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List of works by Nathalie Droin

A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation

scientific article published on 24 April 2019

A constitutive BCL2 down-regulation aggravates the phenotype of PKD1-mutant-induced polycystic kidney disease.

scientific article published on 11 September 2017

A miR-150/TET3 pathway regulates the generation of mouse and human non-classical monocyte subset

scientific article published in Nature Communications

A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE.

scientific article published in August 2007

A role for caspases in the differentiation of erythroid cells and macrophages.

scientific article published on 02 September 2007

A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression.

scientific article

A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome

scientific article published on 01 July 2019

Accumulation of classical monocytes defines a subgroup of MDS that frequently evolves into CMML.

scientific article published on 13 June 2017

Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0

scientific article

Acquired initiating mutations in early hematopoietic cells of CLL patients

scientific article

Activation-induced cell death in T cells

scientific article

Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia.

scientific article published on 28 October 2009

Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells

scientific article published on 4 April 2013

Author Correction: Genomic characterization of metastatic breast cancers

scientific article published on 01 August 2019

BCR-ABL delays apoptosis upstream of procaspase-3 activation

scientific article published on 01 April 1998

Biallelic inactivation of the retinoblastoma gene results in transformation of chronic myelomonocytic leukemia to a blastic plasmacytoid dendritic cell neoplasm: shared clonal origins of two aggressive neoplasms

article

Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia

scientific article published on 20 March 2019

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death.

scientific article published in March 2005

Cancer cell sensitization to fas-mediated apoptosis by sodium butyrate

scientific article published on 01 June 1998

Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27Kip1 mediates its anti-apoptotic activity.

scientific article

Characteristic repartition of monocyte subsets as a diagnostic signature of chronic myelomonocytic leukemia

scientific article published on 7 April 2015

Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial

scientific article published on 12 January 2016

Circulating Immature Granulocytes With T-Cell Killing Functions Predict Sepsis Deterioration*

Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic myelomonocytic leukemia (CMML)-a study of 1084 patients

scientific article published on 13 December 2019

Clonal architecture of chronic myelomonocytic leukemias

scientific article published on 14 January 2013

Cohen syndrome is associated with major glycosylation defects

scientific article

Colony-stimulating factor-1-induced oscillations in phosphatidylinositol-3 kinase/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages

scientific article published on 31 August 2009

Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection

scientific article published on June 2006

Congenital neutropenia with retinopathy, a new phenotype without intellectual deficiency or obesity secondary to VPS13B mutations.

scientific article

Constitutive activation of RAS/MAPK pathway cooperates with trisomy 21 and is therapeutically exploitable in Down syndrome B-cell leukemia

scientific article published on 27 March 2020

DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.

scientific article published on 25 May 2017

DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

scientific article published on 15 February 2016

Death in paradise

scientific article published on 01 July 2002

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

scientific article

Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia

scientific article published on 13 December 2018

Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes

scientific article published on 07 February 2014

Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages

article

Dynamic programming of CD8+ T lymphocyte responses

article

Dynamic regulation of FoxP3 expression controls the balance between CD4+ T cell activation and cell death

scientific article

E2F1 binds to the peptide-binding groove within the BIR3 domain of cIAP1 and requires cIAP1 for chromatin binding

scientific article published in PLoS ONE

ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

scientific article published in March 2017

Editorial: CSF1R, CSF-1, and IL-34, a "menage a trois" conserved across vertebrates.

scientific article published in May 2010

Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses

scientific article

Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines

scientific article published on 13 June 2017

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

scientific article (publication date: 20 April 2006)

Eosinophil-rich tissue infiltrates in chronic myelomonocytic leukemia patients.

scientific article

FAS(CD95) ligand expression by tumor cell variants can be unrelated to their capacity to induce tolerance or immune rejection

scientific article published on 01 July 1999

Familial predisposition to TP53/complex karyotype MDS and leukemia in DNA repair-deficient xeroderma pigmentosum

scientific article published on 26 March 2019

Fine-tuning nucleophosmin in macrophage differentiation and activation.

scientific article

Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53

scientific article published on 01 November 2019

Genomic characterization of metastatic breast cancers

scientific article published on 22 May 2019

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies

scientific article published on 17 August 2015

Heterogeneity of molecular markers in chronic myelomonocytic leukemia: a disease associated with several gene alterations.

scientific article published on 14 March 2012

High prevalence of myeloid neoplasms in adults with non-Langerhans cell histiocytosis.

scientific article

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade

scientific article

Integrative analysis of dysregulated microRNAs and mRNAs in multiple recurrent synchronized renal tumors from patients with von Hippel-Lindau disease

scientific article published on 19 July 2018

Involvement of caspase-2 long isoform in Fas-mediated cell death of human leukemic cells.

scientific article

Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy.

scientific article

MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.

scientific article

Macrophage migration inhibitory factor is overproduced through EGR1 in TET2<sup>low</sup> resting monocytes

scientific article published on 03 February 2022

MiR-142-3p et leucémogenèse

scientific article published on 01 June 2013

Mice Lacking bi-1 Gene Show Accelerated Liver Regeneration

article

Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial.

scientific article

Multilayer intraclonal heterogeneity in chronic myelomonocytic leukemia

scientific article published on 02 May 2019

Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents

scientific article published on 24 February 2016

Mutation of the colony-stimulating factor-3 receptor gene is a rare event with poor prognosis in chronic myelomonocytic leukemia.

scientific article published on 18 June 2013

NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2

scientific article

Next-generation sequencing discriminates myelodysplastic/myeloproliferative neoplasms from paraneoplastic leukemoid reaction in cancer patients with hyperleukocytosis.

scientific article published on 8 November 2017

Non-apoptotic functions of caspases in myeloid cell differentiation.

scientific article published on 17 February 2017

Nonlymphoid Fas ligand in peptide-induced peripheral lymphocyte deletion

scientific article

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia

scientific article published on 29 October 2019

Outcome and molecular landscape of patients with PIK3CA-mutated metastatic breast cancer

scientific article published on 24 January 2020

Positive and negative regulation of apoptotic pathways by cytotoxic agents in hematological malignancies.

scientific article

Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway.

scientific article

Presence of a transcriptionally active glucocorticoid receptor alpha in lens epithelial cells

scientific article published in December 2003

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients

scientific article published on 8 October 2015

Prognostic Role of Gene Mutations in Chronic Myelomonocytic Leukemia Patients Treated With Hypomethylating Agents.

scientific article published on 25 April 2018

Prognostic score including gene mutations in chronic myelomonocytic leukemia.

scientific article

Prognostic value of monocyte subset distribution in chronic myelomonocytic leukemia: results of a multicenter study

scientific article published on 20 July 2020

Proteases, proteolysis, and apoptosis

scientific article published on March 1, 1998

Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells

scientific article published in October 2005

RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

scientific article published on 18 May 2021

Retroperitoneal fibrosis as extramedullary hematopoiesis of a chronic myelomonocytic leukemia

scientific article published on 25 January 2018

Role of Bcl-2 family members in immunity and disease

scientific article published on March 2004

SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias.

scientific article published on 5 February 2013

Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia

scientific article published on 07 March 2019

Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia.

scientific article

TET2 deficiency causes germinal center hyperplasia, impairs plasma cell differentiation and promotes B-cell lymphomagenesis

scientific article published on 01 October 2018

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.

scientific article published on August 2014

TIF1γ: a tumor suppressor gene in chronic myelomonocytic leukemia

scientific article published on 31 August 2011

Targeting apoptosis proteins in hematological malignancies.

scientific article published on 30 June 2011

The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML

scientific article

The emerging specificities of interleukin-34.

scientific article

The inhibitory HVEM-BTLA pathway counter regulates lymphotoxin receptor signaling to achieve homeostasis of dendritic cells

scientific article published on January 2008

The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

scientific article published on October 2002

The role of ARK in stress-induced apoptosis in Drosophila cells

scientific article

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

scientific article

Tumor necrosis factor alpha up-regulates non-lymphoid Fas-ligand following superantigen-induced peripheral lymphocyte activation

scientific article

Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis ⬇️

scientific article published on June 4, 1998

Use of the 46/1 haplotype to model JAK2(V617F) clonal architecture in PV patients: clonal evolution and impact of IFNα treatment.

scientific article

Various functions of caspases in hematopoiesis.

scientific article published on January 2009

[Dynamic role of nuclear CSF1R in the monocytic lineage]

scientific article published on 01 December 2019

p27Kip1 induces drug resistance by preventing apoptosis upstream of cytochrome c release and procaspase-3 activation in leukemic cells.

scientific article

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