List of works - Chetan Eknath Chitnis

A Plasmodium yoelii yoelii erythrocyte binding protein that uses Duffy binding-like domain for invasion: a rodent model for studying erythrocyte invasion ⬇️

scientific article published on April 25, 2003

A Receptor for the Malarial Parasite Plasmodium vivax : the Erythrocyte Chemokine Receptor ⬇️

scientific article published on August 27, 1993

A Research Agenda to Underpin Malaria Eradication

scientific article

Analysis of factors affecting the variability of a quantitative suspension bead array assay measuring IgG to multiple Plasmodium antigens

scientific article published in PLoS ONE

Antibodies raised against receptor-binding domain of Plasmodium knowlesi Duffy binding protein inhibit erythrocyte invasion

scientific article published on April 2002

Antibody response to Plasmodium vivax antigens in Fy-negative individuals from the Colombian Pacific coast.

scientific article published in November 2005

Assessment of the Combined Effect of Epstein-Barr Virus and Plasmodium falciparum Infections on Endemic Burkitt Lymphoma Using a Multiplex Serological Approach

scientific article published on 26 October 2017

Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia

scientific article published in October 2010

Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor

scientific article

Bacterially expressed and refolded receptor binding domain of Plasmodium falciparum EBA-175 elicits invasion inhibitory antibodies.

scientific article published in August 2002

Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study

scientific article

Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites

scientific article (publication date: 2013)

Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen-5 triggers merozoite egress.

scientific article

Changing Trends in P. falciparum Burden, Immunity, and Disease in Pregnancy

scientific article published on October 2015

Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion

scientific article published in July 2013

Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion. ⬇️

scientific article published on 30 November 2012

Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax.

scientific article published in June 2007

Comparison of IgG reactivities to Plasmodium vivax merozoite invasion antigens in a Brazilian Amazon population.

scientific article published in August 2005

Correction: Phase I Clinical Trial of a Recombinant Blood Stage Vaccine Candidate for Plasmodium falciparum Malaria Based on MSP1 and EBA175.

scientific article published on 2 September 2015

Current status of Plasmodium vivax vaccine.

scientific article published on 26 January 2010

Cytoadhesion to gC1qR through Plasmodium falciparum Erythrocyte Membrane Protein 1 in Severe Malaria

scientific article

Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure

scientific article

Definition of structural elements in Plasmodium vivax and P. knowlesi Duffy-binding domains necessary for erythrocyte invasion ⬇️

scientific article

Development of quantitative receptor-ligand binding assay for use as a tool to estimate immune responses against Plasmodium vivax Duffy binding protein Region II.

scientific article published in January 2012

Divergent binding sites on intercellular adhesion molecule-1 (ICAM-1) for variant Plasmodium falciparum isolates

scientific article published on February 2004

Epitope-specific humoral immunity to Plasmodium vivax Duffy binding protein.

scientific article

Expression and characterization of human malaria parasite Plasmodium falciparum origin recognition complex subunit 1

scientific article (publication date: 25 November 2005)

Flow cytometry-based methods for measurement of cytosolic calcium and surface protein expression in Plasmodium falciparum merozoites.

scientific article published in January 2013

Functional and immunological characterization of a Duffy binding-like alpha domain from Plasmodium falciparum erythrocyte membrane protein 1 that mediates rosetting

scientific article published on 22 June 2009

Genetic analysis of the alginate biosynthetic gene cluster of Pseudomonas aeruginosa shows evidence of an operonic structure.

scientific article

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence

scientific article published on 15 December 2008

High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria

scientific article

Host age and expression of genes involved in red blood cell invasion in Plasmodium falciparum field isolates ⬇️

scientific article

Host cell invasion by malaria parasites

scientific article (publication date: October 2000)

Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies.

scientific article

Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development

scientific article published on 17 June 2013

Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

scientific article published on 26 September 2017

Identifying Immune Correlates of Protection Against Plasmodium falciparum Through a Novel Approach to Account for Heterogeneity in Malaria Exposure

scientific article published in February 2018

IgM and IgG against Plasmodium falciparum lysate as surrogates of malaria exposure and protection during pregnancy.

scientific article

Immunogenicity of Duffy binding-like domains that bind chondroitin sulfate A and protection against pregnancy-associated malaria

scientific article

Immunogenicity of a recombinant malaria vaccine based on receptor binding domain of Plasmodium falciparum EBA-175.

scientific article published on 27 September 2006

Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique

scientific article published on 27 March 2014

Impact of intermittent preventive treatment with sulfadoxine-pyrimethamine on antibody responses to erythrocytic-stage Plasmodium falciparum antigens in infants in Mozambique

scientific article published on 21 May 2008

Impact of the RTS,S malaria vaccine candidate on naturally acquired antibody responses to multiple asexual blood stage antigens

scientific article

Improved pregnancy outcomes in women exposed to malaria with high antibody levels against Plasmodium falciparum

scientific article published on 28 February 2013

Improvement in yield and purity of a recombinant malaria vaccine candidate based on the receptor-binding domain of Plasmodium vivax Duffy binding protein by codon optimization.

scientific article published on 23 June 2006

Large-angle keV-energy He-He scattering measurements with use of a correlated two-particle coincidence detector

scientific article published on 01 February 1988

Localization of apical sushi protein in Plasmodium falciparum merozoites

scientific article (publication date: November 2010)

Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case-control study

scientific article

Malaria and HIV infection in Mozambican pregnant women are associated with reduced transfer of antimalarial antibodies to their newborns

scientific article

Malaria vaccine R&D in the Decade of Vaccines: breakthroughs, challenges and opportunities

scientific article

Malaria vaccine candidate based on Duffy-binding protein elicits strain transcending functional antibodies in a Phase I trial

scholarly article by Kavita Singh et al published 2018 in npj Vaccines

Mapping regions containing binding residues within functional domains of Plasmodium vivax and Plasmodium knowlesi erythrocyte-binding proteins.

scientific article published on November 1999

Microsatellite Genotyping of Plasmodium vivax Isolates from Pregnant Women in Four Malaria Endemic Countries

scientific article

Molecular Signaling Involved in Entry and Exit of Malaria Parasites from Host Erythrocytes.

scientific article

Molecular analysis of the cytoadherence phenotype of a Plasmodium falciparum field isolate that binds intercellular adhesion molecule-1.

scientific article published on February 2004

Molecular basis of severe malaria

scientific article

Molecular insights into receptors used by malaria parasites for erythrocyte invasion.

scientific article

Molecular interactions and signaling mechanisms during erythrocyte invasion by malaria parasites.

scientific article published on 29 July 2011

Molecular mechanisms that mediate invasion and egress of malaria parasites from red blood cells

scientific article published on 16 March 2017

Naturally Acquired Binding-Inhibitory Antibodies to Plasmodium vivax Duffy Binding Protein in Pregnant Women Are Associated with Higher Birth Weight in a Multicenter Study

scientific article published on 17 February 2017

Naturally acquired Duffy-binding protein-specific binding inhibitory antibodies confer protection from blood-stage Plasmodium vivax infection

scholarly article

Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG1-4, IgM and IgE using standard and customized reference pools for sero-epidemiological and vaccine studies.

scientific article published in June 2018

Parity and placental infection affect antibody responses against Plasmodium falciparum during pregnancy

scientific article

Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes

scientific article (publication date: May 2014)

Pfcrt haplotypes and in-vivo chloroquine response in Sundergarh district, Orissa, India.

scientific article published on 10 April 2007

Phase I Clinical Trial of a Recombinant Blood Stage Vaccine Candidate for Plasmodium falciparum Malaria Based on MSP1 and EBA175.

scientific article published on 30 April 2015

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

scientific article

Phosphorylation-Dependent Assembly of a 14-3-3 Mediated Signaling Complex during Red Blood Cell Invasion by Plasmodium falciparum Merozoites

scientific article published on 18 August 2020

Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes

scientific article (publication date: 9 November 2016)

Plasmodium falciparum infection elicits both variant-specific and cross-reactive antibodies against variant surface antigens.

scientific article published on February 2003

Plasmodium falciparum reticulocyte binding-like homologue protein 2 (PfRH2) is a key adhesive molecule involved in erythrocyte invasion ⬇️

scientific article

Plasmodium falciparum uses gC1qR/HABP1/p32 as a receptor to bind to vascular endothelium and for platelet-mediated clumping.

scientific article

Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women

scientific article

Plasmodium vivax invasion of human erythrocytes inhibited by antibodies directed against the Duffy binding protein ⬇️

scientific article

Preclinical Assessment of Viral Vectored and Protein Vaccines Targeting the Duffy-Binding Protein Region II of Plasmodium Vivax

scientific article

Preclinical assessment of the receptor-binding domain of Plasmodium vivax Duffy-binding protein as a vaccine candidate in rhesus macaques.

scientific article published on 23 June 2008

Pregnancy and malaria exposure are associated with changes in the B cell pool and in plasma eotaxin levels

scientific article published on 18 August 2014

Production of recombinant PvDBPII, receptor binding domain of Plasmodium vivax Duffy binding protein, and evaluation of immunogenicity to identify an adjuvant formulation for vaccine development.

scientific article published on 11 November 2015

Proinflammatory responses and higher IL-10 production by T cells correlate with protection against malaria during pregnancy and delivery outcomes

scientific article published on 27 February 2015

Protein S-Palmitoylation Is Responsive to External Signals and Plays a Regulatory Role in Microneme Secretion in Plasmodium falciparum Merozoites

scientific article published on 14 February 2020

Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum.

scientific article published on June 1994

Receptor-binding residues lie in central regions of Duffy-binding-like domains involved in red cell invasion and cytoadherence by malaria parasites.

scientific article published on 2 September 2004

Reduction of antimalarial antibodies by HIV infection is associated with increased risk of Plasmodium falciparum cord blood infection

scientific article published on 11 January 2012

Reticulocytes from cryopreserved erythroblasts support Plasmodium vivax infection in vitro.

scientific article published on December 2013

Sequence polymorphisms in the receptor-binding domain of Plasmodium falciparum EBA-175: implications for malaria vaccine development.

scientific article published in December 2005

Signalling in malaria parasites. The MALSIG consortium

scientific article published on September 2009

Signalling mechanisms involved in apical organelle discharge during host cell invasion by apicomplexan parasites.

scientific article published on 23 May 2012

Structural analogs of sialic acid interfere with the binding of erythrocyte binding antigen-175 to glycophorin A, an interaction crucial for erythrocyte invasion by Plasmodium falciparum.

scientific article published in November 2004

Structural basis for Duffy recognition by the malaria parasite Duffy-binding-like domain.

scientific article published on 21 December 2005

Structural insights into chondroitin sulphate A binding Duffy-binding-like domains from Plasmodium falciparum: implications for intervention strategies against placental malaria

scientific article published on 17 April 2009

Sulphated tyrosines mediate association of chemokines and Plasmodium vivax Duffy binding protein with the Duffy antigen/receptor for chemokines (DARC).

scientific article

Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes

scientific article (publication date: 14 July 1995)

Talking to each other to initiate sexual differentiation.

scientific article published in May 2013

Targeted deletion of Plasmodium knowlesi Duffy binding protein confirms its role in junction formation during invasion

scientific article published in March 2005

Targeting TLRs expands the antibody repertoire in response to a malaria vaccine

scientific article published in July 2011

Targeting a Reticulocyte Binding Protein and Duffy Binding Protein to Inhibit Reticulocyte Invasion by Plasmodium vivax. ⬇️

scientific article published on 12 July 2018

Targeting the Plasmodium vivax Duffy-binding protein.

scientific article

The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes ⬇️

scientific article (publication date: December 2014)

The effect of intermittent preventive treatment during pregnancy on malarial antibodies depends on HIV status and is not associated with poor delivery outcomes

scientific article published on January 2010

The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus

scientific article

The role of age and exposure to Plasmodium falciparum in the rate of acquisition of naturally acquired immunity: a randomized controlled trial

scientific article (publication date: 2012)

Workshop report: Malaria vaccine development in Europe--preparing for the future.

scientific article published on 30 September 2015

List of works by Chetan Eknath Chitnis

A Plasmodium yoelii yoelii erythrocyte binding protein that uses Duffy binding-like domain for invasion: a rodent model for studying erythrocyte invasion ⬇️

A Receptor for the Malarial Parasite Plasmodium vivax : the Erythrocyte Chemokine Receptor ⬇️

A Research Agenda to Underpin Malaria Eradication

Analysis of factors affecting the variability of a quantitative suspension bead array assay measuring IgG to multiple Plasmodium antigens

Antibodies raised against receptor-binding domain of Plasmodium knowlesi Duffy binding protein inhibit erythrocyte invasion

Antibody response to Plasmodium vivax antigens in Fy-negative individuals from the Colombian Pacific coast.

Assessment of the Combined Effect of Epstein-Barr Virus and Plasmodium falciparum Infections on Endemic Burkitt Lymphoma Using a Multiplex Serological Approach

Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia

Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor

Bacterially expressed and refolded receptor binding domain of Plasmodium falciparum EBA-175 elicits invasion inhibitory antibodies.

Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study

Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites

Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen-5 triggers merozoite egress.

Changing Trends in P. falciparum Burden, Immunity, and Disease in Pregnancy

Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion

Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion. ⬇️

Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax.

Comparison of IgG reactivities to Plasmodium vivax merozoite invasion antigens in a Brazilian Amazon population.

Correction: Phase I Clinical Trial of a Recombinant Blood Stage Vaccine Candidate for Plasmodium falciparum Malaria Based on MSP1 and EBA175.

Current status of Plasmodium vivax vaccine.

Cytoadhesion to gC1qR through Plasmodium falciparum Erythrocyte Membrane Protein 1 in Severe Malaria

Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure

Definition of structural elements in Plasmodium vivax and P. knowlesi Duffy-binding domains necessary for erythrocyte invasion ⬇️

Development of quantitative receptor-ligand binding assay for use as a tool to estimate immune responses against Plasmodium vivax Duffy binding protein Region II.

Divergent binding sites on intercellular adhesion molecule-1 (ICAM-1) for variant Plasmodium falciparum isolates

Epitope-specific humoral immunity to Plasmodium vivax Duffy binding protein.

Expression and characterization of human malaria parasite Plasmodium falciparum origin recognition complex subunit 1

Flow cytometry-based methods for measurement of cytosolic calcium and surface protein expression in Plasmodium falciparum merozoites.

Functional and immunological characterization of a Duffy binding-like alpha domain from Plasmodium falciparum erythrocyte membrane protein 1 that mediates rosetting

Genetic analysis of the alginate biosynthetic gene cluster of Pseudomonas aeruginosa shows evidence of an operonic structure.

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence

High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria

Host age and expression of genes involved in red blood cell invasion in Plasmodium falciparum field isolates ⬇️

Host cell invasion by malaria parasites

Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies.

Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development

Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

Identifying Immune Correlates of Protection Against Plasmodium falciparum Through a Novel Approach to Account for Heterogeneity in Malaria Exposure

IgM and IgG against Plasmodium falciparum lysate as surrogates of malaria exposure and protection during pregnancy.

Immunogenicity of Duffy binding-like domains that bind chondroitin sulfate A and protection against pregnancy-associated malaria

Immunogenicity of a recombinant malaria vaccine based on receptor binding domain of Plasmodium falciparum EBA-175.

Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique

Impact of intermittent preventive treatment with sulfadoxine-pyrimethamine on antibody responses to erythrocytic-stage Plasmodium falciparum antigens in infants in Mozambique

Impact of the RTS,S malaria vaccine candidate on naturally acquired antibody responses to multiple asexual blood stage antigens

Improved pregnancy outcomes in women exposed to malaria with high antibody levels against Plasmodium falciparum

Improvement in yield and purity of a recombinant malaria vaccine candidate based on the receptor-binding domain of Plasmodium vivax Duffy binding protein by codon optimization.

Large-angle keV-energy He-He scattering measurements with use of a correlated two-particle coincidence detector

Localization of apical sushi protein in Plasmodium falciparum merozoites

Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case-control study

Malaria and HIV infection in Mozambican pregnant women are associated with reduced transfer of antimalarial antibodies to their newborns

Malaria vaccine R&D in the Decade of Vaccines: breakthroughs, challenges and opportunities

Malaria vaccine candidate based on Duffy-binding protein elicits strain transcending functional antibodies in a Phase I trial

Mapping regions containing binding residues within functional domains of Plasmodium vivax and Plasmodium knowlesi erythrocyte-binding proteins.

Microsatellite Genotyping of Plasmodium vivax Isolates from Pregnant Women in Four Malaria Endemic Countries

Molecular Signaling Involved in Entry and Exit of Malaria Parasites from Host Erythrocytes.

Molecular analysis of the cytoadherence phenotype of a Plasmodium falciparum field isolate that binds intercellular adhesion molecule-1.

Molecular basis of severe malaria

Molecular insights into receptors used by malaria parasites for erythrocyte invasion.

Molecular interactions and signaling mechanisms during erythrocyte invasion by malaria parasites.

Molecular mechanisms that mediate invasion and egress of malaria parasites from red blood cells

Naturally Acquired Binding-Inhibitory Antibodies to Plasmodium vivax Duffy Binding Protein in Pregnant Women Are Associated with Higher Birth Weight in a Multicenter Study

Naturally acquired Duffy-binding protein-specific binding inhibitory antibodies confer protection from blood-stage Plasmodium vivax infection

Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG1-4, IgM and IgE using standard and customized reference pools for sero-epidemiological and vaccine studies.

Parity and placental infection affect antibody responses against Plasmodium falciparum during pregnancy

Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes

Pfcrt haplotypes and in-vivo chloroquine response in Sundergarh district, Orissa, India.

Phase I Clinical Trial of a Recombinant Blood Stage Vaccine Candidate for Plasmodium falciparum Malaria Based on MSP1 and EBA175.

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

Phosphorylation-Dependent Assembly of a 14-3-3 Mediated Signaling Complex during Red Blood Cell Invasion by Plasmodium falciparum Merozoites

Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes

Plasmodium falciparum infection elicits both variant-specific and cross-reactive antibodies against variant surface antigens.

Plasmodium falciparum reticulocyte binding-like homologue protein 2 (PfRH2) is a key adhesive molecule involved in erythrocyte invasion ⬇️

Plasmodium falciparum uses gC1qR/HABP1/p32 as a receptor to bind to vascular endothelium and for platelet-mediated clumping.

Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women

Plasmodium vivax invasion of human erythrocytes inhibited by antibodies directed against the Duffy binding protein ⬇️

Preclinical Assessment of Viral Vectored and Protein Vaccines Targeting the Duffy-Binding Protein Region II of Plasmodium Vivax

Preclinical assessment of the receptor-binding domain of Plasmodium vivax Duffy-binding protein as a vaccine candidate in rhesus macaques.

Pregnancy and malaria exposure are associated with changes in the B cell pool and in plasma eotaxin levels

Production of recombinant PvDBPII, receptor binding domain of Plasmodium vivax Duffy binding protein, and evaluation of immunogenicity to identify an adjuvant formulation for vaccine development.