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List of works by Clemens Löwik

'In vivo' optical approaches to angiogenesis imaging

scientific article published on 08 May 2010

2-Methoxyestradiol Analogue ENMD-1198 Reduces Breast Cancer-Induced Osteolysis and Tumor Burden BothIn VitroandIn Vivo ⬇️

scientific article published on March 21, 2011

2D/3D registration of micro-CT data to multi-view photographs based on a 3D distance map

A Dual-Color Bioluminescence Reporter Mouse for Simultaneous in vivo Imaging of T Cell Localization and Function

article by Jan Willem Kleinovink et al published 8 January 2019 in Frontiers in Immunology

A frame-shift mutation in the type I parathyroid hormone (PTH)/PTH-related peptide receptor causing Blomstrand lethal osteochondrodysplasia

scientific article (publication date: October 1999)

A multi-modality platform to image stem cell graft survival in the naïve and stroke-damaged mouse brain

scientific article published on 17 December 2013

A new competition binding assay for determination of the cAMP content of human leukocytes

scientific article published on 01 August 1991

A new multicolor bioluminescence imaging platform to investigate NF-κB activity and apoptosis in human breast cancer cells

scientific article published on 17 January 2014

A new paradigm in the treatment of osteoporosis: Wnt pathway proteins and their antagonists.

scientific article published on April 2007

A novel luciferase fusion protein for highly sensitive optical imaging: from single-cell analysis to in vivo whole-body bioluminescence imaging

scientific article published on 24 June 2014

A transgenic Tie2-GFP athymic mouse model; a tool for vascular biology in xenograft tumors

scientific article published on 29 January 2008

A two-receptor model for the action of parathyroid hormone on osteoblasts: a role for intracellular free calcium and cAMP.

scientific article published in August 1985

Accelerated atherosclerosis and calcification in vein grafts: a study in APOE*3 Leiden transgenic mice.

scientific article

Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors

scientific article published on 15 September 2015

Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging

scientific article published on 20 January 2020

Advances in optical imaging and novel model systems for cancer metastasis research.

scientific article published on 31 October 2007

Alternative delivery of a thermostable inactivated polio vaccine

scientific article published on 13 March 2015

An in situ assay system to measure ornithine decarboxylase activity in primary cultures of chicken osteoblasts: effects of bone-seeking hormones

scientific article published on 01 January 1986

An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: actions of TNP-470, marimastat and the tubulin-binding agent Ang-510.

scientific article published on 14 December 2009

Antigen-adjuvant nanoconjugates for nasal vaccination: an improvement over the use of nanoparticles?

scientific article published on 2 November 2010

Apc bridges Wnt/β-catenin and BMP signaling during osteoblast differentiation of KS483 cells

scientific article published on 22 March 2011

Application of an in vitro model and a clinical protocol in the assessment of the potency of a new bisphosphonate

scientific article published on 01 October 1989

Articulated planar reformation for change visualization in small animal imaging

scientific article published in November 2010

Atlas-based whole-body registration in mice

Atlas-based whole-body segmentation of mice from low-contrast Micro-CT data

scientific article

Automated Registration of Whole-Body Follow-Up MicroCT Data of Mice

article

Automated bone volume and thickness measurements in small animal whole-body MicroCT data

scientific article

BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

scientific article

BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo

scientific article

Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships

scientific article

Bioluminescence Imaging of Bone Metastasis in Rodents ⬇️

scientific article published on 01 January 2012

Bioluminescent imaging: emerging technology for non-invasive imaging of bone tissue engineering

scientific article

Bisphosphonates can reduce osteoclastic bone resorption by two different mechanisms

scientific article published on 01 January 1986

Bisphosphonates in osteoporosis?

scientific article

Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro

scientific article published on August 1996

Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: the role of protein geranylgeranylation in the action of nitrogen-containing bisphosphona

scientific article published in January 2002

Bone matrix degradation by the plasminogen activation system. Possible mechanism of bone destruction in arthritis

scientific article published on January 1997

Bone metastasis imaging with SPECT/CT/MRI: a preclinical toolbox for therapy studies

scientific article

Bone mineral density in sclerosteosis; affected individuals and gene carriers

scientific article

Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer

scientific article

Bone morphogenetic protein 7 inhibits tumor growth of human uveal melanoma in vivo.

scientific article published on November 2007

Bone morphogenetic proteins and their antagonists: the sclerostin paradigm.

scientific article published in January 2005

Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A.

scientific article published on April 2002

Bone resorption and renal calcium reabsorption in renal cell carcinoma-bearing mice: the effects of bisphosphonate

scientific article published on 8 April 2007

CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses

scientific article published on 26 November 2014

CT-based handling and analysis of preclinical multimodality imaging data of bone metastases.

scientific article

Celecoxib enhances doxorubicin-induced cytotoxicity in MDA-MB231 cells by NF-kappaB-mediated increase of intracellular doxorubicin accumulation.

scientific article published on 9 November 2006

Cell-based and molecular imaging tools for validating new therapies in the treatment of bone metabolic disorders and metastases

scientific article published on 01 December 2006

Cell-cell communication: parathyroid hormone-like protein production by squamous carcinoma cells is modulated by fibroblasts. A possible mechanism in the development of humoral hypercalcemia of malignancy

scientific article published on January 1991

Ceramic hydroxyapatite implants for the release of bisphosphonate

scientific article published on 01 May 1994

Characterization and evaluation of the artemis camera for fluorescence-guided cancer surgery

scientific article published on June 2015

Class III β-tubulin, a novel biomarker in the human melanocyte lineage.

scientific article published in April 2013

Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging

scientific article published on 9 January 2018

Clinical translation of ex vivo sentinel lymph node mapping for colorectal cancer using invisible near-infrared fluorescence light

scientific article

Colony stimulating factor-1 plays a role in osteoclast formation and function in bone resorption induced by parathyroid hormone and parathyroid hormone-related protein

scientific article published on October 1996

Combination of Photodynamic Therapy and Specific Immunotherapy Efficiently Eradicates Established Tumors.

scientific article published on 6 November 2015

Combinatorial prospects of nano-targeted chemoimmunotherapy.

scientific article

Contrast enhancement by lipid-based MRI contrast agents in mouse atherosclerotic plaques; a longitudinal study

article

Control of bone formation by osteocytes? lessons from the rare skeletal disorders sclerosteosis and van Buchem disease

scientific article (publication date: December 2005)

Correction: In vivo 808 nm image-guided photodynamic therapy based on an upconversion theranostic nanoplatform

scientific article published on 04 August 2016

Cytokine production by calvariae of osteopetrotic mice

scientific article published on 01 July 1995

Cytotoxic effects of topical antimicrobial and antiseptic agents on human keratinocytes in vitro

scientific article published on July 1993

Degradation of extracellular matrix by metastatic follicular thyroid carcinoma cell lines: role of the plasmin activation system

scientific article published on 01 September 1999

Degradation, intra-articular retention and biocompatibility of monospheres composed of [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers

scientific article published on 2 November 2016

Design of a variant of vascular endothelial growth factor-A (VEGF-A) antagonizing KDR/Flk-1 and Flt-1

scientific article published on 01 April 2002

Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase

scientific article published on 09 January 2018

Detection of oral squamous cell carcinoma and cervical lymph node metastasis using activatable near-infrared fluorescence agents.

scientific article published on June 2011

Development of a Multicolor Bioluminescence Imaging Platform to Simultaneously Investigate Transcription Factor NF-κB Signaling and Apoptosis

scientific article

Development of a three-dimensional in vitro model for longitudinal observation of cell behavior: monitoring by magnetic resonance imaging and optical imaging

scientific article published in December 2009

Different roles for calcium and cyclic AMP in the action of PTH: studies in bone explants and isolated bone cells

scientific article

Differential Effects of Aminosubstituted Analogs of Hydroxy Bisphosphonates on the Growth of Dictyostelium discoideum ⬇️

scientific article published on 01 February 1998

Differential effects of PD98059 and U0126 on osteogenesis and adipogenesis

scientific article published on June 2004

Differential effects of angiotensin II and transforming growth factor beta on the production of heparan sulfate proteoglycan by mesangial cells in vitro

scientific article published on 01 July 1996

Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells.

scientific article published on November 1997

Differential regulation of plasminogen activation in normal keratinocytes and SCC-4 cells by fibroblasts

scientific article published on March 1995

Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates ⬇️

scientific article published on November 1, 2003

Differentiation of murine preosteoblastic KS483 cells depends on autocrine bone morphogenetic protein signaling during all phases of osteoblast formation

scientific article published on December 2002

Disodium 1-hydroxy-3-(1-pyrrolidinyl)-propylidene-1,1-bisphosphonate (EB-1053) is a potent inhibitor of bone resorption in vitro and in vivo

scientific article published on August 1, 1992

Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice.

scientific article

Dissociation of binding and antiresorptive properties of hydroxybisphosphonates by substitution of the hydroxyl with an amino group.

scientific article

Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways

scientific article

Dose-dependent effects of phytoestrogens on bone

scientific article

Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells

scientific article published on 26 June 2005

Dual wavelength tumor targeting for detection of hypopharyngeal cancer using near-infrared optical imaging in an animal model

scientific article published on 6 March 2012

Dual-Wavelength Imaging of Tumor Progression by Activatable and Targeting Near-Infrared Fluorescent Probes in a Bioluminescent Breast Cancer Model ⬇️

scientific article published on February 13, 2012

EGFR targeted nanobody-photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer.

scientific article

Early identification of non-responding locally advanced breast tumors receiving neoadjuvant chemotherapy

scientific article

Effect of PLGA NP size on efficiency to target traumatic brain injury

scientific article published on 18 December 2015

Effect of alendronate treatment on the osteoclastogenic potential of bone marrow cells in mice

scientific article published on 01 April 1997

Effect of angiogenic and antiangiogenic compounds on the outgrowth of capillary structures from fetal mouse bone explants.

scientific article

Effect of interleukin-17 on nitric oxide production and osteoclastic bone resorption: is there dependency on nuclear factor-kappaB and receptor activator of nuclear factor kappaB (RANK)/RANK ligand signaling?

scientific article published on April 2001

Effect of macrophage colony-stimulating factor on in vitro osteoclast generation and bone resorption ⬇️

scientific article published on January 1, 1992

Effect of parathyroid hormone and parathyroid hormone fragments on the intracellular ionized calcium concentration in an osteoblast cell line

scientific article published in June 1988

Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles

scientific article published on 21 August 2019

Effects of exogenous prostanoids on the proliferation of osteoblast-like cells in vitro

article published in 1985

Effects of experimental conditions on the release of 45calcium from prelabeled fetal mouse long bones ⬇️

scientific article published on July 1, 1995

Efficient in vivo knock-down of estrogen receptor alpha: application of recombinant adenovirus vectors for delivery of short hairpin RNA.

scientific article

Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding

scientific article published on August 1999

Endostatin's heparan sulfate-binding site is essential for inhibition of angiogenesis and enhances in situ binding to capillary-like structures in bone explants

article published in 2005

Enhancement of the inhibitory action of APD on the transformation of osteoclast precursors into resorbing cells after dimethylation of the amino group

scientific article published on 01 February 1987

Environmental 24-hr Cycles Are Essential for Health

scientific article published on 13 July 2016

Environmental control of prolactin synthesis in the teleost fish Oreochromis (formerly Sarotherodon) mossambicus

scientific article published on March 1985

EpCAM as multi-tumour target for near-infrared fluorescence guided surgery.

scientific article

Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging

scientific article published on 14 September 2020

Evaluating reporter genes of different luciferases for optimized in vivo bioluminescence imaging of transplanted neural stem cells in the brain

scientific article published in November 2013

Evidence for genomic and nongenomic actions of estrogen in growth plate regulation in female and male rats at the onset of sexual maturation.

scientific article published in November 2002

Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis

scientific article published on March 2002

Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the postnatal growth plate of the rat: evidence for a locally acting growth restraining feedback loop after birth

scientific article published on 01 June 2000

Expression of estrogen receptor alpha and beta in the epiphyseal plate of the rat.

scientific article published in March 2002

Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation

scientific journal article

Expression of the Parathyroid Hormone-Related Peptide Gene in Retinoic Acid-Induced Differentiation: Involvement of ETS and Sp1 ⬇️

scientific article published on September 1, 1997

Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation

scientific article

FULLY AUTOMATED WHOLE-BODY REGISTRATION IN MICE USING AN ARTICULATED SKELETON ATLAS

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates

scientific article published in October 1999

Fate of Multimeric Oligomers, Submicron, and Micron Size Aggregates of Monoclonal Antibodies Upon Subcutaneous Injection in Mice

scientific article published in April 2016

First Report on Ex Vivo Delivery of Paracrine Active Human Mesenchymal Stromal Cells to Liver Grafts During Machine Perfusion

scientific article published on 01 January 2020

First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function

scientific article published on July 2010

Gender differences in expression of androgen receptor in tibial growth plate and metaphyseal bone of the rat

scientific article published on 01 June 2002

Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells

scientific article published on December 2003

Human CD46-transgenic mice in studies involving replication-incompetent adenoviral type 35 vectors

scientific article

IL-1α, IL-1β, IL-6, and TNF-α Steady-State mRNA Levels Analyzed by Reverse Transcription-Competitive PCR in Bone Marrow of Gonadectomized Mice ⬇️

scientific article published on February 1, 1998

Identification of a retinoic acid-inducible element in the murine PTH/PTHrP (parathyroid hormone/parathyroid hormone-related peptide) receptor gene

scientific article published on July 1999

Identification of differentially expressed genes in a renal cell carcinoma tumor model after endostatin-treatment

scientific article published on November 2004

Identification of receptor-type protein tyrosine phosphatase μ as a new marker for osteocytes

scientific article published on 8 April 2015

Image-guided surgery in head and neck cancer: current practice and future directions of optical imaging.

scientific article published on 31 January 2011

Image-guided tumor resection using real-time near-infrared fluorescence in a syngeneic rat model of primary breast cancer ⬇️

scientific article published on September 7, 2010

Imaging Bioluminescent Exogenous Stem Cells in the Intact Guinea Pig Cochlea.

scientific article published on 11 January 2019

Imaging bone morphogenetic protein 7 induced cell cycle arrest in experimental gliomas.

scientific article

Immunohistochemical investigations on the differentiation marker protein E11 in rat calvaria, calvaria cell culture and the osteoblastic cell line ROS 17/2.8.

scientific article published on January 1999

In Vivo Evaluation of Indium-111-Labeled 800CW as a Necrosis-Avid Contrast Agent

scientific article published on 08 June 2020

In Vivo Fluorescence Imaging of IgG1 Aggregates After Subcutaneous and Intravenous Injection in Mice ⬇️

scientific article published on August 15, 2013

In Vivo Molecular Bioluminescence Imaging: New Tools and Applications.

scientific article

In Vivo Non-Invasive Tracking of Macrophage Recruitment to Experimental Stroke

scientific article

In vitro and ex vivo evidence that estrogens suppress increased bone resorption induced by ovariectomy or PTH stimulation through an effect on osteoclastogenesis

scientific article

In vitro and in vivo endochondral bone formation models allow identification of anti-angiogenic compounds

scientific article published on July 2003

In vivo 808 nm image-guided photodynamic therapy based on an upconversion theranostic nanoplatform

scientific article

In vivo bioluminescence imaging of vascular remodeling after stroke

scientific article published on 5 September 2014

In vivo imaging of transcriptionally active estrogen receptors.

scientific article published on 16 December 2002

In vivo quantification of the scattering properties of tissue using multi-diameter single fiber reflectance spectroscopy.

scientific article published on 9 April 2013

Increased plasma calcitonin levels in young spontaneously hypertensive rats: role in disturbed phosphate homeostasis

scientific article published on 01 April 1987

Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor

scientific article published on 13 September 2005

Induced illness in interleukin-6 (IL-6) knock-out mice: a causal role of IL-6 in the development of the low 3,5,3'-triiodothyronine syndrome

scientific article published in December 1996

Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption

scientific article

Induction of ornithine decarboxylase activity in isolated chicken osteoblasts by parathyroid hormone: the role of cAMP and calcium

scientific article published on 01 July 1988

Inhibition of GSK3β Stimulates BMP Signaling and Decreases SOST Expression Which Results in Enhanced Osteoblast Differentiation.

scientific article

Inhibition of Gsk3β in cartilage induces osteoarthritic features through activation of the canonical Wnt signaling pathway.

scientific article published on 27 August 2011

Inhibition of bone resorption and growth of breast cancer in the bone microenvironment

scientific article

Inhibition of intravacuolar acidification by antisense RNA decreases osteoclast differentiation and bone resorption in vitro

scientific journal article

Inhibition of terminal chondrocyte differentiation by bone morphogenetic protein 7 (OP-1) in vitro depends on the periarticular region but is independent of parathyroid hormone-related peptide

scientific article published on 01 October 1999

Integrated visualization of multi-angle bioluminescence imaging and micro CT

scholarly article published 8 March 2007

Integrins and osteoclastic resorption in three bone organ cultures: differential sensitivity to synthetic Arg-Gly-Asp peptides during osteoclast formation

scientific article published on 01 July 1994

Interactive local super-resolution reconstruction of whole-body MRI mouse data: a pilot study with applications to bone and kidney metastases

scientific article

Interference with the microenvironmental support impairs the de novo formation of bone metastases in vivo

scientific article published on September 2005

Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro

scientific article published on October 2002

Interleukin-17: A new bone acting cytokine in vitro

scientific article published on September 1999

Interleukin-6 and the acute phase response during treatment of patients with Paget's disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate

scientific article published on 01 June 1995

Intra-Operative Imaging of the Invasive Tumor Border by a Cathepsin-Sensing Near-Infrared Fluorescence Probe in a Syngeneic Breast Cancer Rat Model.

scientific article published in 2009

Intraoperative fluorescence delineation of head and neck cancer with a fluorescent anti-epidermal growth factor receptor nanobody

scientific article published on 12 December 2013

Intraoperative near-infrared fluorescence imaging of colorectal metastases targeting integrin αvβ3 expression in a syngeneic rat model ⬇️

scientific article published on January 6, 2011

Intrinsic photosensitizer fluorescence measured using multi-diameter single-fiber spectroscopy in vivo

scientific article published in January 2014

Isolation of the biosynthetic products of the PAS positive pars intermedia cells in the cichlid teleost Sarotherodon mossambicus

scientific article published on 01 February 1983

Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases

scientific article published on January 2007

Leukemia inhibitory factor inhibits osteoclastic resorption, growth, mineralization, and alkaline phosphatase activity in fetal mouse metacarpal bones in culture

scientific article

Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice

scientific article

Microscopic analysis of the localization of two chlorin-based photosensitizers in OSC19 tumors in the mouse oral cavity.

scientific article published on 16 January 2014

Migration and phenotypic transformation of osteoclast precursors into mature osteoclasts: the effect of a bisphosphonate.

scientific article

Modulation of IL-6 production and IL-1 activity by keratinocyte-fibroblast interaction

scientific article published on September 1993

Modulation of PTH-stimulated osteoclastic resorption by bisphosphonates in fetal mouse bone explants ⬇️

scientific article published on November 1, 1991

Modulation of the production of a parathyroid hormone-like protein in human squamous carcinoma cell lines by interaction with fibroblasts

scientific article published on June 1990

Molecular imaging of tumor angiogenesis using alphavbeta3-integrin targeted multimodal quantum dots

scientific article

Monitoring metastatic behavior of human tumor cells in mice with species-specific polymerase chain reaction: elevated expression of angiogenesis and bone resorption stimulators by breast cancer in bone metastases

scientific article published on 01 June 2001

Multicolor Fluorescence Imaging of Traumatic Brain Injury in a Cryolesion Mouse Model ⬇️

scientific article published on April 7, 2012

Multimodal imaging and treatment of bone metastasis.

scientific article published on 22 October 2008

Multimodality imaging reveals a gradual increase in matrix metalloproteinase activity at aneurysmal lesions in live fibulin-4 mice.

scientific article published on 30 June 2010

Multiple mechanisms are involved in inhibition of osteoblast differentiation by PTHrP and PTH in KS483 Cells

scientific article published on 29 August 2005

Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration

scientific article

Nanobody-targeted photodynamic therapy induces significant tumor regression of trastuzumab-resistant HER2-positive breast cancer, after a single treatment session

scientific article published on 21 April 2020

Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen

scientific article published on 16 July 2010

Near infrared fluorescence imaging for early detection, monitoring and improved intervention of diseases involving the joint

scientific article

Near-infrared fluorescence imaging in patients undergoing pancreaticoduodenectomy.

scientific article

Near-infrared fluorescence imaging of both colorectal cancer and ureters using a low-dose integrin targeted probe.

scientific article

Near-infrared fluorescence imaging of liver metastases in rats using indocyanine green.

scientific article

Near-infrared fluorescence sentinel lymph node mapping of the oral cavity in head and neck cancer patients ⬇️

scientific article published on August 28, 2012

Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: In vivo tracking and evaluation of antigen-specific CD8(+) T cell immune response.

scientific article published on 28 October 2014

Near‐infrared fluorescence‐guided resection of colorectal liver metastases ⬇️

scientific article published on June 21, 2013

Necroptotic Cell Death in Liver Transplantation and Underlying Diseases: Mechanisms and Clinical Perspective

scientific article published on 01 July 2019

Necrosis avid near infrared fluorescent cyanines for imaging cell death and their use to monitor therapeutic efficacy in mouse tumor models

scientific article

Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo

scientific article published in February 1999

Noninvasive real-time in vivo bioluminescent imaging of gene expression and of tumor progression and metastasis.

scientific article

Normalized volume of interest selection and measurement of bone volume in MicroCT scans ⬇️

scientific article published on September 16, 2011

Novel early target genes of parathyroid hormone-related peptide in chondrocytes

scientific article published on 23 February 2006

Novel intraoperative near-infrared fluorescence camera system for optical image-guided cancer surgery.

scientific article

Novel late response genes of PTHrP in chondrocytes

scientific article published on 25 October 2006

Novel mutations in the parathyroid hormone (PTH)/PTH-related peptide receptor type 1 causing Blomstrand osteochondrodysplasia types I and II.

scientific article published on 12 December 2006

Oestrogenic compounds modulate cytokine-induced nitric oxide production in mouse osteoblast-like cells

scientific article published on December 1999

Optical Imaging of Treatment-Related Tumor Cell Death Using a Heat Shock Protein-90 Alkylator ⬇️

scientific article published on September 10, 2013

Optical advances in skeletal imaging applied to bone metastases.

scientific article published on 03 August 2010

Optical image-guided cancer surgery: challenges and limitations

scientific article published on 14 May 2013

Optical image-guided surgery--where do we stand?

scientific article published on April 2011

Optical imaging of cancer metastasis to bone marrow: a mouse model of minimal residual disease

scientific article published on March 2002

Optical imaging of cell death in traumatic brain injury using a heat shock protein-90 alkylator

scientific article published on 24 January 2013

Optical imaging of oral squamous cell carcinoma and cervical lymph node metastasis

scientific article published on 10 October 2011

Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer

scientific article published on 3 December 2014

Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer ⬇️

scientific article published on July 30, 2011

Optimized Longitudinal Monitoring of Stem Cell Grafts in Mouse Brain Using a Novel Bioluminescent/Near Infrared Fluorescent Fusion Reporter.

scientific article published in December 2017

Organ approximation in μCT data with low soft tissue contrast using an articulated whole-body atlas

Osteoclast formation together with interleukin-6 production in mouse long bones is increased by insulin-like growth factor-I

scientific article published on 01 March 1992

Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling.

scientific article published on February 2008

Ovariectomy and orchidectomy induce a transient increase in the osteoclastogenic potential of bone marrow cells in the mouse

scientific article published in January 1997

Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis

scientific article published on 01 August 1989

Parathyroid hormone related protein and interleukin-6 mRNA expression in larynx and renal cell carcinomas from normocalcaemic and hypercalcaemic patients.

scientific article published on October 1995

Parathyroid hormone-related peptide (PTHrP) induces parietal endoderm formation exclusively via the type I PTH/PTHrP receptor

scientific article published in March 1999

Parathyroid hormone-related peptide as an endogenous inducer of parietal endoderm differentiation.

scientific article

Peroxisome proliferator-activated receptor gamma (PPARgamma ) as a molecular target for the soy phytoestrogen genistein

scientific article (publication date: 10 January 2003)

Photodynamic-Immune Checkpoint Therapy Eradicates Local and Distant Tumors by CD8+ T Cells.

scientific article published on 29 August 2017

Plaque rupture complications in murine atherosclerotic vein grafts can be prevented by TIMP-1 overexpression

scientific article

Plasma nitrate+nitrite levels are regulated by ovarian steroids but do not correlate with trabecular bone mineral density in rats

scientific article

Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging

scientific article published on 08 June 2016

Preclinical studies on tumor-specific fluorescent targeting agents: the need for a gold standard of tumor localization

scientific article

Preclinical uPAR-targeted multimodal imaging of locoregional oral cancer.

scientific article published on 4 January 2017

Prognostic Significance of Periodic Acid-Schiff-Positive Patterns in Primary Breast Cancer and its Lymph Node Metastases

scientific article published on 01 March 2004

Prolonged in vivo gene silencing by electroporation-mediated plasmid delivery of small interfering RNA.

scientific article published on September 2007

Quantification of Adherent and Nonadherent Cells Cultured in 96-Well Plates Using the Supravital Stain Neutral Red ⬇️

scientific article published on 01 September 1993

Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and 99m Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients ⬇️

scientific article published on July 3, 2012

Randomized, double-blind comparison of indocyanine green with or without albumin premixing for near-infrared fluorescence imaging of sentinel lymph nodes in breast cancer patients

scientific article published on March 2011

Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro

scientific article

Regulation of Parathyroid Hormonelike Protein Production in Cultured Normal and Malignant Keratinocytes ⬇️

scientific article published on 01 February 1992

Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha

scientific article published on September 1995

Regulation of the production of plasminogen activators by bone resorption enhancing and inhibiting factors in three types of osteoblast-like cells

scientific article published on 01 September 1991

Removal of hematopoietic cells and macrophages from mouse bone marrow cultures: isolation of fibroblastlike stromal cells

scientific article published on 01 February 1994

Removal of serum factors by charcoal treatment promotes adipogenesis via a MAPK-dependent pathway.

scientific article published on January 2005

Role of Integrins in the Attachment of Metastatic Follicular Thyroid Carcinoma Cell Lines to Bone ⬇️

scientific article published on January 1, 1998

Role of astrocyte-derived tissue-type plasminogen activator in the regulation of endotoxin-stimulated nitric oxide production by microglial cells ⬇️

scientific article published on 01 February 1998

Role of fibroblasts in the regulation of proinflammatory interleukin IL-1, IL-6 and IL-8 levels induced by keratinocyte-derived IL-1.

scientific article published on June 1996

Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine

scientific article published on 25 January 2010

SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development

scientific article published in February 2007

SOST/sclerostin, an osteocyte-derived negative regulator of bone formation

scientific article

Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture.

scientific article published in August 2010

Sclerostin in Mineralized Matrices and van Buchem Disease

scientific article published on 01 June 2009

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

scientific article

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

scientific article

Sclerostin: current knowledge and future perspectives

scientific article

Sensitive dual color in vivo bioluminescence imaging using a new red codon optimized firefly luciferase and a green click beetle luciferase

scientific article (publication date: 2011)

Sex steroid metabolism in the tibial growth plate of the rat

scientific article published on 01 October 2002

Shifting focus in optical image-guided cancer therapy

scientific article published on February 2014

Single and combined effects of alphavbeta3- and alpha5beta1-integrins on capillary tube formation in a human fibrinous matrix

scientific article published on 16 May 2009

Stimulation of bone resorption by inflamed nasal mucosa, dermonecrotic toxin-containing conditioned medium from Pasteurella multocida, and purified dermonecrotic toxin from P. multocida

scientific article

Structural requirements for bisphosphonate actions in vitro

scientific article published on 01 December 1994

Synergistic effect of bisphosphonate and docetaxel on the growth of bone metastasis in an animal model of established metastatic bone disease

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Targeting Nanomedicine to Brain Tumors: Latest Progress and Achievements

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The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death.

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The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery

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The monoclonal antibodies 18d7/91f2 recognize a receptor regulatory protein on mouse bone marrow stromal cells

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The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates

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The role of interleukin-6 in the induction of hypercalcemia in renal cell carcinoma transplanted into nude mice

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The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells

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The use of bisphosphonates in the treatment of osteoporosis

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Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer

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Towards a successful clinical implementation of fluorescence-guided surgery

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Towards integrated analysis of longitudinal whole-body small animal imaging studies

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Traumatic Brain Injury: Preclinical Imaging Diagnostic(s) and Therapeutic Approaches

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Tumor growth delay by laser-generated shock waves

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Tumour progression and angiogenesis in bone metastasis from breast cancer: new approaches to an old problem

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Two distinct effects of recombinant human tumor necrosis factor-alpha on osteoclast development and subsequent resorption of mineralized matrix

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Ultrasound-mediated gene delivery of naked plasmid DNA in skeletal muscles: a case for bolus injections

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Uncomplicated differentiation of stem cells into bipolar neurons and myelinating glia

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Urokinase-receptor/integrin complexes are functionally involved in adhesion and progression of human breast cancer in vivo

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Use of a rat model for the simultaneous assessment of pharmacokinetic and pharmacodynamic aspects of bisphosphonate treatment: application to the study of intravenous 14C-labeled 1-hydroxy-3-(1-pyrrolidinyl)-propylidene-1,1-bisphosphonate

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VEGF and inhibitors of TGFbeta type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha5-integrin expression.

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Validation of a simple and fast method to quantify in vitro mineralization with fluorescent probes used in molecular imaging of bone

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Variations in surgical procedures for hind limb ischaemia mouse models result in differences in collateral formation.

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Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging

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Whole-body optical imaging in animal models to assess cancer development and progression

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Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

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Wnt signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

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pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology

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uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery

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