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List of works by Michael A. Geeves

13 Cryoenzymology: The study of enzyme catalysis at subzero temperatures

scientific article published on January 1, 1979

A kinetic model of the co-operative binding of calcium and ADP to scallop (Argopecten irradians) heavy meromyosin

scientific article published in July 2002

A micro-volume adaptation of a stopped-flow system; use with μg quantities of muscle proteins

scientific article published on 13 June 2019

A modulatory role for the troponin T tail domain in thin filament regulation

scientific article published on 03 June 2002

A novel live-cell imaging system reveals a reversible hydrostatic pressure impact on cell-cycle progression

scientific article published on 06 August 2018

A novel pressure-jump apparatus for the microvolume analysis of protein-ligand and protein-protein interactions: its application to nucleotide binding to skeletal-muscle and smooth-muscle myosin subfragment-1

scientific article

A novel stopped-flow method for measuring the affinity of actin for myosin head fragments using microgram quantities of protein

scientific article published on 01 December 1996

A systematic nomenclature for mammalian tropomyosin isoforms

scientific article published on 5 November 2014

A variable domain near the ATP-binding site in Drosophila muscle myosin is part of the communication pathway between the nucleotide and actin-binding sites.

scientific article

ADP binding induces an asymmetry between the heads of unphosphorylated myosin.

scientific article published on 11 April 2001

ATP-induced dissociation of rabbit skeletal actomyosin subfragment 1. Characterization of an isomerization of the ternary acto-S1-ATP complex

scientific article published on 01 December 1986

Acetylation regulates tropomyosin function in the fission yeast Schizosaccharomyces pombe

scientific article published in May 2007

Acetylation stabilises calmodulin‐regulated calcium signalling

scholarly article

Actin residue glu(93) is identified as an amino acid affecting myosin binding.

scientific article published in October 1999

Actin-tropomyosin activation of myosin subfragment 1 ATPase and thin filament cooperativity. The role of tropomyosin flexibility and end-to-end interactions

scientific article published on 01 November 1997

Actomyosin kinetics and in vitro motility of wild-type Drosophila actin and the effects of two mutations in the Act88F gene.

scientific article

Actomyosin kinetics of pure fast and slow rat myosin isoforms studied by in vitro motility assay approach.

scientific article published on 30 March 2012

Adenosine diphosphate and strain sensitivity in myosin motors.

scientific article

Alpha and beta myosin isoforms and human atrial and ventricular contraction

Alternative N-terminal regions of Drosophila myosin heavy chain II regulate communication of the purine binding loop with the essential light chain

scientific article published on 19 August 2020

Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin head

scientific article

An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis

scientific article

Analysis of biophysical and functional consequences of tropomyosin-fluorescent protein fusions.

scientific article published on 8 August 2016

Bisphosphorylation of cardiac troponin I modulates the Ca(2+)-dependent binding of myosin subfragment S1 to reconstituted thin filaments.

scientific article published in April 1996

Calcium sensitivity of the cross-bridge cycle of Myo1c, the adaptation motor in the inner ear

scientific article

Changes in Mg2+ ion concentration and heavy chain phosphorylation regulate the motor activity of a class I myosin

scientific article published on 4 December 2004

Changes in catalytic activity and association state of pyruvate carboxylase which are dependent on enzyme concentration.

scientific article

Characterization of the cardiac holotroponin complex reconstituted from native cardiac troponin T and recombinant I and C.

scientific article

Characterization of the equilibrium between blocked and closed states of muscle thin filaments.

scientific article

Contractile activation and force generation in skinned rabbit muscle fibres: effects of hydrostatic pressure.

scientific article

Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.

scientific article published on 9 October 2015

Cooperative [Ca²+]-dependent regulation of the rate of myosin binding to actin: solution data and the tropomyosin chain model.

scientific article

Cooperative regulation of myosin-S1 binding to actin filaments by a continuous flexible Tm-Tn chain

scientific article published on 7 October 2012

Cooperative regulation of myosin-actin interactions by a continuous flexible chain I: actin-tropomyosin systems.

scientific article

Cooperative regulation of myosin-actin interactions by a continuous flexible chain II: actin-tropomyosin-troponin and regulation by calcium.

scientific article

Cooperativity and switching within the three-state model of muscle regulation.

scientific article published on January 1999

Cooperativity between the two heads of rabbit skeletal muscle heavy meromyosin in binding to actin.

scientific article published on August 1998

Cooperativity in the Ca2+ regulation of muscle contraction.

scientific article

Cross-talk, cross-bridges, and calcium activation of cardiac contraction.

scientific article published on August 2014

Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments

scientific article published on 16 July 2020

Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1

scientific article published on January 2006

Crystallization and preliminary X-ray crystallographic analysis of full-length yeast tropomyosin 2 from Saccharomyces cerevisiae.

scientific article published on 23 May 2008

Dictyostelium discoideumMyosin II: Characterization of Functional Myosin Motor Fragments†

scientific article published on 01 January 1997

Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosis

scientific article published in February 2006

Differential regulation of the actomyosin interaction by skeletal and cardiac troponin isoforms.

scientific article published on 9 December 2002

Differential scanning calorimetric study of the thermal unfolding of the motor domain fragments of Dictyostelium discoideum myosin II

scientific article published on 01 January 1998

Differing ADP release rates from myosin heavy chain isoforms define the shortening velocity of skeletal muscle fibers.

scientific article

Diffusional barrier crossing in a two-state protein folding reaction

scientific article published on 01 October 1999

Dilated cardiomyopathy myosin mutants have reduced force-generating capacity.

scientific article published on 17 April 2018

Distinct effects of two hearing loss–associated mutations in the sarcomeric myosin MYH7b

scientific article published in 2023

Drosophila ACT88F indirect flight muscle-specific actin is not N-terminally acetylated: a mutation in N-terminal processing affects actin function.

scientific article published in February 2000

Drug effect unveils inter-head cooperativity and strain-dependent ADP release in fast skeletal actomyosin

scientific article published on 11 June 2009

Dynamic interaction between actin and myosin subfragment 1 in the presence of ADP

scientific article published in 1989

Dynamics of the muscle thin filament regulatory switch: the size of the cooperative unit.

scientific article published on July 1994

Dynamics of tropomyosin in muscle fibers as monitored by saturation transfer EPR of bi-functional probe.

scientific article

Effect of Myosin Isoforms on Cardiac Muscle Twitch of Mice, Rats and Humans

scientific article published in 2022

Effects of Hydrostatic-Pressure on Muscle Contraction: A Look Back on Some Experimental Findings

scholarly article

Effects of hydrostatic pressure on fatiguing frog muscle fibres

scientific article published on 01 December 1996

Effects of pressure on equatorial x-ray fiber diffraction from skeletal muscle fibers.

scientific article published on August 1993

Effects of two familial hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on the thermal unfolding of actin-bound tropomyosin

scientific article

Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors.

scientific article published on December 2012

Evidence of functional deficits at the single muscle fiber level in experimentally-induced renal insufficiency

scientific article published on 03 November 2018

Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle

scientific article published in 2022

FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR)

scientific article published on 4 July 2014

Fast pressure jumps can perturb calcium and magnesium binding to troponin C F29W

scientific article published on 23 October 2008

Force generation upon hydrostatic pressure release in tetanized intact frog muscle fibres

scientific article published on 01 August 1999

Functional and biophysical analyses of the class XIV Toxoplasma gondii myosin D.

scientific article published on 10 February 2006

Functional homodimers and heterodimers of recombinant smooth muscle tropomyosin

scientific article published on October 2006

High-speed imaging of glutamate release with genetically encoded sensors

scientific article published on 15 April 2019

Identification of functional differences between recombinant human α and β cardiac myosin motors

scientific article

In vitro formation and characterization of the skeletal muscle α·β tropomyosin heterodimers

scientific article

Inhibition of actin-myosin subfragment 1 ATPase activity by troponin I and IC: relationship to the thin filament states of muscle

scientific article published on 01 August 2000

Interaction of actin and ADP with the head domain of smooth muscle myosin: implications for strain-dependent ADP release in smooth muscle

scientific article published on 01 February 1998

Interactions of the two heads of scallop (Argopecten irradians) heavy meromyosin with actin: influence of calcium and nucleotides

scientific article published in March 2003

Ionic interactions play a role in the regulatory mechanism of scallop heavy meromyosin.

scientific article

Isolation and kinetic characterisation of myosin and myosin S1 from the Drosophila indirect flight muscles.

scientific article published in January 2003

KIF1D is a fast non-processive kinesin that demonstrates novel K-loop-dependent mechanochemistry.

scientific article

Kinetic Analysis ofDictyostelium discoideumMyosin Motor Domains with Glycine-to-Alanine Mutations in the Reactive Thiol Region†

article

Kinetic analyses of a truncated mammalian myosin I suggest a novel isomerization event preceding nucleotide binding

scientific article published on 01 July 2000

Kinetic analysis of Drosophila muscle myosin isoforms suggests a novel mode of mechanochemical coupling

scientific article published on 22 September 2003

Kinetic analysis of the slow skeletal myosin MHC-1 isoform from bovine masseter muscle

scientific article

Kinetic and mechanistic basis of the nonprocessive Kinesin-3 motor NcKin3

scientific article published on 01 October 2006

Kinetic characterization of a cytoplasmic myosin motor domain expressed in Dictyostelium discoideum.

scientific article published on September 1993

Kinetic characterization of the catalytic domain of Dictyostelium discoideum myosin.

scientific article

Kinetics of acto-S1 interaction as a guide to a model for the crossbridge cycle

scientific article published on 01 August 1984

Kinetics of an enzyme-catalyzed reaction measured by electrospray ionization mass spectrometry using a simple rapid mixing attachment.

scientific article published in November 2004

Kinetics of nucleotide binding to pyruvate carboxylase

scientific article published on 01 September 1995

Kinetics of the interaction of 2'(3')-O-(N-methylanthraniloyl)-ATP with myosin subfragment 1 and actomyosin subfragment 1: Characterization of two acto.cntdot.S1.cntdot.ADP complexes ⬇️

scientific article published on January 15, 1991

Looking at long molecules in solution: what happens when they are subjected to Couette flow?

scientific article published on 14 June 2006

Loop 1 of transducer region in mammalian class I myosin, Myo1b, modulates actin affinity, ATPase activity, and nucleotide access.

scientific article published on 26 June 2005

Loop I can modulate ADP affinity, ATPase activity, and motility of different scallop myosins. Transient kinetic analysis of S1 isoforms

scientific article published on 01 May 1998

Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations

scientific article published on 01 April 2019

Mechanism of adenosine 5'-triphosphate cleavage by myosin: studies with oxygen-18-labeled adenosine 5'-triphosphate

scientific article published on 01 October 1980

Mechanism, regulation, and functional properties of Dictyostelium myosin-1B.

scientific article published on 17 December 2007

Mg2+ -free ATP regulates the processivity of native cytoplasmic dynein

scientific article published on 03 January 2019

Microsecond folding of the cold shock protein measured by a pressure-jump technique

scientific article published on 01 March 1999

Modeling the Actin.myosin ATPase Cross-Bridge Cycle for Skeletal and Cardiac Muscle Myosin Isoforms.

scientific article

Modification of loop 1 affects the nucleotide binding properties of Myo1c, the adaptation motor in the inner ear

scientific journal article

Modulation of Actin Affinity and Actomyosin Adenosine Triphosphatase by Charge Changes in the Myosin Motor Domain†

scientific article published on 01 May 1998

Modulation of post-powerstroke dynamics in myosin II by 2'-deoxy-ADP

scientific article published on 31 December 2020

Modulators of actin-myosin dissociation: basis for muscle type functional differences during fatigue

scientific article published on 20 September 2017

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin

scientific article published on 21 October 2019

Molecular mechanism of actomyosin-based motility.

scientific article

More Can Mean Less, or: Simplifying Sometimes Requires Ideas to Be More Complicated.

scientific article

Multiscale modeling of twitch contractions in cardiac trabeculae

Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in Dictyostelium

scientific article published on 22 October 2002

Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in Dictyostelium

scholarly article by Georgios Tsiavaliaris published in December 2002

Myo1c is designed for the adaptation response in the inner ear

scientific article

Myo1c mutations associated with hearing loss cause defects in the interaction with nucleotide and actin.

scientific article

Myosin isoforms and the mechanochemical cross-bridge cycle

scientific article

Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties

scientific article published on 03 October 2019

Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity

scientific article published on 04 April 2019

Overexpression of human cardiac troponin in Escherichia coli: its purification and characterization.

scientific article

Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain

scientific article published on 26 February 2015

Polymorphism in tropomyosin structure and function

scientific article published on 07 July 2013

Pressure sensitivity of active tension in glycerinated rabbit psoas muscle fibres: effects of ADP and phosphate

scientific article published on 01 April 1989

Pressure-induced changes in the isometric contractions of single intact frog muscle fibres at low temperatures

scientific article published on 01 August 1995

Probing nucleotide dissociation from myosin in vitro using microgram quantities of myosin.

scientific article published in January 2003

Production of amino-terminally acetylated recombinant proteins in E. coli

scientific article published on January 2013

Protein-bound adenosine 5'-triphosphate: properties of a key intermediate of the magnesium-dependent subfragment 1 adenosinetriphosphatase from rabbit skeletal muscle

scientific article published on 01 May 1982

Proteins: from chemical to physiological mechanism.

scientific article published on 27 June 2002

Rapid folding of the prion protein captured by pressure-jump

scientific article (publication date: June 2009)

Rapid reaction kinetic techniques.

scientific article published on January 2014

Resolution and uniqueness of estimated parameters of a model of thin filament regulation in solution.

scientific article published on 6 December 2009

Reversible movement of switch 1 loop of myosin determines actin interaction

scientific article published on January 2007

Review: The ATPase mechanism of myosin and actomyosin.

scientific article published on 8 April 2016

Role of the head-to-tail overlap region in smooth and skeletal muscle beta-tropomyosin.

scientific article

Role of the salt-bridge between switch-1 and switch-2 of Dictyostelium myosin.

scientific article

Role of tropomyosin isoforms in the calcium sensitivity of striated muscle thin filaments

scientific article published on 14 April 2007

Selective perturbation of the myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate release

scientific article published on 21 April 2007

Separation and characterization of the two functional regions of troponin involved in muscle thin filament regulation

scientific article published on 01 December 1995

Shaking the myosin family tree: biochemical kinetics defines four types of myosin motor

scientific article published on 04 October 2011

Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils

Stabilization of the Actomyosin Complex by Negative Charges on Myosin†

scientific article published on 01 September 2000

Strain-dependent cross-bridge cycle for muscle.

scientific article published on August 1995

Strain-dependent cross-bridge cycle for muscle. II. Steady-state behavior.

scientific article published on August 1995

Stretching the lever-arm theory.

scientific article published in January 2002

Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V

scientific article

Structural mechanism of muscle contraction.

scientific article published in January 1999

Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis

scientific journal article

TORC2 dependent phosphorylation modulates calcium regulation of fission yeast myosin

preprint

TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium

scientific article published on 30 September 2019

Targeted amino-terminal acetylation of recombinant proteins in E. coli

scientific article

Temperature manifold for a stopped-flow machine to allow measurements from -10 to +40°C.

scientific article published on 7 February 2015

Temperature sensitive point mutations in fission yeast tropomyosin have long range effects on the stability and function of the actin-tropomyosin copolymer

scientific article published on 25 October 2017

Tension responses to increased hydrostatic pressure in glycerinated rabbit psoas muscle fibres

scientific article published on 01 November 1987

The ATPase cycle of human muscle myosin II isoforms: Adaptation of a single mechanochemical cycle for different physiological roles

scientific article published on 06 August 2019

The Hill model for binding myosin S1 to regulated actin is not equivalent to the McKillop-Geeves model

scientific article published on 28 January 2012

The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects

scientific article published on 4 March 2016

The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin II.

scientific article

The XXVIII European Muscle conference. York, UK, 4-7 September 1999

scientific article published on 01 November 1999

The XXXVII European muscle conference: Oxford September 2008

scientific article published on 26 November 2008

The actomyosin ATPase: a two-state system

scientific article published on April 29, 1992

The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization

scientific article (publication date: 27 February 2004)

The dynamics of the interaction between myosin subfragment 1 and pyrene-labelled thin filaments, from rabbit skeletal muscle

scientific article published on 01 October 1986

The effect of hydrostatic pressure on the interaction of actomyosin subfragment 1 with nucleotides

scientific article published on 01 October 1991

The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy

scientific article

The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin

scientific article

The influence of 2,3-butanedione 2-monoxime (BDM) on the interaction between actin and myosin in solution and in skinned muscle fibres

scientific article published on 01 June 1994

The limiting rate of the ATP-mediated dissociation of actin from rabbit skeletal muscle myosin subfragment 1

scientific article published on 01 August 1983

The mechanism of thin filament regulation: Models in conflict?

scientific article published on 30 September 2019

The molecular mechanism of muscle contraction.

scientific article

The myosin-activated thin filament regulatory state, M⁻-open: a link to hypertrophic cardiomyopathy (HCM).

scientific article published on 17 April 2014

The regulation of myosin binding to actin filaments by Lethocerus troponin.

scientific article published on 14 August 2007

The role of three-state docking of myosin S1 with actin in force generation.

scientific article published on April 1995

The slow skeletal muscle isoform of myosin shows kinetic features common to smooth and non-muscle myosins

scientific article published on 26 November 2006

The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb, and IId isoforms.

scientific article

The use of fast kinetic systems for the study of ng-microgram quantities of purified muscle proteins

scientific article published on 01 January 1998

The use of pressure perturbations to investigate the interaction of rabbit muscle myosin subfragment 1 with actin in the presence of MgADP.

scientific article published in April 1982

Three-dimensional stochastic model of actin-myosin binding in the sarcomere lattice.

scientific article

Towards a unified theory of muscle contraction. I: foundations.

scientific article published on 19 July 2008

Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plus-end-directed motor

scientific article

Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.

scientific article published on September 2000

Tropomyosin exon 6b is troponin-specific and required for correct acto-myosin regulation

scientific article published on 28 January 2004

Tuning the calcium sensitivity of cardiac muscle

scientific article

Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities

scientific article

Ultra short yeast tropomyosins show novel myosin regulation

scientific article

Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses.

scientific article

Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation.

scientific article published on 3 September 2011

Use of pyrene-labelled actin to probe actin-myosin interactions: kinetic and equilibrium studies.

scientific article published on January 2014

Using fluorescent myosin to directly visualize cooperative activation of thin filaments

scientific article published on 26 November 2014

What kinesin does at roadblocks: the coordination mechanism for molecular walking

scientific article

What limits the velocity of fast-skeletal muscle contraction in mammals?

scientific article published on 9 November 2005

α-Tropomyosin with a D175N or E180G mutation in only one chain differs from tropomyosin with mutations in both chains

scientific article published on 30 November 2012

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