List of works - Clinton R. Bruce

AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle.

scientific article

AMP-activated protein kinase and muscle insulin resistance

scientific article published on January 2009

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

scientific article published on 7 April 2015

Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance

scientific article

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness

scientific article

Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation

scientific article published on 24 November 2010

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

scientific article published in February 2018

Alpha2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise.

scientific article

Analysis of Mammalian Cell Proliferation and Macromolecule Synthesis Using Deuterated Water and Gas Chromatography-Mass Spectrometry

scientific article

Application of dynamic metabolomics to examine in vivo skeletal muscle glucose metabolism in the chronically high-fat fed mouse.

scientific article

Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

scientific article

Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance

scientific article published on 8 November 2012

Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-alpha

scientific article published on 18 May 2004

Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation

scientific article published on 06 January 2011

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes.

scientific article published on 12 December 2003

Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion.

scientific article

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

scientific article

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

scientific article published on 26 April 2013

Does maternal-fetal transfer of creatine occur in pregnant sheep?

scientific article published on 21 March 2017

Effect of training on activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase pathways in rat soleus muscle

scientific article published on 01 August 2002

Endogenous glucose production after sequential meals in humans: evidence for more prolonged suppression after ingestion of a second meal

scientific article published on 14 August 2018

Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

scientific article published on 7 February 2006

Erratum to: Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

scientific article published in April 2015

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy.

scientific article

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

scientific article published on 22 May 2007

Exercise alters the profile of phospholipid molecular species in rat skeletal muscle

scientific article published on 18 June 2004

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

scientific article published on 15 January 2014

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism.

scientific article published on 22 October 2015

GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women

scientific article published on 26 October 2015

Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation

scientific article published on 04 September 2007

Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle

scientific article published on 21 November 2003

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

scientific article published on 25 September 2017

Interaction of diet and training on endurance performance in rats.

scientific article published in July 2001

Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice

scientific article published on 13 May 2013

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

scientific article published on 11 August 2010

In vivo cardiac glucose metabolism in the high-fat fed mouse: Comparison of euglycemic-hyperinsulinemic clamp derived measures of glucose uptake with a dynamic metabolomic flux profiling approach.

scientific article

It's what you do with the fat that matters!

scientific article published on 01 October 2007

IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade.

scientific article published on March 2012

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation

scientific article published on 14 April 2009

Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism.

scientific article published on 3 March 2017

Marked phenotypic differences of endurance performance and exercise-induced oxygen consumption between AMPK and LKB1 deficiency in mouse skeletal muscle: changes occurring in the diaphragm

scientific article published on 21 May 2013

Measurement of postprandial glucose fluxes in response to acute and chronic endurance exercise in healthy humans.

scientific article published on 19 December 2017

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle

scientific article

Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status

scientific article published on November 2003

No need to sweat: is dieting enough to alleviate insulin resistance in obesity?

scientific article published in November 2009

Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification

scientific article published on 19 December 2006

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance

scientific article published on 10 December 2008

Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet.

scientific article published on 7 December 2014

PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle

scientific article

PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications.

scientific article published on 3 February 2016

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle.

scientific article

Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress - Fibroblast Growth Factor 21 Axis in Skeletal Muscle

scientific article

Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes.

scientific article

Plasma sphingosine-1-phosphate is elevated in obesity

scientific article

Postprandial Aminogenic Insulin and Glucagon Secretion Can Stimulate Glucose Flux in Humans

scientific article published on 04 March 2019

Reactive oxygen species enhance insulin sensitivity

scientific article

Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity

scientific article

Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide.

scientific article published on 27 July 2012

Resolution of glucose intolerance in long-term high-fat, high-sucrose-fed mice.

scientific article published on 30 March 2017

Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis.

scientific article published on 07 June 2016

Skeletal Muscle-Specific Overexpression of Heat Shock Protein 72 Improves Skeletal Muscle Insulin-Stimulated Glucose Uptake But Does Not Alter Whole Body Metabolism.

scientific article published on 13 April 2018

Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice

scientific article published on 26 July 2012

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity

scientific article

The Effect of Ingested Glucose Dose on the Suppression of Endogenous Glucose Production in Humans

scientific article

The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents.

scientific article published on 09 September 2014

The sphingosine-1-phosphate analog FTY720 reduces muscle ceramide content and improves glucose tolerance in high fat-fed male mice

scientific article published on 26 November 2012

α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

scientific article published on 05 August 2016

List of works by Clinton R. Bruce

AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle.

AMP-activated protein kinase and muscle insulin resistance

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness

Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

Alpha2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise.

Analysis of Mammalian Cell Proliferation and Macromolecule Synthesis Using Deuterated Water and Gas Chromatography-Mass Spectrometry

Application of dynamic metabolomics to examine in vivo skeletal muscle glucose metabolism in the chronically high-fat fed mouse.

Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance

Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-alpha

Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes.

Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion.

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

Does maternal-fetal transfer of creatine occur in pregnant sheep?

Effect of training on activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase pathways in rat soleus muscle

Endogenous glucose production after sequential meals in humans: evidence for more prolonged suppression after ingestion of a second meal

Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

Erratum to: Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy.

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

Exercise alters the profile of phospholipid molecular species in rat skeletal muscle

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism.

GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women

Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation

Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

Interaction of diet and training on endurance performance in rats.

Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

In vivo cardiac glucose metabolism in the high-fat fed mouse: Comparison of euglycemic-hyperinsulinemic clamp derived measures of glucose uptake with a dynamic metabolomic flux profiling approach.

It's what you do with the fat that matters!

IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade.

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation

Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism.

Marked phenotypic differences of endurance performance and exercise-induced oxygen consumption between AMPK and LKB1 deficiency in mouse skeletal muscle: changes occurring in the diaphragm

Measurement of postprandial glucose fluxes in response to acute and chronic endurance exercise in healthy humans.

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle

Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status

No need to sweat: is dieting enough to alleviate insulin resistance in obesity?

Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance

Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet.

PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle

PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications.

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle.

Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress - Fibroblast Growth Factor 21 Axis in Skeletal Muscle

Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes.

Plasma sphingosine-1-phosphate is elevated in obesity

Postprandial Aminogenic Insulin and Glucagon Secretion Can Stimulate Glucose Flux in Humans

Reactive oxygen species enhance insulin sensitivity

Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity

Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide.

Resolution of glucose intolerance in long-term high-fat, high-sucrose-fed mice.

Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis.

Skeletal Muscle-Specific Overexpression of Heat Shock Protein 72 Improves Skeletal Muscle Insulin-Stimulated Glucose Uptake But Does Not Alter Whole Body Metabolism.

Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity

The Effect of Ingested Glucose Dose on the Suppression of Endogenous Glucose Production in Humans

The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents.

The sphingosine-1-phosphate analog FTY720 reduces muscle ceramide content and improves glucose tolerance in high fat-fed male mice

α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors