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List of works by Melvin E. Andersen

1,1-Dichloroethylene nephrotoxicity in the rat.

scientific article published in October 1978

3-chlorotyrosine and 3,5-dichlorotyrosine as biomarkers of respiratory tract exposure to chlorine gas.

scientific article published in January 2008

A Multicompartment Geometric Model of the Liver in Relation to Regional Induction of Cytochrome P450s

article

A Perspective on Biologically-Based Approaches to Dioxin Risk Assessment

article

A Physiologically Based Pharmacokinetic Description of the Oral Uptake, Tissue Dosimetry, and Rates of Metabolism of Bromodichloromethane in the Male Rat

scientific article published on 01 June 1998

A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation

scientific article published on 02 October 2018

A biologically based dose-response model for dietary iodide and the hypothalamic-pituitary-thyroid axis in the adult rat: evaluation of iodide deficiency

scientific article published on 3 January 2008

A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity

article

A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin

scientific article

A comprehensive statistical analysis of predicting in vivo hazard using high-throughput in vitro screening

scientific article published on 26 April 2012

A dermatotoxicokinetic model of human exposures to jet fuel

scientific article published on 26 June 2006

A deterministic map of Waddington's epigenetic landscape for cell fate specification

scientific article

A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development.

scientific article

A framework for the next generation of risk science

scientific article

A hybrid CFD-PBPK model for naphthalene in rat and human with IVIVE for nasal tissue metabolism and cross-species dosimetry

scientific article published on 25 March 2014

A map of the PPARα transcription regulatory network for primary human hepatocytes

scientific article published on 22 November 2013

A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure

scientific article

A pharmacokinetic model describing pulsatile uptake of orally-administered carbon tetrachloride

article

A physiological pharmacokinetic model for dermal absorption of vapors in the rat*1

article

A physiologically based description of ethylene oxide dosimetry in the rat

scientific article published on May 1, 1992

A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans

scientific article published in March 1984

A physiologically based dosimetry description of acrylonitrile and cyanoethylene oxide in the rat.

scientific article

A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethyl acrylate and its implications for risk assessment

article

A physiologically based pharmacokinetic model for 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in the rat: tissue distribution and CYP1A induction

scientific article published in July 1993

A physiologically based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice

article

A physiologically based pharmacokinetic model for acrylamide and its metabolite, glycidamide, in the rat.

scientific article published on February 2003

A physiologically based pharmacokinetic model for lactational transfer of PCB 153 with or without PCB 126 in mice

scientific article published on 21 July 2006

A physiologically based pharmacokinetic model for nicotine disposition in the Sprague-Dawley rat.

scientific article published in October 1992

A physiologically based toxicokinetic description of the metabolism of inhaled gases and vapors: Analysis at steady state*1 ⬇️

scientific article published on September 30, 1981

A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish

scientific article published in December 1990

A systems biology perspective on Nrf2-mediated antioxidant response

scientific article

A tissue dose-based comparative exposure assessment of manganese using physiologically based pharmacokinetic modeling-The importance of homeostatic control for an essential metal

scientific article

A toxicogenomic approach for the risk assessment of the food contaminant acetamide

scientific article published on 24 December 2019

Accelerating the development of 21st-century toxicology: outcome of a Human Toxicology Project Consortium workshop

scientific article published on 26 September 2011

Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid

scientific article published on 26 September 2007

Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment

scientific article

Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures

scientific article published on 23 February 2019

Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice

scientific article published on 25 June 2018

Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome

scientific article published on 13 December 2012

Adverse Outcome Pathways can drive non-animal approaches for safety assessment

scientific article published on 5 May 2015

All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin

scientific article published on 26 January 2013

An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury.

scientific article

An improved approximation to the exact solution of the two-stage clonal growth model of cancer

scientific article published in August 1995

An inhalation distribution model for the lactating mother and nursing child

scientific article published in October 1988

An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy

scientific article published on 12 September 2016

Analysis of manganese tracer kinetics and target tissue dosimetry in monkeys and humans with multi-route physiologically based pharmacokinetic models

scientific article published on 27 December 2010

Application of a multi-route physiologically based pharmacokinetic model for manganese to evaluate dose-dependent neurological effects in monkeys

scientific article published on 21 June 2012

Application of a physiologically based pharmacokinetic model for isopropanol in the derivation of a reference dose and reference concentration

scientific article published in August 2002

Application of pharmacokinetic data to the risk assessment of inhaled manganese

scientific article

Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment

scientific article published on 22 November 2010

Applying Simulation Modeling to Problems in Toxicology and Risk Assessment: A Short Perspective ⬇️

scientific article published on August 1, 1995

Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene

scientific article

Approaches for characterizing threshold dose-response relationships for DNA-damage pathways involved in carcinogenicity in vivo and micronuclei formation in vitro

scientific article published on 4 February 2016

Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures?

scientific article published on 22 April 2008

Assessing Kinetic Determinants for Metabolism and Oral Uptake of Octamethylcyclotetrasiloxane (D4) from Inhalation Chamber Studies

scientific article published on 01 February 2008

Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system

scientific article published on 12 September 2018

Assessing children's exposure to manganese in drinking water using a PBPK model

scientific article published on 05 August 2019

Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin

scientific article published on 11 June 2013

Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling.

scientific article published in May 2001

Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures

scientific article published on 23 September 2017

Assessing the relevance of in vitro measures of phthalate inhibition of steroidogenesis for in vivo response

scientific article published on 20 August 2009

Association between arsenic suppression of adipogenesis and induction of CHOP10 via the endoplasmic reticulum stress response

scientific article published on 5 December 2012

Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK)

scientific article

Bayesian estimation of pharmacokinetic and pharmacodynamic parameters in a mode-of-action-based cancer risk assessment for chloroform

scientific article

Binary gene induction and protein expression in individual cells

scientific article

Bioactivation and toxicity of acetaminophen in a rat hepatocyte micropatterned coculture system

scientific article published on 5 August 2013

Biological regulation of receptor-hormone complex concentrations in relation to dose-response assessments for endocrine-active compounds.

scientific article

Biologically Based, Quantitative Risk Assessment of Neurotoxicants

scientific article published on 01 January 1996

Building shared experience to advance practical application of pathway-based toxicology: liver toxicity mode-of-action

scientific article published on 28 January 2014

CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion

scientific article

Can the observed association between serum perfluoroalkyl substances and delayed menarche be explained on the basis of puberty-related changes in physiology and pharmacokinetics?

scientific article published on 29 May 2015

Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation

scientific article published on 4 May 2007

Chemical mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology

journal article published in 2004

Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity

scientific article published on February 2016

Combined exposure to 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone and microsytin-LR increases genotoxicity in Chinese hamster ovary cells through oxidative stress.

scientific article published on 10 January 2013

Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver

scientific article

Comment on M.V. Evans and J.C. Caldwell: evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling of in vivo gas uptake data exposure in female B6C3F1 mice, Toxicol. Appl. Pha

scientific article published on 22 July 2010

Comparing respiratory-tract and hepatic exposure-dose relationships for metabolized inhaled vapors: a pharmacokinetic analysis

scientific article

Comparison and evaluation of pharmacokinetics of PFOA and PFOS in the adult rat using a physiologically based pharmacokinetic model

scientific article published on 4 May 2011

Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model.

scientific article

Competitive inhibition of thyroidal uptake of dietary iodide by perchlorate does not describe perturbations in rat serum total T4 and TSH

scientific article published on 05 January 2009

Comprehensive assessment of exposure to identify health consequences of e-waste.

scientific article published on 23 January 2014

Computational systems biology and dose-response modeling in relation to new directions in toxicity testing

scientific article published in February 2010

Considerations for refining the risk assessment process for formaldehyde: Results from an interdisciplinary workshop

scientific article published on 03 May 2019

Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: examples with vinyl chloride and trichloroethylene.

scientific article

Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents

scientific article published on 2 December 2015

Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes

scientific article published on 3 January 2012

Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene

scientific article

Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage

scientific article

Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study

scientific article published in January 2011

Derivation of a drinking water equivalent level (DWEL) related to the maximum contaminant level goal for perfluorooctanoic acid (PFOA), a persistent water soluble compound.

scientific article published on 22 July 2009

Derivation of an Inhalation Reference Concentration Based upon Olfactory Neuronal Loss in Male Rats following Subchronic Acetaldehyde Inhalation

scientific article published on 01 February 2008

Derivation of whole blood biomonitoring equivalents for lithium for the interpretation of biomonitoring data

scientific article published on 11 January 2020

Deriving an explicit hepatic clearance equation accounting for plasma protein binding and hepatocellular uptake

scientific article published on 17 October 2012

Dermal absorption and penetration of jet fuel components in humans

scientific article published on 23 February 2006

Dermal absorption of dihalomethane vapors

scientific article published in June 1985

Dermal absorption of organic chemical vapors in rats and humans*1

article

Detection and localization of an estrogen receptor beta splice variant protein (ERbeta2) in the adult female rat forebrain and midbrain regions.

scientific article published in November 2007

Determination of the kinetic constants for metabolism of inhaled toxicants in vivo using gas uptake measurements

article

Determining kinetic constants of chlorinated ethane metabolism in the rat from rates of exhalation

scientific article published in June 1989

Developing context appropriate toxicity testing approaches using new alternative methods (NAMs)

scientific article published on 01 January 2019

Developing microphysiological systems for use as regulatory tools--challenges and opportunities

scientific article published on January 2014

Developing tools for defining and establishing pathways of toxicity

scientific article

Development of 3D dynamic flow model of human liver and its application to prediction of metabolic clearance of 7-ethoxycoumarin

scientific article published on 4 March 2014

Development of PBPK models for PFOA and PFOS for human pregnancy and lactation life stages

scientific article

Development of a physiologically based pharmacokinetic model for 2,4-dichlorophenoxyacetic acid dosimetry in discrete areas of the rabbit brain

article

Development of a physiologically based pharmacokinetic model for risk assessment with 1,4-dioxane.

scientific article published in August 1990

Development of a physiologically based pharmacokinetic model for volatile fractions of gasoline using chemical lumping analysis

scientific article published in November 2004

Development of an immunochemical detection method for atrazine-induced albumin adducts

scientific article

Development of an integrated multi-species and multi-dose route PBPK model for volatile methyl siloxanes - D4 and D5.

scientific article published on 23 December 2015

Development of physiologically based pharmacokinetic and physiologically based pharmacodynamic models for applications in toxicology and risk assessment.

scientific article

Dichloroacetate (DCA) dosimetry: interpreting DCA-induced liver cancer dose response and the potential for DCA to contribute to trichloroethylene-induced liver cancer

scientific article published in May 1999

Disposition of diiosononyl phthalate and its effects on sexual development of the male fetus following repeated dosing in pregnant rats.

scientific article

Divergent effects of sulforaphane on basal and glucose-stimulated insulin secretion in β-cells: role of reactive oxygen species and induction of endogenous antioxidants

scientific article published on 07 March 2013

Dose response relationship in anti-stress gene regulatory networks

scientific article

Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages

scientific article published on 17 April 2009

Dose-dependent transitions in mechanisms of toxicity

scientific article

Dose-dependent transitions in mechanisms of toxicity: case studies

scientific article

Dose-incidence modeling: consequences of linking quantal measures of response to depletion of critical tissue targets.

scientific article

Dose-incidence relationships derived from superposition of distributions of individual susceptibility on mechanism-based dose responses for biological effects.

scientific article published on 19 October 2005

Dose-response approaches for nuclear receptor-mediated modes of action for liver carcinogenicity: Results of a workshop

scientific article published on October 2013

Dose-response characteristics of uterine responses in rats exposed to estrogen agonists

scientific article published in October 1998

Dose-response modeling in reproductive toxicology in the systems biology era.

scientific article

Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane

scientific article

Dose-response modeling of etoposide-induced DNA damage response

scientific article published on 16 November 2013

Dose–Response Assessment Strategies for Endocrine-Active Compounds ⬇️

scientific article published on June 1, 1997

Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance

scientific article

Editor's Highlight: Development of an In vitro Assay Measuring Uterine-Specific Estrogenic Responses for Use in Chemical Safety Assessment

scientific article (publication date: November 2016)

Editor's Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis

scientific article

Effect of dose, time, and pretreatment on the biliary excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat.

scientific article published in November 1993

Effects of endogenous formaldehyde in nasal tissues on inhaled formaldehyde dosimetry predictions in the rat, monkey, and human nasal passages

scientific article published on 2 January 2014

Embracing Systems Toxicology at Single-Cell Resolution

scientific article published on 19 April 2019

Endocrine active compounds: from biology to dose response assessment

scientific article published in July 1998

Enhancing and Extending Biological Performance and Resilience

scientific article published on 01 July 2018

Estimating constants for metabolism of atrazine in freshly isolated rat hepatocytes by kinetic modeling

article

Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling

article

Ethyl acrylate risk assessment with a hybrid computational fluid dynamics and physiologically based nasal dosimetry model

scientific article published on 31 March 2004

Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays.

scientific article

Evaluating pharmacokinetic and pharmacodynamic interactions with computational models in supporting cumulative risk assessment ⬇️

scientific article

Evaluating placental transfer and tissue concentrations of manganese in the pregnant rat and fetuses after inhalation exposures with a PBPK model

scientific article published on 2 September 2009

Evaluating transport of manganese from olfactory mucosa to striatum by pharmacokinetic modeling

scientific article published on 19 March 2007

Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model

scientific article published in February 2011

Evaluation of biologically based dose-response modeling for developmental toxicity: a workshop report

scientific article published in April 2000

Evaluation of physiologically based pharmacokinetic models in risk assessment: an example with perchloroethylene

scientific article

Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model

scientific article published on 18 August 2011

Evaluation of potential toxicity from co-exposure to three CNS depressants (toluene, ethylbenzene, and xylene) under resting and working conditions using PBPK modeling

scientific article

Experimental exposure to 1,1,1,3,3-pentafluoropropane (HFC-245fa): uptake and disposition in humans

scientific article published on 13 November 2009

Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound

scientific article published on 30 September 2010

Gas Uptake Studies of Deuterium Isotope Effects on Dichloromethane Metabolism in Female B6C3F1 Mice in Vivo

Gene co-regulation and co-expression in the aryl hydrocarbon receptor-mediated transcriptional regulatory network in the mouse liver

scientific article published on 14 November 2019

Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function

scientific article published on 26 July 2016

Genome-wide analysis of DNA methylation and gene expression changes in the mouse lung following subchronic arsenate exposure

scientific article published on 28 July 2010

Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat.

scientific article published on 21 May 2008

Glutathione S-transferase-mediated mutagenicity of trihalomethanes in Salmonella typhimurium: contrasting results with bromodichloromethane off chloroform.

scientific article published in May 1997

Hepatic Foci in Rats after Diethylnitrosamine Initiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotion: Evaluation of a Quantitative Two-Cell Model and of CYP 1A1/1A2 as a Dosimeter

article

Hepatic sequestration of chlordecone and hexafluoroacetone evaluated by pharmacokinetic modeling

scientific article published on 17 February 2007

Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARγ expression

scientific article published on 23 December 2019

Hormesis and adaptive cellular control systems

scientific article published on 19 March 2008

Identification of Nrf2-dependent airway epithelial adaptive response to proinflammatory oxidant-hypochlorous acid challenge by transcription profiling

scientific article published on 21 December 2007

Identification of a novel hemoglobin adduct in Sprague Dawley rats exposed to atrazine

journal article published in 2006

Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods

scientific article published on 15 October 2019

Implementation of EPA Revised Cancer Assessment Guidelines: Incorporation of Mechanistic and Pharmacokinetic Data.

scientific article published in May 1997

Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment

scientific article published on 25 February 2014

In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane

scientific article

In utero exposure to chloroquine alters sexual development in the male fetal rat.

scientific article published on 22 April 2009

In vitro intestinal and hepatic metabolism of Di(2-ethylhexyl) phthalate (DEHP) in human and rat.

scientific article published on 29 March 2013

In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat.

scientific article published on 13 December 2011

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.

scientific article

In vivo metabolic interactions of benzene and toluene

scientific article published on 01 July 1990

Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing

scientific article

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

scientific article published on 16 July 2010

Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.

scientific article

Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in rats

scientific article

Induction of CYP1A1 in primary rat hepatocytes by 3,3',4,4',5-pentachlorobiphenyl: evidence for a switch circuit element

journal article published in 2004

Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity

scientific article published on 03 September 2016

Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans

scientific article published on 26 June 2008

Inhalation dosimetry of hexamethylene diisocyanate vapor in the rat and human respiratory tracts

scientific article

Inhalation pharmacokinetics: Evaluating systemic extraction, total in vivo metabolism, and the time course of enzyme induction for inhaled styrene in rats based on arterial blood:Inhaled air concentration ratios

article

Inhaled carbon nanotubes reach the subpleural tissue in mice

scientific article (publication date: November 2009)

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: a five chemical case study

scientific article

Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment

scientific article

Iodoacetic Acid Activates Nrf2-Mediated Antioxidant Response in Vitro and in Vivo

article

Is the relationship between prenatal exposure to PCB-153 and decreased birth weight attributable to pharmacokinetics?

scientific article published on 09 August 2013

Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes

scientific article published on 12 October 2013

Keap1 silencing boosts lipopolysaccharide-induced transcription of interleukin 6 via activation of nuclear factor κB in macrophages

scientific article published on 29 July 2013

Kinetic and mechanistic data needs for a human phsiologically based pharmacokinetic (PBPK) model for acrylamide: pharmacokinetic model for acrylamide

scientific article

Kinetics of selected di-n-butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats

scientific article

LETTERS TO THE EDITOR

article

Lactational transfer of manganese in rats: predicting manganese tissue concentration in the dam and pups from inhalation exposure with a pharmacokinetic model

scientific article published on 2 September 2009

Letters to the editor

Linear low-dose extrapolation for noncancer heath effects is the exception, not the rule.

scientific article

Liquid-air partition coefficients of 1,1-difluoroethane (HFC152a), 1,1,1-trifluoroethane (HFC143a), 1,1,1,2-tetrafluoroethane (HFC134a), 1,1,1,2,2-pentafluoroethane (HFC125) and 1,1,1,3,3-pentafluoropropane (HFC245fa).

scientific article published in January 2010

Long isoforms of NRF1 negatively regulate adipogenesis via suppression of PPARγ expression

scientific article published on 28 December 2019

Long-term stability of primary rat hepatocytes in micropatterned cocultures

scientific article

Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress

scientific article

Manganese tissue dosimetry in rats and monkeys: accounting for dietary and inhaled Mn with physiologically based pharmacokinetic modeling

scientific article published on 19 December 2008

Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde.

scientific article published on 27 March 2010

Mechanistic approaches for mixture risk assessments-present capabilities with simple mixtures and future directions

scientific article published on March 2004

Mechanistic modeling of rodent liver tumor promotion at low levels of exposure: an example related to dose-response relationships for 2,3,7,8-tetrachlorodibenzo-p-dioxi

article

Metabolism of inhaled brominated hydrocarbons: validation of gas uptake results by determination of a stable metabolite

scientific article published in October 1982

Metabolism of inhaled dihalomethanes in vivo: Differentiation of kinetic constants for two independent pathways

scientific article published on 01 February 1986

Mixtures

chapter published in 2005

Modeling of Human Dermal Absorption of Octamethylcyclotetrasiloxane (D4) and Decamethylcyclopentasiloxane (D5)

article

Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses

scientific article

Multi-dose-route, multi-species pharmacokinetic models for manganese and their use in risk assessment

scientific article published in January 2010

Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts

scientific article

Mutagenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin and perfluoro-n-decanoic acid in L5178Y mouse-lymphoma cells

scientific article published on 01 December 1982

Mutagenicity of trans-anethole, estragole, eugenol, and safrole in the Ames Salmonella typhimurium assay.

scientific article published in June 1982

Negative selection in hepatic tumor promotion in relation to cancer risk assessment.

scientific article published on September 1995

New directions in incidence-dose modeling

scientific article

New directions in toxicity testing

scientific article published on January 2011

Non-monotonic dose-response relationship in steroid hormone receptor-mediated gene expression

scientific article published in May 2007

Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis

scientific article published on 28 October 2011

Occupational exposure limits in the context of solvent mixtures, consumption of ethanol, and target tissue dose

scientific article

On the incorporation of chemical-specific information in risk assessment

scientific article published on 08 June 2008

Oral absorption and oxidative metabolism of atrazine in rats evaluated by physiological modeling approaches

article

Organic extract contaminants from drinking water activate Nrf2-mediated antioxidant response in a human cell line

scientific article published on 19 April 2013

Organotypic liver culture models: meeting current challenges in toxicity testing

scientific article

PB-PK derived metabolic constants, hepatotoxicity, and lethality of BrCCl3 in rats pretreated with chlordecone, phenobarbital, or mirex

scientific article published in July 1991

PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human

scientific article published on 21 January 2016

PBPK modeling of complex hydrocarbon mixtures: gasoline

scientific article published on March 2004

PBPK modeling/Monte Carlo simulation of methylene chloride kinetic changes in mice in relation to age and acute, subchronic, and chronic inhalation exposure.

scientific article

PBPK-Based Probabilistic Risk Assessment for Total Chlorotriazines in Drinking Water

scientific article published on 21 January 2016

PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthalene

scientific article published on 14 February 2007

Pathway Based Toxicology and Fit-for-Purpose Assays

scientific article published on January 2016

Perfluoro-N-decanoic acid effects on enzymes of fatty acid metabolism

scientific article published on 01 November 1990

Perfluoro-n-decanoic acid: induction of peroxisomal beta-oxidation by a fatty acid with dioxin-like toxicity

scientific article

Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of action

scientific article published on 13 November 2007

Pharmacodynamic model of the rat estrus cycle in relation to endocrine disruptors.

scientific article published in October 1997

Pharmacokinetic Modeling of Manganese in the Rat IV: Assessing Factors that Contribute to Brain Accumulation During Inhalation Exposure

article

Pharmacokinetic Modeling of Manganese. I. Dose Dependencies of Uptake and Elimination

article

Pharmacokinetic Modeling of Manganese. II. Hepatic Processing After Ingestion and Inhalation

article

Pharmacokinetic Modeling of Manganese. III. Physiological Approaches Accounting for Background and Tracer Kinetics

article

Pharmacokinetic bias analysis of the epidemiological associations between serum polybrominated diphenyl ether (BDE-47) and timing of menarche

scientific article published on 15 July 2016

Pharmacokinetic modeling approaches for describing the uptake, systemic distribution, and disposition of inhaled chemicals.

scientific article

Pharmacokinetic modeling of 2, 4-dichlorophenoxyacetic acid (2,4-D) in rat and in rabbit brain following single dose administration

scientific article published on 01 December 1994

Pharmacokinetic modeling of disposition and time-course studies with [14C]atrazine

scientific article

Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys--probing the determinants of long plasma half-lives

scientific article published on 12 August 2006

Pharmacokinetics of tetrachloroethylene*1

scientific article published on 01 March 1988

Pharmacokinetics, biochemical mechanism and mutation accumulation: a comprehensive model of chemical carcinogenesis.

scientific article published in October 1988

Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses

scientific article

Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise

scientific article published in March 2003

Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats.

scientific article published in April 2001

Physiological pharmacokinetics and cancer risk assessment.

scientific article

Physiologically Based Modeling of Vinyl Acetate Uptake, Metabolism, and Intracellular pH Changes in the Rat Nasal Cavity

article

Physiologically based estimation of in vivo rates of bromodichloromethane metabolism.

scientific article published on December 1997

Physiologically based pharmacokinetic (PBPK) models for nasal tissue dosimetry of organic esters: assessing the state-of-knowledge and risk assessment applications with methyl methacrylate and vinyl acetate

scientific article

Physiologically based pharmacokinetic model for vinylidene chloride

scientific article published in September 1988

Physiologically based pharmacokinetic modeling of fetal and neonatal manganese exposure in humans: describing manganese homeostasis during development.

scientific article published on 27 May 2011

Physiologically based pharmacokinetic modeling of styrene and styrene oxide respiratory-tract dosimetry in rodents and humans

scientific article

Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid

scientific article published in March 1990

Physiologically based pharmacokinetic modeling of the pregnant rat: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid

scientific article published in July 1989

Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans

scientific article published in March 1991

Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone

scientific article published in January 1996

Physiologically based pharmacokinetics and the risk assessment process for methylene chloride

scientific article published in February 1987

Physiologically based pharmacokinetics modeling: science and applications

book published in 2005

Physiologically-based pharmacokinetic modeling suggests similar bioavailability of Mn from diet and drinking water

scientific article published on 20 September 2018

Pitfalls and related improvements of in vivo gas uptake pharmacokinetic experimental systems

scientific article published on October 2005

Pollution trees: identifying similarities among complex pollutant mixtures in water and correlating them to mutagenicity

scientific article published on 15 June 2012

Polychlorotrifluoroethylene (PCTFE) oligomer pharmacokinetics in Fischer 344 rats: Development of a physiologically based model*1, *2

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Potentiation of 2,5-hexanedione neurotoxicity by methyl ethyl ketone*1, *2

Predicting Cancer Risk from Vinyl Chloride Exposure with a Physiologically Based Pharmacokinetic Model

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Predicting cytotoxicity of complex mixtures in high cancer incidence regions of the Huai River Basin based on GC-MS spectrum with partial least squares regression.

scientific article published on 20 January 2015

Prediction of in vivo kinetic constants for metabolism of inhaled vapors from kinetic constants measured in vitro12

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Prenatal PCB-153 Exposure and Decreased Birth Weight: Verner et al. Respond

scientific article published on April 2014

Probing the control elements of the CYP1A1 switching module in H4IIE hepatoma cells

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Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage

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Progestin receptor expression in the developing rat brain depends upon activation of estrogen receptor alpha and not estrogen receptor beta.

scientific article published on 28 February 2006

Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response

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Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury

scientific article published in June 2010

Quantitative bias analysis for epidemiological associations of perfluoroalkyl substance serum concentrations and early onset of menopause

scientific article published on 5 December 2016

Quantitative bias analysis of a reported association between perfluoroalkyl substances (PFAS) and endometriosis: The influence of oral contraceptive use.

scientific article published on 6 April 2017

Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods

scientific article published in June 1987

Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results

scientific article published on 06 June 2012

Quantitative interpretation of human biomonitoring data

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RESEARCH STRATEGY IN INDUSTRIAL TOXICOLOGY

scientific article published on 01 May 1987

RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days

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ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function

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Reactive oxygen species as a signal in glucose-stimulated insulin secretion

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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

scientific article published on 23 August 2013

Refined PBPK model of aggregate exposure to methyl tertiary-butyl ether

scientific article published on 30 January 2007

Refinement of the oral exposure description in the cyclic siloxane PBPK model for rats and humans: Implications for exposure assessment

scientific article published on 10 April 2017

Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation.

scientific article published on May 1997

Regional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153

journal article published in 2004

Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells

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Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays

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Reply to Invited Commentaries on Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment

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Risk assessment extrapolations and physiological modeling

scientific article published in December 1985

Risk science in the 21st century: a data-driven framework for incorporating new technologies into chemical safety assessment

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Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: analysis using PBPK models

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Saturable metabolism and the acute toxicity of 1,1-dichloroethylene

scientific article published on February 1, 1979

Single cell analysis of switch-like induction of CYP1A1 in liver cell lines

journal article published in 2004

Some neurotoxic properties of triethylene glycol dinitrate: a comparison with decamethonium

scientific article (publication date: June 1976)

Stochastic modeling of B lymphocyte terminal differentiation and its suppression by dioxin

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Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay

scientific article published on 15 April 2003

Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment

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Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells

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Temporal concordance between apical and transcriptional points of departure for chemical risk assessment.

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The Human Toxome Collaboratorium: A Shared Environment for Multi-Omic Computational Collaboration within a Consortium

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The Toxicity of Single Doses of N-Nitrodimethylamine in Rodents

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The acute toxicity of perfluorooctanoic and perfluorodecanoic acids in male rats and effects on tissue fatty acids

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The acute toxicity of single, oral doses of 1,1-dichloroethylene in the fasted, male rat: Effect of induction and inhibition of microsomal enzyme activities on mortality

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The distribution and metabolism of cyclotrimethylenetrinitramine (RDX) in the rat after subchronic administration

scientific article published on October 1, 1978

The effects of perfluorodecanoic acid on hepatic stearoyl-coenzyme A desaturase and mixed function oxidase activities in rats.

scientific article published in October 1988

The future of toxicity testing

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The human toxome project

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The inhalation toxicity of sulfolane (tetrahydrothiophene-1,1-dioxide)

scientific article published on June 1, 1977

The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiative

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The next generation of risk assessment multi-year study - highlights of findings, applications to risk assessment, and future directions

journal article published in 2016

The role of fit-for-purpose assays within tiered testing approaches: A case study evaluating prioritized estrogen-active compounds in an in vitro human uterotrophic assay

scientific article published on 27 November 2019

The significance of multiple detoxification pathways for reactive metabolites in the toxicity of 1,1-dichloroethylene

scientific article published in March 1980

The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene

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The use of inhalation techniques to assess the kinetic constants of 1,1-dichloroethylene metabolism

scientific article published on February 1, 1979

The use of quantitative histological and molecular data for risk assessment and biologically based model development

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The vision of toxicity testing in the 21st century: moving from discussion to action

scientific article published on 23 June 2010

Time dependencies in perfluorooctylacids disposition in rat and monkeys: a kinetic analysis

scientific article published on 27 December 2007

Tissue dosimetry, physiologically-based pharmacokinetic modeling, and cancer risk assessment

scientific article published on 01 December 1989

Tissue exposures to free and glucuronidated monobutylyphthalate in the pregnant and fetal rat following exposure to di-n-butylphthalate: evaluation with a PBPK model.

scientific article published on 15 March 2008

Toxic effects of nonadecafluoro-n-decanoic acid in rats

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Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment

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Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways

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Toxicity testing in the 21st century: a vision and a strategy

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Toxicity testing in the 21st century: bringing the vision to life

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Toxicity testing in the 21st century: progress in the past decade and future perspectives

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Toxicogenomics for transcription factor-governed molecular pathways: moving on to roles beyond classification and prediction

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Toxicokinetic modeling and its applications in chemical risk assessment

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Toxicokinetics and physiologically based toxicokinetics in toxicology and risk assessment

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Toxicology of cyclotrimethylenetrinitramine: distribution and metabolism in the rat and the miniature swine

scientific article published on March 1, 1977

Ultrasensitive response motifs: basic amplifiers in molecular signalling networks

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Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT-Part I: Program Implementation and Lessons Learned

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Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT-Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment

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Updating physiologically based pharmacokinetic models for manganese by incorporating rapid association/dissociation processes in tissues

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Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans

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Use of short-term transcriptional profiles to assess the long-term cancer-related safety of environmental and industrial chemicals

scientific article published on 23 September 2009

Using gene expression profiling to evaluate cellular responses in mouse lungs exposed to V2O5 and a group of other mouse lung tumorigens and non-tumorigens.

scientific article published on 22 July 2015

Water pollutant fingerprinting tracks recent industrial transfer from coastal to inland China: a case study.

scientific article published on 7 January 2013

Workshop overview: reassessment of the cancer risk of dichloromethane in humans

scientific article published on 28 February 2006

t4 workshop report--lessons learned, challenges, and opportunities: the U.S. Endocrine Disruptor Screening Program

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t4 workshop report: Pathways of Toxicity

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