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List of works by Rose Zamoyska

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

scientific article published on 01 October 1997

A beginner's guide to major histocompatibility complex function

scientific article published on 01 June 1982

A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis

scientific article published on 03 February 2022

Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus.

scientific article published in July 1999

Age-related variation in immunity in a wild mammal population

scientific article

Allosuppression: evidence for the involvement of both “noncytotoxic” and cytotoxic T cells ⬇️

scientific article published on July 1, 1984

An Essential Role for the Stalk Region of CD8 in the Coreceptor Function of CD8

scientific article published on 01 January 2009

Anti-CD3-induced cell death in T cell hybridomas: mitochondrial failure and DNA fragmentation are distinct events.

scientific article published in February 1991

CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses?

scientific article published on February 1998

CD8alpha/alpha homodimers fail to function as co-receptor for a CD8-dependent TCR.

scientific article published on June 2007

Caveolin-1 Influences LFA-1 Redistribution upon TCR Stimulation in CD8 T Cells

scientific article

Cellular and humoral immunity in a wild mammal: Variation with age & sex and association with overwinter survival

scientific article

Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens

scientific article published on January 2012

Centrosome docking at the immunological synapse is controlled by Lck signaling

scientific article

Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells

scientific article (publication date: 2012)

Co-capping studies reveal CD8/TCR interactions after capping CD8β polypeptides and intracellular associations of CD8 with p56lck

scientific article published on 01 February 1998

Differential Survival of Naive CD4 and CD8 T Cells

scientific article published on 01 October 2000

Differential polarization of C-terminal Src kinase between naive and antigen-experienced CD8+ T cells

scientific article published on 20 February 2013

Differential requirement for Lck during primary and memory CD8+ T cell responses

scholarly article

Do CD8 effector cells need IL-7R expression to become resting memory cells?

scientific article

Early growth response (Egr)-1 gene induction in the thymus in response to TCR ligation during early steps in positive selection is not required for CD8 lineage commitment

scientific article published in September 2000

Fyn regulates the duration of TCR engagement needed for commitment to effector function

scientific article published in October 2007

Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice

scientific journal article

How Many Thymocytes Audition for Selection? ⬇️

scientific article published on October 6, 1997

How does the mammalian target of rapamycin (mTOR) influence CD8 T cell differentiation?

scientific article published on 12 August 2010

IL-12 Signals through the TCR To Support CD8 Innate Immune Responses

scientific article published on 12 August 2016

Identification of thymocyte precursors in murine fetal liver

scientific article published on 01 December 1991

Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo.

scientific article published in November 1989

Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

scientific article published on 01 May 2000

Insights into T-Cell Development from Studies Using Transgenic and Knockout Mice

article

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

scientific article

Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells

scientific article

Is CD8 dependence a true reflection of TCR affinity for antigen?

scientific article

Itch-/- alphabeta and gammadelta T cells independently contribute to autoimmunity in Itchy mice

scientific article published on 6 February 2008

LAT polices T cell activation

scientific article published in August 2009

Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.

scientific article

Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response

scientific article

Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor

scientific article

Long-Term Survival But Impaired Homeostatic Proliferation of Naive T Cells in the Absence of p56lck

scientific article published in Science

Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice ⬇️

scientific article published on 10 June 2016

MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells

scientific article published on 16 November 2009

MEK activity regulates negative selection of immature CD4+CD8+ thymocytes

scientific article published in March 2000

Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation

scientific article published on 9 October 2015

Memories are made of this: synergy of T cell receptor and cytokine signals in CD4(+) central memory cell survival

scientific article published on 25 April 2007

Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas

scientific article published on 28 September 2010

Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression.

scientific article published in May 1988

Molecular requirements for lineage commitment in the thymus--antibody-mediated receptor engagements reveal a central role for lck in lineage decisions

scientific article published in October 1998

Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis ⬇️

scientific article published on January 2015

Novel strategy for microsphere-mediated DNA transfection

scientific article published on 15 September 2011

PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation

scientific article

Peripheral tolerance mechanisms prevent the development of autoreactive T cells in chimeras grafted with two minor incompatible thymuses

article

Phosphorylation of murine CD8α is not essential for responses of T cell hybridomas to antigen

article

Problems in the physiology of class I and class II MHC molecules, and of CD45.

scientific article

Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

scientific article published on 17 October 2017

Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice.

scientific article

Proximity of TCR and its CD8 coreceptor controls sensitivity of T cells

scientific article published on 18 November 2013

Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes

article

Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens

scientific article published on 3 November 2010

Regulation of peripheral T-cell homeostasis by receptor signalling

scientific article

Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22. ⬇️

scientific article published on 7 November 2017

Self tolerance is H–2-restricted

scientific article published in Nature

Sensory adaptation in naive peripheral CD4 T cells

scientific article

Signalling in T-cell development: is it all location, location, location?

scientific article published on 15 February 2007

Signalling in T-lymphocyte development: integration of signalling pathways is the key.

scientific article published on April 2004

Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus

scientific article published in May 1997

Structure, sequence, and polymorphism of the Lyt-2 T cell differentiation antigen gene.

scientific article published in August 1986

Structure-Function Relationships of the Human T Lymphocyte CD2 Antigen

scientific article published on 01 January 1989

Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells

scientific article published on 10 July 2017

Superantigens: supersignalers?

scientific article published on 24 October 2006

Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity.

scientific article

Switching sides: transcriptional control of CD4 thymocyte lineage commitment

scientific article published in April 2005

T cell activation results in physical modification of the mouse CD8 beta chain

scientific article published on 01 January 1994

T cell receptor signalling networks: branched, diversified and bounded

scientific article published on April 2013

T-cell differentiation: chromatin remodelling in CD4/CD8 regulation

scientific article published in March 2003

T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

scientific article published on March 2009

TCR and IL-7 receptor signals can operate independently or synergize to promote lymphopenia-induced expansion of naive T cells

scientific article published in October 2002

TCR signals mediated by Src family kinases are essential for the survival of naive T cells

scientific article published in September 2002

The Global Thymus Network: past, present and future

scientific article published on 08 April 2009

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

scientific article

The influence of mTOR on T helper cell differentiation and dendritic cell function

scientific article published on 04 July 2011

The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation

scientific article

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals

scientific article published on 10 August 2014

Transfection of the CD8 gene enhances T-cell recognition.

scientific article

Transgene-encoded human CD2 acts in a dominant negative fashion to modify thymocyte selection signals in mice.

scientific article published in December 1996

Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA.

scientific article published in November 1985

Unprimed T cells are inefficiently stimulated by glycosylphosphatidylinositol-linked H-2Kb because of its lipid anchor rather than defects in CD8 binding

scientific article published on 01 April 1996

Why is there so much CD45 on T cells?

scientific article published on September 2007

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