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List of works by Jonathan P. Little

14-days of ketone supplementation lowers glucose and improves vascular function in obesity: a randomized crossover trial

scientific article published on 26 December 2020

A Multi-Center Comparison of O Trainability Between Interval Training and Moderate Intensity Continuous Training

scientific article published on 05 February 2019

A Pilot Study on In-Task Affect Predicting Free-Living Adherence to HIIT and MICT

scientific article published on 16 October 2020

A ketone monoester drink reduces the glycemic response to an oral glucose challenge in individuals with obesity: a randomized trial

scientific article published on 01 December 2019

A low-carbohydrate protein-rich bedtime snack to control fasting and nocturnal glucose in type 2 diabetes: A randomized trial

scientific article published on 13 March 2020

A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms

scientific article

A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults.

scientific article

Actions of the anti-angiogenic compound angiostatin in an animal model of Alzheimer's disease.

scientific article published on March 2013

Acute endurance exercise increases the nuclear abundance of PGC-1alpha in trained human skeletal muscle.

scientific article published on 27 January 2010

Acute high-intensity interval exercise reduces human monocyte Toll-like receptor 2 expression in type 2 diabetes.

scientific article published on 25 January 2017

Acute high-intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes

scientific article published on 20 February 2012

Adipose-brain crosstalk: do adipokines have a role in neuroprotection?

scientific article published on September 2015

Affective and Enjoyment Responses to High-Intensity Interval Training in Overweight-to-Obese and Insufficiently Active Adults.

scientific article published in April 2015

An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle

scientific article published on 30 March 2011

Brief Exercise Counseling and High-Intensity Interval Training on Physical Activity Adherence and Cardiometabolic Health in Individuals at Risk of Type 2 Diabetes: Protocol for a Randomized Controlled Trial

article

Carbohydrate feeding during recovery alters the skeletal muscle metabolic response to repeated sessions of high-intensity interval exercise in humans.

scientific article published on 7 January 2010

Carbohydrate restriction with postmeal walking effectively mitigates postprandial hyperglycemia and improves endothelial function in type 2 diabetes.

scientific article published on 13 October 2017

Carbohydrate-Restriction with High-Intensity Interval Training: An Optimal Combination for Treating Metabolic Diseases?

scientific article published on 12 October 2017

Cardiorespiratory fitness as a predictor of intestinal microbial diversity and distinct metagenomic functions

scientific article published on 08 August 2016

Cardiovascular benefits of combined interval training and post-exercise nutrition in type 2 diabetes

scientific article

Changes in mechanisms proposed to mediate fat loss following an acute bout of high-intensity interval and endurance exercise

scientific article published on 11 June 2013

Circulating progenitor cells are positively associated with cognitive function among overweight/obese children.

scientific article published on 27 April 2016

Combined Interval Training and Post-exercise Nutrition in Type 2 Diabetes: A Randomized Control Trial

scientific article published on 25 July 2017

Comment on Alarcon et al. Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function. Diabetes 2016;65:438-450

scientific article published on 01 August 2016

Commentary: Why sprint interval training is inappropriate for a largely sedentary population

scientific article published on 01 January 2015

Comparing the Keyto App and Device with Weight Watchers' WW App for Weight Loss: Protocol for a Randomized Trial

scientific article published on 17 August 2020

Creatine Monohydrate Supplementation Does Not Augment Fitness, Performance, or Body Composition Adaptations in Response to Four Weeks of High-Intensity Interval Training in Young Females

scientific article published on 21 October 2016

DXA-derived abdominal fat mass, waist circumference, and blood lipids in postmenopausal women.

scientific article

Detection of Salivary Insulin Following Low versus High Carbohydrate Meals in Humans.

scientific article published on 2 November 2017

Differential impact of acute high-intensity exercise on circulating endothelial microparticles and insulin resistance between overweight/obese males and females

scientific article

Dissociation of increases in PGC-1α and its regulators from exercise intensity and muscle activation following acute exercise

scientific article

Do stair climbing exercise "snacks" improve cardiorespiratory fitness?

scientific article published on 16 January 2019

Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?

scientific article published on 17 November 2011

Editorial: Optimizing Exercise for the Prevention and Treatment of Type 2 Diabetes.

scientific article

Effect of nutritional interventions and resistance exercise on aging muscle mass and strength.

scientific article published on 09 June 2012

Effectiveness and safety of high-intensity interval training in patients with type 2 diabetes

scientific article

Effects of high-intensity interval exercise versus continuous moderate-intensity exercise on postprandial glycemic control assessed by continuous glucose monitoring in obese adults

scientific article published on 18 February 2014

Effects of postmeal exercise on postprandial glucose excursions in people with type 2 diabetes treated with add-on hypoglycemic agents

scientific article published on 8 March 2017

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

scientific article

Exercise and nutritional interventions for improving aging muscle health.

scientific article published on 21 April 2012

Exercise increases mitochondrial PGC-1 α content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.

scientific article

Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.

scientific article

Extremely low volume, whole-body aerobic-resistance training improves aerobic fitness and muscular endurance in females

scientific article published on 20 September 2012

Genes to predict VO2max trainability: a systematic review.

scientific article

Globular adiponectin induces a pro-inflammatory response in human astrocytic cells.

scientific article published on 25 February 2014

Glycemic and Metabolic Effects of Two Long Bouts of Moderate-Intensity Exercise in Men with Normal Glucose Tolerance or Type 2 Diabetes

scientific article published on 11 July 2017

High Glucose Enhances Neurotoxicity and Inflammatory Cytokine Secretion by Stimulated Human Astrocytes.

scientific article published on 16 January 2017

High-Intensity Interval or Continuous Moderate Exercise: A 24-Week Pilot Trial

scientific article published on 01 October 2018

High-intensity interval training as an efficacious alternative to moderate-intensity continuous training for adults with prediabetes

scientific article

High-intensity interval training for improving postprandial hyperglycemia.

scientific article

Human adipose tissue conditioned media from lean subjects is protective against H2O2 induced neurotoxicity in human SH-SY5Y neuronal cells

scientific article

Hyporesponsiveness to the anti-inflammatory action of interleukin-10 in type 2 diabetes

scientific article published on 17 February 2016

IL-6 Induced STAT3 Signalling Is Associated with the Proliferation of Human Muscle Satellite Cells Following Acute Muscle Damage ⬇️

scientific article published on March 9, 2011

Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle

scientific article published on 09 January 2017

Impact of high-intensity interval duration on perceived exertion.

scientific article published in May 2015

Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration

scientific article

Insulinotropic and Muscle Protein Synthetic Effects of Branched-Chain Amino Acids: Potential Therapy for Type 2 Diabetes and Sarcopenia ⬇️

scientific article published on November 8, 2012

Intermittent and continuous high-intensity exercise training induce similar acute but different chronic muscle adaptations

scientific article

Just HIT it! A time-efficient exercise strategy to improve muscle insulin sensitivity

scientific article published on 01 September 2010

Last word on viewpoint: does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?

scientific article published on 01 March 2012

Low-dose creatine combined with protein during resistance training in older men.

scientific article published in September 2008

Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes

scientific article published on 25 August 2011

Low-volume interval training improves muscle oxidative capacity in sedentary adults

scientific article

Markers of skeletal muscle mitochondrial function and lipid accumulation are moderately associated with the homeostasis model assessment index of insulin resistance in obese men

scientific article (publication date: 2013)

Microparticles: a new perspective in central nervous system disorders.

scientific article published on 9 April 2014

Minimal effect of walking before dinner on glycemic responses in type 2 diabetes: outcomes from the multi-site E-PAraDiGM study

scientific article published on 15 May 2019

Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle

scientific article published on 11 July 2016

Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia.

scientific article published on 23 April 2014

Moderate-intensity exercise and high-intensity interval training affect insulin sensitivity similarly in obese adults

scientific article published on 03 June 2020

Modification of insulin sensitivity and glycemic control by activity and exercise

scientific article

Muscle time under tension during resistance exercise stimulates differential muscle protein sub-fractional synthetic responses in men.

scientific article

Nutritional ketone salts increase fat oxidation but impair high-intensity exercise performance in healthy adult males.

scientific article published on 27 July 2017

One-week high-fat diet leads to reduced toll-like receptor 2 expression and function in young healthy men.

scientific article published on 3 September 2014

Oral Ketone Supplementation Acutely Increases Markers of NLRP3 Inflammasome Activation in Human Monocytes

scientific article published on 05 April 2019

Pharmacist-led therapeutic carbohydrate restriction as a treatment strategy for type 2 diabetes: the Pharm-TCR randomized controlled trial protocol

scientific article published on 27 December 2019

Physical activity and exercise attenuate neuroinflammation in neurological diseases.

scientific article published on 25 March 2016

Physiological adaptations to low‐volume, high‐intensity interval training in health and disease ⬇️

scientific article published on January 30, 2012

Physiological basis of brief vigorous exercise to improve health

scientific article published on 20 December 2019

Potential therapeutic effects of exogenous ketone supplementation for type 2 diabetes: a review

scientific article published on 03 February 2020

Prior ingestion of exogenous ketone monoester attenuates the glycemic response to an oral glucose tolerance test in healthy young individuals.

scientific article published on 15 February 2018

Purinergic responses of calcium-dependent signaling pathways in cultured adult human astrocytes.

scientific article published on 22 January 2014

RETRACTED ARTICLE:Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice

retracted scientific article published on January 2015

Reduced cortical BACE1 content with one bout of exercise is accompanied by declines in AMPK, Akt, and MAPK signaling in obese, glucose-intolerant mice.

scientific article

Reduction of AMPK activity and altered MAPKs signalling in peripheral blood mononuclear cells in response to acute glucose ingestion following a short-term high fat diet in young healthy men.

scientific article published on 13 June 2014

Reductions in RIP140 are not required for exercise- and AICAR-mediated increases in skeletal muscle mitochondrial content

scientific article published on 23 June 2011

Regulating the regulators: the role of transcriptional regulatory proteins in the adaptive response to exercise in human skeletal muscle

scientific article published on 01 April 2011

Resistance exercise and nutrition to counteract muscle wasting

scientific article published on October 2009

Resistance-based interval exercise acutely improves endothelial function in type 2 diabetes

scientific article published on 16 September 2016

Restricting carbohydrates at breakfast is sufficient to reduce 24-hour exposure to postprandial hyperglycemia and improve glycemic variability

scientific article published on 01 May 2019

Retraction Note to: Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice

Secreted phospholipase A(2) group IIA is a neurotoxin released by stimulated human glial cells.

scientific article published on 3 March 2012

Self-Monitoring Using Continuous Glucose Monitors with Real-Time Feedback Improves Exercise Adherence in Individuals with Impaired Blood Glucose: A Pilot Study.

scientific article published on 17 February 2016

Short-Term Exercise Training Alters Leukocyte Chemokine Receptors in Obese Adults

scientific article published on 18 March 2017

Short-Term Low-Carbohydrate High-Fat Diet in Healthy Young Males Renders the Endothelium Susceptible to Hyperglycemia-Induced Damage, An Exploratory Analysis

scientific article published on 26 February 2019

Short-term exercise training reduces anti-inflammatory action of interleukin-10 in adults with obesity

scientific article published on 06 June 2018

Short-term exercise training reduces glycaemic variability and lowers circulating endothelial microparticles in overweight and obese women at elevated risk of type 2 diabetes

scientific article published on 18 February 2019

Short-term high-intensity interval and moderate-intensity continuous training reduce leukocyte TLR4 in inactive adults at elevated risk of type 2 diabetes.

scientific article

Short-term low-carbohydrate high-fat diet with or without post-meal walks on glycemic control and inflammation in type 2 diabetes: A randomized trial

scientific article published on 10 October 2018

Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance

scientific article

Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis

scientific article published on 02 September 2011

Spinal cord injury impairs cardiac function due to impaired bulbospinal sympathetic control

scientific article published on 16 March 2022

Sprint exercise snacks: a novel approach to increase aerobic fitness

scientific article published on 07 March 2019

Sprint-interval but not continuous exercise increases PGC-1α protein content and p53 phosphorylation in nuclear fractions of human skeletal muscle

scientific article published on 10 March 2017

Supplements and Nutritional Interventions to Augment High-Intensity Interval Training Physiological and Performance Adaptations-A Narrative Review

scientific article published on 31 January 2020

The Effect of Exogenous Ketone Monoester Ingestion on Plasma BDNF During an Oral Glucose Tolerance Test

scientific article published on 09 September 2020

The Impact of Acute Ingestion of a Ketone Monoester Drink on LPS-Stimulated NLRP3 Activation in Humans with Obesity

scientific article published on 23 March 2020

The Saturated Fatty Acid Palmitate Induces Human Monocytic Cell Toxicity Toward Neuronal Cells: Exploring a Possible Link Between Obesity-Related Metabolic Impairments and Neuroinflammation ⬇️

scientific article published on January 1, 2012

The effect of brief intermittent stair climbing on glycemic control in people with type 2 diabetes: a pilot study

scientific article published on 02 May 2018

The effect of low-volume high-intensity interval training on cardiometabolic health and psychological responses in overweight/obese middle-aged men

scientific article published on 04 June 2020

The impact of acute high-intensity interval exercise on biomarkers of cardiovascular health in type 2 diabetes

scientific article published on 31 May 2017

The influence of high-intensity interval training and moderate-intensity continuous training on sedentary time in overweight and obese adults

scientific article published on 7 February 2018

Therapeutic Potential of Cannabinoids in the Treatment of Neuroinflammation Associated with Parkinsons Disease ⬇️

scientific article published on June 1, 2011

Training intensity modulates changes in PGC-1α and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal muscle

scientific article published on 16 November 2015

Where does HIT fit? An examination of the affective response to high-intensity intervals in comparison to continuous moderate- and continuous vigorous-intensity exercise in the exercise intensity-affect continuum

scientific article

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