List of works - Jinwoong Bok

Albumin-like protein is the major protein constituent of luminal fluid in the human endolymphatic sac.

scientific article

CHD7 mutational analysis and clinical considerations for auditory rehabilitation in deaf patients with CHARGE syndrome

scientific article

CTCF Regulates Otic Neurogenesis via Histone Modification in the Neurog1 Locus.

scientific article

CTCF is required for maintenance of auditory hair cells and hearing function in the mouse cochlea

scientific article published on 11 August 2018

CXCL12 is required for stirrup-shaped stapes formation during mammalian middle ear development

scientific article published on 21 April 2020

Ca2+/calmodulin-dependent protein kinases II and IV both promote survival but differ in their effects on axon growth in spiral ganglion neurons.

scientific article published in April 2003

CaMKII and CaMKIV mediate distinct prosurvival signaling pathways in response to depolarization in neurons.

scientific article published on 27 June 2007

Clinical and molecular characterizations of novel POU3F4 mutations reveal that DFN3 is due to null function of POU3F4 protein.

scientific article

Clinical evaluation of DFN3 patients with deletions in the POU3F4 locus and detection of carrier female using MLPA.

scientific article published in December 2010

Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development

scientific article

Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea

scientific article

Correlation between genotype and phenotype in patients with bi-allelic SLC26A4 mutations.

scientific article published on 3 October 2013

Developmental changes of ENaC expression and function in the inner ear of pendrin knock-out mice as a perspective on the development of endolymphatic hydrops.

scientific article

Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.

scientific article

Different functional consequences of two missense mutations in the GJB2 gene associated with non-syndromic hearing loss.

scientific article published in July 2009

Distinct contributions from the hindbrain and mesenchyme to inner ear morphogenesis.

scientific article published on 6 November 2009

Distinct roles of stereociliary links in the nonlinear sound processing and noise resistance of cochlear outer hair cells

scientific article published on 01 May 2020

Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models

scientific article published on 31 December 2020

Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing.

scientific article

Follistatin regulates the specification of the apical cochlea responsible for low-frequency hearing in mammals

scientific article published in 2022

Functional evaluation of GJB2 variants in nonsyndromic hearing loss.

scientific article

Genetic analysis of the CHD7 gene in Korean patients with CHARGE syndrome

scientific article published on 17 January 2013

Hoxc8 represses BMP-induced expression of Smad6.

scientific article

Identification of a nonsense mutation in the STRC gene in a Korean family with moderate hearing loss

scientific article published on 23 November 2015

Identification of a novel splicing mutation within SLC17A8 in a Korean family with hearing loss by whole-exome sequencing.

scientific article

Identification of evidence for autoimmune pathology of bilateral sudden sensorineural hearing loss using proteomic analysis.

scientific article published on 22 June 2017

Identification of genes concordantly expressed with Atoh1 during inner ear development.

scientific article

Independent mechanisms are utilized for the coordinate and transient accumulation of two differentiation-specific mRNAs during differentiation of Naegleria gruberi amoebae into flagellates

scientific article published on 01 July 1995

Inhibition of the Zeb family prevents murine palatogenesis through regulation of apoptosis and the cell cycle

scientific article published on 19 October 2018

Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling

scientific journal article

Magnetic Force Nanoprobe for Direct Observation of Audio Frequency Tonotopy of Hair Cells.

scientific article

Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells.

scientific article published on 3 November 2013

Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear

scientific journal article

Pannexin 3 is required for normal progression of skeletal development in vertebrates

scientific article published on 16 July 2015

Patterning and morphogenesis of the vertebrate inner ear.

scientific article published on January 2007

Pax3 function is required specifically for inner ear structures with melanogenic fates.

scientific article published on 21 February 2014

Position Specific Alternative Splicing and Gene Expression Profiles Along the Tonotopic Axis of Chick Cochlea

scientific article published on 08 September 2021

Pou3f4 deficiency causes defects in otic fibrocytes and stria vascularis by different mechanisms.

scientific article published on 7 December 2010

Profiling of miRNAs and target genes related to cystogenesis in ADPKD mouse models.

scientific article published on 26 October 2017

Progressive hearing loss in vitamin A-deficient mice which may be protected by the activation of cochlear melanocyte

scientific article published in Scientific Reports

Region-specific endodermal signals direct neural crest cells to form the three middle ear ossicles

scientific article published on 22 January 2019

Role of hindbrain in inner ear morphogenesis: analysis of Noggin knockout mice

scientific article

Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear.

scientific article published on 23 March 2005

Spatiotemporal expression patterns of clusterin in the mouse inner ear.

scientific article

Strong sonic hedgehog signaling in the mouse ventral spinal cord is not required for oligodendrocyte precursor cell (OPC) generation but is necessary for correct timing of its generation.

scientific article published on 6 November 2017

Targeted Gene Delivery into the Mammalian Inner Ear Using Synthetic Serotypes of Adeno-Associated Virus Vectors

article

Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear.

scientific article published in January 2017

The effect of novel mutations on the structure and enzymatic activity of unconventional myosins associated with autosomal dominant non-syndromic hearing loss.

scientific article

The third helix of the murine Hoxc8 homeodomain facilitates protein transduction in mammalian cells

scientific article published in October 2008

Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model

scientific article published in 2022

Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency

scientific article published on 20 November 2018

Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear.

scientific article

Uncovering the Secreted Signals and Transcription Factors Regulating the Development of Mammalian Middle Ear Ossicles

scientific article published on 15 October 2020

rMAPS2: an update of the RNA map analysis and plotting server for alternative splicing regulation

scientific article published on 14 April 2020

List of works by Jinwoong Bok

Albumin-like protein is the major protein constituent of luminal fluid in the human endolymphatic sac.

CHD7 mutational analysis and clinical considerations for auditory rehabilitation in deaf patients with CHARGE syndrome

CTCF Regulates Otic Neurogenesis via Histone Modification in the Neurog1 Locus.

CTCF is required for maintenance of auditory hair cells and hearing function in the mouse cochlea

CXCL12 is required for stirrup-shaped stapes formation during mammalian middle ear development

Ca2+/calmodulin-dependent protein kinases II and IV both promote survival but differ in their effects on axon growth in spiral ganglion neurons.

CaMKII and CaMKIV mediate distinct prosurvival signaling pathways in response to depolarization in neurons.

Clinical and molecular characterizations of novel POU3F4 mutations reveal that DFN3 is due to null function of POU3F4 protein.

Clinical evaluation of DFN3 patients with deletions in the POU3F4 locus and detection of carrier female using MLPA.

Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development

Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea

Correlation between genotype and phenotype in patients with bi-allelic SLC26A4 mutations.

Developmental changes of ENaC expression and function in the inner ear of pendrin knock-out mice as a perspective on the development of endolymphatic hydrops.

Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.

Different functional consequences of two missense mutations in the GJB2 gene associated with non-syndromic hearing loss.

Distinct contributions from the hindbrain and mesenchyme to inner ear morphogenesis.

Distinct roles of stereociliary links in the nonlinear sound processing and noise resistance of cochlear outer hair cells

Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models

Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing.

Follistatin regulates the specification of the apical cochlea responsible for low-frequency hearing in mammals

Functional evaluation of GJB2 variants in nonsyndromic hearing loss.

Genetic analysis of the CHD7 gene in Korean patients with CHARGE syndrome

Hoxc8 represses BMP-induced expression of Smad6.

Identification of a nonsense mutation in the STRC gene in a Korean family with moderate hearing loss

Identification of a novel splicing mutation within SLC17A8 in a Korean family with hearing loss by whole-exome sequencing.

Identification of evidence for autoimmune pathology of bilateral sudden sensorineural hearing loss using proteomic analysis.

Identification of genes concordantly expressed with Atoh1 during inner ear development.

Independent mechanisms are utilized for the coordinate and transient accumulation of two differentiation-specific mRNAs during differentiation of Naegleria gruberi amoebae into flagellates

Inhibition of the Zeb family prevents murine palatogenesis through regulation of apoptosis and the cell cycle

Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling

Magnetic Force Nanoprobe for Direct Observation of Audio Frequency Tonotopy of Hair Cells.

Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells.

Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear

Pannexin 3 is required for normal progression of skeletal development in vertebrates

Patterning and morphogenesis of the vertebrate inner ear.

Pax3 function is required specifically for inner ear structures with melanogenic fates.

Position Specific Alternative Splicing and Gene Expression Profiles Along the Tonotopic Axis of Chick Cochlea

Pou3f4 deficiency causes defects in otic fibrocytes and stria vascularis by different mechanisms.

Profiling of miRNAs and target genes related to cystogenesis in ADPKD mouse models.

Progressive hearing loss in vitamin A-deficient mice which may be protected by the activation of cochlear melanocyte

Region-specific endodermal signals direct neural crest cells to form the three middle ear ossicles

Role of hindbrain in inner ear morphogenesis: analysis of Noggin knockout mice

Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear.

Spatiotemporal expression patterns of clusterin in the mouse inner ear.

Strong sonic hedgehog signaling in the mouse ventral spinal cord is not required for oligodendrocyte precursor cell (OPC) generation but is necessary for correct timing of its generation.

Targeted Gene Delivery into the Mammalian Inner Ear Using Synthetic Serotypes of Adeno-Associated Virus Vectors

Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear.

The effect of novel mutations on the structure and enzymatic activity of unconventional myosins associated with autosomal dominant non-syndromic hearing loss.

The third helix of the murine Hoxc8 homeodomain facilitates protein transduction in mammalian cells

Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model

Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency

Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear.

Uncovering the Secreted Signals and Transcription Factors Regulating the Development of Mammalian Middle Ear Ossicles

rMAPS2: an update of the RNA map analysis and plotting server for alternative splicing regulation