List of works - Christopher Abell

A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry

scientific article

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

scientific article

Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

scientific article

Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes

scientific article

Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity

scientific article

Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases

scientific article

Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51

scientific article

From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo‐Like Kinase 1 ⬇️

scientific article published on March 29, 2011

Hierarchical Self-Assembly of Cellulose Nanocrystals in a Confined Geometry

scientific article

High‐Throughput Interrogation of Ligand Binding Mode Using a Fluorescence‐Based Assay ⬇️

scientific article published on June 22, 2012

Inhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction Intermediate

scientific article

Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

scientific article

Optimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery against Mycobacterium tuberculosis Pantothenate Synthetase

scientific article

Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series TargetingMycobacterium tuberculosisCYP121

scientific article

Structural constraints on protein self-processing in L-aspartate- -decarboxylase

scientific article

Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis

scientific article

Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites

scientific article

Structure ofEscherichia coliaspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation

scientific article

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

scientific article

The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor

scientific article

Threonine 57 is required for the post-translational activation ofEscherichia coliaspartate α-decarboxylase ⬇️

scientific article

Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1

scientific article

Using a Fragment-Based Approach To Target Protein-Protein Interactions

scientific article

Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically

scientific article

pH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study

scientific article

List of works by Christopher Abell

A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes

Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity

Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases

Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51

From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo‐Like Kinase 1 ⬇️

Hierarchical Self-Assembly of Cellulose Nanocrystals in a Confined Geometry

High‐Throughput Interrogation of Ligand Binding Mode Using a Fluorescence‐Based Assay ⬇️

Inhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction Intermediate

Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

Optimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery against Mycobacterium tuberculosis Pantothenate Synthetase

Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series TargetingMycobacterium tuberculosisCYP121

Structural constraints on protein self-processing in L-aspartate- -decarboxylase

Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis

Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites

Structure ofEscherichia coliaspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor

Threonine 57 is required for the post-translational activation ofEscherichia coliaspartate α-decarboxylase ⬇️

Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1

Using a Fragment-Based Approach To Target Protein-Protein Interactions

Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically

pH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study