List of works by Lin Zhang

1,25-Dihydroxyvitamin D3 suppresses gastric cancer cell growth through VDR- and mutant p53-mediated induction of p21.

scientific article

5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers

scientific article published on 18 October 2016

A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells

scientific article published on 01 March 2007

A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery ⬇️

scientific article published on September 18, 2010

A surveillance method to identify patients with sepsis from electronic health records in Hong Kong: a single centre retrospective study

scientific article published on 07 September 2020

ADAR1 is essential for intestinal homeostasis and stem cell maintenance.

scientific article published on 18 April 2013

An apoptosis-independent role of SMAC in tumor suppression

scientific article published on 2 July 2012

An insight into statistical refractive index properties of cell internal structure via low-coherence statistical amplitude microscopy ⬇️

scientific article published on October 11, 2010

Anti-cancer therapy with TNFα and IFNγ: A comprehensive review.

scientific article published on 26 February 2018

Aurora kinase inhibition induces PUMA via NF-κB to kill colon cancer cells

scientific article

Autophagy Mediates HBx-Induced Nuclear Factor-κB Activation and Release of IL-6, IL-8, and CXCL2 in Hepatocytes

scientific article

Autophagy in sepsis: Degradation into exhaustion?

scientific article published on 12 May 2016

BET Inhibitors Potentiate Chemotherapy and Killing of SPOP-Mutant Colon Cancer Cells via Induction of DR5

scientific article published on 23 January 2019

BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade

scientific article published on 06 October 2021

BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs.

scientific article

BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells

scientific article published on 24 June 2016

CASC2: An emerging tumour-suppressing long noncoding RNA in human cancers and melanoma

article

Cathelicidin-encoding Lactococcus lactis promotes mucosal repair in murine experimental colitis

scientific article published on 28 July 2016

Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis ⬇️

scientific article published on November 16, 2010

Cigarette smoking and gastrointestinal diseases: the causal relationship and underlying molecular mechanisms (review).

scientific article published on 22 May 2014

Cleaving Beclin 1 to suppress autophagy in chemotherapy-induced apoptosis.

scientific article

Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress

scientific article published on 21 December 2016

Colorectal cancer prevention: Immune modulation taking the stage

scientific article

Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.

scientific article

Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006-2014.

scientific article published on October 2017

Evaluation of a novel prognostic score based on thrombosis and inflammation in patients with sepsis: a retrospective cohort study

scientific article published on 01 June 2018

FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.

scientific article published on 11 July 2016

FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors

scientific article published on 15 June 2017

Fibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion.

scientific article

Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer

scientific article

Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.

scientific article

Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Gut microbiota‐derived synbiotic formula (SIM01) as a novel adjuvant therapy for COVID‐19: An open‐label pilot study

scientific article published in 2022

Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.

scientific article published on 21 August 2013

IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells

scientific article

Immunogenic cell death in colon cancer prevention and therapy

scientific article published on 25 March 2020

Immunogenic effects of chemotherapy-induced tumor cell death

scientific article published on 17 May 2018

Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth

scientific article published on 30 January 2012

Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice

scientific article published on 04 October 2016

Interferon b drives intestinal regeneration after radiation

scientific article published on 06 October 2021

Investigation of nuclear nano-morphology marker as a biomarker for cancer risk assessment using a mouse model.

scientific article

Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice

scientific article

Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis.

scientific article published on 23 April 2015

Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells

scientific article published on 15 February 2017

Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins

scientific article published on 12 June 2018

Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells

scientific article

NSAIDs downregulate Bcl-X(L) and dissociate BAX and Bcl-X(L) to induce apoptosis in colon cancer cells

scientific article published on January 2008

Nanoscale nuclear architecture for cancer diagnosis beyond pathology via spatial-domain low-coherence quantitative phase microscopy

scientific article

Necroptosis: an alternative cell death program defending against cancer.

scientific article published on 8 March 2016

Non-steroidal anti-inflammatory drugs induce immunogenic cell death in suppressing colorectal tumorigenesis

scientific article published on 18 February 2021

Oncogenes expand during evolution to withstand somatic amplification

scientific article published on 01 November 2018

PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells

scientific article

PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01.

scientific article

PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis

scientific article

PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells

scientific article

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

scientific article

PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome

scientific article

PUMA, a potent killer with or without p53

scientific article

PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.

scientific article

PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice.

scientific article

Pathological Role and Diagnostic Value of Endogenous Host Defense Peptides in Adult and Neonatal Sepsis: A Systematic Review

scientific article published on 09 December 2016

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation

scientific article

Quantitation of faecal Fusobacterium improves faecal immunochemical test in detecting advanced colorectal neoplasia

scientific article published on 24 October 2016

Receptor interactive protein kinase 3 promotes Cisplatin-triggered necrosis in apoptosis-resistant esophageal squamous cell carcinoma cells

scientific article

Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori

scientific article

Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis.

scientific article

Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis.

scientific article published on 20 February 2006

Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer

scholarly article by Kyle Knickelbein published in May 2018

Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer

scientific article

Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death

scientific article published on 31 January 2014

Role of Smac in determining the chemotherapeutic response of esophageal squamous cell carcinoma.

scientific article published on 15 June 2011

Role of apoptosis in colon cancer biology, therapy, and prevention

scientific article published on December 2013

SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events

scientific article

Single-sperm typing.

scientific article published in May 2002

Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway

scientific article

Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies

scientific article published on 01 October 2014

Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation.

scientific article published on 8 February 2013

Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer

scientific article published on 21 March 2022

Targeting p53-dependent stem cell loss for intestinal chemoprotection.

scientific article published in February 2018

The Roles of Histone Demethylase UTX and JMJD3 (KDM6B) in Cancers: Current Progress and Future Perspectives

scientific article published on 24 July 2016

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

scientific article published in August 2017

The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA.

scientific article

Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects

scientific article published on 9 January 2018

Translational genomics in pancreatic ductal adenocarcinoma: A review with re-analysis of TCGA dataset.

scientific article

Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21.

scientific article

Vascular-targeted TNFα and IFNγ inhibits orthotopic colorectal tumor growth

scientific article published on 24 June 2016

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.

scientific article published on 22 September 2015

Vitamin D and Cancer Stem Cells in the Gastrointestinal Tract.

scientific article published on 14 February 2017

Whole genome amplification from a single cell: implications for genetic analysis ⬇️

scientific article published on July 1, 1992

Xenophagy in Helicobacter pylori- and Epstein-Barr virus-induced gastric cancer

scientific article published on June 2014

mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.

scientific article

p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice

scientific article published on 11 March 2019

p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion

scientific article

p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress

scientific journal article

p53/HMGB1 complexes regulate autophagy and apoptosis.

scientific article published on 16 February 2012

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