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List of works by Fred Schaper

A completely foreign receptor can mediate an interferon-gamma-like response

scientific article

A new mechanism for the regulation of Gab1 recruitment to the plasma membrane.

scientific article

A new peptide-affinity tag for the detection and affinity purification of recombinant proteins with a monoclonal antibody

scientific article published on 01 June 2000

A simple work flow for biologically inspired model reduction--application to early JAK-STAT signaling.

scientific article

Activation of NF-kappaB by IL-1beta blocks IL-6-induced sustained STAT3 activation and STAT3-dependent gene expression of the human gamma-fibrinogen gene

scientific article published on May 2007

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression

scientific journal article

Characterization and binding specificity of the monomeric STAT3-SH2 domain

scientific article published on 01 January 1999

Constitutive internalization and association with adaptor protein-2 of the interleukin-6 signal transducer gp130.

scientific article published on December 1998

Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation

scientific article

Cytoplasmic STAT proteins associate prior to activation.

scientific article published on February 2000

Designing optimal experiments to discriminate interaction graph models

scientific article published on 15 March 2018

Different protein turnover of interleukin-6-type cytokine signalling components

scientific article published on 01 October 1999

Dual function of interleukin-1beta for the regulation of interleukin-6-induced suppressor of cytokine signaling 3 expression

scientific article published on 11 August 2004

Functional domains of interferon regulatory factor I (IRF-1) ⬇️

scientific article published on October 1, 1998

Glucagon counteracts interleukin-6-dependent gene expression by redundant action of Epac and PKA

scientific article published on 01 December 2011

Glucocorticoids increase interleukin-6-dependent gene induction by interfering with the expression of the suppressor of cytokine signaling 3 feedback inhibitor

scientific article published on 01 January 2012

Hepatic acute phase proteins – Regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling ⬇️

scientific article published on November 16, 2011

Identification of mammalian cell clones exhibiting highly regulated expression from inducible promoters

scientific article published on 01 June 1995

In vivo formation of IRF-1 homodimers

scientific article published on 01 August 1998

Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability.

scientific article published on 12 January 2018

Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes.

scientific article published on June 1993

Interleukin-6 acts in the fashion of a classical chemokine on monocytic cells by inducing integrin activation, cell adhesion, actin polymerization, chemotaxis, and transmigration.

scientific article

Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-inhibitor REDD1 in a STAT3-dependent manner.

scientific article

Interleukin-6 is a direct mediator of T cell migration

scientific article published on October 2004

Interleukin-6 signalling: More than Jaks and STATs ⬇️

scientific article published on 03 December 2011

Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited.

scientific article

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

scientific article

Interleukin-6: Biology, signaling and strategies of blockade

scientific article published on 04 July 2015

Intragenic regulation of SOCS3 isoforms

scientific article published on 25 June 2019

JAK/STAT signalling--an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology.

scientific article published on 26 February 2013

JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells

scientific article published on 08 April 2013

LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages.

scientific article

Large-scale network models of IL-1 and IL-6 signalling and their hepatocellular specification

scientific article

MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch.

scientific article published on 25 November 2014

Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK.

scientific article

Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling.

scientific article

Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism.

scientific article published on 2 February 2006

Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA

scientific article published on 01 April 1997

Plasticity and cross-talk of interleukin 6-type cytokines

scientific article published on 15 May 2012

Proliferation control of mammalian cells by the tumor suppressor IRF-1.

scientific article

Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation.

scientific article

Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia

scientific article published on 11 April 2013

Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes

scientific article published on 06 February 2006

Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling

scientific article published on 17 May 2019

Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling

scientific article published on 18 January 2019

SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130

scientific article (publication date: 3 January 2003)

SHPS-1/SIRP1alpha contributes to interleukin-6 signalling.

scientific article

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

scientific article (publication date: 28 April 2000)

Self-Organization and Regulation of Intrinsically Disordered Proteins with Folded N-Termini ⬇️

scientific article published on February 15, 2011

Signal transduction in the footsteps of goethe and schiller

scientific article published on 4 February 2009

Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation

scientific article (publication date: September 2000)

Signal transduction--receptors, mediators, and genes

scientific article published on 24 March 2009

Systems biology of IL-6, IL-12 family cytokines

scientific article published on 04 July 2015

The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription

scientific article (publication date: October 2001)

The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction

scientific article published on 01 January 2000

The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells.

scientific article published on 29 March 2017

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner

scientific article published on 24 October 2019

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling ⬇️

scientific article published on March 1, 2004

The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling.

scientific article

mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice

scientific article published on 16 January 2013

“Family reunion” – A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines

article

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