List of works - Rainer Freynhagen

A comprehensive drug safety evaluation of pregabalin in peripheral neuropathic pain

scientific article

A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms

scientific article

A cross-sectional survey of 3035 patients with fibromyalgia: subgroups of patients with typical comorbidities and sensory symptom profiles

scientific article published on 17 March 2010

A retrospective analysis of the long-term test-retest stability of pain descriptors of the painDETECT questionnaire

scientific article published on 4 December 2015

Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system.

scientific article published on 24 April 2009

Are there different predictors of analgesic response between antidepressants and anticonvulsants in painful diabetic neuropathy?

scientific article published on 27 August 2015

Axial low back pain: one painful area--many perceptions and mechanisms

scientific article published on 02 July 2013

Cebranopadol, a novel first-in-class analgesic drug candidate: first experience in patients with chronic low back pain in a randomized clinical trial

scientific article

Cross-cultural adaptation to the Dutch language of the PainDETECT-Questionnaire.

scientific article published on 9 July 2012

Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers

scientific article

Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care

scientific article published in November 2009

Diagnosis and management of neuropathic pain.

scientific article published on 12 August 2009

Diagnostik bei neuropathischen Schmerzen

scientific article published on 01 September 2011

Die Pharmakotherapie neuropathischer Schmerzen - Individuell ausgerichtet, aber eingebettet in ein interdisziplinäres und multimodales Konzept

Differential effects of painful and non-painful stimulation on tactile processing in fibromyalgia syndrome and subjects with masochistic behaviour

scientific article (publication date: 28 December 2010)

Duloxetine and pregabalin: high-dose monotherapy or their combination? The "COMBO-DN study"--a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain

scientific article published on 31 May 2013

Effectiveness and time to onset of pregabalin in patients with neuropathic pain

scientific article

Efficacy and safety of lacosamide in painful diabetic neuropathy

scientific article published on 12 January 2010

Efficacy and safety of pregabalin in treatment refractory patients with various neuropathic pain entities in clinical routine

scientific article published on 24 September 2007

Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens

scientific article

Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses

scientific article published on 3 May 2016

Erratum

scholarly article published in Q1194076

Fatal respiratory depression after multiple intravenous morphine injections

scientific article published on January 2006

Fibromyalgia and neuropathic pain--differences and similarities. A comparison of 3057 patients with diabetic painful neuropathy and fibromyalgia

scientific article

Hereditary sensory and autonomic neuropathy with autonomic crises: a Turkish variant of familial dysautonomia?

scientific article published on 2 December 2011

Higher pain scores, similar opioid doses and side effects associated with antipyretic analgesics in specialised tertiary pain care

scientific article published on 20 May 2010

Hydromorphone-induced hyperalgesia in a patient with metastatic pancreatic cancer

Imaging pain modulation by subanesthetic S-(+)-ketamine

scientific article published in September 2006

Increase in skin temperature after spinal anesthesia in infants.

scientific article published in November 2006

Mechanism- and experience-based strategies to optimize treatment response to the capsaicin 8% cutaneous patch in patients with localized neuropathic pain

scientific article published on 21 March 2013

Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats

scientific article published on 19 December 2005

Modelling the prevalence and cost of back pain with neuropathic components in the general population

scientific article published on 6 February 2009

Neuropathic pain in cancer: systematic review, performance of screening tools and analysis of symptom profiles ⬇️

scientific article published in October 2017

Neuropathic pain phenotyping as a predictor of treatment response in painful diabetic neuropathy: data from the randomized, double-blind, COMBO-DN study

scientific article

Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations ⬇️

scientific article

Nitric oxide and pro-inflammatory cytokines correlate with pain intensity in chronic pain patients

scientific article published on 01 January 2007

Opioids for chronic non-cancer pain

scientific article published in the British Medical Journal

Pain Drawings Improve Subgrouping of Low Back Pain Patients

scientific article

Palliativmedizin

scholarly article published June 2006

Paper versus electronic rating scales for pain assessment: a prospective, randomised, cross-over validation study with 200 chronic pain patients

scientific article published on 15 May 2008

Pathophysiologie des neuropathischen Schmerzes - Optimale Behandlungsstrategien anhand der pathophysiologischen Mechanismen

Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles

scientific article published on 3 November 2016

Postoperative Schmerztherapie im gynäkologischen Alltag

Pregabalin for relief of neuropathic pain associated with diabetic neuropathy: a randomized, double-blind study

scientific article

Pregabalin for the Treatment of Drug and Alcohol Withdrawal Symptoms: A Comprehensive Review

scientific article

Pseudoradicular and radicular low-back pain – A disease continuum rather than different entities? Answers from quantitative sensory testing

scientific article published on 13 June 2007

Pseudoradicular and radicular low-back pain – A disease continuum rather than different entities? Rebuttal: Reply to the letter by M. Schiltenwolf and M. Akbar

Pseudoradicular and radicular low-back pain – A disease continuum rather than different entities? Rebuttal: Reply to the letter “Cheese and Chalk? Missing the real anatomy” by Breck McKay

Pseudoradicular and radicular low-back pain – A disease continuum rather than different entities? Reply to the letters by Leffler and Hansson and by Van Boxem et al

Quantitative sensory testing using DFNS protocol in Europe: an evaluation of heterogeneity across multiple centers in patients with peripheral neuropathic pain and healthy subjects

scientific article published on 20 November 2015

Racemic intrathecal mirtazapine but not its enantiomers acts anti-neuropathic after chronic constriction injury in rats

scientific article published on 20 January 2009

Regeneration of baroafferents after implantation into different vessels

scientific article published on 01 March 2007

Schmerztherapie und Symptomkontrolle in der Palliativmedizin

scholarly article published March 2007

Screening of neuropathic pain components in patients with chronic back pain associated with nerve root compression: a prospective observational pilot study (MIPORT)

scientific article published on 01 March 2006

Sensory symptom profiles and co-morbidities in painful radiculopathy

scientific article (publication date: 9 May 2011)

Sind μ-Opioidrezeptorpolymorphismen wichtig für die Opioidtherapie?

scientific article published on 01 October 2005

Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations

scientific article

Switching from reservoir to matrix systems for the transdermal delivery of fentanyl: a prospective, multicenter pilot study in outpatients with chronic pain.

scientific article published on September 2005

Symptom profiles in the painDETECT Questionnaire in patients with peripheral neuropathic pain stratified according to sensory loss in quantitative sensory testing

scientific article

The effect of mirtazapine in patients with chronic pain and concomitant depression.

scientific article published on February 2006

The efficacy and safety of pregabalin in the treatment of neuropathic pain associated with chronic lumbosacral radiculopathy

scientific article published on 20 May 2010

The evaluation of neuropathic components in low back pain

scientific article published on June 2009

The painDETECT project - far more than a screening tool on neuropathic pain

scientific article

The role of screening tools in diagnosing neuropathic pain

scientific article

Treatment of painful radiculopathies with capsaicin 8% cutaneous patch

scientific article published on 22 April 2017

Uniform distribution of skin-temperature increase after different regional-anesthesia techniques of the lower extremity

scientific article published in January 2007

Using screening tools to identify neuropathic pain

scientific article published on 19 December 2006

Who is healthy? Aspects to consider when including healthy volunteers in QST--based studies-a consensus statement by the EUROPAIN and NEUROPAIN consortia

scientific article

Ziconotide for treatment of severe chronic pain

scientific article published on 21 April 2010

painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain

scientific article published in October 2006

List of works by Rainer Freynhagen

A comprehensive drug safety evaluation of pregabalin in peripheral neuropathic pain

A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms

A cross-sectional survey of 3035 patients with fibromyalgia: subgroups of patients with typical comorbidities and sensory symptom profiles

A retrospective analysis of the long-term test-retest stability of pain descriptors of the painDETECT questionnaire

Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system.

Are there different predictors of analgesic response between antidepressants and anticonvulsants in painful diabetic neuropathy?

Axial low back pain: one painful area--many perceptions and mechanisms

Cebranopadol, a novel first-in-class analgesic drug candidate: first experience in patients with chronic low back pain in a randomized clinical trial

Cross-cultural adaptation to the Dutch language of the PainDETECT-Questionnaire.

Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers

Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care

Diagnosis and management of neuropathic pain.

Diagnostik bei neuropathischen Schmerzen

Die Pharmakotherapie neuropathischer Schmerzen - Individuell ausgerichtet, aber eingebettet in ein interdisziplinäres und multimodales Konzept

Die Pharmakotherapie neuropathischer Schmerzen - Individuell ausgerichtet, aber eingebettet in ein interdisziplinäres und multimodales Konzept

Differential effects of painful and non-painful stimulation on tactile processing in fibromyalgia syndrome and subjects with masochistic behaviour

Duloxetine and pregabalin: high-dose monotherapy or their combination? The "COMBO-DN study"--a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain

Effectiveness and time to onset of pregabalin in patients with neuropathic pain

Efficacy and safety of lacosamide in painful diabetic neuropathy

Efficacy and safety of pregabalin in treatment refractory patients with various neuropathic pain entities in clinical routine

Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens

Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses

Erratum

Fatal respiratory depression after multiple intravenous morphine injections

Fibromyalgia and neuropathic pain--differences and similarities. A comparison of 3057 patients with diabetic painful neuropathy and fibromyalgia

Hereditary sensory and autonomic neuropathy with autonomic crises: a Turkish variant of familial dysautonomia?

Higher pain scores, similar opioid doses and side effects associated with antipyretic analgesics in specialised tertiary pain care

Hydromorphone-induced hyperalgesia in a patient with metastatic pancreatic cancer

Imaging pain modulation by subanesthetic S-(+)-ketamine

Increase in skin temperature after spinal anesthesia in infants.

Mechanism- and experience-based strategies to optimize treatment response to the capsaicin 8% cutaneous patch in patients with localized neuropathic pain

Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats

Modelling the prevalence and cost of back pain with neuropathic components in the general population

Neuropathic pain in cancer: systematic review, performance of screening tools and analysis of symptom profiles ⬇️

Neuropathic pain phenotyping as a predictor of treatment response in painful diabetic neuropathy: data from the randomized, double-blind, COMBO-DN study

Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations ⬇️

Nitric oxide and pro-inflammatory cytokines correlate with pain intensity in chronic pain patients

Opioids for chronic non-cancer pain

Pain Drawings Improve Subgrouping of Low Back Pain Patients

Palliativmedizin

Paper versus electronic rating scales for pain assessment: a prospective, randomised, cross-over validation study with 200 chronic pain patients

Pathophysiologie des neuropathischen Schmerzes - Optimale Behandlungsstrategien anhand der pathophysiologischen Mechanismen

Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles

Postoperative Schmerztherapie im gynäkologischen Alltag

Pregabalin for relief of neuropathic pain associated with diabetic neuropathy: a randomized, double-blind study

Pregabalin for the Treatment of Drug and Alcohol Withdrawal Symptoms: A Comprehensive Review

Pseudoradicular and radicular low-back pain – A disease continuum rather than different entities? Answers from quantitative sensory testing

Pseudoradicular and radicular low-back pain – A disease continuum rather than different entities? Rebuttal: Reply to the letter by M. Schiltenwolf and M. Akbar

Pseudoradicular and radicular low-back pain – A disease continuum rather than different entities? Rebuttal: Reply to the letter “Cheese and Chalk? Missing the real anatomy” by Breck McKay

Pseudoradicular and radicular low-back pain – A disease continuum rather than different entities? Reply to the letters by Leffler and Hansson and by Van Boxem et al

Quantitative sensory testing using DFNS protocol in Europe: an evaluation of heterogeneity across multiple centers in patients with peripheral neuropathic pain and healthy subjects

Racemic intrathecal mirtazapine but not its enantiomers acts anti-neuropathic after chronic constriction injury in rats

Regeneration of baroafferents after implantation into different vessels

Schmerztherapie und Symptomkontrolle in der Palliativmedizin

Screening of neuropathic pain components in patients with chronic back pain associated with nerve root compression: a prospective observational pilot study (MIPORT)

Sensory symptom profiles and co-morbidities in painful radiculopathy

Sind μ-Opioidrezeptorpolymorphismen wichtig für die Opioidtherapie?

Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations

Switching from reservoir to matrix systems for the transdermal delivery of fentanyl: a prospective, multicenter pilot study in outpatients with chronic pain.

Symptom profiles in the painDETECT Questionnaire in patients with peripheral neuropathic pain stratified according to sensory loss in quantitative sensory testing

The effect of mirtazapine in patients with chronic pain and concomitant depression.

The efficacy and safety of pregabalin in the treatment of neuropathic pain associated with chronic lumbosacral radiculopathy

The evaluation of neuropathic components in low back pain

The painDETECT project - far more than a screening tool on neuropathic pain

The role of screening tools in diagnosing neuropathic pain

Treatment of painful radiculopathies with capsaicin 8% cutaneous patch

Uniform distribution of skin-temperature increase after different regional-anesthesia techniques of the lower extremity

Using screening tools to identify neuropathic pain

Who is healthy? Aspects to consider when including healthy volunteers in QST--based studies-a consensus statement by the EUROPAIN and NEUROPAIN consortia

Ziconotide for treatment of severe chronic pain

painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain