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List of works by Paul M. Loadman

5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study ⬇️

scientific article published on April 22, 2003

A Novel Theranostic Strategy for MMP-14-Expressing Glioblastomas Impacts Survival.

scientific article

A liquid chromatography-tandem mass spectrometry method to measure fatty acids in biological samples ⬇️

scientific article

A preclinical pharmacokinetic study of the bioreductive drug AQ4N

scientific article published on 01 April 2001

A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota ⬇️

scientific article published on 26 September 2017

A randomized controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme (The seAFOod Polyp Prevention Trial): study protocol for a randomize

scientific article published on 29 July 2013

A study of inter-individual variability in the Phase II metabolism of xenobiotics in human skin

scientific article published on 27 April 2018

An optimised assay for quantitative, high-throughput analysis of polysialyltransferase activity

scientific article published on 12 August 2016

Analysis of the imidazoacridinone C1311 by high-performance liquid chromatography

scientific article published on 01 March 1997

Angiogenesis in the hollow fiber tumor model influences drug delivery to tumor cells: implications for anticancer drug screening programs

scientific article published on 01 December 1998

Anticancer Drug Development

Anticolorectal cancer activity of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid

scientific article published on 27 January 2014

Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.

scientific article

Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1 targeted tripartite quinone drug delivery system.

scientific article published on December 2007

Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins

scientific article published on 15 April 2013

Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma

scientific article published on 01 January 2000

Comet assay and flow cytometry analysis of DNA repair in normal and cancer cells treated with known mutagens with different mechanisms of action.

scientific article published in January 2003

Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development

scientific article published on 01 June 2003

Detergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification for in situ proteomic investigation of frozen and formalin-fixed paraffin-embedded adenocarcinoma tissue sections

scientific article

Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases ⬇️

scientific article published on July 27, 2010

Development of novel tumor-targeted theranostic nanoparticles activated by membrane-type matrix metalloproteinases for combined cancer magnetic resonance imaging and therapy

scientific article published on 27 August 2013

Drug delivery in a tumour cord model: a computational simulation ⬇️

scientific article

Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells

scientific article

Effects of routes of administration of TCNU on its plasma, tissue and tumour concentrations

scientific article published in August 1988

Eicosapentaenoic acid and/or aspirin for preventing colorectal adenomas during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme: the seAFOod RCT

Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota

scientific article

Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours.

scientific article published on June 1998

Evaluation of the safety of C-1311 (SYMADEX) administered in a phase 1 dose escalation trial as a weekly infusion for 3 consecutive weeks in patients with advanced solid tumours

scientific article published on 22 December 2009

Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry

scientific article

Experimental anti-tumor effects of flavone acetic acid (LM975)

scientific article published on 01 January 1988

Expression of matrix metalloproteinase-10 in human bladder transitional cell carcinoma.

scientific article published on April 2005

Extraction of the synthetic lytic peptide, cecropin B, from biological fluid and analysis using reversed-phase high-performance liquid chromatography.

scientific article published on October 1995

FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms

scientific article

Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid).

scientific article

Gas chromatographic analysis of triethylenethiophosphoramide and triethylenephosphoramide in biological specimens

scientific article published on 01 March 1985

High-performance liquid chromatographic analysis of AQ4N, an alkylaminoanthraquinone N-oxide.

scientific article published on June 2000

How can the potential of the duocarmycins be unlocked for cancer therapy?

scientific article published on 21 November 2020

Identification of stage-specific breast markers using quantitative proteomics

scientific article published on 29 October 2013

Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy.

scientific article published on May 2004

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog

scientific article

In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts.

scientific article

In vivo metabolism of the antitumor imidazoacridinone C1311 in the mouse and in vitro comparison with humans.

scientific article published on February 1999

Inactivation of apaziquone by haematuria: implications for the design of phase III clinical trials against non-muscle invasive bladder cancer

scientific article published on 13 March 2019

Influence of the tissue distribution of ThioTEPA and its metabolite, TEPA, on the response of murine colon tumours

scientific article published on 01 January 1987

MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas.

scientific article

Mathematical and computational models of drug transport in tumours.

scientific article published on 12 March 2014

Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases ⬇️

scientific article published on 07 October 2016

Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: correlation of MMP-14 mRNA expression and proteolytic activity.

scientific article

Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging

scientific article published on 01 May 2008

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

scientific article published on 14 October 2011

Mucosal biomarkers of colorectal cancer risk do not increase at 6 months following sleeve gastrectomy, unlike gastric bypass

scientific article published in January 2014

NAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C.

scientific article published in October 2004

Pharmacokinetic drug interactions with anticancer drugs.

scientific article published on June 1994

Pharmacokinetics and anti-tumour activity of B.4152, a reactive molecular combination of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea, and its uracil analogue

scientific article published on 01 March 1996

Pharmacokinetics and cytotoxicity of B.3839, a molecular combination of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea, in a mouse model

scientific article published on 01 August 1992

Pharmacokinetics and tissue distribution of the imidazoacridinone C1311 in tumour-bearing mice

scientific article published on 01 January 1998

Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9.

scientific article

Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration

scientific article (publication date: 2013)

Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice

scientific article published on 01 April 2000

Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment

scientific article published on 9 September 2016

Potentiation of EO9 anti-tumour activity by hydralazine

scientific article published on 01 January 1993

Preclinical pharmacology of the pyrrolobenzodiazepine (PBD) monomer DRH-417 (NSC 709119).

scientific article published on February 2007

Predicting tumor responses to mitomycin C on the basis of DT-diaphorase activity or drug metabolism by tumor homogenates: implications for enzyme-directed bioreductive drug development

scientific article published on 01 November 2000

Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent.

scientific article published on August 2004

Proteases in cancer drug delivery.

scientific article

Rationalized Computer-Aided Design of Matrix-Metalloprotease-Selective Prodrugs

scientific article published on 4 May 2017

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

scientific article published on 26 July 2013

Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy.

scientific article

Separation methods for anthraquinone related anti-cancer drugs.

scientific article

Structural properties governing drug-plasma protein binding determined by high-performance liquid chromatography method

scientific article

Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties

scientific article

Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation.

scientific article

The relationship between the in vitro chemosensitivity of tumor cells and tumor response in vivo in an experimental tumor model

scientific article published on 01 March 1991

Thin-layer chromatography/matrix-assisted laser desorption/ionisation mass spectrometry and matrix-assisted laser desorption/ionisation mass spectrometry imaging for the analysis of phospholipids in LS174T colorectal adenocarcinoma xenografts treate

scientific article published on July 2015

ThioTEPA pharmacokinetics during intravesical chemotherapy and the influence of Tween 80

scientific article published on 01 January 1990

ThioTEPA pharmacokinetics during intravesical chemotherapy: the influence of dose and volume of instillate on systemic uptake and dose rate to the tumour

scientific article published on 01 January 1996

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

scientific article published on 17 February 2011

Tumor-targeted prodrug ICT2588 demonstrates therapeutic activity against solid tumors and reduced potential for cardiovascular toxicity

scientific article published on 27 March 2014

Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512).

scientific article

Use of matrix-assisted laser desorption/ionisation mass spectrometry in cancer research.

scientific article

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