List of works - Boon Chuan Low

A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation

scientific article published on 4 August 2008

A cooperative jack model of random coil-to-elongation transition of the FH1 domain by profilin binding explains formin motor behavior in actin polymerization

article

A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning

scientific article

Activation of AKT-mTOR Signaling Directs Tenogenesis of Mesenchymal Stem Cells.

scientific article published on 4 January 2018

Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain

scientific article

Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration

scientific article

Actomyosin Contractility Drives Bile Regurgitation as an Early Homeostatic Response to Increased Biliary Pressure in Obstructive Cholestasis

Actomyosin contractility drives bile regurgitation as an early response during obstructive cholestasis

scientific article published on 8 February 2017

An integrated mathematical model of thrombin-, histamine-and VEGF-mediated signalling in endothelial permeability ⬇️

scientific article published on July 15, 2011

Angiotensin II stimulates system y+ and cationic amino acid transporter gene expression in cultured vascular smooth muscle cells

scientific journal article

Annexin-A1 controls an ERK-RhoA-NFκB activation loop in breast cancer cells.

scientific article published on 9 April 2015

Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling

scientific article (publication date: 2 July 1999)

BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain.

scientific article

BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation

scientific article published on 31 July 2020

BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis

scientific article published on 2 September 2015

BNIP-Salpha induces cell rounding and apoptosis by displacing p50RhoGAP and facilitating RhoA activation via its unique motifs in the BNIP-2 and Cdc42GAP homology domain.

scientific article published on April 2006

BNIP2 extra long inhibits RhoA and cellular transformation by Lbc RhoGEF via its BCH domain

scientific article

BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration

scientific article

Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels

scientific article

Characterization of system L and system y+ amino acid transport activity in cultured vascular smooth muscle cells

Concerted modulation of paxillin dynamics at focal adhesions by Deleted in Liver Cancer-1 and focal adhesion kinase during early cell spreading

scientific article published in December 2014

Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1

scientific journal article

Correction: Molecular Mechanistic Insights into the Endothelial Receptor Mediated Cytoadherence of -Infected Erythrocytes

Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control

scientific article

Cross-species analyses identify the BNIP-2 and Cdc42GAP homology (BCH) domain as a distinct functional subclass of the CRAL_TRIO/Sec14 superfamily

scientific article

Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models

scientific article published in July 2013

Derivation of stable microarray cancer-differentiating signatures using consensus scoring of multiple random sampling and gene-ranking consistency evaluation.

scientific article published on October 2007

Differential Depth Sensing Reduces Cancer Cell Proliferation via Rho-Rac-Regulated Invadopodia

scientific article published on 27 June 2017

Enhanced tumor cell killing by ultrasound after microtubule depolymerization

scientific article published on 11 June 2021

Epidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2A

scientific article

Evaluation of virtual screening performance of support vector machines trained by sparsely distributed active compounds.

scientific article

Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2

scientific article

Functional plasticity of the BNIP-2 and Cdc42GAP Homology (BCH) domain in cell signaling and cell dynamics

scientific article published on 21 April 2012

Growth factors stimulate tyrosine dephosphorylation of p75 and its dissociation from the SH2 domain of Grb2.

scientific article published on November 1997

Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing.

scientific article published on November 2010

In-silico approaches to multi-target drug discovery : computer aided multi-target drug design, multi-target virtual screening

scientific article published on 11 March 2010

Interaction of interferon-gamma and epidermal growth factor in the regulation of nitric oxide production and cellular proliferation in a cultured murine mammary cell line, COMMA-D.

scientific article published on May 1997

Interleukin-1 beta and tumor necrosis factor-alpha stimulate the cat-2 gene of the L-arginine transporter in cultured vascular smooth muscle cells

scientific journal article

Juxtanodin: an oligodendroglial protein that promotes cellular arborization and 2',3'-cyclic nucleotide-3'-phosphodiesterase trafficking

scientific journal article

K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis

scientific article

KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.

scientific article

Mechanobiology of Tumor Growth

Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling

scientific article

Molecular mechanistic insights into the endothelial receptor mediated cytoadherence of Plasmodium falciparum-infected erythrocytes

scientific article

Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment.

scientific article

Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons

scientific article

NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force

scientific article (publication date: 2016)

Pathway sensitivity analysis for detecting pro-proliferation activities of oncogenes and tumor suppressors of epidermal growth factor receptor-extracellular signal-regulated protein kinase pathway at altered protein levels

scientific article published in September 2009

Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling

scientific journal article

Reporter Gene System: Green Fluorescent Protein

article

RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous: use of zebrafish as an in vivo model for GTPase signaling

scientific article published on 14 July 2005

SHP2 Associates Directly with Tyrosine Phosphorylated p90 (SNT) Protein in FGF-Stimulated Cells ⬇️

scientific article published on September 8, 1997

Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin

scientific article

Simulation of crosstalk between small GTPase RhoA and EGFR-ERK signaling pathway via MEKK1.

scientific article

Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk

scientific article published on 27 May 2008

SmgGDS antagonizes BPGAP1-induced Ras/ERK activation and neuritogenesis in PC12 cell differentiation

scientific article

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

scientific article

Structural Basis for a Unique ATP Synthase Core Complex from Nanoarcheaum equitans

scientific article

Structural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA)

scientific article

Structural basis for exploring the allosteric inhibition of human kidney type glutaminase

scientific article published on 22 July 2016

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

scientific article

Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2

scientific article

The BNIP-2 and Cdc42GAP homology (BCH) domain of p50RhoGAP/Cdc42GAP sequesters RhoA from inactivation by the adjacent GTPase-activating protein domain.

scientific article

The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence

scientific article

The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

scientific article

The bi-lobe-associated LRRP1 regulates Ran activity in Trypanosoma brucei

scientific article published on 12 September 2014

Topography induces differential sensitivity on cancer cell proliferation via Rho-ROCK-Myosin contractility

scientific article published on 22 January 2016

Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42

scientific article (publication date: 12 November 1999)

Using zebrafish for studying Rho GTPases signaling in vivo

scientific article

YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis

scientific article

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

scientific article published on 18 April 2014

List of works by Boon Chuan Low

A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation

A cooperative jack model of random coil-to-elongation transition of the FH1 domain by profilin binding explains formin motor behavior in actin polymerization

A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning

Activation of AKT-mTOR Signaling Directs Tenogenesis of Mesenchymal Stem Cells.

Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain

Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration

Actomyosin Contractility Drives Bile Regurgitation as an Early Homeostatic Response to Increased Biliary Pressure in Obstructive Cholestasis

Actomyosin contractility drives bile regurgitation as an early response during obstructive cholestasis

An integrated mathematical model of thrombin-, histamine-and VEGF-mediated signalling in endothelial permeability ⬇️

Angiotensin II stimulates system y+ and cationic amino acid transporter gene expression in cultured vascular smooth muscle cells

Annexin-A1 controls an ERK-RhoA-NFκB activation loop in breast cancer cells.

Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling

BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain.

BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation

BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis

BNIP-Salpha induces cell rounding and apoptosis by displacing p50RhoGAP and facilitating RhoA activation via its unique motifs in the BNIP-2 and Cdc42GAP homology domain.

BNIP2 extra long inhibits RhoA and cellular transformation by Lbc RhoGEF via its BCH domain

BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration

Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels

Characterization of system L and system y+ amino acid transport activity in cultured vascular smooth muscle cells

Concerted modulation of paxillin dynamics at focal adhesions by Deleted in Liver Cancer-1 and focal adhesion kinase during early cell spreading

Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1

Correction: Molecular Mechanistic Insights into the Endothelial Receptor Mediated Cytoadherence of -Infected Erythrocytes

Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control

Cross-species analyses identify the BNIP-2 and Cdc42GAP homology (BCH) domain as a distinct functional subclass of the CRAL_TRIO/Sec14 superfamily

Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models

Derivation of stable microarray cancer-differentiating signatures using consensus scoring of multiple random sampling and gene-ranking consistency evaluation.

Differential Depth Sensing Reduces Cancer Cell Proliferation via Rho-Rac-Regulated Invadopodia

Enhanced tumor cell killing by ultrasound after microtubule depolymerization

Epidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2A

Evaluation of virtual screening performance of support vector machines trained by sparsely distributed active compounds.

Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2

Functional plasticity of the BNIP-2 and Cdc42GAP Homology (BCH) domain in cell signaling and cell dynamics

Growth factors stimulate tyrosine dephosphorylation of p75 and its dissociation from the SH2 domain of Grb2.

Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing.

In-silico approaches to multi-target drug discovery : computer aided multi-target drug design, multi-target virtual screening

Interaction of interferon-gamma and epidermal growth factor in the regulation of nitric oxide production and cellular proliferation in a cultured murine mammary cell line, COMMA-D.

Interleukin-1 beta and tumor necrosis factor-alpha stimulate the cat-2 gene of the L-arginine transporter in cultured vascular smooth muscle cells

Juxtanodin: an oligodendroglial protein that promotes cellular arborization and 2',3'-cyclic nucleotide-3'-phosphodiesterase trafficking

K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis

KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.

Mechanobiology of Tumor Growth

Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling

Molecular mechanistic insights into the endothelial receptor mediated cytoadherence of Plasmodium falciparum-infected erythrocytes

Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment.

Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons

NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force

Pathway sensitivity analysis for detecting pro-proliferation activities of oncogenes and tumor suppressors of epidermal growth factor receptor-extracellular signal-regulated protein kinase pathway at altered protein levels

Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling

Reporter Gene System: Green Fluorescent Protein

RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous: use of zebrafish as an in vivo model for GTPase signaling

SHP2 Associates Directly with Tyrosine Phosphorylated p90 (SNT) Protein in FGF-Stimulated Cells ⬇️

Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin

Simulation of crosstalk between small GTPase RhoA and EGFR-ERK signaling pathway via MEKK1.

Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk

SmgGDS antagonizes BPGAP1-induced Ras/ERK activation and neuritogenesis in PC12 cell differentiation

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

Structural Basis for a Unique ATP Synthase Core Complex from Nanoarcheaum equitans

Structural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA)

Structural basis for exploring the allosteric inhibition of human kidney type glutaminase

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2

The BNIP-2 and Cdc42GAP homology (BCH) domain of p50RhoGAP/Cdc42GAP sequesters RhoA from inactivation by the adjacent GTPase-activating protein domain.

The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence

The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

The bi-lobe-associated LRRP1 regulates Ran activity in Trypanosoma brucei

Topography induces differential sensitivity on cancer cell proliferation via Rho-ROCK-Myosin contractility

Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42

Using zebrafish for studying Rho GTPases signaling in vivo

YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

ZO-2 induces cytoplasmic retention of YAP by promoting a LATS1-ZO-2-YAP complex at tight junctions