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List of works by Lorenzo Di Cesare Mannelli

2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation

scientific article published on 7 March 2013

3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.

scientific article

4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles

scientific article published on 28 November 2018

6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells

scientific article

A Series of COX-2 Inhibitors Endowed with NO-Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis

scientific article published on 27 May 2016

A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain

scientific article published on January 2013

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity

scientific article published on 26 April 2013

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

scientific article

A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam

scientific article

A novel manganese complex effective as superoxide anion scavenger and therapeutic agent against cell and tissue oxidative injury

scientific article published on November 2009

A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and pregabalin

scientific article published on 12 October 2017

A smart platform for hyperthermia application in cancer treatment: cobalt-doped ferrite nanoparticles mineralized in human ferritin cages

scientific article published on 8 April 2014

Acetyl-L-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy.

scientific article published on 16 March 2010

Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats

scholarly article by Laura Micheli et al published May 2015 in European Journal of Pharmacology

Acute effect of Capparis spinosa root extracts on rat articular pain

scientific article published on 16 September 2016

Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation

scientific article published on 11 December 2017

Altered nitric oxide calcium responsiveness of aortic smooth muscle cells in spontaneously hypertensive rats depends on low expression of cyclic guanosine monophosphate-dependent protein kinase type I.

scientific article published in June 2009

Aminopyrrolic Synthetic Receptors for Monosaccharides: A Class of Carbohydrate-Binding Agents Endowed with Antibiotic Activity versus Pathogenic Yeasts

scientific article published on 05 March 2012

Analgesic and antineuropathic drugs acting through central cholinergic mechanisms

scientific article published on May 2011

Antiamnesic effect of the two novel ?-opioid agonists, VA-100 and VA-101, in the mouse passive avoidance test

Anticancer properties of erucin, an H2 S-releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC-1)

scientific article published on 10 January 2019

Antidepressant-like effect of artemin in mice: a mechanism for acetyl-L-carnitine activity on depression

scientific article published on 18 May 2011

Antineuropathic profile of N-palmitoylethanolamine in a rat model of oxaliplatin-induced neurotoxicity

scientific article

Antinociceptive profile of the natural cholinesterase inhibitor huperzine A

Apoptotic Process Induced by Oxaliplatin in Rat Hippocampus Causes Memory Impairment

scientific article published on 6 June 2016

Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?

scientific article published on 10 February 2017

BDNF and Artemin are increased in drug-naïve non-depressed GAD patients: preliminary data

scientific article

Bacopa monnieri as augmentation therapy in the treatment of anhedonia, preclinical and clinical evaluation

scientific article published on 01 April 2020

Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects

scientific article published on 21 May 2019

Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis

scientific article published on 15 November 2019

Broad spectrum and prolonged efficacy of dimiracetam in models of neuropathic pain

scientific article published on 31 January 2014

Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus

scientific article published in August 2017

Cannabidiol Protects Dopaminergic Neuronal Cells from Cadmium

scientific article published on 12 November 2019

Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors

scientific article published on 26 November 2015

Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo).

scientific article

Correction to Novel Analgesic/Anti-Inflammatory Agents: 1,5-Diarylpyrrole Nitrooxyalkyl Ethers and Related Compounds as Cyclooxygenase-2 Inhibiting Nitric Oxide Donors

Deepening the Mechanisms of Visceral Pain Persistence: An Evaluation of the Gut-Spinal Cord Relationship

scientific article published on 24 July 2020

Delay of morphine tolerance by palmitoylethanolamide

scientific article published on 22 March 2015

Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis

scientific article published on 11 January 2017

Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors

scientific article published on 16 March 2016

Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology

scientific article published on 09 April 2018

Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects

scientific article published on 19 May 2018

Design, synthesis, and preliminary pharmacological evaluation of a set of small molecules that directly activate gi proteins

scientific article

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

scientific article

Development and characterization of fast dissolving tablets of oxaprozin based on hybrid systems of the drug with cyclodextrins and nanoclays.

scientific article published on 15 May 2017

Development and in vivo evaluation of an innovative "Hydrochlorothiazide-in Cyclodextrins-in Solid Lipid Nanoparticles" formulation with sustained release and enhanced oral bioavailability for potential hypertension treatment in pediatrics

scientific article published on 13 February 2017

Development of a chitosan-derivative micellar formulation to improve celecoxib solubility and bioavailability

article

Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief

scientific article

Different apoptotic pathways activated by oxaliplatin in primary astrocytes vs. colo-rectal cancer cells

scientific article

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

scientific article

Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.

scientific article published on 10 August 2017

Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis

scientific article published on 21 May 2018

Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity

scientific article published on 03 September 2018

Effect of NIR laser therapy by MLS-MiS source against neuropathic pain in rats: in vivo and ex vivo analysis

scientific article published on 26 June 2019

Effect of Vitis vinifera hydroalcoholic extract against oxaliplatin neurotoxicity: in vitro and in vivo evidence

scientific article published in Scientific Reports

Effect of glucoraphanin and sulforaphane against chemotherapy-induced neuropathic pain: Kv7 potassium channels modulation by H S release in vivo

scientific article published on 02 August 2018

Effect of the SOD mimetic MnL4 on in vitro and in vivo oxaliplatin toxicity: Possible aid in chemotherapy induced neuropathy

scientific article published on 28 January 2016

Effect of treatment with the antioxidant alpha-lipoic (thioctic) acid on heart and kidney microvasculature in spontaneously hypertensive rats

scientific article

Effects of Cadmium on ZO-1 Tight Junction Integrity of the Blood Brain Barrier

scientific article published on 29 November 2019

Effects of Hypericum perforatum extract on oxaliplatin-induced neurotoxicity: in vitro evaluations

scientific article

Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats

scientific article published on 21 August 2017

Effects of natural and synthetic isothiocyanate-based H2S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels

scientific article published on 18 April 2017

Efficacy of isothiocyanate-based compounds on different forms of persistent pain

Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors

scientific article published on 18 December 2013

Eruca sativa Mill. seed extract promotes anti-obesity and hypoglycemic effects in mice fed with a high-fat diet

scientific article published on 03 November 2020

Extra virgin olive oil and related by-products (Olea europaea L.) as natural sources of phenolic compounds for abdominal pain relief in gastrointestinal disorders in rats

scientific article published on 25 November 2020

Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release

scientific article

Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists

scientific article published on 12 October 2014

Gc-protein-derived macrophage activating factor counteracts the neuronal damage induced by oxaliplatin.

scientific article published on February 2015

Gi/o proteins: expression for direct activation enquiry

scientific article published on 5 December 2005

Glial role in oxaliplatin-induced neuropathic pain

scientific article published on 23 June 2014

Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines

scientific article published on 29 August 2018

Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme

scientific article published on 18 October 2012

In Vitro Evidence for the Use of Astragali Radix Extracts as Adjuvant against Oxaliplatin-Induced Neurotoxicity

scientific article published on 3 June 2015

Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain

scientific article published on 21 February 2017

Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy

scientific article published on 27 September 2019

Intra-Articular Route for the System of Molecules 14G1862 from Centella Asiatica: Pain Relieving and Protective Effects in a Rat Model of Osteoarthritis

scientific article published on 31 May 2020

Intra-articular mucilages: behavioural and histological evaluations for a new model of articular pain

scientific article published on 19 February 2019

Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity

scientific article published on 5 October 2015

Involvement of α7 nAChR subtype in rat oxaliplatin-induced neuropathy: effects of selective activation

scientific article

Lipoic-based TRPA1/TRPV1 antagonist to treat orofacial pain

scientific article published on 6 January 2015

Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).

scientific article

Local anaesthetic activity of beta-caryophyllene

scientific article

Low dose native type II collagen prevents pain in a rat osteoarthritis model

scientific article

Morphologic features and glial activation in rat oxaliplatin-dependent neuropathic pain

scientific article

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties

scientific article published on 06 June 2019

NAPOR-3 RNA binding protein is required for apoptosis in hippocampus

scientific article published on 10 August 2005

Neuropathy-induced apoptosis: protective effect of physostigmine.

scientific article published in June 2009

Neuroprotective activity of thioctic acid in central nervous system lesions consequent to peripheral nerve injury.

scientific article published on 29 December 2013

Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: a role for the nicotinic receptor

scientific article published in January 2009

Neurorestoration from medicinal plants: an opportunity to treat painful neuropathies

scientific article published on March 2017

New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds

scientific article published on 27 July 2011

Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models

scientific article published on 3 May 2013

Nociceptin/orphanin FQ receptor and pain: Feasibility of the fourth opioid family member

scientific article published on 12 August 2015

Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A1 and A2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells

scientific article published on 16 March 2019

Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors

scientific article published on 11 April 2013

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties

scientific article published on 31 October 2011

Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1.

scientific article published on 10 June 2015

Oxaliplatin neurotoxicity involves peroxisome alterations. PPARγ agonism as preventive pharmacological approach

scientific article

Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin

scientific article

Oxaliplatin-induced oxidative stress in nervous system-derived cellular models: could it correlate with in vivo neuropathy?

scientific article published on 31 March 2013

Oxidative, metabolic, and apoptotic responses of Schwann cells to high glucose levels

scientific article

PPAR- γ impairment alters peroxisome functionality in primary astrocyte cell cultures

scientific article published on 04 March 2014

Pain relieving and protective effects of Astragalus hydroalcoholic extract in rat arthritis models

scientific article published on 29 September 2017

Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-alpha-mediated mechanism.

scientific article published on 25 February 2013

Peroxisome determination in optical microscopy: a useful tool derived by a simplification of an old ultrastructural technique

scientific article published on 28 March 2014

Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat.

scientific article published on 28 July 2017

Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents

scientific article published on 16 February 2017

Pomegranate Mesocarp against Colitis-Induced Visceral Pain in Rats: Effects of a Decoction and Its Fractions

scientific article published on 17 June 2020

Prophylactic role of acetyl-l-carnitine on knee lesions and associated pain in a rat model of osteoarthritis

article

Prophylactic versus Therapeutic Fingolimod: Restoration of Presynaptic Defects in Mice Suffering from Experimental Autoimmune Encephalomyelitis

scientific article

Protective Effects Induced by Two Polyphenolic Liquid Complexes from Olive (Olea europaea, mainly Cultivar Coratina) Pressing Juice in Rat Isolated Tissues Challenged with LPS

scientific article published on 19 August 2019

Protective effect of acetyl-l-carnitine on the apoptotic pathway of peripheral neuropathy

scientific article published on 01 August 2007

Protective effect of alpha7 nAChR: behavioural and morphological features on neuropathy

scientific article published on 8 July 2010

Receptor-independent modulation of reconstituted Galpha(i) protein mediated by liposomes.

scientific article published on 29 January 2009

Relaxant Effect of a Water Soluble Carbon Monoxide-Releasing Molecule (CORM-3) on Spontaneously Hypertensive Rat Aortas

scientific article published on 01 August 2012

Researching New Therapeutic Approaches for Abdominal Visceral Pain Treatment: Preclinical Effects of an Assembled System of Molecules of Vegetal Origin

scientific article published on 20 December 2019

Restoring nitric oxide cytosolic calcium regulation by cyclic guanosine monophosphate protein kinase I alpha transfection in coronary endothelial cells of spontaneously hypertensive rats

scientific article published on 15 March 2012

Serotonergic modulation in neuropathy induced by oxaliplatin: Effect on the 5HT2C receptor

scientific article published on 29 April 2014

Special Issue "Plant Extracts: Biological and Pharmacological Activity"

scientific article published on 04 November 2020

Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235.

scientific article

Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain

Synergic stimulation of serotonin 5-HT1A receptor and α2-adrenoceptors for neuropathic pain relief: Preclinical effects of 2-substituted imidazoline derivatives

scientific article published on 17 June 2017

Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]nonan-8-ones as Potential Nootropic and Analgesic Drugs

scientific article published on 07 March 2011

Synthesis and Biological Evaluation of Novel Neuroprotective Pyridazine Derivatives as Excitatory Amino Acid Transporter 2 (EAAT2) Activators

scientific article published on 19 May 2017

Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis

scientific article published on 23 July 2019

Synthesis and Pharmacological Evaluation of Novel GABAA Subtype Receptor Ligands with Potential Anxiolytic-like and Anti-hyperalgesic Effect

scholarly article by Gabriella Guerrini et al published 11 May 2017 in Journal of Heterocyclic Chemistry

Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity

scientific article published on 28 December 2015

Synthesis and pharmacological evaluation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as potential GABAA-R ligands

scientific article published on 11 February 2017

Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold

scientific article published on 26 September 2011

Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents

scientific article published on 02 September 2015

Synthesis of novel cognition enhancers with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at γ-aminobutyric acid type A (GABA(A)) receptor

scientific article

Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity

scientific article published on 05 August 2019

Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues

scientific article

Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors

scientific article published on 26 December 2014

Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy

scientific article published on 19 June 2018

The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A3 Receptor Agonist, in a Rat Model of Colitis

scientific article published on 21 June 2020

The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1

scientific article published on 25 January 2020

The Protection of Zinc against Acute Cadmium Exposure: A Morphological and Molecular Study on a BBB In Vitro Model

scientific article published on 15 May 2022

The Use of the Selective Imidazoline I1 Receptor Agonist Carbophenyline as a Strategy for Neuropathic Pain Relief: Preclinical Evaluation in a Mouse Model of Oxaliplatin-Induced Neurotoxicity

scientific article published on 22 June 2020

The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor

scientific article published on 30 September 2016

The neuropathy-protective agent acetyl-L-carnitine activates protein kinase C-gamma and MAPKs in a rat model of neuropathic pain.

scientific article published on 17 November 2009

The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress

scientific article published on 8 September 2016

The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII

publication published on 01 December 2022

The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment

scientific article published on 28 April 2016

Therapeutic effects of the superoxide dismutase mimetic compound MnIIMe2DO2A on experimental articular pain in rats

scientific article published on 06 June 2013

Toxicological Profile of the Pain-Relieving Antioxidant Compound Thioctic Acid in Its Racemic and Enantiomeric Forms

scientific article published on 14 August 2020

Treatment of Non-Alcoholic Steatosis: Preclinical Study of a New Nutraceutical Multitarget Formulation

scientific article published on 18 June 2020

Widespread pain reliever profile of a flower extract of Tanacetum parthenium

scientific article published on 27 May 2015

[35S]GTP gamma S binding studies of amphiphilic drugs-activated Gi proteins: a caveat

scientific article published on 28 February 2009

α-conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement

scientific article

α2 Adrenoceptor: a Target for Neuropathic Pain Treatment

scientific article

α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity

scientific article published on 3 June 2015

β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity

scientific article published on 22 April 2020

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