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List of works by Mario Santinami

A phase II trial of vaccination with autologous, tumor-derived heat-shock protein peptide complexes Gp96, in combination with GM-CSF and interferon-α in metastatic melanoma patients

article by Lorenzo Pilla et al published 8 October 2005 in Cancer Immunology, Immunotherapy

A variant in FTO shows association with melanoma risk not due to BMI

scientific article

Accuracy and prognostic value of sentinel lymph node biopsy in head and neck melanomas.

scientific article published on 23 October 2013

Adjuvant Dabrafenib plus Trametinib in Stage III BRAF-Mutated Melanoma.

scientific article published on 10 September 2017

Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial

scientific article

Adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma: a phase III randomized controlled trial of health-related quality of life and symptoms by the European Organisation for Research and Treatment of C

scientific article published on 11 May 2009

Advanced Extremity Soft Tissue Sarcoma: Prognostic Effect of Isolated Limb Perfusion in a Series of 88 Patients Treated at a Single Institution

scientific article published on 23 November 2006

Alternative activation of human plasmacytoid DCs in vitro and in melanoma lesions: involvement of LAG-3.

scientific article

Analysis of surrogate gene expression markers in peripheral blood of melanoma patients to predict treatment outcome of adjuvant pegylated interferon alpha 2b (EORTC 18991 side study).

scientific article published on 27 April 2013

Antitumor activity of hyperthermia alone or in combination with cisplatin and melphalan in primary cultures of human malignant melanoma

article

Armed antibodies for cancer treatment: a promising tool in a changing era.

scientific article

Association of promoter polymorphism -765G>C in the PTGS2 gene with malignant melanoma in Italian patients and its correlation to gene expression in dermal fibroblasts.

scientific article published in October 2014

Atypical pleomorphic epithelioid angiomyolipoma localized to the pelvis: a case report and review of the literature.

scientific article published on March 2004

Automated segmentation of pigmented skin lesions in multispectral imaging.

scientific article published in November 2005

Banked venous homograft replacement of the inferior vena cava for primary leiomyosarcoma

scientific article published on 13 November 2006

Biological insights into BRAF(V600) mutations in melanoma patient: Not mere therapeutic targets

scientific article published on 3 July 2013

CDKN2A and MC1R variants influence dermoscopic and confocal features of benign melanocytic lesions in multiple melanoma patients.

scientific article published in June 2013

Chordoma: natural history and results in 28 patients treated at a single institution.

scientific article

Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).

scientific article published on 28 September 2009

Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes

scientific article published on 13 December 2012

Constitutive expression and costimulatory function of LIGHT/TNFSF14 on human melanoma cells and melanoma-derived microvesicles.

scientific article

Cutaneous Melanoma in Childhood and Adolescence Shows Frequent Loss of INK4A and Gain of KIT

article

Cutaneous melanoma in children and adolescents: the Italian rare tumors in pediatric age project experience.

scientific article published on 16 November 2013

DNA fragmentation and cell proliferation correlated with tumor grade in patients with hepatocellular carcinoma

scientific article published on 01 October 2002

Deliberate hypoxic pelvic and limb chemoperfusion in the treatment of recurrent melanoma.

scientific article published in January 2002

Detection of mutated BRAFV600E variant in circulating DNA of stage III–IV melanoma patients

scientific article published on 01 June 2007

Differences in Clinicopathological Features and Distribution of Risk Factors in Italian Melanoma Patients

article

Does Melanoma Behave Differently in Younger Children Than in Adults? A Retrospective Study of 33 Cases of Childhood Melanoma From a Single Institution

scientific article published on 01 March 2005

Effect of long-term adjuvant therapy with interferon alpha-2a in patients with regional node metastases from cutaneous melanoma: a randomised trial

scientific article published in September 2001

Effects of cyclophosphamide and IL-2 on regulatory CD4+ T cell frequency and function in melanoma patients vaccinated with HLA-class I peptides: impact on the antigen-specific T cell response

scientific article published on 16 April 2013

Elective lymph node dissection for melanoma: two perspectives

scientific article published on March 1, 1992

Electrochemotherapy: a good idea in recurrent basal cell carcinoma treatment

scientific article published on 25 February 2015

Enrichment of CD56(dim)KIR + CD57 + highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients

scientific article

Enrichment of KIR+CD57+ highly cytotoxic NK cells in sentinel lymph nodes of melanoma patients.

scientific article published on 6 May 2014

Excision of Primary Melanoma Should Allow Primary Closure of the Wound ⬇️

scientific article published on January 1, 1995

Factors predictive of pelvic lymph node involvement and outcomes in melanoma patients with metastatic sentinel lymph node of the groin: A multicentre study

scientific article published on 11 March 2015

HLA antigens in familial and sporadic cutaneous melanoma.

scientific article published in December 1988

Heat shock proteins and their use as anticancer vaccines.

scientific article

High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients

scientific article

Hypoxic pelvic and limb perfusion with melphalan and mitomycin C for recurrent limb melanoma

scientific article published on 01 February 2003

Immediate or delayed dissection of regional nodes in patients with melanoma of the trunk: a randomised trial. WHO Melanoma Programme

scientific article

Immunization of stage IV melanoma patients with Melan-A/MART-1 and gp100 peptides plus IFN-alpha results in the activation of specific CD8(+) T cells and monocyte/dendritic cell precursors.

scientific article published in May 2006

Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells.

scientific article published on 14 June 2016

Immunotherapy of melanoma

scientific article published on 01 December 2003

Impact of Clinical Trials on the Treatment of Melanoma ⬇️

scientific article published on 01 October 2001

Impaired STAT phosphorylation in T cells from melanoma patients in response to IL-2: association with clinical stage

scientific article published on 09 June 2009

Intralesional administration of L19-IL2/L19-TNF in stage III or stage IVM1a melanoma patients: results of a phase II study

scientific article published on 14 May 2015

Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): an open-label, single-arm phase 2 trial

scientific article

Isolated limb perfusion with the tumor-targeting human monoclonal antibody-cytokine fusion protein L19-TNF plus melphalan and mild hyperthermia in patients with locally advanced extremity melanoma

article published in 2012

Isolation perfusion in extracorporeal circulation with interleukin-2 and lymphokine-activated killer cells in the treatment of in-transit metastases from limb cutaneous melanoma

scientific article published on 01 January 1995

Isolation perfusion of the lower limb with platinum

scientific article published on 01 June 1988

Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma ⬇️

scientific article published on May 15, 2003

Limited induction of tumor cross-reactive T cells without a measurable clinical benefit in early melanoma patients vaccinated with human leukocyte antigen class I-modified peptides

scientific article published on 2 October 2012

Long-term results of the randomized phase III trial EORTC 18991 of adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma

scientific article published on 24 September 2012

Longer Follow-Up Confirms Relapse-Free Survival Benefit With Adjuvant Dabrafenib Plus Trametinib in Patients With Resected BRAF V600-Mutant Stage III Melanoma

article

Management of nodal metastases from head and neck melanoma

scientific article published on 01 September 1989

Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential.

scientific article published on 22 February 2007

Melanoma immunology: past, present and future.

scientific article published on March 2007

Micro-melanoma detection: a clinical study on 206 consecutive cases of pigmented skin lesions with a diameter < or = 3 mm

scientific article published on 01 September 2006

Modified peptides in anti-cancer vaccines: are we eventually improving anti-tumour immunity?

scientific article published on 08 November 2008

Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes.

scientific article

Multispectral imaging and artificial neural network: mimicking the management decision of the clinician facing pigmented skin lesions

scientific article published on 17 April 2007

NFATc2 is an intrinsic regulator of melanoma dedifferentiation

scientific article published on 21 September 2015

New common variants affecting susceptibility to basal cell carcinoma

scientific article

Number of excised lymph nodes as a quality assurance measure for lymphadenectomy in melanoma

scientific article published in July 2014

Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b

scientific article published on 14 December 2015

Patient-reported outcomes in patients with resected, high-risk melanoma with BRAFV600E or BRAFV600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD): a randomised, placebo-controlled, phase 3 trial

scientific article published on 27 March 2019

Phase III trial comparing adjuvant treatment with pegylated interferon Alfa-2b versus observation: prognostic significance of autoantibodies--EORTC 18991.

scientific article

Prediction of survival in patients with thin melanoma: results from a multi-institution study.

scientific article

Prognosis of skin melanoma with regional node metastases (stage II)

scientific article published on 01 April 1984

Prognostic factors in Merkel cell carcinoma patients undergoing sentinel node biopsy.

scientific article published on 25 May 2017

Pure desmoplastic melanoma: a melanoma with distinctive clinical behavior.

scientific article published in December 2010

Quality of surgery and outcome in extra-abdominal aggressive fibromatosis: a series of patients surgically treated at a single institution.

scientific article

Radical dissection after positive groin sentinel biopsy in melanoma patients: rate of further positive nodes

scientific article published in April 2009

Reply to E. Hindié and K.R. Hess

scientific article published on 02 April 2019

Response to Griewank and Bastian

Retroperitoneal soft tissue sarcomas: patterns of recurrence in 167 patients treated at a single institution.

scientific article published in June 2004

Sentinel and nonsentinel node status in stage IB and II melanoma patients: two-step prognostic indicators of survival.

scientific article

Seven years experience with hyperthermic perfusions in extracorporeal circulation for melanoma of the extremities

scientific article published on 01 November 1989

Sex-specific effect of RNASEL rs486907 and miR-146a rs2910164 polymorphisms' interaction as a susceptibility factor for melanoma skin cancer.

scientific article

Single-institution series of early-stage Merkel cell carcinoma: long-term outcomes in 95 patients managed with surgery alone

scientific article published on 16 July 2009

Small nodular melanoma: the beginning of a life-threatening lesion. A clinical study on 11 cases.

scientific article published in January 2011

The number of excised lymph nodes is associated with survival of melanoma patients with lymph node metastasis

scientific article published in January 2014

The use of polytetrafluoroethylene to facilitate the vascular access in recurrent melanoma to limbs.

scientific article published on 27 September 2012

Three-year follow-up of advanced melanoma patients who received ipilimumab plus fotemustine in the Italian Network for Tumor Biotherapy (NIBIT)-M1 phase II study

scientific article published on 23 December 2014

Transcriptional profiling of melanoma sentinel nodes identify patients with poor outcome and reveal an association of CD30(+) T lymphocytes with progression

scientific article published on January 2014

Treatment of primary or relapsing limb cancer by isolation perfusion with high-dose alpha-tumor necrosis factor, gamma-interferon, and melphalan

scientific article published on 01 January 1994

Tumor-reactive CD8+ early effector T cells identified at tumor site in primary and metastatic melanoma.

scientific article published on 21 September 2010

Ulceration and stage are predictive of interferon efficacy in melanoma: results of the phase III adjuvant trials EORTC 18952 and EORTC 18991.

scientific article published on 5 November 2011

Vaccination: role in metastatic melanoma.

scientific article published on August 2006

World Health Organization experience in the treatment of melanoma.

scientific article

microRNA Expression in Sentinel Nodes from Progressing Melanoma Patients Identifies Networks Associated with Dysfunctional Immune Response

scientific article published on 14 December 2016

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

scientific article published on July 2010

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