List of works - Kasper Skytte Harpsøe

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

scientific article published on 19 January 2018

A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro

scientific article published on 06 December 2021

Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands.

scientific article published on April 2009

Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

scientific article published on 25 May 2012

Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed.

scientific article published on 26 July 2013

Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs

scientific article published on 04 August 2020

Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide.

scientific article published on February 2017

Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

scientific article published on 27 February 2019

Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

scientific article published on 05 June 2019

GPCRdb in 2018: adding GPCR structure models and ligands.

scientific article published on 16 November 2017

GPCRdb: an information system for G protein-coupled receptors.

scientific article published on 17 November 2015

GPCRdb: the G protein-coupled receptor database - an introduction

scientific article

Identification of a putative binding site for 5-alkyl-benzothiadiazides in the AMPA receptor dimer interface

scientific article published on 11 July 2006

Integrating structural and mutagenesis data to elucidate GPCR ligand binding.

scientific article

Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine 4 2 Receptors: UNIQUE ROLE OF HALOGEN BONDING REVEALED

scientific article

Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analog

scientific article

Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

scientific article published on 10 December 2012

Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139.

scientific article published on 10 November 2016

Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators

scientific article published on 16 August 2012

Prediction of the binding mode of biarylpropylsulfonamide allosteric AMPA receptor modulators based on docking, GRID molecular interaction fields and 3D-QSAR analysis.

scientific article

Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

scientific article published on 11 February 2019

Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives

scientific article

Revision of the classical dopamine D2 agonist pharmacophore based on an integrated medicinal chemistry, homology modelling and computational docking approach.

scientific article

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants

scientific article published on 11 September 2015

Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

scientific article

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs

scientific article published on 22 December 2016

Structural insights into the lipid and ligand regulation of serotonin receptors

Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

scientific article

Structure-activity relationships for negative allosteric mGluR5 modulators

scientific article

Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359

scientific article published on 12 July 2018

Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation

scientific article published on 05 January 2021

Total synthesis and structure-activity relationship studies of a series of selective G protein inhibitors

scientific article published on 25 July 2016

Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors.

scientific article published in July 2011

mGluR5: exploration of orthosteric and allosteric ligand binding pockets and their applications to drug discovery

scientific article

List of works by Kasper Skytte Harpsøe

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro

Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands.

Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed.

Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs

Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide.

Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

GPCRdb in 2018: adding GPCR structure models and ligands.

GPCRdb: an information system for G protein-coupled receptors.

GPCRdb: the G protein-coupled receptor database - an introduction

Identification of a putative binding site for 5-alkyl-benzothiadiazides in the AMPA receptor dimer interface

Integrating structural and mutagenesis data to elucidate GPCR ligand binding.

Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine 4 2 Receptors: UNIQUE ROLE OF HALOGEN BONDING REVEALED

Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analog

Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139.

Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators

Prediction of the binding mode of biarylpropylsulfonamide allosteric AMPA receptor modulators based on docking, GRID molecular interaction fields and 3D-QSAR analysis.

Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives

Revision of the classical dopamine D2 agonist pharmacophore based on an integrated medicinal chemistry, homology modelling and computational docking approach.

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants

Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs

Structural insights into the lipid and ligand regulation of serotonin receptors

Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

Structure-activity relationships for negative allosteric mGluR5 modulators

Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359

Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation

Total synthesis and structure-activity relationship studies of a series of selective G protein inhibitors

Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors.

mGluR5: exploration of orthosteric and allosteric ligand binding pockets and their applications to drug discovery