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List of works by John Silke

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

scientific article published in Nature Communications

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

scientific article

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

scientific article published on 19 June 2020

A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity

scientific article published on 21 September 2020

A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II

scientific article

A type III effector antagonizes death receptor signalling during bacterial gut infection

scientific article published on September 2013

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.

scientific article published on 03 May 2013

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

scientific article

Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

scientific article published on 25 April 2019

An appointment with death, : 2013 Cold Spring Harbor Asia meeting 'mechanisms and functions of non-apoptotic cell death'

scientific article

An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA

scientific article

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

scientific article published on 29 June 2020

Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism

scientific article published on 01 October 2001

Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation

scientific article

Another facet of ubiquitylation: death

scientific article published on 30 September 2009

Antagonism of IAPs Enhances CAR T-cell Efficacy

scientific article published on 16 January 2019

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

scientific article

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

scientific article

Asymmetric recruitment of cIAPs by TRAF2

scientific article

Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies

scientific article published on 15 April 2014

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.

scientific article

CARP2 deficiency does not alter induction of NF-kappaB by TNFalpha.

scientific article published in January 2009

CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex.

scientific article published on 29 August 2013

Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease

scientific article published on 08 July 2020

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

scientific journal article

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

scientific article

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus.

scientific article

Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo

scientific article published on 17 August 2020

Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors

scientific article published on 07 December 2018

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

scientific article

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

scientific article published on 27 June 2017

Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death

scientific article published on 14 October 2011

Cytoplasmic p53 is not required for PUMA-induced apoptosis

scientific article published on 09 November 2007

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response

scientific article published on 7 February 2011

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

scientific article

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

scientific article published on 19 April 2022

Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke

scientific journal article

Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.

scientific article published in June 2001

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

scientific article

Dysregulation of hepatocyte cell cycle and cell viability by hepatitis B virus

scientific article published on 26 September 2009

Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis.

scientific article published on 20 April 2015

Evidence for erosion of mouse CpG islands during mammalian evolution

article

Evolutionary divergence of the necroptosis effector MLKL.

scientific article published on 12 February 2016

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

scientific article

HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death

scientific article published on 2 October 2014

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death.

scientific article published on 14 January 2016

Hepatitis C virus-induced hepatocyte cell death and protection by inhibition of apoptosis

scientific article published on 27 June 2014

Hepatitis C-induced hepatocyte apoptosis following liver transplantation is enhanced by immunosuppressive agents

scientific article published on 11 May 2016

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

scientific article

HtrA2/Omi, a sheep in wolf's clothing

scientific article published in October 2003

Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease

scientific article

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

scientific article

IAP family of cell death and signaling regulators

scientific article

IAPS and ubiquitylation

scientific article published on 23 February 2012

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

scientific article published on 19 October 2008

IAPs limit activation of RIP kinases by TNF receptor 1 during development

scientific article published on 10 February 2012

IAPs, RINGs and ubiquitylation

scientific article

IAPs, TNF, inflammation and Jürg Tschopp; a personal perspective

scientific article published in January 2012

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

scientific article

Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs

scientific article published on 23 June 2006

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8

scientific article

Influence of DNA Sequence and Methylation Status on Bisulfite Conversion of Cytosine Residues

scientific article published in 1995

Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors

scientific article

Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation

scientific article

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation

scientific article published in February 2012

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

scientific article

Is SIRT2 required for necroptosis?

scientific article published on February 2014

Jekyll and Hyde; changing places, changing faces.

scientific article published in April 2002

Killing Lymphoma with Smac-Mimetics: As Easy as ABC?

scientific article published on April 2016

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

scientific article published in Nature Communications

Lack of reproducible growth inhibition by Schlafen1 and Schlafen2 in vitro

scientific article published on 13 May 2008

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

scientific article published on 18 November 2016

Linear ubiquitination prevents inflammation and regulates immune signalling

scientific article

Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.

scientific article

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

scientific article published on 19 June 2020

Mammalian mitochondrial IAP binding proteins ⬇️

scientific article published on May 9, 2003

Masters, marionettes and modulators: intersection of pathogen virulence factors and mammalian death receptor signaling

scientific article published on 22 June 2013

Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.

scientific article published on 18 February 2011

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

More than cell death: caspases and caspase inhibitors on the move

scientific article published in July 2004

NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2.

scientific article published on 8 November 2007

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

scientific article published on 2 January 2012

Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity

scientific article

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop

scientific article published on 17 August 2015

Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted

scientific article published on 11 December 2017

Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response

scientific article

Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins

scientific article published on 25 September 2008

Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury.

scientific article

New Perspectives in TNF-R1-Induced NF-κB Signaling

scientific article published on 01 January 2011

OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling

scientific article published in 2022

Programmed cell death: Superman meets Dr Death

scientific article

Progranulin does not inhibit TNF and lymphotoxin-α signalling through TNF receptor 1.

scientific article published on 8 October 2013

Questions & Controversies

scientific article published on 19 October 2015

RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.

scientific article published on 20 November 2009

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

scientific article published on 05 September 2018

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

scientific article

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

scientific article

Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs

scientific article published on January 2010

Response to Heard et al.

scientific article published in October 2015

Response to the letter to the editor

scientific article published on 01 April 2014

SPATA2 - Keeping the TNF signal short and sweet.

scientific article published on 28 July 2016

Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid?

scientific article published in December 2000

Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization

scientific article published on 10 March 2011

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

scientific article

Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment

scientific article

Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases

scientific article published in December 2010

TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL.

scientific article

TNF AND CD95 PROMOTE IL-8 GENE TRANSACTIVATION VIA INDEPENDENT ELEMENTS IN COLON CARCINOMA CELLS

article

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

scientific article published on December 2009

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

scientific article published on 23 December 2015

TWEAK shall inherit the earth

scientific article published on 25 August 2006

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

scientific article published on 7 July 2008

Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death

scientific article published on 11 May 2022

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

scientific article published in February 2016

Targeting triple-negative breast cancers with the Smac-mimetic birinapant

scientific article published on 27 April 2020

The FLIP Side of Life ⬇️

scientific article published on January 15, 2013

The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites

scientific article

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

scientific article published on 14 February 2018

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

scientific article

The diverse role of RIP kinases in necroptosis and inflammation

scientific article published on June 2015

The importance of being chaperoned: HSP90 and necroptosis

scientific article published on February 2016

The intersection of cell death and inflammasome activation

scientific article

The majority of long non-stop reading frames on the antisense strand can be explained by biased codon usage.

scientific article published on July 1997

The polycomb repressive complex 2 governs life and death of peripheral T cells

scientific article published on 20 June 2014

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

scientific article

The regulation of TNF signalling: what a tangled web we weave ⬇️

scientific article published on September 13, 2011

The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells

scientific article published on 25 September 2012

Till death do us part

scientific article published in July 2001

Transcriptional repression by methylation: cooperativity between a CpG cluster in the promoter and remote CpG-rich regions

scientific article published on 01 February 1996

Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins

scientific article published on 25 September 2008

Tumor immune evasion arises through loss of TNF sensitivity

scientific article published on 01 May 2018

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

scientific article

Ubiquitylation and cancer development

scientific article published on March 2008

Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis

scientific article published on 21 October 2003

Workshop summary: novel aspects of the functions of the TRAFs and cIAPs

scientific article published on 01 January 2011

XIAP discriminates between type I and type II FAS-induced apoptosis

scientific article

c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18.

scientific article published on September 2010

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

scientific article published on 04 February 2014

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