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List of works by Jose Luis Rosa

6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia

scientific article

A new homozygous HERC1 gain-of-function variant in MDFPMR syndrome leads to mTORC1 hyperactivation and reduced autophagy during cell catabolism

scientific article published on 04 September 2020

A nonsense variant in HERC1 is associated with intellectual disability, megalencephaly, thick corpus callosum and cerebellar atrophy

scientific article published on 8 July 2015

ACVR1 Function in Health and Disease

scientific article published on 31 October 2019

Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids.

scientific article published on 2 March 2013

Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling

scientific article

Analysis of Protein Oligomerization by Electrophoresis

scientific article published in January 2016

Antiproliferative effect of catechin in GRX cells.

scientific article

BMP-2 decreases Mash1 stability by increasing Id1 expression

scientific article

Capsaicin modulates proliferation, migration, and activation of hepatic stellate cells.

scientific article published on March 2014

Class I PI-3-Kinase Signaling Is Critical for Bone Formation Through Regulation of SMAD1 Activity in Osteoblasts.

scientific article

Contribution of S6K1/MAPK signaling pathways in the response to oxidative stress: activation of RSK and MSK by hydrogen peroxide

scientific article

Correction: Contribution of S6K1/MAPK Signaling Pathways in the Response to Oxidative Stress: Activation of RSK and MSK by Hydrogen Peroxide

scholarly article published in PLOS ONE

Corrigendum to "ERK and p38 pathways regulate amino acid signalling" [BBA-Mol. Cell. Res. Volume 1783/12 (2008) 2241-2254]

scientific article published on 25 June 2019

Direct Binding of Smad1 and Smad4 to Two Distinct Motifs Mediates Bone Morphogenetic Protein-specific Transcriptional Activation ofId1 Gene ⬇️

scientific article published on November 7, 2001

ERK and p38 pathways regulate amino acid signalling

scientific article published on 6 September 2008

Extracellular calcium promotes bone formation from bone marrow mesenchymal stem cells by amplifying the effects of BMP-2 on SMAD signalling

scientific article

Fructose-1,6-bisphosphate protects against Zymosan-induced acute lung injury in mice

scientific article published on 01 June 2012

Fructose-1,6-bisphosphate reduces the mortality in Candida albicans bloodstream infection and prevents the septic-induced platelet decrease

scientific article published on 01 August 2012

Functional EF-hands in neuronal calcium sensor GCAP2 determine its phosphorylation state and subcellular distribution in vivo, and are essential for photoreceptor cell integrity

scientific article

Functional and pathological relevance of HERC family proteins: a decade later.

scientific article

Glucose Restriction Promotes Osteocyte Specification by Activating a PGC-1α-Dependent Transcriptional Program

scientific article published on 12 April 2019

Guaraná, a Highly Caffeinated Food, Presents in vitro Antitumor Activity in Colorectal and Breast Cancer Cell Lines by Inhibiting AKT/mTOR/S6K and MAPKs Pathways

scientific article published in June 2017

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study.

scientific article published on 18 April 2016

HERC Ubiquitin Ligases in Cancer

scientific article published on 22 June 2020

HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory

scientific article published on 19 November 2020

HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System.

scientific article published on 30 March 2018

HERCing: Structural and Functional Relevance of the Large HERC Ubiquitin Ligases

scientific article published on 07 August 2019

Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP-2.

scientific article published in January 2002

Inhibition of phosphatidylinositol 3-kinase α (PI3Kα) prevents heterotopic ossification

scientific article published on 02 August 2019

Interaction between HERC1 and M2-type pyruvate kinase

scientific article

Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology

scientific article published on 26 September 2019

Large HERCs Function as Tumor Suppressors

scientific article published on 18 June 2019

Leucine reduces the proliferation of MC3T3-E1 cells through DNA damage and cell senescence.

scientific article

Liraglutide improves liver microvascular dysfunction in cirrhosis: Evidence from translational studies.

scientific article published on 12 June 2017

Mesenchymal Stem Cells Within Gelatin/CaSO4 Scaffolds Treated Ex Vivo with Low Doses of BMP-2 and Wnt3a Increase Bone Regeneration

scientific article

Mesenchymal stem cells decrease lung inflammation during sepsis, acting through inhibition of the MAPK pathway.

scientific article published on 22 December 2017

Mesenchymal stem cells improves survival in LPS-induced acute lung injury acting through inhibition of NETs formation.

scientific article published on 23 January 2017

Mitogen-activated protein kinase (MAPK)-regulated interactions between Osterix and Runx2 are critical for the transcriptional osteogenic program

scientific article published on 13 August 2014

Mutation of HERC2 causes developmental delay with Angelman-like features.

scientific article

NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization.

scientific article published on 27 June 2017

NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression

scientific article published on 24 December 2020

PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli

scientific article

Pfkfb3 is transcriptionally upregulated in diabetic mouse liver through proliferative signals.

scientific article published on 18 July 2009

Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions

scientific article published on 07 April 2020

Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells

scientific article

Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase

scientific article

Regulation of the MDM2-p53 pathway by the ubiquitin ligase HERC2

scientific article published on 15 November 2019

Regulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiation

scientific article (publication date: 28 August 2003)

Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins

scientific article

Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway.

scientific article

Simultaneous electrophoretic analysis of proteins of very high and low molecular mass using Tris-acetate polyacrylamide gels.

scientific article published on April 2010

Simultaneous electrophoretic analysis of proteins of very high and low molecular weights using low-percentage acrylamide gel and a gradient SDS-PAGE gel.

scientific article published in October 2006

TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells

scientific article published on 20 August 2017

TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.

scientific article published on 7 February 2006

The E3 ubiquitin ligase HERC1 controls the ERK signaling pathway targeting C-RAF for degradation

scientific article published on 31 July 2018

The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization

scientific article published on 9 April 2014

The HERC1 ubiquitin ligase regulates presynaptic membrane dynamics of central synapses

scientific article published on 21 July 2020

The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination.

scientific article published on 12 August 2016

The RCC1 superfamily: from genes, to function, to disease.

scientific article published on 10 April 2008

The combination of sirolimus and rosiglitazone produces a renoprotective effect on diabetic kidney disease in rats

scientific article published on 18 June 2010

The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells.

scientific article

The transcriptional activation of the cyclooxygenase-2 gene in zymosan-activated macrophages is dependent on NF-kappa B, C/EBP, AP-1, and CRE sites

scientific article published on December 2011

The ubiquitin ligase HERC1 regulates cell migration via RAF-dependent regulation of MKK3/p38 signaling

scientific article published on 21 January 2020

Therapeutic ultrasound stimulates MC3T3-E1 cell proliferation through the activation of NF-κB1, p38α, and mTOR.

scientific article published on 28 September 2015

Treatment with N-methyl-D-aspartate receptor antagonist (MK-801) protects against oxidative stress in lipopolysaccharide-induced acute lung injury in the rat.

scientific article published on 3 February 2011

Tris-Acetate Polyacrylamide Gradient Gels for the Simultaneous Electrophoretic Analysis of Proteins of Very High and Low Molecular Mass

scientific article published on 01 January 2019

Tris-acetate polyacrylamide gradient gel electrophoresis for the analysis of protein oligomerization.

scientific article published on 11 January 2016

Tris-acetate polyacrylamide gradient gels for the simultaneous electrophoretic analysis of proteins of very high and low molecular mass

scientific article published in January 2012

p53 inhibits SP7/Osterix activity in the transcriptional program of osteoblast differentiation

scientific article published on 04 August 2017

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