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Authors whose works are in public domain in at least one jurisdiction

List of works by Hirotaka Watada

2-Methoxyestradiol ameliorates glucose tolerance with the increase in β-cell mass in db/db mice

scientific article

2-Methoxyestradiol reduces monocyte adhesion to aortic endothelial cells in ovariectomized rats

scientific article published on 08 September 2007

A decrease in plasma glucose levels is required for increased endogenous glucose production with a single administration of an SGLT2 inhibitor tofogliflozin

scientific article published on 29 December 2020

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

scientific article published on 05 September 2010

A new En face method is useful to quantitate endothelial damage in vivo

scientific article published on 01 September 2003

A single nucleotide polymorphism in KCNQ1 is associated with susceptibility to diabetic nephropathy in japanese subjects with type 2 diabetes.

scientific article published on 7 January 2010

A single nucleotide polymorphism within DUSP9 is associated with susceptibility to type 2 diabetes in a Japanese population

scientific article

A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations

scientific article

Acarbose improves glycemic control and reduces body weight: Subanalysis data of South Asia region

scientific article

Acarbose reduces body weight irrespective of glycemic control in patients with diabetes: results of a worldwide, non-interventional, observational study data pool

scientific article

Acarbose, an alpha-glucosidase inhibitor, improves endothelial dysfunction in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation

scientific article published on 02 May 2006

Accumulation of somatic mutation in mitochondrial DNA and atherosclerosis in diabetic patients

scientific article

Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice

scientific article

Activin A-induced expression of PAX4 in AR42J-B13 cells involves the increase in transactivation of E47/E12.

scientific article published on January 2006

Aldose reductase inhibitor, epalrestat, reduces lipid hydroperoxides in type 2 diabetes.

scientific article

Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A).

scientific article published on December 2015

Alpha-glucosidase inhibitor, acarbose, improves glycamic control and reduces body weight in type 2 diabetes: Findings on indian patients from the pooled data analysis

scientific article

Alterations in the mitral flow velocity pattern induced by acute myocardial infarction. Doppler findings before and after infarction

scientific article published on 01 May 1995

Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice

scientific article published on 09 November 2006

Angiotensin II receptor blocker provides pancreatic beta-cell protection independent of blood pressure lowering in diabetic db/db mice

scientific article published in February 2007

Angiotensin II type 1 receptor blocker reduces monocyte adhesion to endothelial cells in spontaneously hypertensive rats

scientific article published on 20 July 2007

Anti-oxidative effect of fluvastatin in hyperlipidemic type 2 diabetic patients.

scientific article

Assessing the clinical utility of a genetic risk score constructed using 49 susceptibility alleles for type 2 diabetes in a Japanese population

scientific article published on 16 August 2013

Association between atherosclerosis and newly classified chronic kidney disease stage for Japanese patients with type 2 diabetes.

scientific article published on 14 February 2009

Association between expression of FABPpm in skeletal muscle and insulin sensitivity in intramyocellular lipid-accumulated nonobese men

scientific article published on 17 June 2014

Association between myocardial triglyceride content and cardiac function in healthy subjects and endurance athletes.

scientific article

Association of C-reactive protein with early-stage carotid atherosclerosis in Japanese patients with early-state type 2 diabetes mellitus

scientific article published on 23 August 2006

Association of T2 relaxation time determined by magnetic resonance imaging and intramyocellular lipid content of the soleus muscle in healthy subjects

scientific article

Association of methylenetetrahydrofolate reductase gene polymorphism with carotid arterial wall thickening and myocardial infarction risk in NIDDM

scientific article published on 01 December 1997

Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese

scientific article

Attempted suicide with liraglutide overdose did not induce hypoglycemia ⬇️

scientific article published on November 11, 2012

Autophagy in health and disease. 4. The role of pancreatic beta-cell autophagy in health and diabetes.

scientific article published on 24 March 2010

Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

scientific article published on October 2008

Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter

scientific article (publication date: 24 November 2000)

Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice

scientific article published on 21 April 2006

Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlled db/db mice

scientific article published on 05 October 2013

Benefits of the fixed-ratio combination of insulin glargine 100 units/mL and lixisenatide (iGlarLixi) in Japanese people with type 2 diabetes: A subgroup and time-to-control analysis of the LixiLan JP phase 3 trials

scientific article published on 01 September 2020

Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains.

scientific article published on May 2000

Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease: An Individual Participant Data Meta-Analysis.

scientific article

Carotid intima-media thickness progression predicts cardiovascular events in Japanese patients with type 2 diabetes ⬇️

scientific article published on July 5, 2013

Changes in carotid intima-media thickening in patients with type 2 diabetes mellitus: Subanalysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation.

scientific article published on March 2017

Characteristics associated with elevated 1-h plasma glucose levels during a 75-g oral glucose tolerance test in non-obese Japanese men

scientific article published on 04 March 2020

Characteristics of Japanese subjects who progress from normal to impaired glucose tolerance. Longitudinal study excluding changes in body weight.

scientific article published in December 2005

Characteristics of patients with graves disease and intrathyroid hypovascularity compared to painless thyroiditis.

scientific article

Chemotactic cytokine receptor 5 (CCR5) gene promoter polymorphism (59029A/G) is associated with diabetic nephropathy in Japanese patients with type 2 diabetes: a 10-year longitudinal study

scientific article published on 25 January 2006

Chronological analysis with fluorescent timer reveals unique features of newly generated β-cells.

scientific article published on 16 May 2014

Clinical characteristics influencing the effectiveness of metformin on Japanese type 2 diabetes receiving sulfonylureas

scientific article published on 16 February 2007

Clinical evidence regarding factors linking metabolic abnormal obesity to pancreatic beta cell dysfunction

scientific article published on 04 April 2020

Combination therapy of miglitol and insulin in type 1 diabetes mellitus patients.

scientific article

Combination treatment of db/db mice with exendin-4 and gastrin preserves β-cell mass by stimulating β-cell growth and differentiation.

scientific article

Combined expression of transcription factors induces AR42J-B13 cells to differentiate into insulin-producing cells.

scientific article

Comparison of effects of azelnidipine and trichlormethiazide in combination with olmesartan on blood pressure and metabolic parameters in hypertensive type 2 diabetic patients

scientific article

Comparison of effects of cilnidipine and azelnidipine on blood pressure, heart rate and albuminuria in type 2 diabetics with hypertension: A pilot study

scientific article

Comparison of effects of pitavastatin and atorvastatin on glucose metabolism in type 2 diabetic patients with hypercholesterolemia

scientific article

Comparison of glycated albumin (GA) and glycated hemoglobin (HbA1c) in type 2 diabetic patients: usefulness of GA for evaluation of short-term changes in glycemic control

scientific article published on 11 December 2006

Comparison of insulin lispro mix 25 with insulin lispro mix 50 as an insulin starter in Asian patients with type 2 diabetes: a phase 4, open-label, randomized trial (CLASSIFY study).

scientific article published on 7 May 2016

Comparison of sitagliptin with nateglinide on postprandial glucose and related hormones in drug-naïve Japanese patients with type 2 diabetes mellitus: A pilot study

scientific article

Comparison of the therapeutic effects of prednisolone and nonsteroidal anti-inflammatory drugs in patients with subacute thyroiditis

scientific article published on 29 September 2016

Comparison of thrice-daily lispro 50/50 vs thrice-daily lispro in combination with sulfonylurea as initial insulin therapy for type 2 diabetes

scientific article

Continuous glucose monitoring system: Is it really accurate, safe and clinically useful?

scientific article published on June 2012

Coronary microvascular function is independently associated with left ventricular filling pressure in patients with type 2 diabetes mellitus

scientific article published on 5 August 2015

Correlates of insulin clearance in apparently healthy non-obese Japanese men.

scientific article

Cutoff value of thyroid uptake of (99m)Tc-pertechnetate to discriminate between Graves' disease and painless thyroiditis: a single center retrospective study.

scientific article published on 19 November 2015

Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan

scientific article published on 01 August 1997

Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men.

scientific article

Diabetes mellitus related common medical disorders: recent progress in diagnosis and treatment. Topics: I. Pathophysiology, diagnosis and treatment; 11. Atherosclerosis

scientific article published in April 2013

Differences between rosuvastatin and atorvastatin in lipid-lowering action and effect on glucose metabolism in Japanese hypercholesterolemic patients with concurrent diabetes. Lipid-lowering with highly potent statins in hyperlipidemia with type 2 d

scientific article published on 02 September 2014

Diffusional kurtosis imaging analysis in patients with hypertension.

scientific article published on 11 January 2014

Disorder of vascular smooth muscle cell and platelet function in diabetes

scientific article published in May 2010

Disorganized Steroidogenesis in Adrenocortical Carcinoma, a Case Study

scientific article published on 18 July 2016

Distinct gene expression programs function in progenitor and mature islet cells.

scientific article published on 25 February 2003

Dobutamine stress echocardiography predicts reversible dysfunction and quantitates the extent of irreversibly damaged myocardium after reperfusion of anterior myocardial infarction

scientific article published on 01 September 1994

Dose-Dependent Effect of Sitagliptin on Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus Receiving Insulin Treatment: A Post Hoc Analysis.

scientific article published on 20 September 2017

Dose-dependent requirement of patched homologue 1 in mouse pancreatic beta cell mass

scientific article

Downregulation of ZnT8 expression in pancreatic β-cells of diabetic mice

scientific article published on 01 September 2009

Dramatic improvement of blood glucose control after pioglitazone treatment in poorly controlled over-weight diabetic patients with myotonic dystrophy.

scientific article

EDIC(1) study

scientific article published on November 2010

ELMO1 increases expression of extracellular matrix proteins and inhibits cell adhesion to ECMs

scientific article published on 04 October 2006

Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis.

scientific article

Effect of AST-120 on Endothelial Dysfunction in Adenine-Induced Uremic Rats.

scientific article published on 14 April 2014

Effect of Real-life insulin pump with predictive low-glucose management use for 3 months: Analysis of the patients treated in a Japanese center

scientific article published on 06 May 2020

Effect of Repetitive Glucose Spike and Hypoglycaemia on Atherosclerosis and Death Rate in Apo E-Deficient Mice.

scientific article published on 20 August 2015

Effect of cilostazol, a phosphodiesterase inhibitor, on carotid IMT in Japanese type 2 diabetic patients.

scientific article published in December 2004

Effect of sitagliptin on plaque changes in coronary artery following acute coronary syndrome in diabetic patients: The ESPECIAL-ACS study

scientific article published on 15 September 2016

Effect of treatment guidance using a retrospective continuous glucose monitoring system on glycaemic control in outpatients with type 2 diabetes mellitus: A randomized controlled trial

scientific article published on 7 December 2015

Effects of Pemafibrate, a Novel Selective PPARα Modulator, on Lipid and Glucose Metabolism in Patients With Type 2 Diabetes and Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial

scientific article published on 3 January 2018

Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study

scientific article published on 09 January 2017

Effects of angiotensin II type 1 receptor blocker on islet of diabetic db/db mice

scientific article published in April 2007

Effects of changes in basal/total daily insulin ratio in type 2 diabetes patients on intensive insulin therapy including insulin glargine (JUN-LAN Study 6)

scientific article published on 16 May 2008

Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients.

scientific article

Effects of diet-induced moderate weight reduction on intrahepatic and intramyocellular triglycerides and glucose metabolism in obese subjects

scientific article

Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents.

scientific article published on 21 October 2009

Effects of linagliptin monotherapy compared with voglibose on postprandial blood glucose responses in Japanese patients with type 2 diabetes: Linagliptin Study of Effects on Postprandial blood glucose (L-STEP).

scientific article

Effects of linagliptin vs. voglibose on daily glucose excursions during continuous glucose monitoring of Japanese type 2 diabetes patients (L-CGM): A randomized, open-label, two-arm, parallel comparative trial.

scientific article published on 22 September 2017

Effects of sitagliptin on ectopic fat contents and glucose metabolism in type 2 diabetic patients with fatty liver: A pilot study

scientific article

Efficacy and Safety of 1:1 Fixed-Ratio Combination of Insulin Glargine and Lixisenatide Versus Lixisenatide in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs: The LixiLan JP-O1 Randomized Clinical Trial

scientific article published on 15 April 2020

Efficacy and Safety of Vildagliptin as an Add-On Therapy in Inadequately Controlled Type 2 Diabetes Patients Treated With Basal Insulin

scientific article published on 25 January 2017

Efficacy and safety of dapagliflozin in Japanese patients with inadequately controlled type 1 diabetes (DEPICT-5): 52-week results from a randomized, open-label, phase III clinical trial

scientific article published on 26 December 2019

Efficacy and safety of modified Yale insulin infusion protocol in Japanese diabetic patients after open-heart surgery.

scientific article published on 16 June 2008

Efficacy and safety of nateglinide plus vildagliptin combination therapy compared with switching to vildagliptin in type 2 diabetes patients inadequately controlled with nateglinide.

scientific article

Efficacy and safety of pemafibrate in people with type 2 diabetes and elevated triglyceride levels: 52-week data from the PROVIDE study

scientific article published on 01 April 2019

Efficacy and safety of sitagliptin in Japanese patients with type 2 diabetes

scientific article

Efficacy and safety of the GPR119 agonist DS-8500a in Japanese type 2 diabetes mellitus patients with inadequate glycemic control on sitagliptin: A phase 2 randomized placebo-controlled study.

scientific article published in April 2018

Efficacy of acarbose in different geographical regions of the world: analysis of a real-life database

scientific article published on 12 October 2014

Efficacy of pioglitazone on glycemic control and carotid intima-media thickness in type 2 diabetes patients with inadequate insulin therapy

scientific article

Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes

scientific article published on 17 April 2006

Endothelial PGC-1α mediates vascular dysfunction in diabetes.

scientific article

Erratum. Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A). Diabetes Care 2016;39

scientific article

Erratum. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE). A Randomized Controlled Trial. Diabet

scientific article published on 18 April 2017

Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer

scientific article published on 01 June 1994

Evaluation of myocardial triglyceride accumulation assessed on 1H-magnetic resonance spectroscopy in apparently healthy Japanese subjects

scientific article published in January 2015

Evanescent Hyperechoic Changes After Fine-Needle Aspiration Biopsy of the Thyroid in a Series With a Low Overall Prevalence of Complications

scientific article

Evidence-based comparison of glucagon-like peptide receptor agonists and sodium-glucose cotransporter 2 inhibitors

scientific article published on 17 September 2019

Exendin-4 improves β-cell function in autophagy-deficient β-cells

scientific journal article

Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces intimal thickening after vascular injury

scientific article published on 05 January 2011

Exercise-induced enhancement of insulin sensitivity is associated with accumulation of M2-polarized macrophages in mouse skeletal muscle

scientific article published on 10 October 2013

Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle

scientific article

Expression mechanism of tryptophan hydroxylase 1 in mouse islets during pregnancy

scientific article

Expression of CD38 gene, but not of mitochondrial glycerol-3-phosphate dehydrogenase gene, is impaired in pancreatic islets of GK rats

scientific article published on 01 September 1995

Expression of heparin-binding epidermal growth factor-like growth factor during pancreas development. A potential role of PDX-1 in transcriptional activation

scientific article published in November 1997

Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway.

scientific article published on October 2010

Fulminant emphysematous pyelonephritis (EPN) in a diabetic patient suspected of having multiple tumors

scientific article published on 01 November 2010

Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism.

scientific article published on 24 August 2017

GPR119 Agonist DS-8500a Effects on Pancreatic β-Cells in Japanese Type 2 Diabetes Mellitus Patients.

scientific article published on 6 April 2018

Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population

scientific article published on 10 September 2011

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

scientific article published on 28 January 2016

Genome-wide association study identifies three novel loci for type 2 diabetes

scientific article

Global Patterns of Comprehensive Cardiovascular Risk Factor Control in Patients with Type 2 Diabetes Mellitus: Insights from the DISCOVER Study

scientific article published on 26 August 2020

Glucagon like Peptide-1 and atherosclerosis.

scientific article published on December 2012

Glucose fluctuation on the progression of diabetic macroangiopathy--new findings from monocyte adhesion to endothelial cells

scientific article published on 25 April 2007

Glucose homeostasis in a diabetic patient during liver transplantation: a case report

scientific article published on 04 September 2007

Glucose monitoring after fruit peeling: pseudohyperglycemia when neglecting hand washing before fingertip blood sampling: wash your hands with tap water before you check blood glucose level ⬇️

scientific article published on 31 January 2011

Glycaemic control in patients with type 2 diabetes initiating second-line therapy: Results from the global DISCOVER study programme

scientific article published on 01 October 2019

Golgi membrane-associated degradation pathway in yeast and mammals.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Gut dysbiosis and detection of "live gut bacteria" in blood of Japanese patients with type 2 diabetes.

scientific article

Hypoglycemia following a nateglinide overdose in a suicide attempt.

scientific article published in January 2005

IRS-2 deficiency in macrophages promotes their accumulation in the vascular wall

scientific article published on 02 November 2011

Identification and comparison of insulin pharmacokinetics injected with a new 4-mm needle vs 6- and 8-mm needles accounting for endogenous insulin and C-peptide secretion kinetics in non-diabetic adult males

scientific article

Identification of subgroups of patients with type 2 diabetes with differences in renal function preservation, comparing patients receiving sodium-glucose co-transporter-2 inhibitors with those receiving dipeptidyl peptidase-4 inhibitors, using a sup

scientific article published on 03 June 2019

Impact of diet on the efficacy of insulin lispro mix 25 and insulin lispro mix 50 as starter insulin in East Asian patients with type 2 diabetes: Subgroup analysis of the Comparison Between Low Mixed Insulin and Mid Mixed Insulin as Starter Insulin

scientific article published on 05 October 2016

Impact of whole body irradiation and vascular endothelial growth factor-A on increased beta cell mass after bone marrow transplantation in a mouse model of diabetes induced by streptozotocin.

scientific article

Impaired insulin clearance as a cause rather than a consequence of insulin resistance.

scientific article published on 28 July 2017

Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice

scientific article published on 16 December 2006

Impaired peripheral insulin sensitivity in non-obese Japanese patients with type 2 diabetes mellitus and fatty liver.

scientific article published on 24 August 2017

Improvement of quality of life through glycemic control by liraglutide, a GLP-1 analog, in insulin-naive patients with type 2 diabetes mellitus: the PAGE1 study

scientific article published on 07 January 2017

In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid.

scientific article

Incidence and time course of left ventricular dilation in the early convalescent stage of reperfused anterior wall acute myocardial infarction

scientific article published on 01 March 1994

Increased expression of ERp57/GRP58 is protective against pancreatic beta cell death caused by autophagic failure

scientific journal article

Increased intramyocellular lipid/impaired insulin sensitivity is associated with altered lipid metabolic genes in muscle of high responders to a high-fat diet

scientific article

Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus ⬇️

scientific article published on February 27, 2013

Ingestion of an Exogenous Ketone Monoester Improves the Glycemic Response during Oral Glucose Tolerance Test in Subjects with Impaired Glucose Tolerance: A Crossover Randomized Trial

scientific article published on 03 October 2020

Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4.

scientific article

Insulin and nateglinide reduce monocyte adhesion to endothelial cells in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation

scientific article published on 18 September 2006

Insulin exocytosis in Goto-Kakizaki rat beta-cells subjected to long-term glinide or sulfonylurea treatment.

scientific article published in May 2008

Insulin lispro 25/75 and insulin lispro 50/50 as starter insulin in Japanese patients with type 2 diabetes: subanalysis of the CLASSIFY randomized trial

scientific article

Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice

scientific article

Lack of evident atherosclerosis despite multiple risk factors in glycogen storage disease type 1a with hyperadiponectinemia.

scientific article published in October 2007

Large-scale clinical studies on diabetic complications

scientific article published on April 2016

Letter by Watada et al regarding article, "Two-year clinical outcomes with drug-eluting stents for diabetic patients with de novo coronary lesion".

scientific article published in October 2008

Linagliptin monotherapy provides superior glycaemic control versus placebo or voglibose with comparable safety in Japanese patients with type 2 diabetes: a randomized, placebo and active comparator-controlled, double-blind study

scientific article published on 17 January 2012

Lipoprotein-X in cholestatic patients causes xanthomas and promotes foam cell formation in human macrophages

scientific article published on 5 November 2016

Long-term effect of combination therapy with mitiglinide and once daily insulin glargine in patients who were successfully switched from intensive insulin therapy in short-term study

scientific article published on 21 December 2006

Long-term efficacy of insulin glargine after switching from NPH insulin as intensive replacement of basal insulin in Japanese diabetes mellitus. Comparison of efficacy between type 1 and type 2 diabetes (JUN-LAN Study 1.2).

scientific article published on 14 November 2007

Long-term safety and efficacy of tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, as monotherapy or in combination with other oral antidiabetic agents in Japanese patients with type 2 diabetes mellitus: multicenter, open-label

scientific article published on 11 February 2014

Long-term safety of linagliptin monotherapy in Japanese patients with type 2 diabetes.

scientific article published on 7 December 2012

Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle

scientific article

Lower intake of saturated fatty acids is associated with persistently higher arterial stiffness in patients with type 2 diabetes

scientific article published on 06 July 2020

Masked Hypertension, Endothelial Dysfunction, and Arterial Stiffness in Type 2 Diabetes Mellitus: A Pilot Study ⬇️

scientific article published on November 17, 2011

Mechanism of progression of atherosclerosis in patients with impaired glucose tolerance (IGT)

scientific article

Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects.

scientific article published in September 2008

Minireview: Autophagy in pancreatic β-cells and its implication in diabetes

scientific article

Monocyte and Basophil Counts as Predictors of Neutrophil Count Recovery in Patients with Thiamazole-Induced Agranulocytosis

scientific article published on 24 May 2016

Morningness-eveningness questionnaire score and metabolic parameters in patients with type 2 diabetes mellitus

scientific article published on 7 August 2014

Morningness-eveningness questionnaire score correlates with glycated hemoglobin in middle-aged male workers with type 2 diabetes mellitus

scientific article

Myocardial triglyceride content in patients with left ventricular hypertrophy: comparison between hypertensive heart disease and hypertrophic cardiomyopathy

scientific article published on 3 May 2016

N-(carboxymethyl)valine residues in hemoglobin (CMV-Hb) reflect accumulation of oxidative stress in diabetic patients.

scientific article published on 13 April 2005

NEUROD1-deficient diabetes (MODY6): Identification of the first cases in Japanese and the clinical features.

scientific article

Nateglinide reduces carotid intima-media thickening in type 2 diabetic patients under good glycemic control

scientific article published on 13 September 2007

Neurogenin 3 is a key transcription factor for differentiation of the endocrine pancreas.

scientific article

Neurogenin3 activates the islet differentiation program while repressing its own expression

scientific article

Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4.

scientific article published on July 2003

New factors secreted from islets expand β-cell mass

scientific article published on 26 April 2013

New role for alpha cells as a source for new beta cells.

scientific article published on January 2011

Normal pancreatic β-cell function in mice with RIP-Cre-mediated inactivation of p62/SQSTM1.

scientific article published on 4 October 2017

One year follow-up after a randomized controlled trial of a 130 g/day low-carbohydrate diet in patients with type 2 diabetes mellitus and poor glycemic control

scientific article published on 4 December 2017

Overexpression of acetyl-coenzyme A carboxylase beta increases proinflammatory cytokines in cultured human renal proximal tubular epithelial cells

scientific article published in June 2010

Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase.

scientific article published in December 2003

PAX6 mutation as a genetic factor common to aniridia and glucose intolerance

scientific article

PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells.

scientific article published on August 2002

PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin

scientific article published on 01 December 1996

Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity.

scientific article

Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.

scientific article published on 16 July 2003

Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor linagliptin: a 4-week multicenter, randomized, double-blind, placebo-controlled phase IIa study in Japanese type 2 diabetes patients

scientific article published on 2 July 2011

Pharmacokinetics and pharmacodynamics of dapagliflozin in combination with insulin in Japanese patients with type 1 diabetes

scientific article published on 21 December 2018

Polymorphism of the solute carrier family 12 (sodium/chloride transporters) member 3, SLC12A3, gene at exon 23 (+78G/A: Arg913Gln) is associated with elevation of urinary albumin excretion in Japanese patients with type 2 diabetes: a 10-year longitu

scientific article published on 25 May 2005

Poor sleep quality is associated with increased arterial stiffness in Japanese patients with type 2 diabetes mellitus

scientific article published on 18 June 2015

Preferable effect of pravastatin compared to atorvastatin on beta cell function in Japanese early-state type 2 diabetes with hypercholesterolemia

scientific article published on 25 April 2007

Preliminary report: mitochondrial DNA 5178 polymorphism in male elite Japanese endurance runners

scientific article published on 29 August 2009

Presence of alpha-smooth muscle actin-positive endothelial cells in the luminal surface of adult aorta

scientific article published on 27 January 2009

Preserving expression of Pdx1 improves β-cell failure in diabetic mice

scientific article published on 22 December 2016

Prevalence of amiodarone-induced thyrotoxicosis and associated risk factors in Japanese patients.

scientific article

Probiotic reduces bacterial translocation in type 2 diabetes mellitus: A randomised controlled study

scientific article published on 21 September 2017

Probucol preserves pancreatic beta-cell function through reduction of oxidative stress in type 2 diabetes.

scientific article

Proposed Cutoff Value of Brachial-Ankle Pulse Wave Velocity for the Management of Hypertension.

scientific article

Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells

scientific article published on 29 November 2006

Protocol for a large-scale prospective observational study with alogliptin in patients with type 2 diabetes: J-BRAND Registry

scientific article

Rationale and Design for the J-DISCOVER Study: DISCOVERing the Treatment Reality of Type 2 Diabetes in a Real-World Setting in Japan-A Protocol.

scientific article published on 19 December 2017

Rationale and design of a randomized trial to test the safety and non-inferiority of canagliflozin in patients with diabetes with chronic heart failure: the CANDLE trial.

scientific article published on 4 April 2016

Rationale, Design, and Baseline Characteristics of the Utopia Trial for Preventing Diabetic Atherosclerosis Using an SGLT2 Inhibitor: A Prospective, Randomized, Open-Label, Parallel-Group Comparative Study.

scientific article published on September 2017

Rationale, design, and baseline characteristics of a clinical trial for prevention of atherosclerosis in patients with insulin-treated type 2 diabetes mellitus using DPP-4 inhibitor: the Sitagliptin Preventive study of Intima-media thickness Evaluat

scientific article published on 10 March 2014

Rationale, design, and baseline characteristics of a trial for the prevention of diabetic atherosclerosis using a DPP-4 inhibitor: the Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A).

scientific article published on 20 August 2013

Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1.

scientific article published on July 2004

Regulation of the pancreatic pro-endocrine gene neurogenin3.

scientific article

Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23-25 kg/m2.

scientific article published on 06 July 2016

Relationship between dietary pattern and cognitive function in elderly patients with type 2 diabetes mellitus.

scientific article published on 21 May 2015

Relationship between dietary patterns and risk factors for cardiovascular disease in patients with type 2 diabetes mellitus: a cross-sectional study

scientific article published on 4 February 2016

Relationship between frequency of hypoglycemic episodes and changes in carotid atherosclerosis in insulin-treated patients with type 2 diabetes mellitus

scientific article published on 9 January 2017

Relationship between olfactory dysfunction and cognitive impairment in elderly patients with type 2 diabetes mellitus

scientific article published on 5 October 2014

Relationships Among Conventional Cardiovascular Risk Factors and Lifestyle Habits With Arterial Stiffness in Type 2 Diabetic Patients.

scientific article published on 21 February 2017

Relationships between lifestyle patterns and cardio-renal-metabolic parameters in patients with type 2 diabetes mellitus: A cross-sectional study

scientific article

Repetitive hypoglycaemia increases serum adrenaline and induces monocyte adhesion to the endothelium in rat thoracic aorta ⬇️

scientific article published on April 16, 2011

Repetitive hypoglycemia increases circulating adrenaline level with resultant worsening of intimal thickening after vascular injury in male Goto-Kakizaki rat carotid artery

scientific article published on 31 March 2014

Repetitive postprandial hypertriglyceridemia induces monocyte adhesion to aortic endothelial cells in Goto-Kakizaki rats.

scientific article published in April 2008

Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta-Analysis of Genome-Wide Association Studies

scientific article

Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes

scientific article published on 7 May 2015

Replication study for the association of 9 East Asian GWAS-derived loci with susceptibility to type 2 diabetes in a Japanese population

scientific article

Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population

scientific article published on 18 April 2013

Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population

scientific article

Response to Comment on Mita et al. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomize

scientific article published on 01 July 2016

Retraction. Angiotensin II receptor blocker provides pancreatic beta-cell protection independent of blood pressure lowering in diabetic db/db mice

scientific article published on 01 October 2007

Role of autophagy in pancreatic beta-cell homeostasis

scientific article published on 01 May 2012

SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell

scientific article published on 20 May 2015

Safety and efficacy of metformin up-titration in Japanese patients with type 2 diabetes mellitus treated with vildagliptin and low-dose metformin

scientific article published on 15 November 2017

Sequential introduction and dosage balance of defined transcription factors affect reprogramming efficiency from pancreatic duct cells into insulin-producing cells.

scientific article published on 25 January 2014

Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy

scientific article

Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non-obese men

scientific article published on 05 February 2020

Strict glycemic control ameliorates the increase of carotid IMT in patients with type 2 diabetes

scientific article published in February 2006

Superior HbA1c control with the fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with a maximum dose of 50 units of insulin degludec in Japanese individuals with type 2 diabetes in a phase 3, double-blind, randomized t

scientific article published on 17 September 2019

Superior thyroid artery mean peak systolic velocity for the diagnosis of thyrotoxicosis in Japanese patients

scientific article published on 06 March 2010

Superior thyroid artery mean peak systolic velocity for the diagnosis of thyrotoxicosis in Japanese patients

scientific article published on 01 January 2010

Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells.

scientific article

Sustained expression of GLP-1 receptor differentially modulates β-cell functions in diabetic and nondiabetic mice

scientific article

Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice

scientific article published on 04 May 2007

Switching from Twice-Daily Basal Insulin Injections to Once-Daily Insulin Degludec Injection for Basal-Bolus Insulin Regimen in Japanese Patients with Type 1 Diabetes: A Pilot Study.

scientific article

Temporary hyperglycaemia provokes monocyte adhesion to endothelial cells in rat thoracic aorta.

scientific article published on 8 November 2005

The Arg192 isoform of paraoxonase with low sarin-hydrolyzing activity is dominant in the Japanese

scientific article published on 01 November 1997

The Effect of Sitagliptin on the Regression of Carotid Intima-Media Thickening in Patients with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation

scientific article

The Influence of Sitagliptin on Treatment-Related Quality of Life in Patients with Type 2 Diabetes Mellitus Receiving Insulin Treatment: A Prespecified Sub-Analysis

scientific article

The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

scientific article

The emerging role of autophagy in the pathophysiology of diabetes mellitus

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The impact of PNPLA3 and JAZF1 on hepatocellular carcinoma in non-viral hepatitis patients with type 2 diabetes mellitus.

scientific article published on 3 September 2015

The impact of strict glycemic control on diabetic microangiopathy

scientific article published on November 2010

The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients.

scientific article published in January 2003

The role of autophagy in pancreatic beta-cell and diabetes.

scientific article published on 19 February 2009

The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1.

scientific article

Therapeutic effectiveness of potassium iodine in drug-naïve patients with Graves' disease: a single-center experience

scientific article published on 4 February 2014

Towards an improved global understanding of treatment and outcomes in people with type 2 diabetes: Rationale and methods of the DISCOVER observational study program

scientific article published on 05 April 2017

Transforming growth factor β1 T868C gene polymorphism is associated with cerebral infarction in Japanese patients with type 2 diabetes

scientific article published on 31 August 2011

Treatment patterns and associated factors in 14 668 people with type 2 diabetes initiating a second-line therapy: Results from the global DISCOVER study programme

scientific article published on 05 August 2019

Type 2 Diabetes and Bacteremia.

scientific article published on 28 September 2017

Unappreciated role of low-density lipoprotein receptor-related protein 1 in pancreatic β cells: Multiple roles of low-density lipoprotein receptor-related protein 1 in glucose and lipid metabolism

scientific article published on 16 October 2018

White matter alteration in metabolic syndrome: diffusion tensor analysis

scientific article published on 19 November 2012

Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression

scientific article published on 30 August 2017

[ARB as a drug for diabetic microangiopathy]

scientific article published on 01 April 2009

[Autophagy in pancreatic β cells]

scientific article published on 01 August 2012

[Compensation and distress in pancreatic beta cells]

scientific article published on 01 May 2012

[Genetic factors of diabetes mellitus]

scientific article published on 01 January 2010

[Glinides]

scientific article published on 01 May 2012

[NEMOes, a new method to evaluate early atherosclerosis in rodent model]

scientific article published on 01 November 2006

[Organic solvent psychosis--report of two cases utilizing day care treatment]

scientific article published on 01 April 2007

[Protective effects of incretin on atherosclerosis]

scientific article published on 01 May 2011

[Sodium glucose cotransporter inhibitors]

scientific article published on 01 May 2012

[Targeted therapy for diabetes]

scientific article published on 01 November 2012

[The cutting-edge of medicine; autophagy in pancreatic beta cell--a novel pathogenic factor in diabetes]

scientific article published on 01 August 2011

[The measurement of intima-media thickness using carotid ultrasonography]

scientific article published on 01 January 2011

[The wrist-cutting syndrome]

scientific article published on 01 January 2003

[Transcription factors for the insulin gene]

scientific article published on 01 October 1994

β-cell autophagy: A novel mechanism regulating β-cell function and mass: Lessons from β-cell-specific Atg7-deficient mice.

scientific article published on September 2009

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