List of works - Juan Pedro Martinez-Barbera

60 YEARS OF NEUROENDOCRINOLOGY: Biology of human craniopharyngioma: lessons from mouse models

scientific article

Absence of SIX3 mutations in patients with congenital hypopituitarism

scientific article published on 01 December 2009

Activated WNT signaling in postnatal SOX2-positive dental stem cells can drive odontoma formation

scientific article

Adamantinomatous craniopharyngioma: pathology, molecular genetics and mouse models.

scientific article

Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage

scientific article

Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism

scientific article published on 6 November 2008

Author Correction: P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development

scientific article published in Nature Communications

CR-16EXPRESSION ANALYSIS OF ADAMANTINOMATOUS CRANIOPHARYNGIOMA REVEALS NETWORKS OF CO-EXPRESSED GENE NETWORKS ASSOCIATED WITH DIFFERENT CELLULAR COMPARTMENTS.

scientific article published on 30 May 2016

CTNNB1 mutations are clonal in adamantinomatous craniopharyngioma

scientific article published on 03 March 2020

Cell Senescence in Neuropathology: a Focus on Neurodegeneration and Tumours

scientific article published on 30 December 2020

Characterization of a novel HESX1 mutation in a pediatric case of septo-optic dysplasia.

scientific article published on 02 March 2017

Cloning and expression of three members of the zebrafish Bmp family: Bmp2a, Bmp2b and Bmp4.

scientific article published in October 1997

Cloning of a somatolactin-encoding cDNA from sole (Solea senegalensis).

scientific article published on September 1994

Cloning of the sole (Solea senegalensis) growth hormone-encoding cDNA.

scientific article published on August 1994

Cloning, expression, and characterization of a recombinant gilthead seabream growth hormone.

scientific article published on November 1994

Concise Review: Paracrine Role of Stem Cells in Pituitary Tumors: A Focus on Adamantinomatous Craniopharyngioma

scientific article

Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision

scientific article published on 19 February 2019

Conservation of BF-1 expression in amphioxus and zebrafish suggests evolutionary ancestry of anterior cell types that contribute to the vertebrate telencephalon.

scientific article published in October 1998

DNMT1 interacts with the developmental transcriptional repressor HESX1

scientific article

Developmental mechanisms directing early anterior forebrain specification in vertebrates

scientific article published on 09 February 2013

Dynamic haematopoietic cell contribution to the developing and adult epicardium

scientific article

Erratum: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

scholarly article published in Nature Cell Biology

Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors.

scholarly article

Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development

scientific journal article

Genetically engineered mouse models of craniopharyngioma: an opportunity for therapy development and understanding of tumor biology.

scientific article published on May 2017

Growth hormone as a function of age and dietary protein: energy ratio in a marine teleost, the gilthead sea bream (Sparus aurata)

scientific article published on 01 December 1996

HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain

scientific article

HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death

scientific article published on 2 October 2014

Heterozygous mutations of OTX2 cause severe ocular malformations

scientific article

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

scientific journal article

Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors

scientific article published on 14 August 2017

IMMU-05. MOLECULAR ANALYSES DEMONSTRATE AN IMMUNOSUPPRESSIVE PHENOTYPE IN THE CYST AND SOLID TUMOR COMPARTMENTS OF ADAMANTINOMATOUS CRANIOPHARYNGIOMA.

scientific article published on 31 May 2017

Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma

scientific article

Imaging Invasion: Micro-CT imaging of adamantinomatous craniopharyngioma highlights cell type specific spatial relationships of tissue invasion

scientific article (publication date: 2016)

In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A.

scientific article published on November 2005

Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans

scientific article

Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain

scientific article

Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement

scientific article

MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.

scientific article published on 15 May 2017

Magnetic resonance virtual histology for embryos: 3D atlases for automated high-throughput phenotyping

scientific article

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma.

scientific article

Molecular pathology of adamantinomatous craniopharyngioma: review and opportunities for practice

scientific article published on December 2016

NOA36/ZNF330 is a conserved cystein-rich protein with proapoptotic activity in human cells.

scientific article published on 4 November 2009

Neuropathy target esterase impairments cause Oliver-McFarlane and Laurence-Moon syndromes.

scientific article published on 05 December 2014

New outlook on the diagnosis, treatment and follow-up of childhood-onset craniopharyngioma

scientific article published on 3 February 2017

Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction

scientific article

Novel application of luciferase assay for the in vitro functional assessment of KAL1 variants in three females with septo-optic dysplasia (SOD).

scientific article published on 13 September 2015

Otx genes in evolution: are they involved in instructing the vertebrate brain morphology?

article

P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development.

scientific article

PCM-02A GENETICALLY ENGINEERED MOUSE MODEL RECAPITULATES RADIOLOGICAL FEATURES OF HUMAN ADAMANTINOMATOUS CRANIOPHARYNGIOMA.

scientific article

PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption.

scientific article published on 30 March 2012

Paracrine roles of cellular senescence in promoting tumourigenesis

scientific article published on 19 April 2018

Preclinical transgenic and patient-derived xenograft models recapitulate the radiological features of human adamantinomatous craniopharyngioma.

scientific article published on 8 May 2017

Role of Otx transcription factors in brain development

article

SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma

scientific article published on 01 March 2019

SOX2 haploinsufficiency is associated with slow progressing hypothalamo-pituitary tumours

scientific article

SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development

scientific article

SOX2 regulates the hypothalamic-pituitary axis at multiple levels

scientific article

SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer

scientific article

Senescence drives non-cell autonomous tumorigenesis in the pituitary gland.

scientific article published on 13 February 2018

Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential

scientific article published in October 2013

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.

scientific article published on 28 November 2017

Stem cells and their role in pituitary tumorigenesis

scientific article

Stem/progenitor cells in pituitary organ homeostasis and tumourigenesis

scientific article published on 30 August 2017

Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes.

scientific article published on 31 July 2009

Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes.

scientific article published in June 2010

Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis

scientific article

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

scientific article published on 07 December 2018

The future of genomic endocrinology.

scientific article published on 25 May 2011

The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation

scientific article (publication date: June 2000)

The role of the sonic hedgehog signalling pathway in patients with midline defects and congenital hypopituitarism

scientific article published on 9 December 2014

The use of recombinant gilthead sea bream (Sparus aurata) growth hormone for radioiodination and standard preparation in radioimmunoassay

scientific article published on 01 April 1995

Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans

scientific article published on 13 January 2016

Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target.

scientific article published on 14 March 2018

Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia.

scientific article published on 5 February 2013

WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome

scientific article published on 20 December 2017

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

scientific article

List of works by Juan Pedro Martinez-Barbera

60 YEARS OF NEUROENDOCRINOLOGY: Biology of human craniopharyngioma: lessons from mouse models

Absence of SIX3 mutations in patients with congenital hypopituitarism

Activated WNT signaling in postnatal SOX2-positive dental stem cells can drive odontoma formation

Adamantinomatous craniopharyngioma: pathology, molecular genetics and mouse models.

Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage

Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism

Author Correction: P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development

CR-16EXPRESSION ANALYSIS OF ADAMANTINOMATOUS CRANIOPHARYNGIOMA REVEALS NETWORKS OF CO-EXPRESSED GENE NETWORKS ASSOCIATED WITH DIFFERENT CELLULAR COMPARTMENTS.

CTNNB1 mutations are clonal in adamantinomatous craniopharyngioma

Cell Senescence in Neuropathology: a Focus on Neurodegeneration and Tumours

Characterization of a novel HESX1 mutation in a pediatric case of septo-optic dysplasia.

Cloning and expression of three members of the zebrafish Bmp family: Bmp2a, Bmp2b and Bmp4.

Cloning of a somatolactin-encoding cDNA from sole (Solea senegalensis).

Cloning of the sole (Solea senegalensis) growth hormone-encoding cDNA.

Cloning, expression, and characterization of a recombinant gilthead seabream growth hormone.

Concise Review: Paracrine Role of Stem Cells in Pituitary Tumors: A Focus on Adamantinomatous Craniopharyngioma

Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision

Conservation of BF-1 expression in amphioxus and zebrafish suggests evolutionary ancestry of anterior cell types that contribute to the vertebrate telencephalon.

DNMT1 interacts with the developmental transcriptional repressor HESX1

Developmental mechanisms directing early anterior forebrain specification in vertebrates

Dynamic haematopoietic cell contribution to the developing and adult epicardium

Erratum: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors.

Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development

Genetically engineered mouse models of craniopharyngioma: an opportunity for therapy development and understanding of tumor biology.

Growth hormone as a function of age and dietary protein: energy ratio in a marine teleost, the gilthead sea bream (Sparus aurata)

HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain

HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death

Heterozygous mutations of OTX2 cause severe ocular malformations

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors

IMMU-05. MOLECULAR ANALYSES DEMONSTRATE AN IMMUNOSUPPRESSIVE PHENOTYPE IN THE CYST AND SOLID TUMOR COMPARTMENTS OF ADAMANTINOMATOUS CRANIOPHARYNGIOMA.

Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma

Imaging Invasion: Micro-CT imaging of adamantinomatous craniopharyngioma highlights cell type specific spatial relationships of tissue invasion

In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A.

Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans

Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain

Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement

MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.

Magnetic resonance virtual histology for embryos: 3D atlases for automated high-throughput phenotyping

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma.

Molecular pathology of adamantinomatous craniopharyngioma: review and opportunities for practice

NOA36/ZNF330 is a conserved cystein-rich protein with proapoptotic activity in human cells.

Neuropathy target esterase impairments cause Oliver-McFarlane and Laurence-Moon syndromes.

New outlook on the diagnosis, treatment and follow-up of childhood-onset craniopharyngioma

Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction

Novel application of luciferase assay for the in vitro functional assessment of KAL1 variants in three females with septo-optic dysplasia (SOD).

Otx genes in evolution: are they involved in instructing the vertebrate brain morphology?

P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development.

PCM-02A GENETICALLY ENGINEERED MOUSE MODEL RECAPITULATES RADIOLOGICAL FEATURES OF HUMAN ADAMANTINOMATOUS CRANIOPHARYNGIOMA.

PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption.

Paracrine roles of cellular senescence in promoting tumourigenesis

Preclinical transgenic and patient-derived xenograft models recapitulate the radiological features of human adamantinomatous craniopharyngioma.

Role of Otx transcription factors in brain development

SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma

SOX2 haploinsufficiency is associated with slow progressing hypothalamo-pituitary tumours

SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development

SOX2 regulates the hypothalamic-pituitary axis at multiple levels

SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer

Senescence drives non-cell autonomous tumorigenesis in the pituitary gland.

Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.

Stem cells and their role in pituitary tumorigenesis

Stem/progenitor cells in pituitary organ homeostasis and tumourigenesis

Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes.

Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes.

Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

The future of genomic endocrinology.

The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation

The role of the sonic hedgehog signalling pathway in patients with midline defects and congenital hypopituitarism

The use of recombinant gilthead sea bream (Sparus aurata) growth hormone for radioiodination and standard preparation in radioimmunoassay

Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans

Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target.

Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia.

WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype