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List of works by Joel M Guthridge

A comprehensive and universal method for assessing the performance of differential gene expression analyses

scientific article

A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus

scientific article

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

article

A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus

scholarly article by Zubin Patel published in April 2018

ABIN1 dysfunction as a genetic basis for lupus nephritis

scientific article published on 22 August 2013

Aberrant Epstein-Barr viral infection in systemic lupus erythematosus

scientific article

Activation-Dependent Apoptosis in CD4+ T Cells during Murine AIDS

article

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production

scientific article

Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations

scientific article published on 26 October 2013

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

scientific article

Antibodies to periodontogenic bacteria are associated with higher disease activity in lupus patients

scientific article published on 25 June 2018

Association of IFIH1 and pro-inflammatory mediators: Potential new clues in SLE-associated pathogenesis

scientific article

Association of a functional IRF7 variant with systemic lupus erythematosus

scientific article

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

scientific article

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility

scientific article

Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus

scientific article

Author Correction: Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

scientific article published on 01 November 2019

Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity

scientific article published on 01 March 2019

Autoantibody-Positive Healthy Individuals Display Unique Immune Profiles That May Regulate Autoimmunity

scientific article published on 05 April 2016

B lymphocyte stimulator levels in systemic lupus erythematosus: higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels

scientific article published on December 2011

B-Cell and Monocyte Contribution to Systemic Lupus Erythematosus Identified by Cell-Type-Specific Differential Expression Analysis in RNA-Seq Data

scientific article

Brief Report: Patients With Primary Sjögren's Syndrome Who Are Positive for Autoantibodies to Tripartite Motif-Containing Protein 38 Show Greater Disease Severity

scientific article published on 4 December 2015

CR2-C3D COMPLEX STRUCTURE

Characterization of a complement receptor 2 (CR2, CD21) ligand binding site for C3. An initial model of ligand interaction with two linked short consensus repeat modules

scientific article published on May 1995

Characterization of a low molecular weight isoform of IL-1 receptor antagonist ⬇️

scientific article published on August 15, 1998

Clinical and serological features distinguish patients with incomplete lupus classification from systemic lupus erythematosus patients and controls

scientific article published on 24 January 2017

Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus

scientific article published on 9 June 2016

Comparison of autoantibody specificities between traditional and bead-based assays in a large, diverse collection of patients with systemic lupus erythematosus and family members

scientific article

Complement C3 activation is required for antiphospholipid antibody-induced fetal loss

scientific article

Complement inhibitor, complement receptor 1-related gene/protein y-Ig attenuates intestinal damage after the onset of mesenteric ischemia/reperfusion injury in mice

scientific journal article

Complement is activated in kidney by endotoxin but does not cause the ensuing acute renal failure

scientific article published on 01 October 2000

Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation

scientific article

Complement receptor 2–mediated targeting of complement inhibitors to sites of complement activation

Complement receptor chimaeric conjugate CR2-Ig

Crry-IG, an inhibitor of C3 activation, blocks anti-phospholipid AB (aPL) induced fetal loss

Crry-Ig, a complement activation inhibitor, protects mice from ischemia /reperfusion (IR) induced intestinal injury

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.

scientific article

Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features.

scientific article published on 18 November 2016

Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies

scientific article published on 20 June 2016

Early targets of nuclear RNP humoral autoimmunity in human systemic lupus erythematosus

scientific article

Effects of IRF5 lupus risk haplotype on pathways predicted to influence B cell functions

scientific article published on 22 February 2012

Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks

scientific article published in Nature Communications

Epitope Mapping Using the X-Ray Crystallographic Structure of Complement Receptor Type 2 (CR2)/CD21: Identification of a Highly Inhibitory Monoclonal Antibody That Directly Recognizes the CR2-C3d Interface

scientific article published on 01 November 2001

Epstein Barr Virus Interleukin 10 Suppresses Anti-inflammatory Phenotype in Human Monocytes

Erratum: Genetic associations of LYN with systemic lupus erythematosus

article

Erratum: Systemic lupus erythematosus (SLE) and chromosome 16: confirmation of linkage to 16q12–13 and evidence for genetic heterogeneity

scholarly article by Swapan K Nath et al published 22 July 2004 in European Journal of Human Genetics

Ethical and practical issues associated with aggregating databases

scientific article published on 23 September 2008

Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction

scientific article

Evaluation of TRAF6 in a large multiancestral lupus cohort

scientific article

Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).

scientific article

Evidence of dynamically dysregulated gene expression pathways in hyperresponsive B cells from African American lupus patients

scientific article

Expression and methylation data from SLE patient and healthy control blood samples subdivided with respect to ARID3a levels

scientific article

Extended flexible linker structures in the complement chimaeric conjugate CR2-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy

scientific article published on 5 December 2005

Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups

scientific article published on 17 August 2012

Fine specificity mapping of autoantigens targeted by anti-centromere autoantibodies

scientific article published in December 2006

Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse

scientific article published on 18 February 2013

Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes

scientific article

Generation of novel C3dg tetramers for the analysis of CD21 binding and function

Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK.

scientific article published on 6 October 2011

Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study.

scientific article

Genetic associations of LYN with systemic lupus erythematosus

scientific article published on 16 April 2009

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

scientific article

Herpes zoster vaccination in SLE: a pilot study of immunogenicity

scientific article published on 15 September 2013

High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups

scientific article published on April 2009

Human effector B lymphocytes express ARID3a and secrete interferon alpha

scientific article

Human monoclonal antibodies generated following vaccination with AVA provide neutralization by blocking furin cleavage but not by preventing oligomerization ⬇️

scientific article published on March 14, 2012

IFN-β treatment requires B cells for efficacy in neuroautoimmunity.

scientific article

ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry

scientific article

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study

scientific article published on 29 March 2012

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons

scientific article

Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study

scientific article

Identification of multiple genetic susceptibility loci in Takayasu arteritis

scientific article

Identification of unique microRNA signature associated with lupus nephritis

scientific article

Immunologic findings precede rapid lupus flare after transient steroid therapy.

scientific article published on 13 June 2019

Influenza vaccination can induce new-onset anticardiolipins but not β2-glycoprotein-I antibodies among patients with systemic lupus erythematosus

scientific article published on February 2012

Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features

scientific article

Inhibiting the complement system does not reduce injury in renal ischemia reperfusion

scientific article

Inhibition of ischemia reperfusion-induced intestinal injury and systemic inflammation by a novel complement regulatory protein

Interaction of calcium and Ro60: increase of antigenicity

scientific article published in July 2004

Internal standard-based analysis of microarray data2--analysis of functional associations between HVE-genes

scientific article

Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients

Less than 7 hours of sleep per night is associated with transitioning to systemic lupus erythematosus

article by K A Young et al published August 2018 in Lupus

Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression

scientific article

Lupus risk variants in the PXK locus alter B-cell receptor internalization

scientific article

Mice Deficient in Complement Receptors 1 and 2 Lack a Tissue Injury-Inducing Subset of the Natural Antibody Repertoire

scientific article published on 01 August 2002

Model of mouse Crry-Ig determined by solution scattering, curve fitting and homology modelling

scholarly article published 3 February 2004

Model of rat Crry determined by solution scattering, curve fitting and homology modelling

scholarly article published 3 February 2004

Multiple Autoantibodies Display Association with Lymphopenia, Proteinuria, and Cellular Casts in a Large, Ethnically Diverse SLE Patient Cohort

scientific article

Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d.

scientific article

Mycophenolate mofetil reduces STAT3 phosphorylation in systemic lupus erythematosus patients

scholarly article by Samantha Slight-Webb et al published 24 January 2019 in JCI insight

Novel inhibitory monoclonal antibodies to human CR2/CD21 ligand binding domains

Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction

scientific article

Overlapping B cell pathways in severe COVID-19 and lupus

scientific article published on 02 November 2020

PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21

scientific article published on 17 October 2019

PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes

scientific article

Pathways of impending disease flare in African-American systemic lupus erythematosus patients

scientific article published on 2 February 2017

Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA.

scientific article

Proinflammatory adaptive cytokine and shed tumor necrosis factor receptor levels are elevated preceding systemic lupus erythematosus disease flare

scientific article

Regulation of B cell:T cell interactions: potential involvement of an endogenous B cell sialidase

scientific article published on November 1994

Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population

scientific article published on 02 April 2009

Role of CR2- and CD19-regulated natural antibodies in intestinal ischemia reperfusion-induced injury

Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis

scientific article published on 22 December 2011

SLE patients and autoantibody-positive healthy individuals display unique cytokine profiles: shared features of inflammation as well as select features of immunosuppression in autoantibody-positive healthy individuals.

scientific article

Sa.54. Positional Identification of Integrin- αMβ2 (ITGAM) as a Susceptibility Gene for Systematic Lupus Erythematosus (SLE)

article

Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

scientific article

Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking

scientific article published on 26 July 2018

Smoking is not associated with autoantibody production in systemic lupus erythematosus patients, unaffected first-degree relatives, nor healthy controls

scientific article published on 21 January 2014

Strong viral associations with SLE among Filipinos

scientific article published on 28 July 2017

Structural analysis of recombinant human CD21 ligand binding domains

Structural studies in solution of the recombinant N-terminal pair of short consensus/complement repeat domains of complement receptor type 2 (CR2/CD21) and interactions with its ligand C3dg

scientific article

Systemic lupus erythematosus (SLE) and chromosome 16: confirmation of linkage to 16q12–13 and evidence for genetic heterogeneity

article

The Biomarkers of Lupus Disease Study: A Bold Approach May Mitigate Interference of Background Immunosuppressants in Clinical Trials

scientific article published on 3 March 2017

The Clinical Efficacy and Safety of Baminercept, a Lymphotoxin-β Receptor Fusion Protein, in Primary Sjögren's Syndrome: Results from a Randomized, Double-Blind, Placebo-Controlled Phase II Trial

scientific article published on 31 March 2018

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share

scientific article

The Transcription Factor ARID3a Is Important for In Vitro Differentiation of Human Hematopoietic Progenitors

scientific article published on 18 December 2015

The curiously suspicious: a role for Epstein-Barr virus in lupus

scientific article published on January 2006

The effect of inversion at 8p23 on BLK association with lupus in Caucasian population

scientific article

The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy

scientific article (publication date: 6 June 2003)

The role of genetic variation near interferon-kappa in systemic lupus erythematosus

scientific article

Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4.

scientific article

Transancestral mapping and genetic load in systemic lupus erythematosus

scientific article published on 17 July 2017

Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

scientific article published on 20 May 2019

Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription

scientific article published on April 2014

Unique Sjögren's syndrome patient subsets defined by molecular features

scientific article published on 01 April 2020

Unique clinical characteristics, autoantibodies and medication use in Native American patients with systemic lupus erythematosus

scientific article published on 27 February 2018

Use of SLICC criteria in a large, diverse lupus registry enables SLE classification of a subset of ACR-designated subjects with incomplete lupus

scientific article published on 17 March 2017

Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry

scientific article

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

scientific article published on 6 October 2013

Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries

scientific article

Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus

scientific article

Vitamin d deficiency in a multiethnic healthy control cohort and altered immune response in vitamin D deficient European-American healthy controls

scientific article

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome

scientific article published on 29 December 2015

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