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List of works by Lorella Marselli

A circular RNA generated from an intron of the insulin gene controls insulin secretion

scientific article published on 05 November 2020

A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells

scientific article

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets.

scientific article

ADCY5 couples glucose to insulin secretion in human islets

scientific article

Adiponectin increases glucose-induced insulin secretion through the activation of lipid oxidation

scientific article published on 27 February 2013

An alternative and simple method to consistently prepare viable isolated human islets for clinical transplantation

scientific article published on 01 April 2004

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

scientific article published on 22 May 2020

Anti-inflammatory signaling during ex vivo liver perfusion improves the preservation of pig liver grafts before transplantation

scientific article published on 01 May 2017

Are we overestimating the loss of beta cells in type 2 diabetes?

scientific article published on 01 February 2014

Automated assessment of β-cell area and density per islet and patient using TMEM27 and BACE2 immunofluorescence staining in human pancreatic β-cells

scientific article

Autophagy in human type 2 diabetes pancreatic beta cells.

scientific article

BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic β-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2.

scientific article published on 7 March 2014

Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass

scientific article published on September 2011

C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells

scientific article

Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection.

scientific article

Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice

scientific article published on 21 June 2016

Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells

scientific journal article

Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

scholarly article

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis

scientific article

Direct effects of rosuvastatin on pancreatic human beta cells.

scientific article published on 17 March 2013

Effects of Acute or Prolonged Exposure to Human Leptin on Isolated Human Islet Function

scientific article published in 1999

Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets

scientific article published in January 2005

Entrapment of dispersed pancreatic islet cells in CultiSpher-S macroporous gelatin microcarriers: Preparation, in vitro characterization, and microencapsulation.

scientific article published in December 2001

Erratum to: Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

scholarly article published in Diabetologia

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

scientific article published on 29 December 2015

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

scientific article

Frequency and characteristics of diabetes in 300 pre-liver transplant patients.

scientific article

Functional and molecular defects of pancreatic islets in human type 2 diabetes

scientific article published in March 2005

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim

scientific journal article

Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection

scientific article

Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes

scientific article

Gluco-incretins regulate beta-cell glucose competence by epigenetic silencing of Fxyd3 expression

scientific article

Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis

scientific article

Hedgehog signaling during expansion of human pancreatic islet-derived precursors

scientific article

Histopathology and ex vivo insulin secretion of pancreatic islets in gestational diabetes: A case report

scientific article published on 01 September 2011

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells.

scientific article published on 5 January 2018

IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets

scientific article published on 19 December 2013

Improved insulin secretory function and reduced chemotactic properties after tissue culture of islets from type 1 diabetic patients.

scientific article

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

scientific article published on 29 July 2008

Insulin release from isolated, human islets after acute or prolonged exposure to glimepiride

scientific article published on 01 January 2000

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes.

scientific article published on 6 January 2017

Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes.

scientific article

Joint effect of insulin signaling genes on insulin secretion and glucose homeostasis.

scientific article

LYMPHOKINE RELEASE FROM HUMAN LYMPHOMONONUCLEAR CELLS AFTER CO-CULTURE WITH ISOLATED PANCREATIC ISLETS: EFFECTS OF ISLET SPECIES, LONG-TERM CULTURE, AND MONOCYTE-MACROPHAGE CELL REMOVAL

article

Labeling and Tracking of Human Pancreatic Islets Using Carbon Nanotubes

scientific article published on April 2015

Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling

scientific article

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells.

scientific article

Mast cells infiltrate pancreatic islets in human type 1 diabetes.

scientific article

MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion

scientific article

Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction

scientific article published on 12 December 2012

Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction

scientific article

Nova1 is a master regulator of alternative splicing in pancreatic beta cells.

scientific article

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource.

scientific article

PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.

scientific article

Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets

scientific article

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

scientific article

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets

scientific article published on 18 October 2017

Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes

scientific article published on 23 May 2017

Pancreatic Glucagon Damages Isolated Human Islet Function

scientific article published on 01 March 1998

Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.

scientific article published in November 2004

Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion

scientific journal article

Prevention by metformin of alterations induced by chronic exposure to high glucose in human islet beta cells is associated with preserved ATP/ADP ratio

scientific article published on 03 January 2014

Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis.

scientific article published on 05 June 2017

Protective unfolded protein response in human pancreatic beta cells transplanted into mice

scientific article

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate

scientific article published on 30 December 2013

Risk factors for cardiovascular disease in patients with functioning kidney grafts

scientific article published on 01 August 1998

Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion.

scientific article published on 18 November 2003

Salvage of an Octogenarian Liver Graft Using Normothermic Perfusion: A Case Report

scientific article published in May 2017

Subcapsular Renal Hematoma in Simultaneous Pancreas Kidney Transplantation

scientific article published on 11 May 2020

Suppressor of cytokine signaling gene expression in human pancreatic islets: modulation by cytokines

scientific article published on March 2005

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

scientific article published on 28 November 2017

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

scientific article published on 3 August 2015

The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation

scientific article

The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA

scientific article published on 13 April 2020

The beta-cell in human type 2 diabetes.

scientific article published on January 2010

The direct effects of tacrolimus and cyclosporin A on isolated human islets: A functional, survival and gene expression study.

scientific article published on September 2009

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

scientific article

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines

scientific article

The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic islets

scientific article

The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells

scientific article

Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes

scientific article

Ultrastructural alterations of pancreatic beta cells in human diabetes mellitus.

scientific article

Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes

article

Universal screening and intensive metabolic management of gestational diabetes: cost-effectiveness in Italy

article

Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia

scientific article

Upregulation of mitochondrial peripheral benzodiazepine receptor expression by cytokine-induced damage of human pancreatic islets

scientific article published in January 2002

dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure.

scientific article published on 10 January 2017

tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans

scientific article

β-Cell inflammation in human type 2 diabetes and the role of autophagy.

scientific article

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