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List of works by Chris Goodnow

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.

scientific article

A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy.

scientific article published on 15 July 2016

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

scientific journal article

A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.

scientific article

A critical role for complement in maintenance of self-tolerance

scientific article published on 01 November 1998

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

scientific article published on 01 November 2019

A mechanism for Ikaros regulation of human globin gene switching.

scientific article published on 3 March 2008

A missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouse

scientific article

A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development

scientific journal article

A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation.

scientific article published on 8 November 2017

A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.

scientific article published in August 1997

A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence

scientific article published on 30 November 2006

A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes.

scientific article

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage.

scientific article published on 26 September 2016

A timeline demarcating two waves of clonal deletion and Foxp3 upregulation during thymocyte development.

scientific article published on 29 October 2015

ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes

scientific journal article

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

scientific article

Abortive proliferation of rare T cells induced by direct or indirect antigen presentation by rare B cells in vivo.

scientific article

Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice.

scientific article published on 20 February 2006

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

scientific article published on August 1988

Analysis of B cell memory formation using DNA microarrays.

scientific article published in December 2002

Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival

scientific article published on 01 December 2005

Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells

scientific article

Antigen-driven EGR2 expression is required for exhausted CD8<sup>+</sup> T cell stability and maintenance

scientific article published on 13 May 2021

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

scientific article

Autoimmune tolerance and type 1 (insulin-dependent) diabetes mellitus

scientific article published on December 1, 1992

Autoimmunity. The Fas track.

scientific article published on November 1995

Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100.

scientific article

B Cell Antigen Receptor Signalling in the Balance of Tolerance and Immunity ⬇️

scientific article published on 01 January 1998

B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects

scientific article published on 20 February 2019

B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle.

scientific article

Breakdown of self-tolerance in anergic B lymphocytes.

scientific article published in August 1991

Brief Report: Identification of a Pathogenic Variant in TREX1 in Early-Onset Cerebral Systemic Lupus Erythematosus by Whole-Exome Sequencing

scientific article published on 01 December 2014

Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory.

scientific article

C3d of complement as a molecular adjuvant: bridging innate and acquired immunity

scientific article

CD19-Regulated Signaling Thresholds Control Peripheral Tolerance and Autoantibody Production in B Lymphocytes ⬇️

scientific article published on December 1, 1997

CD45-mediated control of TCR tuning in naïve and memory CD8(+) T cells.

scientific article

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation. ⬇️

scientific article

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells ⬇️

scientific article published on July 13, 1995

COVID-19, varying genetic resistance to viral disease, and immune tolerance checkpoints

scientific article published on 28 October 2020

Candidate gene discovery in autoimmunity by using extreme phenotypes, next generation sequencing and whole exome capture

scientific article

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

scientific article published on 16 September 2015

Cellular mechanisms of self-tolerance.

scientific article published on December 1989

Censoring of self-reactive B cells with a range of receptor affinities in transgenic mice expressing heavy chains for a lysozyme-specific antibody

scientific article published on 01 September 1994

Chance encounters and organized rendezvous.

scientific article

Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity

scientific article published on 26 September 2019

Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization.

scientific article published on 13 June 2016

Comparison of predicted and actual consequences of missense mutations

scientific article

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.

scientific article published in September 1994

Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens

scientific article published on 27 August 2020

Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system.

scientific article

Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation.

scientific article

Control systems and decision making for antibody production.

scientific article published on 20 July 2010

Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL

scientific article published on 15 August 2011

DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns

scientific article published on 01 February 2019

DNA drives autoimmunity

scientific article published in Nature

Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3–positive regulatory versus TH2 effector cells to cause allergy ⬇️

scientific article published on February 12, 2011

Dedicator of cytokinesis 8-deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells.

scientific article published on 20 August 2016

DeepSNVMiner: a sequence analysis tool to detect emergent, rare mutations in subsets of cell populations

scientific article published on 24 May 2016

Defective T-cell function leading to reduced antibody production in a kleisin-beta mutant mouse.

scientific article published on 4 April 2008

Delayed control of herpes simplex virus infection and impaired CD4(+) T-cell migration to the skin in mouse models of DOCK8 deficiency

scientific article published on 17 March 2015

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

scientific article published on 18 September 2019

Dependence of germinal center B cells on expression of CD21/CD35 for survival.

scientific article published in April 1998

Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice

scientific article published on 01 February 1992

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.

scientific article published on 8 August 2006

Differential regulation of early and late stages of B lymphocyte development by the mu and delta membrane heavy chains of Ig.

scientific article published in December 1994

Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells

scientific article

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

scientific article

ERK signaling is a molecular switch integrating opposing inputs from B cell receptor and T cell cytokines to control TLR4-driven plasma cell differentiation.

scientific article published in October 2006

Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.

scientific article published in February 1993

Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors

scientific article

Entry of B cell receptor into signaling domains is inhibited in tolerant B cells.

scientific article

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

scientific article published on 01 January 2010

Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.

scientific article published in October 1996

Expression of T-cell receptor alpha-chain genes in transgenic mice.

scientific article published on December 1988

Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.

scientific article

Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.

scientific article

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

scientific article

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

scientific article published in December 2004

Genes, pathways and checkpoints in lymphocyte development and homeostasis.

scientific article

Genetic lesions in T-cell tolerance and thresholds for autoimmunity.

scientific article

Genomic-scale gene expression analysis of lymphocyte growth, tolerance and malignancy.

scientific article

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.

scientific article published in April 2018

HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse.

scientific article published on 23 October 2015

Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.

scientific article published on 21 January 2013

Helper T cell immunity in humans with inherited CD4 deficiency

scientific article published in 2024

Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion

scientific article

High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes

scientific article published on 16 July 2019

How host defense is encoded in the mammalian genome

scientific article published on 25 December 2010

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis.

scientific article published on February 2000

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production.

scientific article

IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation

article

IL-2 prevents deletion of developing T-regulatory cells in the thymus.

scientific article published on 31 March 2017

IRF2 transcriptionally induces GSDMD expression for pyroptosis

scientific article published on 21 May 2019

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

scientific article published on 22 June 2015

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

scientific article

IgD attenuates the IgM-induced anergy response in transitional and mature B cells.

scientific article

IgD expression on B cells is more efficient than IgM but both receptors are functionally equivalent in up-regulation CD80/CD86 co-stimulatory molecules

scientific article published on 01 July 1995

Immune Responses: costimulatory receptors have their say.

scientific article

Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen ⬇️

scientific article published on October 1, 1992

Immunology. Discriminating microbe from self suffers a double toll

scientific article published on 01 June 2006

Immunology. Memory needs no reminders.

scientific article published in October 2000

Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.

scientific article published on 18 May 2009

Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling

scientific article published on January 2007

Indirect presentation in the thymus limits naïve and regulatory T cell differentiation by promoting deletion of self-reactive thymocytes.

scientific article published on 7 February 2018

Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen.

scientific article published on March 1991

Induction of self-tolerance in mature peripheral B lymphocytes

scientific article published in Nature

Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo

scientific article published on 25 July 2016

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

scientific article published on April 1996

Intrinsic in vitro abnormalities in dendritic cell generation caused by non-MHC non-obese diabetic genes

scientific article published on 01 April 2002

LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility

scientific journal article

Loss of hnRNPLL-dependent splicing of Ptprc has no impact on B-cell development, activation and terminal differentiation into antibody-secreting cells

scientific article published on 17 December 2020

Lymphocyte homing: the scent of a follicle.

scientific article published on April 1997

Lymphoma and the control of B cell growth and differentiation.

scientific article

Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.

scientific article

Mechanisms of self-tolerance and autoimmunity: from whole-animal phenotypes to molecular pathways.

scientific article

Molecular Profiling and Clonal Tracking of Secreted Rheumatoid Factors in Primary Sjögren's Syndrome

scientific article published on 03 August 2018

Multistep pathogenesis of autoimmune disease.

scientific article published on July 2007

Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation.

scientific article

Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells

scientific article published on 13 January 2014

Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome

scientific article

Nossal and Pike 1975: a turning point in the effort to define self-tolerance mechanisms.

scientific article published in November 2007

Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren's syndrome

scientific article published on 2 June 2015

Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

scientific article

Pathways for self-tolerance and the treatment of autoimmune diseases.

scientific article

Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords ⬇️

scientific article published on August 1, 1995

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

scientific article published on 9 December 2015

Polygenic Autoimmune Traits: Lyn, CD22, and SHP-1 Are Limiting Elements of a Biochemical Pathway Regulating BCR Signaling and Selection ⬇️

scientific article published on April 1, 1998

Positive versus negative signaling by lymphocyte antigen receptors ⬇️

scientific article published on January 1, 1998

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.

scientific article published in January 1995

Quantitative and Qualitative Control of Antigen Receptor Signalling in Tolerant B Lymphocytes ⬇️

scientific article published on 01 January 1998

Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.

scientific article

RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility

scientific article

Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.

scientific article published on 12 December 2013

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.

scientific article

Regulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway.

scientific article

Reliably Detecting Clinically Important Variants Requires Both Combined Variant Calls and Optimized Filtering Strategies

scientific article published on 23 November 2015

Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T Cells ⬇️

scientific article published on August 17, 1998

Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

scientific article published on 11 May 2003

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

scientific article

STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles

scientific article published on 23 February 2018

Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling.

scientific article published on November 2003

Self tolerance in the B-cell repertoire.

scientific article published on August 1991

Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells.

scientific article published in December 1997

Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing.

scientific article

Sequence interpretation. Functional annotation of mouse genome sequences

scientific article

Signaling through murine CD38 is impaired in antigen receptor-unresponsive B cells.

scientific article published on May 1995

Single epitope multiple staining to detect ultralow frequency B cells.

scientific article

SnapShot: Interactions between B Cells and T Cells

scientific article published on August 2015

Spontaneous B cell hyperactivity in autoimmune-prone MRL mice

scientific article published on 30 May 2006

Spontaneous Follicular Exclusion of SHP1-deficient B Cells Is Conditional on the Presence of Competitor Wild-type B Cells ⬇️

scientific article published on March 16, 1998

Structural basis of antigen recognition: crystal structure of duck egg lysozyme

scientific article published on 25 October 2017

Synergistic cooperation and crosstalk between MYD88L265P and mutations that dysregulate CD79B and surface IgM.

scientific article published on 12 July 2017

Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.

scientific article

T cells and follicular dendritic cells in germinal center B-cell formation and selection.

scientific article published on September 2010

T-cell receptor gene structure and function

scientific article published on 01 April 1986

TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints.

scientific article

The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA.

scientific article

The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8+ T Cell Tolerance Checkpoint to High-Dose Antigen

scientific article published on 01 July 2018

The coming of transgenic mice: tolerance and immune reactivity

scientific article published on 01 March 1990

The essential role of DOCK8 in humoral immunity

scientific article published on January 2010

The in vivo balance between B cell clonal expansion and elimination is regulated by CD95 both on B cells and in their micro-environment.

scientific article published in October 1998

The need for central and peripheral tolerance in the B cell repertoire

scientific article

The regulation of self-reactive B cells.

scientific article published on December 1995

The role of endoplasmic reticulum stress in nonimmune diabetes: NOD.k iHEL, a novel model of beta cell death.

scientific article

The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity.

scientific article

Tracing the action of IL-2 in tolerance to islet-specific antigen

scientific article published on 20 March 2007

Transgenic mice and analysis of B-cell tolerance

scientific article published on January 1, 1992

Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment.

scientific article published on May 1997

Two levels of protection for the B cell genome during somatic hypermutation.

scientific article

Understanding Immune Tolerance of Cancer: Re-Purposing Insights from Fetal Allografts and Microbes

scientific article published on 04 June 2018

Understanding the immunological impact of the human mutation explosion ⬇️

scientific article published on January 16, 2013

Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids.

scientific article

Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes.

scientific article

Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment.

scientific article

Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes.

scientific article

αβ T-cell receptors with a central CDR3 cysteine are enriched in CD8αα intraepithelial lymphocytes and their thymic precursors

scientific article published on 03 May 2018

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