List of works - Akira Shigenaga

A photoinduced growth system of peptide nanofibres addressed by DNA hybridization.

scientific article published on 17 March 2015

A structure-activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP47

scientific article published on 21 April 2010

Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes

scientific article

An N-sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins.

scientific article published on 5 May 2016

Application of N-C- or C-N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation

scientific article published on 19 May 2011

Asymmetric Synthesis of α-Amino Phosphonic Acids using Stable Imino Phosphonate as a Universal Precursor

scientific article published on 20 September 2019

CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis.

scientific article published on 11 May 2013

Chemical synthesis of biologically active monoglycosylated GM2-activator protein analogue using N-sulfanylethylanilide peptide

scientific article published on 13 June 2013

Chemical synthesis of proteins using N-sulfanylethylanilide peptides, based on N-S acyl transfer chemistry.

scientific article published in January 2015

Cysteine-derived s-protected oxazolidinones: potential chemical devices for the preparation of peptide thioesters

scientific article published on 01 February 2006

Deprotection of S-acetamidomethyl cysteine with copper(II) and 1,2-aminothiols under aerobic conditions

scientific article published on 28 August 2020

Development of Stimulus-responsive Amino Acids and Their Application to Chemical Biology Use ⬇️

scientific article published on January 1, 2012

Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System

scientific article published on 28 April 2015

Development of a reduction-responsive amino acid that induces peptide bond cleavage in hypoxic cells.

scientific article published on 13 April 2012

Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins

scientific article published on 01 June 2014

Development of an Intein-Inspired Amide Cleavage Chemical Device

scientific article published on 8 December 2015

Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein

scientific article published on 13 April 2014

Dimeric peptides of the C-terminal region of CXCL14 function as CXCL12 inhibitors

scientific article published on 23 October 2013

Dual kinetically controlled native chemical ligation using a combination of sulfanylproline and sulfanylethylanilide peptide

scientific article published on 14 September 2011

Effect of Phosphatidylserine and Cholesterol on Membrane-mediated Fibril Formation by the N-terminal Amyloidogenic Fragment of Apolipoprotein A-I.

scientific article published on 3 April 2018

Efficient one-pot synthesis of CXCL14 and its derivative using an N-sulfanylethylanilide peptide as a peptide thioester equivalent and their biological evaluation

scientific article published on 3 July 2015

Elucidation of inhibitor-binding pockets of d-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology

scientific article published on 16 May 2017

Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides.

scientific article

Examination of native chemical ligation using peptidyl prolyl thioesters.

scientific article

Facile Preparation of Peptides with C-Terminal N-Alkylamide via Radical-Initiated Dethiocarboxylation

scientific article published on 01 January 2016

Formation of stable nanodiscs by bihelical apolipoprotein A-I mimetic peptide.

scientific article published on 19 January 2016

Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators

scientific article published on 23 December 2015

Light-induced propulsion of a giant liposome driven by peptide nanofibre growth.

scientific article published on 19 April 2018

Liquid-phase synthesis of bridged peptides using olefin metathesis of a protected peptide with a long aliphatic chain anchor

scientific article published on 28 January 2015

Molecular complex composed of β-cyclodextrin-grafted Chitosan and pH-sensitive amphipathic peptide for enhancing cellular cholesterol efflux under acidic pH.

scientific article published on 2 March 2015

N-->S acyl-transfer-mediated synthesis of peptide thioesters using anilide derivatives

scientific article published on 01 February 2009

N-sulfanylethylanilide peptide as a crypto-thioester peptide.

scientific article published on 7 July 2011

One-Pot/Sequential Native Chemical Ligation Using Photocaged Crypto-thioester

scientific article published on 12 January 2016

One-pot/sequential native chemical ligation using N-sulfanylethylanilide peptide

scientific article published on 23 August 2012

Photo-triggered fluorescent labelling of recombinant proteins in live cells.

scientific article

Preparation of peptide thioesters from naturally occurring sequences using reaction sequence consisting of regioselective S-cyanylation and hydrazinolysis

scientific article published on 26 October 2015

Stereoselective synthesis of (Z)-alkene-containing proline dipeptide mimetics

scientific article published on 01 June 2006

Synthesis and DNA damaging ability of enediyne model compounds possessing photo-triggering devices.

scientific article

Synthesis of amide-type fluoroalkene dipeptide isosteres by an intramolecular redox reaction

scientific article published on 01 May 2009

Synthesis of fluoroalkene dipeptide isosteres by an intramolecular redox reaction utilizing N-heteorocyclic carbenes (NHCs)

scientific article published on 01 May 2009

Synthetic procedure for N-Fmoc amino acyl-N-sulfanylethylaniline linker as crypto-peptide thioester precursor with application to native chemical ligation

scientific article published on 02 August 2012

The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils

scientific article

The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate.

scientific article

Theoretical study on reaction mechanism of phosphate-catalysed N-S acyl transfer of N-sulfanylethylanilide (SEAlide)

scientific article published on 25 November 2020

Traceless synthesis of protein thioesters using enzyme-mediated hydrazinolysis and subsequent self-editing of the cysteinyl prolyl sequence

scientific article published on 29 May 2019

List of works by Akira Shigenaga

A photoinduced growth system of peptide nanofibres addressed by DNA hybridization.

A structure-activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP47

Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes

An N-sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins.

Application of N-C- or C-N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation

Asymmetric Synthesis of α-Amino Phosphonic Acids using Stable Imino Phosphonate as a Universal Precursor

CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis.

Chemical synthesis of biologically active monoglycosylated GM2-activator protein analogue using N-sulfanylethylanilide peptide

Chemical synthesis of proteins using N-sulfanylethylanilide peptides, based on N-S acyl transfer chemistry.

Cysteine-derived s-protected oxazolidinones: potential chemical devices for the preparation of peptide thioesters

Deprotection of S-acetamidomethyl cysteine with copper(II) and 1,2-aminothiols under aerobic conditions

Development of Stimulus-responsive Amino Acids and Their Application to Chemical Biology Use ⬇️

Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System

Development of a reduction-responsive amino acid that induces peptide bond cleavage in hypoxic cells.

Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins

Development of an Intein-Inspired Amide Cleavage Chemical Device

Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein

Dimeric peptides of the C-terminal region of CXCL14 function as CXCL12 inhibitors

Dual kinetically controlled native chemical ligation using a combination of sulfanylproline and sulfanylethylanilide peptide

Effect of Phosphatidylserine and Cholesterol on Membrane-mediated Fibril Formation by the N-terminal Amyloidogenic Fragment of Apolipoprotein A-I.

Efficient one-pot synthesis of CXCL14 and its derivative using an N-sulfanylethylanilide peptide as a peptide thioester equivalent and their biological evaluation

Elucidation of inhibitor-binding pockets of d-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology

Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides.

Examination of native chemical ligation using peptidyl prolyl thioesters.

Facile Preparation of Peptides with C-Terminal N-Alkylamide via Radical-Initiated Dethiocarboxylation

Formation of stable nanodiscs by bihelical apolipoprotein A-I mimetic peptide.

Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators

Light-induced propulsion of a giant liposome driven by peptide nanofibre growth.

Liquid-phase synthesis of bridged peptides using olefin metathesis of a protected peptide with a long aliphatic chain anchor

Molecular complex composed of β-cyclodextrin-grafted Chitosan and pH-sensitive amphipathic peptide for enhancing cellular cholesterol efflux under acidic pH.

N-->S acyl-transfer-mediated synthesis of peptide thioesters using anilide derivatives

N-sulfanylethylanilide peptide as a crypto-thioester peptide.

One-Pot/Sequential Native Chemical Ligation Using Photocaged Crypto-thioester

One-pot/sequential native chemical ligation using N-sulfanylethylanilide peptide

Photo-triggered fluorescent labelling of recombinant proteins in live cells.

Preparation of peptide thioesters from naturally occurring sequences using reaction sequence consisting of regioselective S-cyanylation and hydrazinolysis

Stereoselective synthesis of (Z)-alkene-containing proline dipeptide mimetics

Synthesis and DNA damaging ability of enediyne model compounds possessing photo-triggering devices.

Synthesis of amide-type fluoroalkene dipeptide isosteres by an intramolecular redox reaction

Synthesis of fluoroalkene dipeptide isosteres by an intramolecular redox reaction utilizing N-heteorocyclic carbenes (NHCs)

Synthetic procedure for N-Fmoc amino acyl-N-sulfanylethylaniline linker as crypto-peptide thioester precursor with application to native chemical ligation

The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils

The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate.

Theoretical study on reaction mechanism of phosphate-catalysed N-S acyl transfer of N-sulfanylethylanilide (SEAlide)

Traceless synthesis of protein thioesters using enzyme-mediated hydrazinolysis and subsequent self-editing of the cysteinyl prolyl sequence