cytokine expression and activation of the apoptotic pathway in patients who require left ventricular assist devices

scientific article published on 18 September 2001

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

scientific article

Rapamycin (sirolimus) inhibits heart cell growth in vitro

scientific article published on 01 November 1998

Recovery of Cardiac Function in Cardiomyopathy Caused by Titin Truncation.

scientific article

Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy

scientific article published on 27 January 2020

Regulated inositol-requiring protein 1-dependent decay as a mechanism of corin RNA and protein deficiency in advanced human systolic heart failure.

scientific article

Reverse remodelling and recovery from heart failure are associated with complex patterns of gene expression.

scientific article

Review and Updates in Regenerative and Personalized Medicine, Preclinical Animal Models, and Clinical Care in Cardiovascular Medicine.

scientific article

Role of interleukin-1beta in acute inflammation and graft death after cell transplantation to the heart.

scientific article published on September 2004

SNP at your own risk

scientific article published on 01 May 2002

Sequential expression of three known protective genes in cardiac biopsies after transplantation.

scientific article published in March 2005

Structural characterization of the human fast skeletal muscle troponin I gene (TNNI2)

scientific article (publication date: 25 January 2000)

Structure and regulation of human troponin genes.

scientific article

Structure and sequence of the myosin alkali light chain gene expressed in adult cardiac atria and fetal striated muscle.

scientific article

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart

scientific article (publication date: 16 September 2011)

The Calcineurin Variant CnAβ1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation

scientific article published on 28 September 2016

The Egyptian Collaborative Cardiac Genomics (ECCO-GEN) Project: defining a healthy volunteer cohort

scientific article published on 23 October 2020

The Translational Landscape of the Human Heart

scientific article published on 30 May 2019

The actin and myosin multigene families

scientific article

The effects of pre- and post-transplant anemia on 1-year survival after cardiac transplantation

scientific article published on 01 April 2008

The myosin alkali light chain proteins and their genes

scientific article

The myosin alkali light chains of mouse ventricular and slow skeletal muscle are indistinguishable and are encoded by the same gene

scientific article published on 01 July 1985

The use of restriction-enzyme fragments of cloned deoxyribonucleic acid for human globin-gene mapping ⬇️

scientific article published on 01 April 1980

Titin truncating mutations: A rare cause of dilated cardiomyopathy in the young

Titin-truncating variants affect heart function in disease cohorts and the general population.

scientific article

Titin: a phenotype-genotype descriptive comparison of dilated cardiomyopathy.

scientific article published on 16 January 2014

Towards clinical molecular diagnosis of inherited cardiac conditions: a comparison of bench-top genome DNA sequencers

scientific article

Troponin I and T protein expression in experimental cardiac hypertrophy

scientific article published on 01 March 1995

Troponin I gene expression during human cardiac development and in end-stage heart failure

scientific article

Truncating Variants in Titin Independently Predict Early Arrhythmias in Patients With Dilated Cardiomyopathy.

scientific article published on May 2017

Truncations of titin causing dilated cardiomyopathy.

scientific article

Using High-Resolution Variant Frequencies Empowers Clinical Genome Interpretation and Enables Investigation of Genetic Architecture

scientific article published on 01 January 2019

Using high-resolution variant frequencies to empower clinical genome interpretation.

scientific article published on 18 May 2017

Vascular endothelial growth factor release following coronary artery bypass surgery: extracorporeal circulation versus 'beating heart' surgery

scientific article published on 01 October 2000

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

scientific article published on 09 August 2019

Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins

scientific article published on 09 July 2019

ZBTB17 ( MIZ1 ) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure

article

List of works by Paul J Barton

A 5' duplication of the alpha-cardiac actin gene in BALB/c mice is associated with abnormal levels of alpha-cardiac and alpha-skeletal actin mRNAs in adult cardiac tissue.

A gene expression profile of the myocardial response to clenbuterol.

A gene-centric strategy for identifying disease-causing rare variants in dilated cardiomyopathy

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy

A quantitative gene expression profile of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) in the myocardium of patients with deteriorating heart failure requiring left ventricular assist device support.

A skeletal muscle-specific enhancer regulated by factors binding to E and CArG boxes is present in the promoter of the mouse myosin light-chain 1A gene

AMP deaminase 1 gene polymorphism and heart disease-a genetic association that highlights new treatment

ATP-binding cassette subfamily B member 1 polymorphisms do not determine cyclosporin exposure, acute rejection or nephrotoxicity after heart transplantation.

Advances in induced pluripotent stem cells, genomics, biomarkers, and antiplatelet therapy highlights of the year in JCTR 2013.

An intrinsic timer that controls cell-cycle withdrawal in cultured cardiac myocytes

Analysis of Cardiac Myocyte Biology in Transgenic Mice: A Protocol for Preparation of Neonatal Mouse Cardiac Myocyte Cultures

Assignment of the human cardiac/slow skeletal muscle troponin C gene (TNNC1) between D3S3118 and GCT4B10 on the short arm of chromosome 3 by somatic cell hybrid analysis

Assignment of the human fast skeletal muscle troponin C gene (TNNC2) between D20S721 and GCT10F11 on chromosome 20 by somatic cell hybrid analysis ⬇️

Association of Titin-Truncating Genetic Variants With Life-threatening Cardiac Arrhythmias in Patients With Dilated Cardiomyopathy and Implanted Defibrillators

Author Correction: WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

C34T AMP deaminase 1 gene mutation protects cardiac function in donors.

Calcineurin splicing variant calcineurin Aβ1 improves cardiac function after myocardial infarction without inducing hypertrophy.

CardioClassifier: disease- and gene-specific computational decision support for clinical genome interpretation.

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy

Changes in sarcomeric and non-sarcomeric cytoskeletal proteins and focal adhesion molecules during clinical myocardial recovery after left ventricular assist device support.

Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals

Choice of cell-delivery route for skeletal myoblast transplantation for treating post-infarction chronic heart failure in rat.

Chronic treatment with clenbuterol modulates endothelial progenitor cells and circulating factors in a murine model of cardiomyopathy.

Clinical, molecular, and genomic changes in response to a left ventricular assist device

Close physical linkage of human troponin genes: organization, sequence, and expression of the locus encoding cardiac troponin I and slow skeletal troponin T

Contemporary Insights Into the Genetics of Hypertrophic Cardiomyopathy: Toward a New Era in Clinical Testing?

Cyclin-dependent kinase inhibitor expression in human heart failure. A comparison with fetal development.

Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes.

Detection of myosin gene expression in the developing heart using probes derived by polymerase chain reaction

Determination of the 5' exon structure of the human cardiac alpha-myosin heavy chain gene

Development of a Comprehensive Sequencing Assay for Inherited Cardiac Condition Genes

Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro

Developmental regulation of myosin gene expression in mouse cardiac muscle

Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development ⬇️

Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model.

Effect of ABCB1 genotype on pre- and post-cardiac transplantation plasma lipid concentrations

Effect of AMP-deaminase 3 knock-out in mice on enzyme activity in heart and other organs

Effect of adenosine monophosphate deaminase-1 C34T allele on the requirement for donor inotropic support and on the incidence of early graft dysfunction after cardiac transplantation.

Efficiency of a high-titer retroviral vector for gene transfer into skeletal myoblasts.

Elevated expression of Nkx-2.5 in developing myocardial conduction cells.

Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy

Elevated tumor necrosis factor-alpha and interleukin-6 in myocardium and serum of malfunctioning donor hearts

Expression of RGS3, RGS4 and Gi alpha 2 in acutely failing donor hearts and end-stage heart failure

Expression of extracellular matrix genes during myocardial recovery from heart failure after left ventricular assist device support

Expression of homeobox genes Msx-1 (Hox-7) and Msx-2 (Hox-8) during cardiac development in the chick

Expression of human membrane skeleton protein genes for protein 4.1 and betaIISigma2-spectrin assayed by real-time RT-PCR.

Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy.

FineSplice, enhanced splice junction detection and quantification: a novel pipeline based on the assessment of diverse RNA-Seq alignment solutions.

Gene expression during cardiac development

Gene therapy--the state of play.

Genetic Etiology for Alcohol-Induced Cardiac Toxicity.

Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy

Genetic association studies: personalized medicine in cardiac transplantation

Genetic modifiers to the PLN L39X mutation in a patient with DCM and sustained ventricular tachycardia?

Genomic Organisation, Alternative Splicing and Polymorphisms of the Human Cardiac Troponin T Gene ⬇️

Heterogeneic nature of adult cardiac side population cells.

Histiocytoid cardiomyopathy and microphthalmia with linear skin defects syndrome: phenotypes linked by truncating variants in NDUFB11.

Hyperubiquitination of proteins in dilated cardiomyopathy

Identification of a new target of miR-16, Vacuolar Protein Sorting 4a.

Identification of cis-acting DNA elements required for expression of the human cardiac troponin I gene promoter

Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure

Increased toll-like receptor 4 in the myocardium of patients requiring left ventricular assist devices

Influence of glutathione-S-transferase (GST) inhibition on lung epithelial cell injury: role of oxidative stress and metabolism.

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross

Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients

Isolation and characterization of the human cardiac troponin I gene (TNNI3)

Left ventricular assist device-induced molecular changes in the failing myocardium.

Localization of the acetylcholine receptor gamma subunit gene to human chromosome 2q32----qter.

Localization of the fast skeletal muscle troponin I gene (TNNI2) to 11p15.5: genes for troponin I and T are organized in pairs

Mapping transcriptional start sites and in silico DNA footprinting

Molecular cloning of human cardiac troponin T isoforms: expression in developing and failing heart.

Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy

Myocardial dysfunction in donor hearts. A possible etiology

Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalized after recovery: potential implications for local creatine synthesis

Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapy.

Myosin light chain gene expression in developing and denervated fetal muscle in the mouse

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.