List of works by Chaitan Khosla

A Balancing Act for Taxol Precursor Pathways in E. coli ⬇️

scientific article published on October 1, 2010

A Switch for the transfer of substrate between nonribosomal peptide and polyketide modules of the rifamycin synthetase assembly line

scientific article published in November 2003

A Turnstile Mechanism for the Controlled Growth of Biosynthetic Intermediates on Assembly Line Polyketide Synthases

scientific article published on 6 January 2016

A food-grade enzyme preparation with modest gluten detoxification properties

scientific article published in 2009

A non-human primate model for gluten sensitivity

scientific article

A scaleable manufacturing process for pro-EP-B2, a cysteine protease from barley indicated for celiac sprue

scientific article

A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases

scientific article published in August 2003

Activation of extracellular transglutaminase 2 by thioredoxin

scientific article

An antibiotic factory caught in action

scientific article

An unprecedented dual antagonist and agonist of human Transglutaminase 2.

scientific article published on 15 May 2015

Analysis and refactoring of the A-74528 biosynthetic pathway

scientific article published on 4 March 2013

Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry

scientific article published in September 2005

Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase

scientific article published on August 2011

Antibiotic activity of polyketide products derived from combinatorial biosynthesis: Implications for directed evolution ⬇️

scientific article published on February 1, 1996

Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction

scientific article published on 10 August 2020

Antigen Presentation to Celiac Lesion-Derived T Cells of a 33-Mer Gliadin Peptide Naturally Formed by Gastrointestinal Digestion

scientific article

Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthase

scientific article

Assembly line polyketide synthases: mechanistic insights and unsolved problems ⬇️

scientific article published on May 2014

Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli

scientific article

Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase

scientific article published in December 2004

Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host

scientific article

Building-block selectivity of polyketide synthases ⬇️

scientific article published on April 1, 2003

Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase

scientific article (publication date: February 2003)

Celiac Disease: Lessons for and from Chemical Biology.

scientific article published on 6 February 2017

Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase

scientific article

Chemistry and biology of macrolide antiparasitic agents

scientific article

Chemistry. A new route to designer antibiotics

scientific article published in April 2005

Cholestyramine as a promising, strong anion exchange resin for direct capture of genetic biomarkers from raw pancreatic fluids

scientific article published in November 2016

Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue

scientific article

Combinatorial biosynthesis of polyketides--a perspective.

scientific article

Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases

scientific article

Complete Reconstitution and Deorphanization of the 3 MDa Nocardiosis-Associated Polyketide Synthase

scientific article published on 20 March 2020

Computational identification and analysis of orphan assembly-line polyketide synthases

scientific article

Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange

scientific article published on 29 October 2013

Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis

scientific article

Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway

scientific article

Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease.

scientific article

Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative Mechanism

scientific article published on 28 March 2018

Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase

scientific article published in March 2003

Discovery and characterization of a thioesterase-specific monoclonal antibody that recognizes the 6-deoxyerythronolide B synthase

scientific article published on 17 October 2018

Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity

scientific article published on 09 March 2022

Effect of barley endoprotease EP-B2 on gluten digestion in the intact rat.

scientific article

Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue

scientific article

Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo

scientific article

Elevated transglutaminase 2 activity is associated with hypoxia-induced experimental pulmonary hypertension in mice

scientific article published on 5 November 2013

Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay

scientific article published on 6 July 2017

Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases

scientific article published on 21 April 2017

Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange

scientific article

Engineered biosynthesis of aklanonic acid analogues

scientific article

Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.

scientific article published on 29 July 2003

Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains

scientific article published on 11 February 2019

Enhancement of dietary protein digestion by conjugated bile acids

scientific article published on 14 April 2007

Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase

scientific article published in November 2003

Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues

scientific article published on 10 February 2016

Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase

scientific article published in March 2003

Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2.

scientific article

Erythromycin Biosynthesis. Highly Efficient Incorporation of Polyketide Chain Elongation Intermediates into 6-Deoxyerythronolide B in an Engineered Streptomyces Host ⬇️

scientific article published on 01 July 1995

Evolution and Diversity of Assembly-Line Polyketide Synthases

scientific article published on 15 December 2019

Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase

scientific article published in May 2003

Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2) ⬇️

scientific article published on August 1, 1995

Expression of intracellular hemoglobin improves protein synthesis in oxygen-limited Escherichia coli

scientific article published on September 1, 1990

Expression of recombinant proteins in Escherichia coli using an oxygen-responsive promoter

scientific article published on June 1, 1990

Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase

scientific article published in October 2002

Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase

scientific article published on March 2006

Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from Myxococcus xanthus: implications for Celiac Sprue therapy

scientific article

Genetic Engineering of Escherichia coli for Biofuel Production ⬇️

scientific article published on January 1, 2010

Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease

scientific article published on 28 February 2013

HEx: A heterologous expression platform for the discovery of fungal natural products. ⬇️

scientific article published on 11 April 2018

HEx: a heterologous expression platform for the discovery of fungal natural products

Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli.

scientific article published on 12 April 2017

Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease

scientific article

High selectivity of human tissue transglutaminase for immunoactive gliadin peptides: implications for celiac sprue

scientific article

INFORMATION ACCESS: Building A "GenBank" of the Published Literature

scientific article (publication date: 23 March 2001)

Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue

scientific article

Improved precursor-directed biosynthesis in E. coli via directed evolution.

scientific article

In Living Color: Bacterial Pigments as an Untapped Resource in the Classroom and Beyond ⬇️

scientific article published on October 5, 2010

In Vitro Reconstitution of Metabolic Pathways: Insights into Nature's Chemical Logic

scientific article published in January 2015

In vitro reconstitution and analysis of the 6-deoxyerythronolide B synthase

scientific article

In vivo and in vitro analysis of the hedamycin polyketide synthase

scientific article published on November 2009

Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin

scientific article published on February 2006

Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases

scientific article

Interferon-gamma released by gluten-stimulated celiac disease-specific intestinal T cells enhances the transepithelial flux of gluten peptides

scientific article

Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition

scientific article published in April 2003

Intestinal digestive resistance of immunodominant gliadin peptides

scientific article published in October 2002

KIR<sup>+</sup>CD8<sup>+</sup> T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

scientific article published on 15 April 2022

Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity

scientific article published in June 2003

Low-dose gluten challenge in celiac sprue: malabsorptive and antibody responses

scientific article published in July 2005

Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase

scientific article

Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule.

scientific article published on 12 April 2005

Manipulation and analysis of polyketide synthases

scientific article published in January 2004

Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis.

scientific article published on 3 February 2017

Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis

scientific article

Mechanism and specificity of an acyltransferase domain from a modular polyketide synthase

scientific article published on 5 March 2013

Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase

scientific article

Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules

scientific article published in May 2003

Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli

scientific article

Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2.

scientific article

Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase

scientific article

Noninflammatory gluten peptide analogs as biomarkers for celiac sprue

scientific article published on August 2009

Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds

scientific article

Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas ⬇️

scientific article published on September 8, 2010

Orthogonal protein interactions in spore pigment producing and antibiotic producing polyketide synthases

scientific article published in October 2005

Polyketide chain length control by chain length factor

scientific article (publication date: 22 October 2003)

Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase

scientific article published on December 2005

Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket

scientific article

Precursor-Directed Biosynthesis of Erythromycin Analogs by an Engineered Polyketide Synthase ⬇️

scientific article published on July 18, 1997

Precursor-Directed polyketide biosynthesis in Escherichia coli

scientific article published in November 2003

Precursor-directed biosynthesis of epothilone in Escherichia coli

scientific article published in June 2004

Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides

scientific article published in January 2002

Probing the interactions of an acyl carrier protein domain from the 6-deoxyerythronolide B synthase

scientific article published on July 2011

Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization

scientific article published on 9 September 2004

Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases

scientific article

Protein-protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthases

scientific article

Putative efficacy and dosage of prolyl endopeptidase for digesting and detoxifying gliadin peptides

scientific article

Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases

scientific article published on January 2003

Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases

scientific article published on April 2002

Rational design of combination enzyme therapy for celiac sprue.

scientific article

Real-Time in Vivo Detection of H2O2 Using Hyperpolarized 13C-Thiourea.

scientific article

Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases ⬇️

scientific article published on 27 April 2016

Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase

scientific article published on November 2004

Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway

scientific article

Redox regulation of transglutaminase 2 activity

scientific article

Regulation of the activities of the mammalian transglutaminase family of enzymes

scientific article published on 9 November 2012

Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation

scientific article published on 27 February 2012

Resolving multiple protein-peptide binding events: implication for HLA-DQ2 mediated antigen presentation in celiac disease.

scientific article

Revisiting the modularity of modular polyketide synthases

scientific article published on 11 February 2009

Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases

scientific article

Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation

scientific article published on 15 August 2014

Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase

scientific article published on 21 July 2016

Selective inhibition of extracellular thioredoxin by asymmetric disulfides

scientific article published on 31 January 2013

Solution Structure and Backbone Dynamics of the Holo Form of the Frenolicin Acyl Carrier Protein, ⬇️

scientific article (publication date: 29 April 2003)

Solution Structure and Conformational Flexibility of a Polyketide Synthase Module

scientific article published on 27 December 2021

Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase

scientific article

Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis

scientific article published in August 2005

Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases

scientific article published on 13 May 2013

Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase

scientific article published on 12 August 2008

Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

scientific article published on 6 October 2007

Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase

scientific article published on October 2010

Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase ( Hed KR): Molecular Basis of Stereo- and Regiospecificities

scientific article

Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B Synthase

scientific article

Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2).

scientific article

Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease

scientific article

Structure and Mechanism of the Ketosynthase-Chain Length Factor Didomain from a Prototypical Polyunsaturated Fatty Acid Synthase

scientific article published on 07 December 2020

Structure and Mechanism of the trans -Acting Acyltransferase from the Disorazole Synthase

scientific article

Structure and mechanism of assembly line polyketide synthases

scientific article published on 4 June 2016

Structure and mechanism of the 6-deoxyerythronolide B synthase

scientific article published on January 2007

Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2)

scientific article published on 3 October 2022

Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module

scientific article published on 18 May 2018

Structure-activity relationships of semisynthetic mumbaistatin analogs

scientific article

Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2.

scientific article published on 13 June 2007

Structure-based dissociation of a type I polyketide synthase module

scientific article

Substrate tolerance of module 6 of the epothilone synthetase

scientific article

Targeted gene replacements in a Streptomyces polyketide synthase gene cluster: role for the acyl carrier protein

scientific article published on November 1, 1992

The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

scholarly article

The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.

scientific article

The Stanford Institute for Chemical Biology

scientific article published in September 2013

The biochemical basis for stereochemical control in polyketide biosynthesis

scientific article published on December 2009

The loading and initial elongation modules of rifamycin synthetase collaborate to produce mixed aryl ketide products

scientific article published in April 2002

Thioredoxin-1 Selectively Activates Transglutaminase 2 in the Extracellular Matrix of the Small Intestine: IMPLICATIONS FOR CELIAC DISEASE.

scientific article published on 21 December 2016

Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease.

scientific article published in February 2005

Transglutaminase 2 in pulmonary and cardiac tissue remodeling in experimental pulmonary hypertension

scientific article published on 3 August 2017

Transglutaminase 2 undergoes a large conformational change upon activation

scientific article published in December 2007

Tunable Enzymatic Synthesis of the Immunomodulator Lipid IVA To Enable Structure-Activity Analysis

scientific article published on 11 June 2019

Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.

scientific article published on 15 August 2003

Use of transmission electron microscopy to identify nanocrystals of challenging protein targets

scientific article

Utilization of Enzymatically Phosphopantetheinylated Acyl Carrier Proteins and Acetyl−Acyl Carrier Proteins by the Actinorhodin Polyketide Synthase ⬇️

scientific article published on September 30, 1997

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