List of works - Rafael V. Guido

2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

scientific article

2D Quantitative structure-activity relationship studies on a series of cholesteryl ester transfer protein inhibitors

scientific article published on 13 June 2007

A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin K

scientific article published on 12 November 2015

A novel scaffold to fight Pseudomonas aeruginosa pyocyanin production: early steps to novel antivirulence drugs

scientific article published on 10 August 2020

A pharmacophore-based virtual screening approach for the discovery of Trypanosoma cruzi GAPDH inhibitors.

scientific article

Advances in prodrug design.

scientific article

Antiplasmodial profile of selected compounds from Malaria Box: in vitro evaluation, speed of action and drug combination studies

scientific article published on 30 December 2019

Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity

scientific article published on 25 June 2018

Discovery of new inhibitors of Mycobacterium tuberculosis InhA enzyme using virtual screening and a 3D-pharmacophore-based approach.

scientific article

Discovery of new inhibitors of Schistosoma mansoni PNP by pharmacophore-based virtual screening.

scientific article

Encapsulation of metalloporphyrins improves their capacity to block the viability of the human malaria parasite Plasmodium falciparum.

scientific article published on 15 November 2014

Identification of electronic and structural descriptors of adenosine analogues related to inhibition of leishmanial glyceraldehyde-3-phosphate dehydrogenase.

scientific article published on 29 April 2013

In silico screening strategies for novel inhibitors of parasitic diseases

scientific article published on 05 March 2011

Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth.

scientific article published on 21 April 2010

Modern drug discovery technologies: opportunities and challenges in lead discovery.

scientific article published on December 2011

Molecular features for antitrypanosomal activity of thiosemicarbazones revealed by OPS-PLS QSAR studies

scientific article published in November 2012

Natural Compounds as Non-Nucleoside Inhibitors of Zika Virus Polymerase through Integration of In Silico and In Vitro Approaches

scientific article published in 2022

Pattern recognition techniques applied to the study of leishmanial glyceraldehyde-3-phosphate dehydrogenase inhibition

scientific article published on 21 February 2014

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

scientific article published on 20 April 2021

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

scientific article published on 20 April 2022

QSAR studies on benzothiophene derivatives as Plasmodium falciparum N-myristoyltransferase inhibitors: Molecular insights into affinity and selectivity

scientific article published on 11 February 2020

Quantitative structure-activity relationships for a series of inhibitors of cruzain from Trypanosoma cruzi: molecular modeling, CoMFA and CoMSIA studies.

scientific article published on 14 March 2009

Quantitative structure-activity studies on a series of migrastatin analogs as inhibitors of cancer cell metastasis

scientific article published on 01 May 2011

REPLY to Nanomedicine: NMB, 2015; 11:1035.

scientific article published on 10 February 2015

Structural basis for selective inhibition of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase: molecular docking and 3D QSAR studies.

scientific article

Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor

scientific article published on January 2015

Structure-activity relationships for a class of selective inhibitors of the major cysteine protease from Trypanosoma cruzi

scientific article published on 01 December 2008

Structure-based drug discovery for tropical diseases

scientific article

Synthetic chalcones and sulfonamides as new classes of Yersinia enterocolitica YopH tyrosine phosphatase inhibitors.

scientific article

The (5Z)-5-Pentacosenoic and 5-Pentacosynoic Acids Inhibit the HIV-1 Reverse Transcriptase.

scientific article published on 7 September 2015

The development of an immobilized enzyme reactor containing glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi: the effect of species' specific differences on the immobilization.

scientific article

Virtual screening and its integration with modern drug design technologies.

scientific article published on January 2008

List of works by Rafael V. Guido

2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

2D Quantitative structure-activity relationship studies on a series of cholesteryl ester transfer protein inhibitors

A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin K

A novel scaffold to fight Pseudomonas aeruginosa pyocyanin production: early steps to novel antivirulence drugs

A pharmacophore-based virtual screening approach for the discovery of Trypanosoma cruzi GAPDH inhibitors.

Advances in prodrug design.

Antiplasmodial profile of selected compounds from Malaria Box: in vitro evaluation, speed of action and drug combination studies

Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity

Discovery of new inhibitors of Mycobacterium tuberculosis InhA enzyme using virtual screening and a 3D-pharmacophore-based approach.

Discovery of new inhibitors of Schistosoma mansoni PNP by pharmacophore-based virtual screening.

Encapsulation of metalloporphyrins improves their capacity to block the viability of the human malaria parasite Plasmodium falciparum.

Identification of electronic and structural descriptors of adenosine analogues related to inhibition of leishmanial glyceraldehyde-3-phosphate dehydrogenase.

In silico screening strategies for novel inhibitors of parasitic diseases

Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth.

Modern drug discovery technologies: opportunities and challenges in lead discovery.

Molecular features for antitrypanosomal activity of thiosemicarbazones revealed by OPS-PLS QSAR studies

Natural Compounds as Non-Nucleoside Inhibitors of Zika Virus Polymerase through Integration of In Silico and In Vitro Approaches

Pattern recognition techniques applied to the study of leishmanial glyceraldehyde-3-phosphate dehydrogenase inhibition

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

QSAR studies on benzothiophene derivatives as Plasmodium falciparum N-myristoyltransferase inhibitors: Molecular insights into affinity and selectivity

Quantitative structure-activity relationships for a series of inhibitors of cruzain from Trypanosoma cruzi: molecular modeling, CoMFA and CoMSIA studies.

Quantitative structure-activity studies on a series of migrastatin analogs as inhibitors of cancer cell metastasis

REPLY to Nanomedicine: NMB, 2015; 11:1035.

Structural basis for selective inhibition of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase: molecular docking and 3D QSAR studies.

Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor

Structure-activity relationships for a class of selective inhibitors of the major cysteine protease from Trypanosoma cruzi

Structure-based drug discovery for tropical diseases

Synthetic chalcones and sulfonamides as new classes of Yersinia enterocolitica YopH tyrosine phosphatase inhibitors.

The (5Z)-5-Pentacosenoic and 5-Pentacosynoic Acids Inhibit the HIV-1 Reverse Transcriptase.

The development of an immobilized enzyme reactor containing glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi: the effect of species' specific differences on the immobilization.

Virtual screening and its integration with modern drug design technologies.