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List of works by Tao Chen

A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation

scientific article published on 13 April 2014

A synthetic microbial consortium of Shewanella and Bacillus for enhanced generation of bioelectricity

scientific article published on 6 September 2016

Abolishing the imbalance supply of precursors in Bacillus subtilis RH44 to increase riboflavin production

article published in 2008

Activation of glyoxylate pathway without the activation of its related gene in succinate-producing engineered Escherichia coli

scientific article published on 19 July 2013

Adaptive Laboratory Evolution of <i>Halomonas bluephagenesis</i> Enhances Acetate Tolerance and Utilization to Produce Poly(3-hydroxybutyrate)

scientific article published on 08 May 2022

Aerobic production of succinate from arabinose by metabolically engineered Corynebacterium glutamicum.

scientific article

An engineered non-oxidative glycolysis pathway for acetone production in Escherichia coli

scientific article published on 4 May 2016

Aroma improvement by repeated freeze-thaw treatment during Tuber melanosporum fermentation

scientific article

Artificial consortium that produces riboflavin regulates distribution of acetoin and 2,3-butanediol by Paenibacillus polymyxa CJX518

scientific article published on 10 July 2017

Characterization of genome-reduced Bacillus subtilis strains and their application for the production of guanosine and thymidine

scientific article published on 03 June 2016

Collaborative regulation of CO2 transport and fixation during succinate production in Escherichia coli

scientific article

Combinatorial expression of different β-carotene hydroxylases and ketolases in Escherichia coli for increased astaxanthin production

scientific article published on 11 July 2019

Combinatorial optimization of CO2 transport and fixation to improve succinate production by promoter engineering

scientific article published in January 2016

Comparative transcriptome analysis for metabolic engineering

scientific article published in January 2013

Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic podophyllum derivatives display antitumor activity

scientific article

Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4'-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways

scientific article published on 30 March 2014

Development of a markerless gene replacement system in Corynebacterium glutamicum using upp as a counter-selection marker.

scientific article published on 7 November 2014

Directed evolution of adenylosuccinate synthetase from Bacillus subtilis and its application in metabolic engineering

scientific article

Directed pathway evolution of the glyoxylate shunt in Escherichia coli for improved aerobic succinate production from glycerol

scientific article published on 2 October 2013

Engineering Bacillus subtilis for acetoin production from glucose and xylose mixtures

scientific article published on 9 October 2013

Engineering Escherichia coli for fumaric acid production from glycerol.

scientific article

Engineering Escherichia coli for succinate production from hemicellulose via consolidated bioprocessing

scientific article published on 29 March 2012

Engineering central pathways for industrial-level (3R)-acetoin biosynthesis in Corynebacterium glutamicum

scientific article published on 12 May 2020

Engineering microorganisms based on molecular evolutionary analysis: a succinate production case study

scientific article

Engineering of Serine-Deamination pathway, Entner-Doudoroff pathway and pyruvate dehydrogenase complex to improve poly(3-hydroxybutyrate) production in Escherichia coli

scientific article

Engineering of acetate recycling and citrate synthase to improve aerobic succinate production in Corynebacterium glutamicum

scientific article

Enhanced Riboflavin Production by Expressing Heterologous Riboflavin Operon from B. cereus ATCC14579 in Bacillus subtilis

Enhancement of riboflavin production by deregulating gluconeogenesis in Bacillus subtilis

scientific article published on 30 January 2014

Enhancement of riboflavin production by overexpression of acetolactate synthase in a pta mutant of Bacillus subtilis

scientific article published in January 2007

Enhancement of riboflavin production with Bacillus subtilis by expression and site-directed mutagenesis of zwf and gnd gene from Corynebacterium glutamicum

scientific article published on 03 December 2010

Enhancing riboflavin production by genetic modification of purine pathway in Bacillus subtilis

Establishment of a markerless mutation delivery system in Bacillus subtilis stimulated by a double-strand break in the chromosome

scientific article

Evolutionary engineering of Escherichia coli for improved anaerobic growth in minimal medium accelerated lactate production

scientific article published on 08 January 2019

Expression of Vitreoscilla hemoglobin enhances growth and production of riboflavin in recombinant Bacillus subtilis

Expression of galactose permease and pyruvate carboxylase in Escherichia coli ptsG mutant increases the growth rate and succinate yield under anaerobic conditions

scientific article published in January 2006

Fluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells

scientific article

Genome shuffling: Progress and applications for phenotype improvement

scientific article published on 19 May 2009

High-yield anaerobic succinate production by strategically regulating multiple metabolic pathways based on stoichiometric maximum in Escherichia coli

scientific article published on 12 August 2016

Improved poly(3-hydroxybutyrate) production in Escherichia coli by inactivation of cytochrome bd-II oxidase or/and NDH-II dehydrogenase in low efficient respiratory chains

scientific article published on 2 October 2014

Improved succinate production in Corynebacterium glutamicum by engineering glyoxylate pathway and succinate export system

scientific article

Improvement of the riboflavin production by engineering the precursor biosynthesis pathways in Escherichia coli

scholarly article by Zhibo Xu et al published November 2015 in Chinese Journal of Chemical Engineering

Improving Furfural Tolerance of <i>Escherichia coli</i> by Integrating Adaptive Laboratory Evolution with CRISPR-Enabled Trackable Genome Engineering (CREATE)

scientific article published in 2022

Improving riboflavin production by knocking down ribF, purA and guaC genes using synthetic regulatory small RNA

scientific article published in 2021

In silico metabolic engineering of Bacillus subtilis for improved production of riboflavin, Egl-237, (R,R)-2,3-butanediol and isobutanol

scientific article published on 10 May 2013

Increased production of riboflavin by metabolic engineering of the purine pathway in Bacillus subtilis

article published in 2009

Increased riboflavin production by knockout of 6-phosphofructokinase I and blocking the Entner-Doudoroff pathway in Escherichia coli

scientific article published on 12 April 2016

Integrating metabolomics into a systems biology framework to exploit metabolic complexity: strategies and applications in microorganisms

scientific article

Inverse metabolic engineering of Bacillus subtilis for xylose utilization based on adaptive evolution and whole-genome sequencing

scientific article published on 22 October 2014

Isolation and characterization of polysaccharides with the antitumor activity from Tuber fruiting bodies and fermentation system

scientific article published on 24 November 2013

Metabolic engineering of Bacillus subtilis for chiral pure meso-2,3-butanediol production

scientific article published on 19 April 2016

Metabolic engineering of Bacillus subtilis for enhanced production of acetoin

scientific article published on 20 June 2012

Metabolic engineering of Corynebacterium glutamicum for efficient production of 5-aminolevulinic acid

scientific article published on 30 November 2015

Metabolic engineering of Escherichia coli and in silico comparing of carboxylation pathways for high succinate productivity under aerobic conditions

scientific article published on 6 October 2013

Metabolic engineering of Escherichia coli for poly(3-hydroxybutyrate) production via threonine bypass

scientific article

Metabolic engineering of Escherichia coli for the production of riboflavin

scientific article

Metabolic engineering of Escherichia coli using CRISPR-Cas9 meditated genome editing

scientific article published on 30 June 2015

Metabolic engineering of thermophilic Bacillus licheniformis for chiral pure D-2,3-butanediol production

scientific article published on 10 January 2012

Metabolism of L-methionine linked to the biosynthesis of volatile organic sulfur-containing compounds during the submerged fermentation of Tuber melanosporum

scientific article published on 5 October 2013

Model-based reconstruction of synthetic promoter library in Corynebacterium glutamicum

scientific article published on 31 March 2018

Modular Engineering of the Flavin Pathway in Escherichia coli for Improved Flavin Mononucleotide and Flavin Adenine Dinucleotide Production

scientific article published on 03 June 2019

Multiplex iterative plasmid engineering for combinatorial optimization of metabolic pathways and diversification of protein coding sequences

scientific article

NADH plays the vital role for chiral pure D-(-)-2,3-butanediol production in Bacillus subtilis under limited oxygen conditions

scientific article published on 28 May 2014

Optimization of riboflavin production by recombinant Bacillus subtilis RH44 using statistical designs

scientific article

Over-expression of glucose dehydrogenase improves cell growth and riboflavin production in Bacillus subtilis

scientific article published on 16 August 2006

Overexpression of glucose-6-phosphate dehydrogenase enhances riboflavin production in Bacillus subtilis

scientific article published on 25 September 2009

Production of 5-aminolevulinic acid by cell free multi-enzyme catalysis

scientific article published on 21 March 2016

Production of Acetoin through Simultaneous Utilization of Glucose, Xylose, and Arabinose by Engineered Bacillus subtilis

scientific article

Production of riboflavin and related cofactors by biotechnological processes

scientific article published on 13 February 2020

Purification and functional characterization of thermostable 5-aminolevulinic acid synthases

scientific article published on 22 August 2015

Ranking the significance of fermentation conditions on the volatile organic compounds of Tuber melanosporum fermentation system by combination of head-space solid phase microextraction and chromatographic fingerprint similarity analysis

scientific article published on 13 August 2013

Rational Engineering of Escherichia coli for High-Level Production of Riboflavin

scientific article published in 2021

Recent progress in metabolic engineering of microbial formate assimilation

scientific article published on 21 June 2020

Redirection electron flow to high coupling efficiency of terminal oxidase to enhance riboflavin biosynthesis

scientific article published on 31 May 2006

Screening, expression, purification and characterization of CoA-transferases for lactoyl-CoA generation

scientific article published on 08 April 2019

Significance of metal ion supplementation in the fermentation medium on the structure and anti-tumor activity of Tuber polysaccharides produced by submerged culture of Tuber melanosporum

scientific article published in 2014

Strain improvement of Sporolactobacillus inulinus ATCC 15538 for acid tolerance and production of D-lactic acid by genome shuffling

scientific article published on 24 September 2009

Transcriptome analysis guided metabolic engineering of Bacillus subtilis for riboflavin production.

scientific article published on 13 May 2009

Tubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity

scientific article published on 11 May 2015

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