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List of works by Charles Brenner

31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions

scientific article published on 9 February 2005

5′-Nucleotidases and their new roles in NAD+ and phosphate metabolism

article published in 2010

A cultivated taste for yeast

scientific article

A knockdown with smoke model reveals FHIT as a repressor of Heme oxygenase 1

scientific article published on January 2014

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

scientific article published on 01 August 2018

A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction

scientific article

Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter

scientific article published on 12 July 2019

Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3

scientific article

Altered specificity of Hint-W123Q supports a role for Hint inhibition by ASW in avian sex determination

scientific article published on 26 October 2004

An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes

scientific article

Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants

scientific article

Author Correction: Senescent cells promote tissue NAD<sup>+</sup> decline during ageing via the activation of CD38<sup>+</sup> macrophages

scientific article published on 10 December 2020

Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors

scientific article published on 24 February 2004

Boosting NAD to spare hearing

scientific article published in December 2014

Calorie restriction-mediated replicative lifespan extension in yeast is non-cell autonomous

scientific article published on 29 January 2015

Catalysis in the nitrilase superfamily

scientific article

Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance

scientific article

Changes in chemistry and biochemistry education: Creative responses to medical college admissions test revisions in the age of the genome ⬇️

scientific article published on January 1, 2013

Chemical genomics in yeast

scientific article

Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging

scientific article

Condensing the RNA world

scientific article published on 01 October 2000

Control of dinucleoside polyphosphates by the FHIT-homologous HNT2 gene, adenine biosynthesis and heat shock in Saccharomyces cerevisiae

scientific article

Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1

scientific article

Coronavirus and PARP expression dysregulate the NAD Metabolome: a potentially actionable component of innate immunity

scientific article published on 19 April 2020

Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers

scientific article

Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins

scientific article

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding

scientific article

Desperately seeking Flexner: time to reemphasize basic science in medical education

scientific article

Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the α-β bridging oxygen and β phosphorus replacement ⬇️

scientific article published on January 1, 2001

Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans

scientific article

Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors

scientific article published on 3 May 2017

Disease-associated mutations inactivate AMP-lysine hydrolase activity of Aprataxin

scientific article published on 23 March 2005

Emerging Potential Benefits of Modulating NAD+ Metabolism in Cardiovascular Disease

scientific article published on 22 December 2017

Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase

scientific article

Evolution of NAD Biosynthetic Enzymes

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

article by Ainslie B. Parsons et al published August 2006 in Cell

FHA-RING ubiquitin ligases in cell division cycle control

scientific article published on November 2008

FHIT

Feminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimer

scientific article

Fhit

Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates

scientific article

Fhitness and cancer in the mouse

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

scientific article

Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit

scientific article

Glutamine-dependent NAD+Synthetase

scientific article published in Journal of Biological Chemistry

Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases ⬇️

scientific article

Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma ⬇️

scientific article

Histidine Triad (HIT) Superfamily

Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside.

scientific article

KRAS-driven miR-29b expression is required for tumor suppressor gene silencing

scientific article published on 19 August 2017

Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.

scientific article

Letting off electrons to cope with metabolic stress

scientific article published on 01 June 2020

Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring

scientific article published on 01 January 2019

Metabolism: Targeting a fat-accumulation gene

scientific article published in Nature

Microbial NAD metabolism: lessons from comparative genomics

scientific article published on September 2009

Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications

scientific article

Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity

scientific article

NAD as a genotype-specific drug target

scientific article published on November 2013

NAD+ metabolism in health and disease

scientific article

NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity

scientific article

NNMT: A Bad Actor in Fat Makes Good in Liver.

scientific article published on August 2015

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

scientific article

New Tripodal, “Supercharged” Analogues of Adenosine Nucleotides: Inhibitors for the Fhit Ap3A Hydrolase

scientific article published on 01 May 1999

Nicotinamide Adenine Dinucleotide Metabolome Is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol-Related Liver Disease

scientific article published on 31 May 2020

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

scientific article published in March 2018

Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk.

scientific article published on 6 April 2016

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

scientific article published on 27 May 2016

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.

scientific article published on 7 December 2017

Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism

scientific article

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

scientific article published on 10 October 2016

Nicotinamide riboside kinase structures reveal new pathways to NAD+

scientific article

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells.

scientific article

Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

scientific article

Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder

scientific article published on 22 June 2020

Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats

scientific article published on 30 January 2017

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration

scientific article

Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

scientific article

Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans

scientific article

Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding

scientific article published on 26 January 2006

Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside

scientific article

Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production

scientific article

On the Nonspecific Degradation of NAD+ to Nicotinamide Riboside ⬇️

scientific article published on May 20, 2011

One-step site-directed mutagenesis of the Kex2 protease oxyanion hole.

scientific article published in August 1993

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

scientific article published on 22 August 2019

Pharmacological bypass of NAD salvage pathway protects neurons from chemotherapy-induced degeneration

article published in the Proceedings of the National Academy of Sciences of the United States of America

Pterostilbene raises low density lipoprotein cholesterol in people

scientific article published on 13 October 2018

Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein ⬇️

scientific article published on December 1, 1997

Quantification of protein copy number in yeast: the NAD+ metabolome

scientific article

Quantitative assessment of enzyme specificity in vivo: P2 recognition by Kex2 protease defined in a genetic system

scientific article published on September 1998

RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation

scientific article

RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis.

scientific article

Recent progress in the study of the intracellular functions of diadenosine polyphosphates

Rethinking Premedical and Health Professional Curricula in Light of MCAT 2015

article

Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1.

scientific article

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

scientific article published on 05 July 2019

Scaffolding functions of arrestin-2 revealed by crystal structure and mutagenesis

scientific article

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

scientific article published on 16 November 2020

Stereochemical analysis of diastereomeric 1,3-bis(adenosine-5'-O-phosphorothioyl)glycerols

scientific article published in May 2003

Structural and enzymatic characterization of a purified prohormone-processing enzyme: secreted, soluble Kex2 protease

scientific article

Subtleties among subtilases. The structural biology of Kex2 and furin-related prohormone convertases

scientific article published on October 2003

Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation

scientific article

Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions

scientific article published on 7 June 2006

Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans

scientific article

Targeted, LCMS-based Metabolomics for Quantitative Measurement of NAD(+) Metabolites

scientific article

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

scientific article

The histidine triad superfamily of nucleotide-binding proteins

scientific article

The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1

scientific article

The reported human NADsyn2 is ammonia-dependent NAD synthetase from a pseudomonad

scientific article

Transcriptional Response of White Adipose Tissue to Withdrawal of Vitamin B3

scientific article published on 16 April 2019

Two Hydrolase Resistant Analogues of Diadenosine 5',5'''-P,P-Triphosphate for Studies with FHIT, The Human Fragile Histidine Triad Protein ⬇️

scientific article published on January 1, 1998

Why Is Mom Stressed: Homeorhesis as the Potential Problem and Nicotinamide Riboside as the Potential Solution

scientific article published on 13 August 2019

Yeast Chfr homologs retard cell cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-dependent ubiquitination

scientific article

[11] Biochemical and genetic methods for analyzing specificity and activity of a precursor-processing enzyme: Yeast Kex2 protease, kexin

article

p53 activation by knockdown technologies

scientific article

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