List of works - Nina Wettschureck

Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes

scientific article published on 01 November 2001

Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling

scientific article

Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages.

scientific article published on 16 October 2017

Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling

scientific article published on 3 November 2015

Anaphylactic shock depends on endothelial Gq/G11.

scientific article published on 26 January 2009

Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13.

scientific article

Characteristic defects in neural crest cell-specific Galphaq/Galpha11- and Galpha12/Galpha13-deficient mice

scientific article

Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy

scientific journal article

Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction.

scientific article published on 26 May 2017

Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes

scientific article published on 7 April 2010

Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein Gα11.

scientific article published on 29 December 2010

Dual action by fumaric acid esters synergistically reduces adhesion to human endothelium

scientific article

EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells.

scientific article published in January 2017

Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis.

scientific article

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

scientific article published on 31 October 2016

Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation

scientific article

G alpha(q) signal in osteoblasts is inhibitory to the osteoanabolic action of parathyroid hormone

scientific article published on 23 February 2011

G(12)/G(13)-mediated signalling in mammalian physiology and disease

scientific article published on 22 September 2008

G(13)-mediated signaling pathway is required for pressure overload-induced cardiac remodeling and heart failure

scientific article

G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension

scientific article

G12/G13 family G proteins regulate marginal zone B cell maturation, migration, and polarization

scientific article

G13 controls angiogenesis through regulation of VEGFR-2 expression

scientific article published on 9 May 2013

G13 is an essential mediator of platelet activation in hemostasis and thrombosis

scientific journal article

G13-mediated signaling as a potential target for antiplatelet drugs

scientific article (publication date: October 2004)

GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.

scientific article published on 17 March 2016

Galpha12/Galpha13 deficiency causes localized overmigration of neurons in the developing cerebral and cerebellar cortices

scientific article

GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion

scientific article

Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility.

scientific article published on 30 April 2009

Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization

scientific article

Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice

scientific article

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE.

scientific article

Increased apoptosis and browning of TAK1-deficient adipocytes protects against obesity

scientific article published on 19 May 2016

Lineage tracing of cells involved in atherosclerosis.

scientific article published on 11 June 2016

Loss of Gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice

scientific article

Lysophospholipids Control Integrin-dependent Adhesion in Splenic B Cells through Giand G12/G13Family G-proteins but Not through Gq/G11

scientific article published in Journal of Biological Chemistry

Mammalian G proteins and their cell type specific functions

scientific article

Mouse models to study G-protein-mediated signaling

scientific article published on January 2004

Muscarinic ACh receptor-mediated control of thalamic activity via G(q)/G (11)-family G-proteins

scientific article

P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.

scientific article

Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor

scientific article published on 20 September 2006

Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor.

scientific article published on 27 June 2013

Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling.

scientific article

Response to Harper et al

scientific article published on 01 September 2013

Rho/Rho-kinase mediated signaling in physiology and pathophysiology

scientific article

RhoGEF12 controls cardiac remodeling by integrating G protein- and integrin-dependent signaling cascades.

scientific article published on 25 March 2013

S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population.

scientific article published on 24 November 2015

Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation

scientific article

Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system

scientific article

Tamoxifen-inducible Cre-mediated recombination in adipocytes

scientific article published on October 2010

Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice

scientific article published on 2 May 2016

The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice

scientific article

The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway

scientific article

Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development

scientific article published in September 2007

Transforming growth factor-β-activated kinase 1 regulates angiogenesis via AMP-activated protein kinase-α1 and redox balance in endothelial cells

scientific article published on 26 September 2013

Unresponsiveness of platelets lacking both Galpha(q) and Galpha(13). Implications for collagen-induced platelet activation

scientific article

List of works by Nina Wettschureck

Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes

Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling

Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages.

Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling

Anaphylactic shock depends on endothelial Gq/G11.

Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13.

Characteristic defects in neural crest cell-specific Galphaq/Galpha11- and Galpha12/Galpha13-deficient mice

Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy

Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction.

Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes

Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein Gα11.

Dual action by fumaric acid esters synergistically reduces adhesion to human endothelium

EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells.

Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis.

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation

G alpha(q) signal in osteoblasts is inhibitory to the osteoanabolic action of parathyroid hormone

G(12)/G(13)-mediated signalling in mammalian physiology and disease

G(13)-mediated signaling pathway is required for pressure overload-induced cardiac remodeling and heart failure

G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension

G12/G13 family G proteins regulate marginal zone B cell maturation, migration, and polarization

G13 controls angiogenesis through regulation of VEGFR-2 expression

G13 is an essential mediator of platelet activation in hemostasis and thrombosis

G13-mediated signaling as a potential target for antiplatelet drugs

GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.

Galpha12/Galpha13 deficiency causes localized overmigration of neurons in the developing cerebral and cerebellar cortices

GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion

Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility.

Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization

Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE.

Increased apoptosis and browning of TAK1-deficient adipocytes protects against obesity

Lineage tracing of cells involved in atherosclerosis.

Loss of Gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice

Lysophospholipids Control Integrin-dependent Adhesion in Splenic B Cells through Giand G12/G13Family G-proteins but Not through Gq/G11

Mammalian G proteins and their cell type specific functions

Mouse models to study G-protein-mediated signaling

Muscarinic ACh receptor-mediated control of thalamic activity via G(q)/G (11)-family G-proteins

P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.

Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor

Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor.

Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling.

Response to Harper et al

Rho/Rho-kinase mediated signaling in physiology and pathophysiology

RhoGEF12 controls cardiac remodeling by integrating G protein- and integrin-dependent signaling cascades.

S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population.

Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation

Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system

Tamoxifen-inducible Cre-mediated recombination in adipocytes

Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice

The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice

The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway

Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development

Transforming growth factor-β-activated kinase 1 regulates angiogenesis via AMP-activated protein kinase-α1 and redox balance in endothelial cells

Unresponsiveness of platelets lacking both Galpha(q) and Galpha(13). Implications for collagen-induced platelet activation