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List of works by Célio L Silva

A dynamic analysis of tuberculosis dissemination to improve control and surveillance

scientific article

Antibody response from whole-cell pertussis vaccine immunized Brazilian children against different strains of Bordetella pertussis.

scientific article

Antigen-presenting cells transfected with Hsp65 messenger RNA fail to treat experimental tuberculosis.

scientific article published on 18 September 2012

Antimycobacterial activity of 2-phenoxy-1-phenylethanone, a synthetic analogue of neolignan, entrapped in polymeric microparticles

scientific article published on 19 August 2011

Antimycobacterial brominated metabolites from two species of marine sponges

scientific article published on 01 April 2006

Attenuation of experimental asthma by mycobacterial protein combined with CpG requires a TLR9-dependent IFN-γ-CCR2 signalling circuit

scientific article published on 5 May 2015

B-lymphocytes in bone marrow or lymph nodes can take up plasmid DNA after intramuscular delivery.

scientific article published in September 2003

BCG and BCG/DNAhsp65 vaccinations promote protective effects without deleterious consequences for experimental autoimmune encephalomyelitis

scientific article published on 29 October 2013

Bacille Calmette-Guérin/DNAhsp65 prime-boost is protective against diabetes in non-obese diabetic mice but not in the streptozotocin model of type 1 diabetes.

scientific article published in September 2013

Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis.

scientific article published on March 2004

Combined immunization using DNA-Sm14 and DNA-Hsp65 increases CD8+ memory T cells, reduces chronic pathology and decreases egg viability during Schistosoma mansoni infection

scientific article

Comparison of different delivery systems of vaccination for the induction of protection against tuberculosis in mice

scientific article published on 01 May 2001

Comprehensive gene expression profiling in lungs of mice infected with Mycobacterium tuberculosis following DNAhsp65 immunotherapy.

scientific article

Control of experimental pulmonary tuberculosis depends more on immunostimulatory leukotrienes than on the absence of immunosuppressive prostaglandins.

scientific article published on 31 May 2011

Cytoplasmic and extracellular expression of pharmaceutical-grade mycobacterial 65-kDa heat shock protein in Lactococcus lactis

scientific article published on 27 April 2012

Cytotoxic T cells and mycobacteria.

scientific article

DNA immunizations with M2 muscarinic and beta1 adrenergic receptor coding plasmids impair cardiac function in mice.

scientific article published in May 2005

DNA vaccines against tuberculosis

scientific article published on 01 December 1997

DNA-hsp65 Vaccine as Therapeutic Strategy to Treat Experimental Chromoblastomycosis Caused by Fonsecaea Pedrosoi ⬇️

scientific article published on November 22, 2012

DNAhsp65 vaccination induces protection in mice against Paracoccidioides brasiliensis infection.

scientific article

Disturbances in the production of interleukin-1 and tumor necrosis factor in disseminated murine sporotrichosis

scientific article published on 01 September 1994

Downmodulation of CD18 and CD86 on macrophages and VLA-4 on lymphocytes in experimental tuberculosis

scientific article published on 01 December 2001

Downmodulation of peripheral MOG-specific immunity by pVAXhsp65 treatment during EAE does not reach the CNS

scientific article published on 06 January 2014

Effectiveness, against tuberculosis, of pseudo-ternary complexes: peptide-DNA-cationic liposome

scientific article published on 24 September 2011

Effects of extrusion, lipid concentration and purity on physico-chemical and biological properties of cationic liposomes for gene vaccine applications

scientific article published on 21 May 2012

Efficacy of DNA-hsp65 vaccination for tuberculosis varies with method of DNA introduction in vivo

scientific article published in December 2003

Efficacy of cell-free antigens in evaluating cell immunity and inducing protection in a murine model of histoplasmosis

scientific article published on 14 March 2005

Endocytosis of DNA-Hsp65 alters the pH of the late endosome/lysosome and interferes with antigen presentation

scientific article

Enhancement of immunocompetence in tuberculosis by DNA vaccination

scientific article published on 01 February 2000

Experimental tuberculosis: designing a better model to test vaccines against tuberculosis.

scientific article published on 25 February 2010

Exposure to Mycobacterium avium decreases the protective effect of the DNA vaccine pVAXhsp65 against Mycobacterium tuberculosis-induced inflammation of the pulmonary parenchyma

scientific article published on 01 April 2011

Exposure to high endotoxin concentration increases wheezing prevalence among laboratory animal workers: a cross-sectional study.

scientific article

Expression of Mycobacterium leprae HSP65 in tobacco and its effectiveness as an oral treatment in adjuvant-induced arthritis

scientific article published on 06 June 2010

Genetic aspects and microenvironment affect expression of CD18 and VLA-4 in experimental tuberculosis

scientific article published on 01 August 2002

Genetic vaccination against tuberculosis.

scientific article published on January 1997

Gr-1+ cells play an essential role in an experimental model of disseminated histoplasmosis

scientific article published on 12 December 2006

Granulomatous reaction induced by lipids isolated from Paracoccidioides brasiliensis

scientific article published on 01 January 1985

HSP65 DNA as therapeutic strategy to treat experimental paracoccidioidomycosis

scientific article published on 31 December 2009

Helminth coinfection does not affect therapeutic effect of a DNA vaccine in mice harboring tuberculosis.

scientific article

Histoplasma capsulatum inhibits apoptosis and Mac-1 expression in leucocytes

scientific article published on 01 October 2002

Host genetic background affects regulatory T-cell activity that influences the magnitude of cellular immune response against Mycobacterium tuberculosis.

scientific article published on 19 October 2010

IL-5 drives eosinophils from bone marrow to blood and tissues in a guinea-pig model of visceral larva migrans syndrome

scientific article published on January 1996

Identification and characterization of murine cytotoxic T cells that kill Mycobacterium tuberculosis

scientific article

Immune modulation induced by tuberculosis DNA vaccine protects non-obese diabetic mice from diabetes progression

scientific article published on 22 June 2007

Immune regulatory effect of pHSP65 DNA therapy in pulmonary tuberculosis: activation of CD8+ cells, interferon-gamma recovery and reduction of lung injury

scientific article published on 01 September 2004

Immunization with plasmids encoding M2 acetylcholine muscarinic receptor epitopes impairs cardiac function in mice and induces autophagy in the myocardium

scientific article published on 01 August 2018

Immunomodulation and protection induced by DNA-hsp65 vaccination in an animal model of arthritis

scientific article published on 01 November 2005

Immunotherapy of tuberculosis with Mycobacterium leprae Hsp65 as a DNA vaccine triggers cross-reactive antibodies against mammalian Hsp60 but not pathological autoimmunity.

scientific article published on 07 March 2014

Immunotherapy with plasmid DNA encoding mycobacterial hsp65 in association with chemotherapy is a more rapid and efficient form of treatment for tuberculosis in mice.

scientific article published in February 2005

In vitro and in vivo activities of leukotriene B4-loaded biodegradable microspheres.

scientific article published in December 2006

Increased levels of interferon-gamma primed by culture filtrate proteins antigen and CpG-ODN immunization do not confer significant protection against Mycobacterium tuberculosis infection

scientific article published on 13 April 2007

Intranasal vaccination with messenger RNA as a new approach in gene therapy: use against tuberculosis

scientific article

Investigation of local anesthetic and antimycobacterial activity of Ottonia martiana Miq. (Piperaceae).

scientific article published on 27 November 2015

Leukotrienes are involved in leukocyte recruitment induced by live Histoplasma capsulatum or by the beta-glucan present in their cell wall

scientific article

Leukotrienes are not essential for the efficacy of a heterologous vaccine against Mycobacterium tuberculosis infection.

scientific article

Low-dose plasmid DNA treatment increases plasma vasopressin and regulates blood pressure in experimental endotoxemia.

scientific article

Mast cells modulate pulmonary acute inflammation and host defense in a murine model of tuberculosis

scientific article published in October 2007

MicroRNA expression signatures in lungs of mice infected with Mycobacterium tuberculosis

scientific article

Modulation of angiogenic factor VEGF by DNA-hsp65 vaccination in a murine CNS tuberculosis model.

scientific article published on 13 March 2013

Mycobacterial Hsp65 antigen upregulates the cellular immune response of healthy individuals compared with tuberculosis patients

scientific article published on 6 January 2017

Mycobacterium hsp65 DNA entrapped into TDM-loaded PLGA microspheres induces protection in mice against Leishmania (Leishmania) major infection.

scientific article published on 24 January 2006

Mycobacterium leprae 65hsp antigen expressed from a retroviral vector in a macrophage cell line is presented to T cells in association with MHC class II in addition to MHC class I

scientific article published on January 1, 1992

Mycobacterium tuberculosis culture filtrate proteins plus CpG Oligodeoxynucleotides confer protection to Mycobacterium bovis BCG-primed mice by inhibiting interleukin-4 secretion.

scientific article published on 14 September 2009

Mycobacterium tuberculosis expressing phospholipase C subverts PGE2 synthesis and induces necrosis in alveolar macrophages.

scientific article

Nanobiotechnological approaches to delivery of DNA vaccine against fungal infection.

scientific article published in February 2013

Neonatal BCG immunization followed by DNAhsp65 boosters: highly immunogenic but not protective against tuberculosis - a paradoxical effect of the vector?

scientific article published on 01 February 2010

New strategy for testing efficacy of immunotherapeutic compounds for diabetes in vitro.

scientific article

P2×7 purinergic signaling in dilated cardiomyopathy induced by auto-immunity against muscarinic M2 receptors: autoantibody levels, heart functionality and cytokine expression

scientific article

Phase I trial of DNA-hsp65 immunotherapy for advanced squamous cell carcinoma of the head and neck

article

Plasma eicosanoid profiles determined by high-performance liquid chromatography coupled with tandem mass spectrometry in stimulated peripheral blood from healthy individuals and sickle cell anemia patients in treatment.

scientific article

Prime-boost vaccination based on DNA and protein-loaded microspheres for tuberculosis prevention.

scientific article published in May 2004

Progress towards a new tuberculosis vaccine

scientific article published on 01 September 1998

Protection against tuberculosis by a plasmid DNA vaccine.

scientific article

Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes.

scientific article

Protection conferred by heterologous vaccination against tuberculosis is dependent on the ratio of CD4(+) /CD4(+)  Foxp3(+) cells

scientific article published on 01 November 2012

Protective efficacy of different strategies employingMycobacterium lepraeheat-shock protein 65 against tuberculosis

scientific article published on 01 September 2008

Purification of 1-monoacylglycerols containing alpha-branched-beta-hydroxylated fatty acids from lipids of Corynebacterium pseudotuberculosis

scientific article published on 01 September 1979

Recombinant BCG Expressing LTAK63 Adjuvant induces Superior Protection against Mycobacterium tuberculosis

scientific article published on 18 May 2017

Recombinant DNA immunotherapy ameliorate established airway allergy in a IL‐10 dependent pathway ⬇️

scientific article published on September 1, 2011

Requirement of MyD88 and Fas pathways for the efficacy of allergen-free immunotherapy.

scientific article published on 24 December 2014

Role of trehalose dimycolate in recruitment of cells and modulation of production of cytokines and NO in tuberculosis.

scientific article published on September 2001

Single dose of a vaccine based on DNA encoding mycobacterial hsp65 protein plus TDM-loaded PLGA microspheres protects mice against a virulent strain of Mycobacterium tuberculosis ⬇️

scientific article published on April 1, 2003

Structure activity relationship, acute toxicity and cytotoxicity of antimycobacterial neolignan analogues

scientific article published on 19 May 2011

Synergy of chemotherapy and immunotherapy revealed by a genome-scale analysis of murine tuberculosis

scientific article published on 16 February 2015

TGF-beta and CD23 are involved in nitric oxide production by pulmonary macrophages activated by beta-glucan from Paracoccidioides brasiliensis

scientific article published on 01 December 2009

TLR2-dependent mast cell activation contributes to the control of Mycobacterium tuberculosis infection

scientific article

The Impact of Transcriptomics on the Fight against Tuberculosis: Focus on Biomarkers, BCG Vaccination, and Immunotherapy ⬇️

scientific article published on December 20, 2010

The contribution of a murine CNS-TB model for the understanding of the host–pathogen interactions in the formation of granulomas ⬇️

scientific article published on February 24, 2012

The role of fractions from Paracoccidioides brasiliensis in the genesis of inflammatory response

scientific article published on 01 January 1987

The synergy between structural stability and DNA-binding controls the antibody production in EPC/DOTAP/DOPE liposomes and DOTAP/DOPE lipoplexes

scientific article

Therapeutic efficacy of Cintredekin Besudotox (IL13-PE38QQR) in murine lung fibrosis is unaffected by immunity to Pseudomonas aeruginosa exotoxin A.

scientific article

Therapy of tuberculosis in mice by DNA vaccination.

scientific article

Thimet oligopeptidase (EC 3.4.24.15), a novel protein on the route of MHC class I antigen presentation

scientific article published on 01 February 1999

Thimet oligopeptidase and the stability of MHC class I epitopes in macrophage cytosol.

scientific article

Towards a DNA vaccine against tuberculosis.

scientific article published on December 1994

pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity.

scientific article published on 21 February 2017

pcDNA-IL-12 vaccination blocks eosinophilic inflammation but not airway hyperresponsiveness following murine Toxocara canis infection

scientific article published on 29 November 2007

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