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List of works by Christian Gaiddon

A balancing act: using small molecules for therapeutic intervention of the p53 pathway in cancer

scientific article published on 01 September 2020

A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53

scientific article published on 17 October 2018

A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin.

scientific article

A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP.

scientific article published on 23 June 2009

Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway

scientific article published on 01 August 2000

Apoptosis-independent organoruthenium anticancer complexes that overcome multidrug resistance: self-assembly and phenotypic screening strategies

Bifunctional ligand design for modulating mutant p53 aggregation in cancer

scientific article published on 07 October 2019

Brain-derived neurotrophic factor stimulates AP-1 and cyclic AMP-responsive element dependent transcriptional activity in central nervous system neurons.

scientific article published in June 1996

Ca2+/calmodulin kinase types II and IV regulate c-fos transcription in the AtT20 corticotroph cell line.

scientific article published on June 1996

Cancer cell cytotoxicity of cyclometalated compounds obtained with osmium(II) complexes.

scientific article

Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons

scientific article published on 14 October 2011

Could a Feeding Jejunostomy be Integrated into a Standardized Preoperative Management of Oeso-gastric Junction Adenocarcinoma?

scientific article

Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.

scientific article published on 3 April 2003

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.

scientific article

DNA binding to an anticancer organo-ruthenium complex

article

Flavaglines as potent anticancer and cytoprotective agents

scientific article published on 23 October 2012

Gold-phosphine-porphyrin as potential metal-based theranostics

scientific article published on 05 December 2014

HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway

scientific article published on 07 November 2019

Holographic Traction Force Microscopy

scientific article published on 14 February 2018

Impact of cyclometalated ruthenium(II) complexes on lactate dehydrogenase activity and cytotoxicity in gastric and colon cancer cells

scientific article published on 26 July 2016

Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: passing the nanomolar barrier.

scientific article

Monomeric Ti(iv)-based complexes incorporating luminescent nitrogen ligands: synthesis, structural characterization, emission spectroscopy and cytotoxic activities

scientific article published on 01 November 2016

Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis

scientific article published on 07 September 2007

Novel flavaglines displaying improved cytotoxicity.

scientific article published on 13 December 2010

Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.

scientific article published in December 2005

Pituitary adenylate cyclase-activating polypeptide transduces through cAMP/PKA and PKC pathways and stimulates proopiomelanocortin gene transcription in mouse melanotropes

scientific article published on 01 July 1996

Preferential Response of Basal-Like Head and Neck Squamous Cell Carcinoma Cell Lines to EGFR-Targeted Therapy Depending on EREG-Driven Oncogenic Addiction

scientific article published on 08 June 2019

Reactivity of Cu(ii)-, Zn(ii)- and Fe(ii)-thiosemicarbazone complexes with glutathione and metallothionein: from stability to dissociation to transmetallation

scientific article published on 01 May 2019

Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.

scientific article

Regulation of a Notch3-Hes1 pathway and protective effect by a tocopherol-omega alkanol chain derivative in muscle atrophy.

scientific article

Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action

scientific article published on 14 February 2018

Ruthenium (II)-derived organometallic compounds induce cytostatic and cytotoxic effects on mammalian cancer cell lines through p53-dependent and p53-independent mechanisms.

scientific article published on 16 September 2005

Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival.

scientific article published on 29 June 2007

Structural Determinants of p53-Independence in Anticancer Ruthenium-Arene Schiff-Base Complexes.

scientific article published on 13 May 2016

Subcellular localization and transport kinetics of ruthenium organometallic anticancer compounds in living cells: a dose-dependent role for amino acid and iron transporters

scientific article published on 01 May 2014

The retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca2+/calmodulin kinases II and IV activity

scientific article published on 01 April 1999

The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

scientific article published on 2 November 2016

The Champagne sign.

scientific article published on 10 March 2018

Tissue specificity and regulation of the N-terminal diversity of reticulon 3

scientific article

Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63.

scientific article published on 26 February 2016

Transcriptional effects in GH3 cells of Gs alpha mutants associated with human pituitary tumors: stimulation of adenosine 3',5'-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activi

scientific article published on 01 October 1995

Use of a case-mix approach to study the trends in the incidence of second primary cancers.

scientific article published on 15 February 2018

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

scientific article published on February 1999

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