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List of works by Saskia N de Wildt

A Comparative Analysis of Preemptive Versus Targeted Sedation on Cardiovascular Stability After High-Risk Cardiac Surgery in Infants

scientific article

A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation

scientific article

A proof of concept using the Ussing chamber methodology to study pediatric intestinal drug transport and age‐dependent differences in absorption

scientific article published in 2022

A systematic review of the therapeutic effects of Reiki

scientific article

Acute liver failure after recommended doses of acetaminophen in patients with myopathies

scientific article published on April 2011

Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement

scientific article published on 26 July 2017

Analgesia-sedation in PICU and neurological outcome: a secondary analysis of long-term neuropsychological follow-up in meningococcal septic shock survivors*.

scientific article published in March 2014

CYP2D6 polymorphisms and codeine analgesia in postpartum pain management: a pilot study.

scientific article

Challenges for drug studies in children: CYP3A phenotyping as example

scientific article published on 07 September 2008

Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach

scientific article published on 30 July 2018

Clinically effective implementation of intravenous paracetamol as primary analgesia after major surgery in neonates and young infants

scientific article published on 10 July 2018

Clonidine as a First-Line Sedative Agent After Neonatal Cardiac Surgery: Retrospective Cohort Study.

scientific article published on 24 February 2016

Combining Brain Microdialysis and Translational Pharmacokinetic Modeling to Predict Drug Concentrations in Pediatric Severe Traumatic Brain Injury: The Next Step Toward Evidence-Based Pharmacotherapy?

scientific article published on 06 September 2018

Critical Illness Is a Major Determinant of Midazolam Clearance in Children Aged 1 Month to 17 Years ⬇️

scientific article published on August 1, 2012

Developing a paediatric drug formulary for the Netherlands.

scientific article published on 31 October 2016

Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics

scientific article

Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis

scientific article published on 13 June 2019

Developmental patterns in human blood-brain barrier and blood-cerebrospinal fluid barrier ABC drug transporter expression

scientific article published on 24 May 2020

Diagnosis and Treatment of Chronic Neuropathic and Mixed Pain in Children and Adolescents: Results of a Survey Study amongst Practitioners

scientific article published on 02 November 2020

Differences in P-glycoprotein activity in human and rodent blood-brain barrier assessed by mechanistic modelling

scientific article published on 15 July 2021

Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

scientific article published on 12 July 2018

Dose-linearity of the pharmacokinetics of an intravenous [14 C]midazolam microdose in children

scientific article published on 30 July 2019

Effects of renal denervation on cardiovascular and renal responses to ACE inhibition in conscious lambs ⬇️

scientific article published on 01 August 1997

Ethics of drug research in the pediatric intensive care unit

scientific article

Evaluation of drug formularies for pediatric intensive care

scientific article published on 01 January 2011

Evidence-based morphine dosing for postoperative neonates and infants

scientific article published in June 2014

External Validation of Model-Based Dosing Guidelines for Vancomycin, Gentamicin, and Tobramycin in Critically Ill Neonates and Children: A Pragmatic Two-Center Study

scientific article published on 08 June 2020

First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates.

scientific article

Genetic variants associated with thermal pain sensitivity in a paediatric population.

scientific article published on 14 July 2016

Hemodynamic Tolerance to IV Clonidine Infusion in the PICU

scientific article published on 01 August 2018

Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants

scientific article published on 14 April 2016

Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children

scientific article

Intoxication of a Young Girl Reveals the Pitfalls of GHB Rapid Screening.

scientific article published on 28 August 2015

Knowledge of developmental pharmacology and modeling approaches should be used to avoid useless trials in children

scientific article published on 25 April 2009

Low Bioavailability of Oral Tacrolimus Suspension in Pediatric Kidney Transplant Patients

scientific article published on 13 August 2020

Macrolide prescription in Dutch children: compliance with guidelines

scientific article published on 24 January 2019

Microdosing and Other Phase 0 Clinical Trials: Facilitating Translation in Drug Development.

scientific article published on 26 February 2016

Non-inferiority double-blind randomised controlled trial comparing gabapentin versus tramadol for the treatment of chronic neuropathic or mixed pain in children and adolescents: the GABA-1 trial-a study protocol

scientific article published on 20 February 2019

Ontogeny of midazolam glucuronidation in preterm infants

scientific article

Optimal sedation in pediatric intensive care patients: a systematic review

scientific article published on 19 June 2013

Oral lorazepam can be substituted for intravenous midazolam when weaning paediatric intensive care patients off sedation

scientific article published on 23 March 2018

Pediatric microdose study of [(14)C]paracetamol to study drug metabolism using accelerated mass spectrometry: proof of concept

scientific article

Perspectives of adolescents on decision making about participation in a biobank study: a pilot study

scientific article published on 23 August 2017

Pharmacokinetic studies in children: recommendations for practice and research.

scientific article published on 19 April 2018

Pharmacokinetics and metabolism of intravenous midazolam in preterm infants

scientific article published on December 1, 2001

Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome.

scientific article published on 16 March 2018

Pharmacotherapeutic management of paediatric heart failure and ACE-I use patterns: a European survey

scientific article published on 31 January 2019

Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients.

scientific article published on July 2003

Population pharmacokinetics of intravenous clonidine for sedation during paediatric extracorporeal membrane oxygenation and continuous venovenous hemofiltration.

scientific article published on 12 January 2017

Predicting CYP3A-mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure.

scientific article

Prevention of Low Cardiac Output Syndrome in children: where is the evidence?

article

Proenkephalin as a new biomarker for pediatric acute kidney injury - reference values and performance in children under one year of age

scientific article published on 29 June 2020

Profound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children ⬇️

scientific article published on 08 May 2011

Propylene Glycol–Related Delirium After Esmolol Infusion

scientific article published on 31 March 2014

Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life

scientific article published on 21 April 2016

Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants

scientific article published in November 2018

Question 1: How safe are ACE inhibitors for heart failure in children?

scientific article published on 26 October 2017

Rectal Omeprazole in Infants With Gastroesophageal Reflux Disease: A Randomized Pilot Trial

scientific article published on 27 June 2020

Reference intervals for renal injury biomarkers neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in young infants

scientific article published on July 2015

Reply

Reply to Stamer, Ulrike; Stüber, Frank, regarding their comment 'Analgesic efficacy of dipyrone children - Still an absence of evidence'

scientific article published on 01 December 2018

Reply to Ziesenitz, Victoria; Erb Thomas; Trachsel, Daniel; van den Anker Johannes, regarding their comment "Safety of dipryone (metamizole) in children-what's the risk of agranulocytosis?"

scientific article published in March 2018

Roles of Clinical Research Networks in Pediatric Drug Development.

scientific article

SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants

scientific article published on 01 August 2016

Sample collection, biobanking, and analysis

scientific article published on January 2011

Short-Term Health-Related Quality of Life of Critically Ill Children Following Daily Sedation Interruption

scientific article published on 22 September 2016

Striving for an effective but parsimonious use of sedation in pediatric intensive care.

scientific article published on 31 March 2016

Successful Use of [14C]Paracetamol Microdosing to Elucidate Developmental Changes in Drug Metabolism

scientific article published on 2 February 2017

Tailor-made drug treatment for children: creation of an infrastructure for data-sharing and population PK-PD modeling

scientific article

The Effect of Weight and CYP3A5 Genotype on the Population Pharmacokinetics of Tacrolimus in Stable Paediatric Renal Transplant Recipients

scientific article published on 30 April 2016

The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling

scientific article published on 01 February 2019

The effect of critical illness and inflammation on midazolam therapy in children

scientific article published in January 2012

The interactions of age, genetics, and disease severity on tacrolimus dosing requirements after pediatric kidney and liver transplantation

scientific article published on 23 June 2011

The potential impact of hematocrit correction on evaluation of tacrolimus target exposure in pediatric kidney transplant patients

scientific article published on 30 October 2018

The status of paediatric medicines initiatives around the world--What has happened and what has not?

scientific article published on 06 July 2011

The use of dipyrone (metamizol) as an analgesic in children: What is the evidence? A review.

scientific article published on 12 October 2017

Unintended pregnancy during radiotherapy for cancer

scientific article published on 27 January 2009

Urinary neutrophil gelatinase-associated lipocalin identifies critically ill young children with acute kidney injury following intensive care admission: a prospective cohort study

scientific article published on 21 April 2015

Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.

scientific article published on 9 February 2017

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