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List of works by Cheryl Arrowsmith

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

scientific article

1H(C) and 1H(N) total NOE correlations in a single 3D NMR experiment. 15N and 13C time-sharing in t1 and t2 dimensions for simultaneous data acquisition.

scientific article

1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR

scientific article (publication date: March 2002)

A Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro

scientific article published on 04 March 2014

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

scientific article published on 15 October 2019

A Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function Screen

scientific article

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

scientific article published on 24 November 2015

A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5

scientific article published on 23 December 2015

A SPOT on the chromatin landscape? Histone peptide arrays as a tool for epigenetic research

scientific article published on 04 June 2008

A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

scientific article

A Suite of Biochemical Assays for Screening RNA Methyltransferase BCDIN3D

scientific article published on 27 September 2016

A Suite of Triple Resonance NMR Experiments for the Backbone Assignment of 15N, 13C, 2H Labeled Proteins with High Sensitivity

scientific article published in 1994

A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1

scientific article

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

scientific article published in Nature Communications

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

scientific article published on 28 October 2019

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

scientific article

A chemical toolbox for the study of bromodomains and epigenetic signaling

scientific article published on 23 April 2019

A combinatorial anticancer drug screen identifies off-target effects of epigenetic chemical probes

A community resource of experimental data for NMR / X-ray crystal structure pairs.

scientific article

A correlation between .beta.-hydrogen isotope effects on carbon-13 NMR chemical shifts in unsaturated systems and the strength of hyperconjugative interactions

scientific article published in 1986

A global assessment of cancer genomic alterations in epigenetic mechanisms

scientific article published on 04 December 2014

A ligand discovery toolbox for the WWE domain family of human E3 ligases

scientific article published in 2024

A meanfield approach to the thermodynamics of a protein-solvent system with application to the oligomerization of the tumor suppressor p53

scientific article published on August 2000

A novel member of the YchN-like fold: solution structure of the hypothetical protein Tm0979 from Thermotoga maritima

scientific article published on January 2005

A novel member of the split betaalphabeta fold: Solution structure of the hypothetical protein YML108W from Saccharomyces cerevisiae

scientific article (publication date: May 2003)

A novel strategy for NMR resonance assignment and protein structure determination

scientific article

A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer

scientific article

A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3)

scientific article

A pulsed field gradient isotope-filtered 3D 13C HMQC-NOESY experiment for extracting intermolecular NOE contacts in molecular complexes.

scientific article

A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants

scientific article

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity

scientific article published on 23 October 2009

AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation

scientific article published on 20 March 2019

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells

scientific article published in September 2017

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.

scientific article published on 11 July 2017

AT-21INTEGRATED (EPI)GENOMIC ANALYSES IDENTIFY SUB-GROUP SPECIFIC THERAPEUTIC TARGETS IN CNS RHABDOID TUMORS.

scientific article published on 30 May 2016

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

scientific article

Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate

scientific article published on 8 May 2014

Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1

scientific article published on 01 August 2019

Altered RNA splicing initiates the viral mimicry response from inverted SINEs following type I PRMT inhibition in Triple-Negative Breast Cancer

Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1

scientific article published on 01 July 2020

An HNCA Pulse Scheme for the Backbone Assignment of 15N,13C,2H-Labeled Proteins: Application to a 37-kDa Trp Repressor-DNA Complex

scientific article published in 1994

An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates

scientific article published on 10 May 2016

An NMR approach to structural proteomics

scientific article

An allosteric inhibitor of protein arginine methyltransferase 3

scientific article

An integrated platform for automated analysis of protein NMR structures.

scientific article

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1

scientific article

An unusual mode of galactose recognition by a family 32 carbohydrate-binding module

scientific article

Analysis of binding site similarity, small-molecule similarity and experimental binding profiles in the human cytosolic sulfotransferase family

scientific article

Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei

Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface.

scientific article

Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells

scientific article published on 11 October 2018

Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643

scientific article

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

scientific article published on 15 November 2017

Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation

scientific article published on 29 June 2015

Assignment of 1H(N), 15N, 13C(alpha), 13CO and 13C(beta) resonances in a 67 kDa p53 dimer using 4D-TROSY NMR spectroscopy

scientific article published on 01 October 2000

Assignment of15N,13Cα,13Cβ, and HN Resonances in an15N,13C,2H Labeled 64 kDa Trp Repressor−Operator Complex Using Triple-Resonance NMR Spectroscopy and2H-Decoupling

scientific article published in 1996

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation

scientific article

Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine

scientific article

Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

scientific article published on 26 May 2020

BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models

scientific article

Backbone and side chain 1H, 13C, and 15N resonance assignments of AF2241 from Archaeoglobus fulgidus

scientific article published on 06 January 2007

Basic Tilted Helix Bundle - a new protein fold in human FKBP25/FKBP3 and HectD1

scientific article published on 22 March 2014

Biochemical and Structural Characterization of a Novel Family of Cystathionine β-Synthase Domain Proteins Fused to a Zn Ribbon-Like Domain

scientific article

Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis

scientific article

Biophysical characterization of recombinant proteins: a key to higher structural genomics success

scientific article

Blind testing of routine, fully automated determination of protein structures from NMR data

scientific article

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor

scientific article published on 30 January 2013

CUL7 is a novel antiapoptotic oncogene

scientific article

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

scientific article

Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner

scientific article published on 19 March 2015

Characterization of binding-induced changes in dynamics suggests a model for sequence-nonspecific binding of ssDNA by replication protein A.

scientific article published on October 2002

Characterization of inv(3) cell line OCI-AML-20 with stroma dependent CD34 expression

scientific article published on 22 October 2018

Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions?

scientific article published in January 2005

Chemical Biology Approaches for Characterization of Epigenetic Regulators.

scientific article published on 16 February 2016

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

scientific article

Chemical shift changes provide evidence for overlapping single-stranded DNA- and XPA-binding sites on the 70 kDa subunit of human replication protein A

scientific article

Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes

Conformational dynamics of the TTD-PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability

scientific article published on 26 October 2017

Consistent blind protein structure generation from NMR chemical shift data

scientific article

Control of the hippo pathway by Set7-dependent methylation of Yap.

scientific article published on 11 July 2013

Cooperative interaction between the DNA-binding domains of PU.1 and IRF4.

scientific article published in June 1998

Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

scientific article published on 17 March 2016

Correction to Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening

scientific article published on 03 August 2016

Correction to “Structure–Activity Relationship of USP5 Inhibitors”

Correction: A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

scientific article published on 15 October 2020

Correction: Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases

scientific article

Cruciform structures are a common DNA feature important for regulating biological processes.

scientific article

Crystal Structure of Fushi Tarazu Factor 1 Ligand Binding Domain/Fushi Tarazu Peptide Complex Identifies New Class of Nuclear Receptors

scientific article

Crystal Structure of Thermotoga maritima 0065, a Member of the IclR Transcriptional Factor Family

scientific article

Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase

scientific article published in November 2002

Crystal structure of Methanobacterium thermoautotrophicum conserved protein MTH1020 reveals an NTN-hydrolase fold

scientific article

Crystal structure ofEscherichia coli EC1530, a glyoxylate induced protein YgbM

scientific article

Crystal structures of MTH1187 and its yeast ortholog YBL001c

scientific article

DNA binding specificity studies of four ETS proteins support an indirect read-out mechanism of protein-DNA recognition.

scientific article published in September 2000

DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models.

scientific article published on 15 May 2018

Data mining crystallization databases: knowledge-based approaches to optimize protein crystal screens

scientific article

De novo design of immunoglobulin-like domains

scientific article published in 2022

Deep trefoil knot implicated in RNA binding found in an archaebacterial protein

scientific article

Design and characterization of mutant and wildtype huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems

scientific article published on 06 March 2019

Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1).

scientific article published on 13 July 2016

Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1.

scientific article published on 6 November 2015

Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex

scientific article published on 20 November 2018

Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2

scientific article

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.

scientific article published on 29 April 2015

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

scientific article published on 6 February 2017

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).

scientific article

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.

scientific article

Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain

scientific article published on 12 November 2019

Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain

scientific article published on 21 March 2018

Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila

scientific article published in April 2018

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

scientific article

Discovery of a Dual PRMT5-PRMT7 Inhibitor

scientific article published on 2 March 2015

Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor

scientific article published on 05 May 2020

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor

scientific article

Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening

scientific article

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)

scientific article published on 24 July 2019

Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.

scientific article published on September 2016

Discovery of a chemical probe for PRDM9

scientific article published on 17 December 2019

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

scientific article published on 6 January 2013

Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8

scientific article (publication date: 14 August 2014)

Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

scientific article published on 31 October 2013

Discovery of selective activators of PRC2 mutant EED-I363M

scientific article published on 25 April 2019

Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain

Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation

Diverse modes of galacto-specific carbohydrate recognition by a family 31 glycoside hydrolase from Clostridium perfringens

scientific article

Domain–domain motions in proteins from time-modulated pseudocontact shifts

Donated chemical probes for open science

scientific article published on 20 April 2018

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids

scientific article

Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation.

scientific article

Elongation factor TFIIS contains three structural domains: solution structure of domain II

scientific article

Elongin from Saccharomyces cerevisiae.

scientific article

Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells

scientific article

Enzyme genomics: Application of general enzymatic screens to discover new enzymes.

scientific article

Epigenetic protein families: a new frontier for drug discovery

scientific article (publication date: 13 April 2012)

Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma

scientific article

Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer

scientific article published on 16 June 2020

Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers

scientific article published on 22 October 2020

Erratum to: ‘Structural genomics and drug discovery: all in the family’ [Curr Opin Chem Biol (2008) 12:32–39]

scholarly article published in Current Opinion in Chemical Biology

Erratum: A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

article

Erratum: Corrigendum: Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

scientific article published in Nature Communications

Erratum: Corrigendum: The promise and peril of chemical probes

scientific article published in November 2015

Erratum: L3MBTL1 recognition of mono- and dimethylated histones

scholarly article published in Nature Structural & Molecular Biology

Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

scholarly article by Florian Grebien et al published October 2015 in Nature Chemical Biology

Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex

scientific article published in July 2017

Expanding the Huntington’s disease research toolbox; validated subdomain protein constructs for biochemical and structural investigation of huntingtin

preprint

Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors

scientific article

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.

scientific article published on 30 August 2017

Fluorescence-based methods for screening writers and readers of histone methyl marks

scientific article

Four p(53)s in a pod

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

scientific article published on 08 July 2019

Functional diversification of the NleG effector family in enterohemorrhagic

article published in the Proceedings of the National Academy of Sciences of the United States of America

Functional interdependence of BRD4 and DOT1L in MLL leukemia

scientific article published on 13 June 2016

Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7.

scientific article published on 14 August 2010

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

scientific article published on 21 August 2020

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

scientific article

Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms

scientific article published on 13 November 2006

Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family

scientific article published on 21 September 2006

Global analysis of protein folding using massively parallel design, synthesis, and testing

scientific article published on July 2017

Guiding COMPASS: Dpy-30 Positions SET1/MLL Epigenetic Signaling

scientific article published on 01 December 2018

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

preprint

HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells

scientific article published on 01 March 2020

HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells

scientific article published on 02 December 2019

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1

scientific article

High throughput screening of purified proteins for enzymatic activity

scientific article published on 01 January 2008

High-throughput production of prokaryotic membrane proteins

scientific article published in January 2005

Histone recognition and large-scale structural analysis of the human bromodomain family

scientific article

Histone recognition by human malignant brain tumor domains

scientific article

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

scientific article

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1

scientific article published on 08 December 2021

Hydroxyl Radical Footprinting of DNA Complexes of the Ets Domain of PU.1 and Its Comparison to the Crystal Structure†

article

Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold

scientific article

Identification and Structure-Activity Relationship of HDAC6 Zinc-finger Ubiquitin Binding Domain Inhibitors

Identification and Structure–Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors

scientific article published on 09 May 2018

Identification and characterization of the first fragment hits for SETDB1 Tudor domain

scientific article published on 12 July 2019

Identification of Rpl29 as a major substrate of the lysine methyltransferase Set7/9

scientific article published on 29 June 2018

Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.

scientific article

Identification of a novel archaebacterial thioredoxin: determination of function through structure

scientific article

In situ proteolysis for protein crystallization and structure determination

scientific article

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

scientific article

Integrating Structure, Bioinformatics, and Enzymology to Discover Function: BioH, A NEW CARBOXYLESTERASE FROM ESCHERICHIA COLI

scientific article (publication date: 11 July 2003)

Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53

scientific article

KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation

scientific article

Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2

scientific article

L3MBTL1 recognition of mono- and dimethylated histones

scientific article

LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity

scientific article published on 23 April 2018

LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.

scientific article published on 30 March 2015

LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression.

scientific article

Latent and active p53 are identical in conformation

scientific article published on 01 September 2001

Letter to the Editor: Complete 1H, 13C and 15N NMR assignments of MTH0776 from Methanobacterium thermoautotrophicum

Letter to the Editor:1H,13C and15N Assignments of Single-Stranded DNA Binding Domains from the 70 kDa Subunit of Human Replication Protein A

scientific article published on 01 February 2004

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

scientific article published on 25 November 2015

MTH187 from Methanobacterium thermoautotrophicum has three HEAT-like repeats

scientific article published on 31 May 2006

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

article

Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities

scientific article published on 19 June 2018

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

scientific article published on 20 May 2020

Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2

scientific article

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation

scientific article published on 25 March 2014

Methyltransferase inhibitors for modulation of the epigenome and beyond

scientific article published on 16 June 2016

Molecular basis of Pirh2-mediated p53 ubiquitylation

scientific article

Molecular recognition of p53 and MDM2 by USP7/HAUSP

scientific article

Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation

scientific article published on June 2013

Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha

scientific article

NMR and X-ray crystallography, complementary tools in structural proteomics of small proteins.

scientific article

NMR data collection and analysis protocol for high-throughput protein structure determination

scientific article

NMR solution structure of Thermotoga maritima protein TM1509 reveals a Zn-metalloprotease-like tertiary structure

scientific article published on 01 January 2005

NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein

scientific journal article

NMR structure of hypothetical protein TA0938 from Thermoplasma acidophilum

scientific article

NMR structure of protein PA2021 from Pseudomonas aeruginosa

scientific article published on 01 November 2006

NMR structure of the Escherichia coli protein YacG: a novel sequence motif in the zinc-finger family of proteins

scientific article

NMR structure of the conserved novel-fold protein TA0743 from Thermoplasma acidophilum

scientific article published on March 2006

NMR structure of the hypothetical protein encoded by the YjbJ gene from Escherichia coli

article

NMR studies of the Escherichia coli trp aporepressor. Sequence-specific assignment of the aromatic proton resonances.

scientific article

Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8.

scientific article published on 28 December 2012

New perceptions of transcription factor properties from NMR

scientific article published in 1998

NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases

scientific article published in 2010

Novel projected 4D triple resonance experiments for polypeptide backbone chemical shift assignment

scientific article published on 01 September 2002

Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines

scientific article

Optimization of resolution and sensitivity of 4D NOESY using Multi-dimensional Decomposition

scientific article published on 01 September 2005

Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins

scientific article published on 5 October 2015

PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase

scientific article published on 29 April 2016

PRMT5 inhibition disrupts splicing and stemness in glioblastoma

scientific article published on 12 February 2021

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

scientific article published on 11 March 2022

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

preprint

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

scientific article published on 01 September 2019

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

scientific article published on 01 May 2019

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

scientific article published on 14 May 2020

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

scientific article

Preclinical target validation using patient-derived cells

scientific article

Prediction and Validation of a Protein’s Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence

scientific article published on 22 December 2021

Preferential binding of IFI16 protein to cruciform structure and superhelical DNA.

scientific article

Probing the epigenome

scientific article published in August 2015

Probing the mechanism of Cbl-b inhibition by a small-molecule inhibitor

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

scientific article

Protein arginine methylation: from enigmatic functions to therapeutic targeting

Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP

scientific article (publication date: 28 November 2003)

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines

scientific article

Protein production and purification

scientific article

Quantitative Hydroxyl Radical Footprinting Reveals Cooperative Interactions between DNA-Binding Subdomains of PU.1 and IRF4 ⬇️

scientific article published on July 7, 1998

Quantitative determination of conformational, dynamic, and kinetic parameters of a ligand-protein/DNA complex from a complete relaxation and conformational exchange matrix analysis of intermolecular transferred NOESY.

scientific article

RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation

scientific article

Rapid corepressor exchange from the trp-repressor/operator complex: an NMR study of [ul-13C/15N]-L-tryptophan.

scientific article

Recognition and Specificity Determinants of the Human Cbx Chromodomains

scientific article

Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein

scientific article

Refolding out of guanidine hydrochloride is an effective approach for high-throughput structural studies of small proteins

scientific article published in September 2003

Resonance Assignments for the Hypothetical Protein TA0938 from Termoplasma Acidophilum

scientific article published on 01 January 2006

Revealing the Protein Propionylation Activity of the Histone Acetyltransferase Males absent on the first (MOF).

scientific article published on 10 January 2018

Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins

scientific article

Role for NMR in structural genomics

scientific article published on 01 January 2002

Role of Pirh2 in mediating the regulation of p53 and c-Myc

scientific article

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling

scientific article published on April 2016

SETDB1 Triple Tudor Domain Ligand, ( )-59, Promotes Methylation of Akt1 in Cells

Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: an AlphaScreen-based assay for antagonists of methyl-lysine binding proteins

scientific article

Screening proteins for NMR suitability

scientific article published on January 2014

Secretion and Circular Dichroism Analysis of the C-Terminal Signal Peptides of HlyA and LktA

article

Segmental differences in the stability of the trp-repressor peptide backbone.

scientific article published in November 1991

Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase

scientific article published on 03 September 2019

Self-renewal as a therapeutic target in human colorectal cancer.

scientific article

Sequence Specific Resonance Assignment of a Hypothetical Protein PA0128 from Pseudomonas Aeruginosa

scientific article published on 01 January 2006

Sequence specific resonance assignment via Multicanonical Monte Carlo search using an ABACUS approach.

scientific article

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock

scientific article

Simultaneous prediction of protein folding and docking at high resolution

scientific article published on 28 October 2009

Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A

scientific article

Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin

scientific article

Small-Molecule Ligands of Methyl-Lysine Binding Proteins

scientific article

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

scientific article published on January 2013

Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.

scientific article

Solution NMR in structural genomics

scientific article published on 30 August 2006

Solution NMR structure and histone binding of the PHD domain of human MLL5.

scientific article

Solution NMR structure of hypothetical protein CV_2116 encoded by a viral prophage element in Chromobacterium violaceum

scientific article

Solution NMR structure of the HLTF HIRAN domain: a conserved module in SWI2/SNF2 DNA damage tolerance proteins.

scientific article

Solution Structure of MTH0776 from Methanobacterium Thermoautotrophicum

Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide

scientific article

Solution structure of MTH1821, a putative structure homologue to RNA polymerase α subunit from Methanobacterium thermoautotrophicum

scientific article

Solution structure of TA0895, a MoaD homologue from Thermoplasma acidophilum

scientific article published on 01 December 2006

Solution structure of TA1092, a ribosomal protein S24e from Thermoplasma acidophilum

scientific article published on 01 September 2006

Solution structure of YKR049C, a putative redox protein from Saccharomyces cerevisiae

scientific article published on 01 September 2005

Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain.

scientific article

Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum

scientific article

Solution structure of acyl carrier protein from Nitrosomonas europaea

scientific article published on 01 August 2006

Solution structure of hypothetical protein TA1414 from Thermoplasma acidophilum

scientific article

Solution structure of ribosomal protein L40E, a unique C4 zinc finger protein encoded by archaeon Sulfolobus solfataricus

scientific article

Solution structure of ribosomal protein S28E fromMethanobacterium thermoautotrophicum

scientific article

Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum

scientific article

Solution structure of the hypothetical protein MTH0637 from Methanobacterium thermoautotrophicum.

scientific article

Solution structure of the hypothetical protein Mth677 from Methanobacterium thermoautotrophicum: a novel alpha+beta fold

scientific article published on June 2004

Solution structure of the tetrameric minimum transforming domain of p53

scientific article

Solution structure of the yeast ubiquitin-like modifier protein Hub1

scientific article

Solution-state NMR structure of the putative morphogene protein BolA (PFE0790c) from Plasmodium falciparum

scientific article published on 18 April 2015

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

scientific article published on 29 December 2010

Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors

scientific article

Structural Basis of E2-25K/UBB+1 Interaction Leading to Proteasome Inhibition and Neurotoxicity

scientific article

Structural Biology of Human H3K9 Methyltransferases

scientific article

Structural Characterization of Interaction between Human Ubiquitin-specific Protease 7 and Immediate-Early Protein ICP0 of Herpes Simplex Virus-1.

scientific article published on 29 July 2015

Structural Proteomics: Toward High-Throughput Structural Biology as a Tool in Functional Genomics

scientific article published on 01 March 2003

Structural and Biochemical Characterization of Phage   FI Protein (gpFI) Reveals a Novel Mechanism of DNA Packaging Chaperone Activity

scientific article

Structural and Functional Characterization of DUF1471 Domains of Salmonella Proteins SrfN, YdgH/SssB, and YahO

scientific article

Structural and Functional Survey of Environmental Aminoglycoside Acetyltransferases Reveals Novel Functionality of Resistance Enzymes.

scientific article

Structural and chemical profiling of the human cytosolic sulfotransferases

scientific article

Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2.

scientific article

Structural basis for molecular recognition and presentation of histone H3 by WDR5

scientific article

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

scientific article

Structural basis of HMCES interactions with DNA reveals multivalent substrate recognition: Supplementary files

Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition

scientific article published on 24 June 2019

Structural characterization of a flexible two-domain protein in solution using small angle X-ray scattering and NMR data

scientific article

Structural genomics and drug discovery: all in the family

scientific article published on February 2008

Structural insights into aldosterone synthase substrate specificity and targeted inhibition

scientific article

Structural proteomics: a tool for genome annotation

scientific article published on February 2004

Structure Activity Relationship of USP5 Allosteric Inhibitors

Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation

scientific article

Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing

scientific article

Structure and functionality of a designed p53 dimer

scientific article

Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle

scientific article

Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

scientific article

Structure of the archaeal translation initiation factor aIF2 from Methanobacterium thermoautotrophicum: Implications for translation initiation

scientific article

Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization

scientific article (publication date: April 2005)

Structure- and function-based characterization of a new phosphoglycolate phosphatase from Thermoplasma acidophilum

scientific article

Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors

scientific article published on 28 July 2016

Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase

scientific article

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).

scientific article

Structure-activity relationship studies of G9a-like protein (GLP) inhibitors

scientific article published on 19 June 2017

Structure-based functional classification of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum

scientific article

Structure–Activity Relationship of USP5 Inhibitors

Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction

scientific article published on 04 February 2013

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma

scientific article published on 6 April 2018

Tackling reproducibility in academic preclinical drug discovery

scientific article published on 21 September 2015

Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks

scientific article

Target 2035: probing the human proteome

scientific article published on 03 July 2019

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

scientific article published on 29 March 2019

Targeting human SET1/MLL family of proteins

scientific article

Targeting non-bromodomain chromatin readers

scientific article published on 03 October 2019

Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

scientific article published on 16 April 2020

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex

scientific article published on 30 January 2017

The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2',3'-cyclic phosphodiesterase, 2'-nucleotidase, and phosphatase activities

scientific article

The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions

scientific article published on 01 September 2019

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase

scientific article published on 01 April 2022

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.

scientific article published on 13 April 2017

The SMX DNA Repair Tri-nuclease

scientific article published on March 2017

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

scientific article published on 23 January 2017

The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism

scientific article

The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer

scientific article

The central region of BRCA1 binds preferentially to supercoiled DNA.

scientific article

The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53

scientific article

The crystal structure of hypothetical protein MTH1491 fromMethanobacterium thermoautotrophicum

scientific article

The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor

scientific article

The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates

scientific article published in Nature Communications

The effect of selective deuteration on magnetization transfer in larger proteins

scientific article published on March 1, 1992

The hypothetical protein Atu4866 from Agrobacterium tumefaciens adopts a streptavidin-like fold

scientific article published on 27 November 2007

The promise and peril of chemical probes

scientific article

The second round of Critical Assessment of Automated Structure Determination of Proteins by NMR: CASD-NMR-2013.

scientific article

The solution structure of bacteriophage lambda protein W, a small morphogenetic protein possessing a novel fold

scientific article

The solution structure of ribosomal protein S17E from Methanobacterium thermoautotrophicum: A structural homolog of the FF domain

scientific article

The solution structure of the bacteriophage lambda head-tail joining protein, gpFII

scientific article

The solution structure of the protein ydhA from Escherichia coli.

scientific article

The solution structures of Escherichia coli trp repressor and trp aporepressor at an intermediate resolution.

scientific article

The solution structures of the trp repressor-operator DNA complex

scientific article

The structural basis for methylmalonic aciduria. The crystal structure of archaeal ATP:cobalamin adenosyltransferase

scientific article published on 25 March 2004

The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface

scientific article

The study of epigenetic mechanisms based on the analysis of histone modification patterns by flow cytometry

scientific article published on 26 August 2013

The use of selective deuteration for the sequence specific 1H NMR assignment of larger proteins

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation

scientific article published on 01 August 2019

Thermodynamic analysis of the structural stability of the tetrameric oligomerization domain of p53 tumor suppressor

article

Toward the solution structure of large (>30 kDa) proteins and macromolecular complexes

scholarly article published 1995

Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding

scientific article published on 28 March 2012

Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein

scientific article published on 14 March 2014

Tritium isotope effects on carbon-13 NMR chemical shifts

scientific article published in 1986

Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1.

scientific article

Unique opportunities for NMR methods in structural genomics.

scientific article

WD40 repeat domain proteins: a novel target class?

scientific article

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

X-ray crystal structure of CutA from Thermotoga maritima at 1.4 Å resolution

scientific article

X-ray crystal structure of MTH938 from Methanobacterium thermoautotrophicum at 2.2 A resolution reveals a novel tertiary protein fold

scientific article

Yeast Transcript Elongation Factor (TFIIS), Structure and Function

scientific article published in Journal of Biological Chemistry

Yeast Transcript Elongation Factor (TFIIS), Structure and Function

scientific article published on 01 August 1998

Zinc is required for structural stability of the C-terminus of archaeal translation initiation factor aIF2β

scientific article published on 01 April 2002

Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum

scientific article

Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A

scientific article

p53 transcriptional activation domain: a molecular chameleon?

scientific article published in March 2006

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