Search filters

List of works by Paul G Ekert

A novel Apaf-1-independent putative caspase-2 activation complex

scientific article

A prospective evaluation of whole-exome sequencing as a first-tier molecular test in infants with suspected monogenic disorders

scientific article published on 3 March 2016

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations.

scientific article published on 21 June 2013

Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism

scientific article published on 01 October 2001

Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells.

scientific article published in July 1998

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

scientific article

Apoptosis and the immune system ⬇️

scientific article published on January 1, 1997

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

scientific article

Apoptosis, haemopoiesis and leukaemogenesis.

scientific article published on September 1997

Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

scientific article published on 01 January 2019

Autophagy and AML--food for thought.

scientific article

BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis

scientific article

Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

scientific article

Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma

scientific article published on 17 September 2018

Caspase inhibitors.

scientific article

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

scientific article published on 01 August 2002

Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7.

scientific article

Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis

scientific article published on March 2004

Chemotherapy-related cardiotoxicity: are Australian practitioners missing the point?

scientific article

Clinicopathological Correlations in Postasphyxial Organ Damage: A Donor Organ Perspective

scientific article published on 01 June 1997

Clinker: visualising fusion genes detected in RNA-seq data

article

Clinker: visualizing fusion genes detected in RNA-seq data

article

Crossing paths: interactions between the cell death machinery and growth factor survival signals

scientific article published on 16 February 2010

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins

scientific article

Cytoplasmic p53 is not required for PUMA-induced apoptosis

scientific article published on 09 November 2007

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

scientific article

Dexamethasone prevents apoptosis in a neonatal rat model of hypoxic-ischemic encephalopathy (HIE) by a reactive oxygen species-independent mechanism.

scientific article published on January 1997

Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.

scientific article published in June 2001

Dysregulation of BCL-2 family proteins by leukemia fusion genes

scientific article

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.

scientific article published on 29 November 2013

Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor

publication published on 12 February 2021

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1.

scientific article

Epithelial bridging on burn patients following primary excision and grafting

scientific article published in April 1989

Exploring the feasibility and utility of exome-scale tumour sequencing in a clinical setting

scientific article published on 01 July 2018

Exploring the utility of human DNA methylation arrays for profiling mouse genomic DNA.

scientific article published on 29 April 2013

Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia

scientific article published on 14 October 2016

Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML

article

Genetic determinants of anthracycline cardiotoxicity - ready for the clinic?

scientific article published on 24 January 2017

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

scientific article published on 29 October 2018

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

scientific article

High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

scientific article published on November 2013

Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

scientific article published on 19 July 2013

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

scientific article

Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1

scientific article published on 15 June 2006

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions

scientific article published on 21 March 2019

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

scientific journal article

Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs

scientific article published on 23 June 2006

Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors

scientific article

In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8.

scientific article published in January 2013

Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors

scientific article

Insights into the pathogenesis of cerebral lesions in incontinentia pigmenti

scientific article

Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer

scientific article published on 09 October 2018

Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia

scientific article published on 5 March 2014

JAFFAL: detecting fusion genes with long-read transcriptome sequencing

scientific article published on 06 January 2022

Letting the breaks off MYCN.

scientific article

Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice.

scientific article published on 11 July 2014

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes.

scientific article published on 22 January 2010

MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data

scientific article published on 22 October 2021

MicroRNA-155 expression and function in AML: An evolving paradigm

scientific article published on 27 March 2018

Molecular basis of cytokine receptor activation

scientific article published on July 2010

Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis

scientific article (publication date: June 2005)

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation.

scientific article

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

scholarly article by Behrouz Hassannia et al published 1 August 2018 in Journal of Clinical Investigation

Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway.

scientific article

Predicting the outcome of postasphyxial hypoxic-ischemic encephalopathy within 4 hours of birth

scientific article published in October 1997

Preterm maturation of the somatosensory evoked potential.

scientific article published in September 1996

Programmed anuclear cell death delimits platelet life span.

scientific article

Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival

scientific article

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

scientific article

Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death

scientific article published on 26 April 2017

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis

scientific article published on 8 May 2014

Recurrent SPECC1L-NTRK fusions in paediatric sarcoma and brain tumours

scientific article published on 03 November 2020

Role of p53 in cAMP/PKA pathway mediated apoptosis.

scientific article published on December 2013

Role of the β Common (βc) Family of Cytokines in Health and Disease

scientific article

SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia

scientific article published on 01 April 2022

Seeking a MCL-1 inhibitor

scientific article published on November 2013

Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid?

scientific article published in December 2000

Signalling by the βc family of cytokines

scientific article published on 25 March 2013

Stuck long line syndrome.

scientific article published on June 2005

Targeted therapy and disease monitoring in CNTRL-FGFR1-driven leukaemia

scientific article published on 28 June 2019

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription.

scientific article published on 17 June 2013

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

scientific article published on 12 September 2016

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

scientific article published in February 2016

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

scientific article published on 01 April 2007

The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast

scientific article published on 01 December 2004

The GM-CSF receptor family: mechanism of activation and implications for disease

scientific article published on 18 January 2012

The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites

scientific article

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

scientific article

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

scientific article published on 12 May 2009

The mitochondrial death squad: hardened killers or innocent bystanders?

scientific article

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

scientific journal article

The molecular relationships between apoptosis, autophagy and necroptosis

scientific article

The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts

scientific article

The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis.

scientific article published in December 2002

Till death do us part

scientific article published in July 2001

Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins

scientific article published on 25 September 2008

Two sisters with IMAGe syndrome: Cytomegalic adrenal histopathology, support for autosomal recessive inheritance and literature review

scientific article published on 01 August 2006

Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis

scientific article published on 21 October 2003

Upper cervical spinal cord injury in neonates: The use of magnetic resonance imaging

scientific article published on 01 January 2001

Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

scientific article published on 05 October 2020

p53-Dependent transcriptional responses to interleukin-3 signaling

scientific article

Paulina is supported by:

About Paulina

Help