List of works - Mahmoud A Al-Sha'er

Application of docking-based comparative intermolecular contacts analysis to validate Hsp90α docking studies and subsequent in silico screening for inhibitors ⬇️

scientific article published on June 16, 2012

Combination of pharmacophore modeling and 3D-QSAR analysis of potential glyoxalase-I inhibitors as anticancer agents

scientific article published on 25 March 2019

Combined High Throughput Screening with QSAR Analysis Unravel Potential Glyoxalase-I inhibitors

scientific article published on 16 January 2020

Design, Synthesis and Biological Evaluation of N4-Sulfonamido-Succinamic, Phthalamic, Acrylic and Benzoyl Acetic Acid Derivatives as Potential DPP IV Inhibitors.

scientific article

Discovery of New Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors via Virtual Screening using Crystallography-derived Pharmacophore Modelling and QSAR Analysis

scientific article published on 01 January 2019

Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.

scientific article published on 18 July 2014

Discovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation

scientific article published on 28 August 2016

Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay.

scientific article published on 30 June 2010

Discovery of novel potent nuclear factor kappa-B inhibitors (IKK-β) via extensive ligand-based modeling and virtual screening

scientific article

Discovery of novel urokinase plasminogen activator (uPA) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.

scientific article published on 28 January 2014

Elaborate ligand-based modeling reveal new migration inhibitory factor inhibitors.

scientific article published on 28 March 2013

Elaborate ligand-based modeling reveals new nanomolar heat shock protein 90α inhibitors.

scientific article published on September 2010

Elaboration of Novel TTK1 Inhibitory Leads via QSAR-Guided Selection of Crystallographic Pharmacophores Followed By In vitro Assay

scientific article published on 11 June 2020

Evaluation of novel Akt1 inhibitors as anticancer agents using virtual co-crystallized pharmacophore generation.

scientific article published on 17 October 2015

Ligand Based Pharmacophore Modeling Followed by Biological Screening Lead to Discovery of Novel PDK1 Inhibitors as Anticancer Agents

scientific article published on 23 December 2019

Ligand-based modeling of Akt3 lead to potent dual Akt1/Akt3 inhibitor

scientific article

Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation.

scientific article published on 29 December 2010

List of works by Mahmoud A Al-Sha'er

Application of docking-based comparative intermolecular contacts analysis to validate Hsp90α docking studies and subsequent in silico screening for inhibitors ⬇️

Combination of pharmacophore modeling and 3D-QSAR analysis of potential glyoxalase-I inhibitors as anticancer agents

Combined High Throughput Screening with QSAR Analysis Unravel Potential Glyoxalase-I inhibitors

Design, Synthesis and Biological Evaluation of N4-Sulfonamido-Succinamic, Phthalamic, Acrylic and Benzoyl Acetic Acid Derivatives as Potential DPP IV Inhibitors.

Discovery of New Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors via Virtual Screening using Crystallography-derived Pharmacophore Modelling and QSAR Analysis

Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.

Discovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation

Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay.

Discovery of novel potent nuclear factor kappa-B inhibitors (IKK-β) via extensive ligand-based modeling and virtual screening

Discovery of novel urokinase plasminogen activator (uPA) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.

Elaborate ligand-based modeling reveal new migration inhibitory factor inhibitors.

Elaborate ligand-based modeling reveals new nanomolar heat shock protein 90α inhibitors.

Elaboration of Novel TTK1 Inhibitory Leads via QSAR-Guided Selection of Crystallographic Pharmacophores Followed By In vitro Assay

Evaluation of novel Akt1 inhibitors as anticancer agents using virtual co-crystallized pharmacophore generation.

Ligand Based Pharmacophore Modeling Followed by Biological Screening Lead to Discovery of Novel PDK1 Inhibitors as Anticancer Agents

Ligand-based modeling of Akt3 lead to potent dual Akt1/Akt3 inhibitor

Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation.