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Authors whose works are in public domain in at least one jurisdiction

List of works by David L Vaux

A biased comment on double-blind review.

scientific article published on September 2011

A boom time for necrobiology

scientific article

A chronology of cell death

scientific article published on 01 January 1997

A novel Apaf-1-independent putative caspase-2 activation complex

scientific article

A tumour suppressor function of caspase-8?

scientific article published on 01 September 2008

ABT-737, proving to be a great tool even before it is proven in the clinic

scientific article published on 01 May 2008

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

scientific article published on 17 January 2017

Alterations in the apoptotic machinery and their potential role in anticancer drug resistance ⬇️

scientific article published on October 20, 2003

An evolutionary perspective on apoptosis.

scientific article published on March 1994

Analysis of the role of bcl-2 in apoptosis.

scientific article

Another twist in the on and off affair between cell suicide and inflammation.

scientific article published in August 2013

Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells.

scientific article published in July 1998

Antibody production by single, hapten-specific B lymphocytes: an antigen-driven cloning system free of filler or accessory cells ⬇️

scientific article published on December 1, 1981

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

scientific article

Apoptogenic factors released from mitochondria

scientific article published on 14 August 2010

Apoptosis and the immune system ⬇️

scientific article published on January 1, 1997

Apoptosis and toxicology--what relevance?

scientific article

Apoptosis genes and autoimmunity.

scientific article

Apoptosis in the development and treatment of cancer

scientific article published on 16 September 2004

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

scientific article

Apoptosis, haemopoiesis and leukaemogenesis.

scientific article published on September 1997

Apoptosis. A cinderella caspase takes center stage

scientific article published on August 2002

Apoptosis. A sticky business.

scientific article published on June 1995

Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation

scientific article

Asymmetric recruitment of cIAPs by TRAF2

scientific article

Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 1994: HYPOTHESIS: APOPTOSIS CAUSED BY CYTOTOXINS REPRESENTS A DEFENSIVE RESPONSE THAT EVOLVED TO COMBAT INTRACELLULAR PATHOGENS

scientific article published on 01 November 1995

Australia needs an Ombudsman or Office for Research Integrity.

scientific article published in October 2016

Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion.

scientific article published on 11 December 2017

BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux

scientific article published on 12 May 2016

BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy

scientific article published on 27 June 2014

Basic statistics in cell biology

scientific article published on 02 July 2014

Bcl-2 gene prevents apoptosis in murine acth-secreting adenoma cells induced by bromocriptine

scientific article

Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes

scientific article published on 01 June 1997

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

scientific article published on July 1, 1992

Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

scientific article

CARP2 deficiency does not alter induction of NF-kappaB by TNFalpha

scientific article published in January 2009

CED-4—The Third Horseman of Apoptosis ⬇️

scientific article published on August 8, 1997

Caspase inhibitors.

scientific article

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

scientific article published on 01 August 2002

Caspases and apoptosis – biology and terminology

scientific article published on 01 June 1999

Cell Death in Development

scientific article published on 01 January 1999

Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion

scientific article published on 15 July 2016

Cell death regulation by the mammalian IAP antagonist Diablo/Smac.

scientific article

Cell death: shadow baxing.

scientific article

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death

scientific article

Cloning of mouse RP-8 cDNA and its expression during apoptosis of lymphoid and myeloid cells.

scientific article published on March 1995

Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts.

scientific article published in May 1998

Correction: TAK1 Is Required for Survival of Mouse Fibroblasts Treated with TRAIL, and Does So by NF-κB Dependent Induction of cFLIPL.

scientific article published on 3 December 2010

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

scientific article published on 27 June 2017

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

scientific article published in October 1996

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins

scientific article

Cytoplasmic p53 is not required for PUMA-induced apoptosis

scientific article published on 09 November 2007

DNA fragmentation in cytolysis

scientific article published on 01 October 1989

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response

scientific article published on 7 February 2011

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

scientific article

Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.

scientific article published in June 2001

Early work on the function of Bcl-2, an interview with David Vaux

scientific article

Effects of viral inhibitors of apoptosis in models of mammalian cell death

scientific article published on 01 October 1996

Entamoeba histolytica: target cells killed by trophozoites undergo DNA fragmentation which is not blocked by Bcl-2.

scientific article

Error bars in experimental biology

scientific article

Error message

scientific article published in April 2004

Evolutionary divergence of the necroptosis effector MLKL.

scientific article published on 12 February 2016

Expression of candidate cell death genes in cell lines during apoptosis.

scientific article published on November 1994

Expression of the integrin alpha 4 beta 1 on melanoma cells can inhibit the invasive stage of metastasis formation.

scientific article

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

scientific article

HtrA2/Omi, a sheep in wolf's clothing

scientific article published in October 2003

Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1

scientific article published on 15 June 2006

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

scientific article

IAP gene deletion and conditional knockout models

scientific article published on 26 December 2014

IAPs limit activation of RIP kinases by TNF receptor 1 during development

scientific article published on 10 February 2012

IAPs, RINGs and ubiquitylation

scientific article

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

scientific journal article

Identification of an Xiap-like pseudogene on mouse chromosome 7

scientific article

Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs

scientific article published on 23 June 2006

Immunology. Ways around rejection

scientific article published on 01 July 1998

Immunopathology of apoptosis--introduction and overview.

scientific article published on January 1998

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8

scientific article

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.

scientific article published on January 2016

In defense of the somatic mutation theory of cancer

scientific article published on 01 May 2011

In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it.

scientific article

In support of errors

In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose

scientific article published on 15 February 2019

In vivo expression of interleukin 5 induces an eosinophilia and expanded Ly-1B lineage populations

scientific article published on 01 January 1990

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

scientific article

Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors

scientific article

Inhibitor of Apoptosis (IAP) proteins as drug targets for the treatment of cancer ⬇️

scientific article published on October 29, 2009

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs

scientific article

Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation

scientific article published in April 1999

Integrity at Cancer Medicine: the research we publish, how we evaluate it, and what we ask of our authors

scientific article published on 17 July 2012

Lymphoid neoplasia and the control of haemopoietic differentiation

scientific article published on January 1989

Mammalian mitochondrial IAP binding proteins ⬇️

scientific article published on May 9, 2003

Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane

scientific article

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

scientific article

Molecular mechanisms of apoptosis: an overview

scientific article published on 01 January 1999

Necroptosis induced by RIPK3 requires MLKL but not Drp1.

scientific article published on 27 February 2014

Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2.

scientific article published on November 1993

Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

scientific article (publication date: 18 December 1992)

Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak.

scientific article

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

scientific article

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis

scientific article published on 8 May 2014

RIPK1- and RIPK3-induced cell death mode is determined by target availability

scientific article

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

scientific article

Rapid recovery of DNA from agarose gels

scientific article published on 01 March 1992

Rapid recovery of DNA from agarose gels

Replicates and repeats--what is the difference and is it significant? A brief discussion of statistics and experimental design

scientific article

Requirements for Proteolysis during Apoptosis ⬇️

scientific article published on November 1, 1997

Research methods: Know when your numbers are significant

scientific article published on December 2012

Response to Heard et al.

scientific article published in October 2015

Response to “The tissue organization field theory of cancer: A testable replacement for the somatic mutation theory” DOI: 10.1002/bies.201100025

scientific article published on 07 July 2011

Science down under

scientific article published on 01 May 2000

Signalling by CD95 and TNF receptors: not only life and death.

scientific article

Single cell studies on hapten-specific B lymphocytes: differential cloning efficiency of cells of various sizes

scientific article

Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization

scientific article published on 10 March 2011

Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat

scientific article

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

scientific article

Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment

scientific article

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

scientific article

TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL.

scientific article

TNF AND CD95 PROMOTE IL-8 GENE TRANSACTIVATION VIA INDEPENDENT ELEMENTS IN COLON CARCINOMA CELLS

article

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.

scientific article published on 17 January 2013

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

scientific article

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

scientific article published on December 2009

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

scientific article published on 23 December 2015

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

scientific article published on 7 July 2008

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

scientific article published on 12 September 2016

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

scientific article published in February 2016

Targeting triple-negative breast cancers with the Smac-mimetic birinapant

scientific article published on 27 April 2020

The 2019 Lasker Award: T cells and B cells, whose life and death are essential for function of the immune system

scientific article published on 17 October 2019

The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites

scientific article

The buzz about BAFF ⬇️

scientific article published on January 1, 2002

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

scientific article

The medical significance of physiological cell death.

scientific article published on July 1995

The mitochondrial death squad: hardened killers or innocent bystanders?

scientific article

The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system.

scientific article published on February 1997

The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone

scientific journal article

The transgenic window on lymphoid malignancy

scientific article published on 01 January 1989

Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies

scientific article published on January 2016

Tissue distribution of Diablo/Smac revealed by monoclonal antibodies.

scientific article

Toward an understanding of the molecular mechanisms of physiological cell death.

scientific article

Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts.

scientific article

Transgenic mouse models for hematopoietic tumorigenesis

scientific article published on 01 January 1988

Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins

scientific article published on 25 September 2008

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding

scientific article published on 01 August 2017

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

scientific article

Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis.

scientific article

Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis

scientific article published on 21 October 2003

Viewing BCL2 and cell death control from an evolutionary perspective

scientific article

Viral, worm and radical implications for apoptosis.

scientific article

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

scientific article published on July 2017

XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland.

scientific article published in January 2005

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

scientific article published on 04 February 2014

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