List of works - Juan Pedro Martinez-Barbera

Heterozygous mutations of OTX2 cause severe ocular malformations

scientific article

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

scientific article

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

scientific journal article

The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation

scientific article (publication date: June 2000)

Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential

scientific article published in October 2013

In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A.

scientific article published on November 2005

Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans

scientific article

Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis

scientific article

HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death

scientific article published on 2 October 2014

Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement

scientific article

Cloning and expression of three members of the zebrafish Bmp family: Bmp2a, Bmp2b and Bmp4.

scientific article published in October 1997

SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development

scientific article

Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma

scientific article

Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage

scientific article

Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes.

scientific article published on 31 July 2009

Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain

scientific article

Conservation of BF-1 expression in amphioxus and zebrafish suggests evolutionary ancestry of anterior cell types that contribute to the vertebrate telencephalon.

scientific article published in October 1998

SOX2 regulates the hypothalamic-pituitary axis at multiple levels

scientific article

Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction

scientific article

Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development

scientific journal article

Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors.

scholarly article

PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption.

scientific article published on 30 March 2012

Magnetic resonance virtual histology for embryos: 3D atlases for automated high-throughput phenotyping

scientific article

Developmental mechanisms directing early anterior forebrain specification in vertebrates

scientific article published on 09 February 2013

Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2

scientific article published on December 1, 2001

Neuropathy target esterase impairments cause Oliver-McFarlane and Laurence-Moon syndromes.

scientific article published on 05 December 2014

Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism

scientific article published on 6 November 2008

HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain

scientific article

Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia.

scientific article published on 5 February 2013

New outlook on the diagnosis, treatment and follow-up of childhood-onset craniopharyngioma

scientific article published on 3 February 2017

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.

scientific article published on 28 November 2017

Adamantinomatous craniopharyngioma: pathology, molecular genetics and mouse models.

scientific article

SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer

scientific article

DNMT1 interacts with the developmental transcriptional repressor HESX1

scientific article

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma.

scientific article

Cloning, expression, and characterization of a recombinant gilthead seabream growth hormone.

scientific article published on November 1994

Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans

scientific article published on 13 January 2016

Concise Review: Paracrine Role of Stem Cells in Pituitary Tumors: A Focus on Adamantinomatous Craniopharyngioma

scientific article

MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.

scientific article published on 15 May 2017

Dynamic haematopoietic cell contribution to the developing and adult epicardium

scientific article

SOX2 haploinsufficiency is associated with slow progressing hypothalamo-pituitary tumours

scientific article

Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target

scientific article published on 14 March 2018

Activated WNT signaling in postnatal SOX2-positive dental stem cells can drive odontoma formation

scientific article

Molecular pathology of adamantinomatous craniopharyngioma: review and opportunities for practice

scientific article published on December 2016

60 YEARS OF NEUROENDOCRINOLOGY: Biology of human craniopharyngioma: lessons from mouse models

scientific article

Imaging Invasion: Micro-CT imaging of adamantinomatous craniopharyngioma highlights cell type specific spatial relationships of tissue invasion

scientific article (publication date: 2016)

WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome

scientific article published on 20 December 2017

Paracrine roles of cellular senescence in promoting tumourigenesis

scientific article published on 19 April 2018

Cloning of a somatolactin-encoding cDNA from sole (Solea senegalensis).

scientific article published on September 1994

P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development.

scientific article

List of works by Juan Pedro Martinez-Barbera

Heterozygous mutations of OTX2 cause severe ocular malformations

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation

Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential

In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A.

Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans

Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis

HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death

Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement

Cloning and expression of three members of the zebrafish Bmp family: Bmp2a, Bmp2b and Bmp4.

SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development

Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma

Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage

Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes.

Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain

Conservation of BF-1 expression in amphioxus and zebrafish suggests evolutionary ancestry of anterior cell types that contribute to the vertebrate telencephalon.

SOX2 regulates the hypothalamic-pituitary axis at multiple levels

Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction

Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development

Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors.

PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption.

Magnetic resonance virtual histology for embryos: 3D atlases for automated high-throughput phenotyping

Developmental mechanisms directing early anterior forebrain specification in vertebrates

Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2

Neuropathy target esterase impairments cause Oliver-McFarlane and Laurence-Moon syndromes.

Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism

HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain

Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia.

New outlook on the diagnosis, treatment and follow-up of childhood-onset craniopharyngioma

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.

Adamantinomatous craniopharyngioma: pathology, molecular genetics and mouse models.

SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer

DNMT1 interacts with the developmental transcriptional repressor HESX1

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma.

Cloning, expression, and characterization of a recombinant gilthead seabream growth hormone.

Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans

Concise Review: Paracrine Role of Stem Cells in Pituitary Tumors: A Focus on Adamantinomatous Craniopharyngioma

MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.

Dynamic haematopoietic cell contribution to the developing and adult epicardium

SOX2 haploinsufficiency is associated with slow progressing hypothalamo-pituitary tumours

Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target

Activated WNT signaling in postnatal SOX2-positive dental stem cells can drive odontoma formation

Molecular pathology of adamantinomatous craniopharyngioma: review and opportunities for practice

60 YEARS OF NEUROENDOCRINOLOGY: Biology of human craniopharyngioma: lessons from mouse models

Imaging Invasion: Micro-CT imaging of adamantinomatous craniopharyngioma highlights cell type specific spatial relationships of tissue invasion

WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome

Paracrine roles of cellular senescence in promoting tumourigenesis

Cloning of a somatolactin-encoding cDNA from sole (Solea senegalensis).

P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development.