List of works - David Sedmera

A quantitative study of the ventricular myoarchitecture in the stage 21-29 chick embryo following decreased loading

scientific article published in April 1998

Abnormal myocardial and coronary vasculature development in experimental hypoxia

scientific article published on 01 October 2008

Acute temperature effects on function of the chick embryonic heart

scientific article published on 12 May 2016

Adenylyl cyclase signaling in the developing chick heart: the deranging effect of antiarrhythmic drugs

scientific article

Adverse effects of Hif1a mutation and maternal diabetes on the offspring heart.

scientific article

Analysis of Siamese Crocodile (Crocodylus siamensis) Eggshell Proteome

scientific article published on 22 November 2017

Apoptosis and epicardial contributions act as complementary factors in remodeling of the atrioventricular canal myocardium and atrioventricular conduction patterns in the embryonic chick heart

scientific article published on 28 August 2018

Arrhythmias in the developing heart.

scientific article

Bendiocarb effect on liver and central nervous system in the chick embryo.

scientific article

Blood-borne stem cells differentiate into vascular and cardiac lineages during normal development

scientific article published on 01 February 2006

Cardiac expression patterns of endothelin-converting enzyme (ECE): implications for conduction system development.

scientific article published on June 2008

Cardiac neural crest ablation inhibits compaction and electrical function of conduction system bundles

scientific article

Cellular changes in experimental left heart hypoplasia.

scientific article

Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload

scientific article published on 25 August 2016

Changes in activation sequence of embryonic chick atria correlate with developing myocardial architecture

scientific article

Chick development and high dose of bendiocarb.

scientific article

Comparison of different tissue clearing methods and 3D imaging techniques for visualization of GFP-expressing mouse embryos and embryonic hearts.

scientific article

Confocal imaging of the embryonic heart: how deep?

scientific article published in June 2005

Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology--a position statement of the development, anatomy, and pathology ESC Working Group.

scientific article published on 11 January 2016

Current issues and perspectives in hypoplasia of the left heart.

scientific article

Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat

scientific journal article

Developmental anatomy of the heart: a tale of mice and man.

scientific article published on 11 November 2003

Developmental changes in cardiac recovery from anoxia-reoxygenation

scientific article published in August 2002

Developmental determinants of cardiac sensitivity to hypoxia.

scientific article published on 03 April 2014

Developmental mechanisms driving complex tooth shape in reptiles

scientific article published on 14 December 2019

Developmental patterning of the myocardium

scientific article

Developmental transitions in electrical activation patterns in chick embryonic heart

scientific article published in October 2004

Effect of increased pressure loading on heart growth in neonatal rats.

scientific article published in March 2003

Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.

scientific article

Effects of mechanical loading on early conduction system differentiation in the chick

scientific article published on 12 March 2010

Embryogenesis of the heart muscle.

scientific article

Endocardial Fibroelastosis is Secondary to Hemodynamic Alterations in the Chick Embryonic Model of Hypoplastic Left Heart Syndrome

scientific article

Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats

scientific article published on 29 April 2019

Erbb2 is required for cardiac atrial electrical activity during development

scientific article

Fibroblast Growth Factor-2 regulates proliferation of cardiac myocytes in normal and hypoplastic left ventricles in the developing chick

scientific article published on 6 February 2009

Form follows function: developmental and physiological view on ventricular myocardial architecture.

scientific article

Function and form in the developing cardiovascular system ⬇️

scientific article published on 02 March 2011

Growing the coronary tree: the quail saga

scientific article published on 01 September 2006

HIF-1α is required for development of the sympathetic nervous system

scientific article published on 13 June 2019

HNK-1 in Morphological Study of Development of the Cardiac Conduction System in Selected Groups of Sauropsida

article

Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo

scientific article published on 11 January 2013

Hemodynamic-dependent patterning of endothelin converting enzyme 1 expression and differentiation of impulse-conducting Purkinje fibers in the embryonic heart

scientific article

Hemodynamics is a key epigenetic factor in development of the cardiac conduction system

scientific article published on 29 May 2003

High-frequency ultrasonographic imaging of avian cardiovascular development

scientific article published in December 2007

Identification of a hybrid myocardial zone in the mammalian heart after birth.

scientific article

Identification of the building blocks of ventricular septation in monitor lizards (Varanidae)

scientific article published on 29 July 2019

Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes

scientific article published on 22 April 2013

Increased ventricular preload is compensated by myocyte proliferation in normal and hypoplastic fetal chick left ventricle

scientific article published on 05 April 2007

Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1α via downregulation of prolyl hydroxylase 3

scientific article published on 03 August 2018

Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice

scientific article published in November 2016

Knockout of the neural and heart expressed gene HF-1b results in apical deficits of ventricular structure and activation

scientific article

Letter by Gourdie and Sedmera regarding article, "abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal-targeted deletion of Alk3/Bmpr1a receptor"

scientific article published on 01 August 2008

Low incidence of atrial septal defects in nonmammalian vertebrates

scientific article published on 09 October 2019

Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats

scientific article published on 05 April 2011

Morphometric alterations, steatosis, fibrosis and active caspase-3 detection in carbamate bendiocarb treated rabbit liver

scientific article

Multiple Roles of Pitx2 in Cardiac Development and Disease.

scientific article

Myocardial morphological characteristics and proarrhythmic substrate in the rat model of heart failure due to chronic volume overload

scientific article published on 02 November 2010

Myocyte proliferation in the developing heart

scientific article published on 2 May 2011

Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease　- Comparison With Targeted Left Ventricular Myocardial Biopsy

scientific article published on 17 March 2016

New Imaging Markers of Clinical Outcome in Asymptomatic Patients with Severe Aortic Regurgitation

scientific article published on 11 October 2019

New role for endothelin signalling during development.

scientific article

Novel approaches to study coronary vasculature development in mice

scientific article published on 01 July 2018

On the Development of Cetacean Extremities: I. Hind Limb Rudimentation in the Spotted Dolphin (Stenella attenuata)

scientific article (publication date: February 1997)

On the development of Cetacean extremities: II. Morphogenesis and histogenesis of the flippers in the spotted dolphin (Stenella attenuata).

scientific article

Optical mapping of electrical activation in the developing heart

scientific article published on 01 June 2005

Optimisation of the formation and distribution of protoporphyrin IX in the urothelium: an in vitro approach

scientific article published on 01 August 1999

Ossification pattern in forelimbs of the Siamese crocodile (Crocodylus siamensis): Similarity in ontogeny of carpus among crocodylian species

scientific article

Pacing redistributes glycogen within the developing myocardium.

scientific article

Pacing-induced ventricular remodeling in the chick embryonic heart

scientific article published on 01 June 1999

Partial deficiency of HIF-1α stimulates pathological cardiac changes in streptozotocin-induced diabetic mice.

scientific article

Pathways to embryonic heart failure.

scientific article

Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardium

scientific article published on 23 November 2011

Preclinical alternative model for analysis of porous scaffold biocompatibility in bone tissue engineering

scientific article published on 23 November 2018

Pressure overload alters stress-strain properties of the developing chick heart

scientific article published on 10 July 2003

Proteomic analysis of cardiac ventricles: baso-apical differences.

scientific article published on 4 January 2018

Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2.

scientific article published on 11 November 2011

Quantitative volumetric analysis of cardiac morphogenesis assessed through micro-computed tomography.

scientific article

Relative position of the atrioventricular canal determines the electrical activation of developing reptile ventricles.

scientific article published on 19 April 2018

Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system.

scientific article published in September 2003

Specialized impulse conduction pathway in the alligator heart.

scientific article published on 22 March 2018

Stress and strain adaptation in load-dependent remodeling of the embryonic left ventricle ⬇️

scientific article published on December 20, 2012

Studying dynamic events in the developing myocardium

scientific article

Teratology Society: Lecture Abstracts ⬇️

scientific article published on May 1, 2013

The chick embryo heart as an experimental setup for the assessment of myocardial remodeling induced by pacing

scientific article published on 01 May 1999

The effect of connexin40 deficiency on ventricular conduction system function during development

scientific article published on 27 June 2012

The formation of the atrioventricular conduction axis is linked in development to ventricular septation

scientific article published on 12 October 2020

The role of connexin40 in developing atrial conduction

scientific article published on 31 January 2014

Tissue clearing and imaging methods for cardiovascular development

publication published on 01 April 2021

Trabecular Architecture Determines Impulse Propagation Through the Early Embryonic Mouse Heart

scientific article published on 01 January 2018

Trabeculation in the embryonic heart

scientific article published on 01 July 1996

Transitions in early embryonic atrioventricular valvular function correspond with changes in cushion biomechanics that are predictable by tissue composition

scientific article published on 3 May 2007

Wnt11 and Wnt7a are up-regulated in association with differentiation of cardiac conduction cells in vitro and in vivo.

scientific article published in August 2003

List of works by David Sedmera

A quantitative study of the ventricular myoarchitecture in the stage 21-29 chick embryo following decreased loading

Abnormal myocardial and coronary vasculature development in experimental hypoxia

Acute temperature effects on function of the chick embryonic heart

Adenylyl cyclase signaling in the developing chick heart: the deranging effect of antiarrhythmic drugs

Adverse effects of Hif1a mutation and maternal diabetes on the offspring heart.

Analysis of Siamese Crocodile (Crocodylus siamensis) Eggshell Proteome

Apoptosis and epicardial contributions act as complementary factors in remodeling of the atrioventricular canal myocardium and atrioventricular conduction patterns in the embryonic chick heart

Arrhythmias in the developing heart.

Bendiocarb effect on liver and central nervous system in the chick embryo.

Blood-borne stem cells differentiate into vascular and cardiac lineages during normal development

Cardiac expression patterns of endothelin-converting enzyme (ECE): implications for conduction system development.

Cardiac neural crest ablation inhibits compaction and electrical function of conduction system bundles

Cellular changes in experimental left heart hypoplasia.

Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload

Changes in activation sequence of embryonic chick atria correlate with developing myocardial architecture

Chick development and high dose of bendiocarb.

Comparison of different tissue clearing methods and 3D imaging techniques for visualization of GFP-expressing mouse embryos and embryonic hearts.

Confocal imaging of the embryonic heart: how deep?

Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology--a position statement of the development, anatomy, and pathology ESC Working Group.

Current issues and perspectives in hypoplasia of the left heart.

Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat

Developmental anatomy of the heart: a tale of mice and man.

Developmental changes in cardiac recovery from anoxia-reoxygenation

Developmental determinants of cardiac sensitivity to hypoxia.

Developmental mechanisms driving complex tooth shape in reptiles

Developmental patterning of the myocardium

Developmental transitions in electrical activation patterns in chick embryonic heart

Effect of increased pressure loading on heart growth in neonatal rats.

Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.

Effects of mechanical loading on early conduction system differentiation in the chick

Embryogenesis of the heart muscle.

Endocardial Fibroelastosis is Secondary to Hemodynamic Alterations in the Chick Embryonic Model of Hypoplastic Left Heart Syndrome

Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats

Erbb2 is required for cardiac atrial electrical activity during development

Fibroblast Growth Factor-2 regulates proliferation of cardiac myocytes in normal and hypoplastic left ventricles in the developing chick

Form follows function: developmental and physiological view on ventricular myocardial architecture.

Function and form in the developing cardiovascular system ⬇️

Growing the coronary tree: the quail saga

HIF-1α is required for development of the sympathetic nervous system

HNK-1 in Morphological Study of Development of the Cardiac Conduction System in Selected Groups of Sauropsida

Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo

Hemodynamic-dependent patterning of endothelin converting enzyme 1 expression and differentiation of impulse-conducting Purkinje fibers in the embryonic heart

Hemodynamics is a key epigenetic factor in development of the cardiac conduction system

High-frequency ultrasonographic imaging of avian cardiovascular development

Identification of a hybrid myocardial zone in the mammalian heart after birth.

Identification of the building blocks of ventricular septation in monitor lizards (Varanidae)

Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes

Increased ventricular preload is compensated by myocyte proliferation in normal and hypoplastic fetal chick left ventricle

Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1α via downregulation of prolyl hydroxylase 3

Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice

Knockout of the neural and heart expressed gene HF-1b results in apical deficits of ventricular structure and activation

Letter by Gourdie and Sedmera regarding article, "abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal-targeted deletion of Alk3/Bmpr1a receptor"

Low incidence of atrial septal defects in nonmammalian vertebrates

Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats

Morphometric alterations, steatosis, fibrosis and active caspase-3 detection in carbamate bendiocarb treated rabbit liver

Multiple Roles of Pitx2 in Cardiac Development and Disease.

Myocardial morphological characteristics and proarrhythmic substrate in the rat model of heart failure due to chronic volume overload

Myocyte proliferation in the developing heart

Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease - Comparison With Targeted Left Ventricular Myocardial Biopsy

New Imaging Markers of Clinical Outcome in Asymptomatic Patients with Severe Aortic Regurgitation

New role for endothelin signalling during development.

Novel approaches to study coronary vasculature development in mice

On the Development of Cetacean Extremities: I. Hind Limb Rudimentation in the Spotted Dolphin (Stenella attenuata)

On the development of Cetacean extremities: II. Morphogenesis and histogenesis of the flippers in the spotted dolphin (Stenella attenuata).

Optical mapping of electrical activation in the developing heart

Optimisation of the formation and distribution of protoporphyrin IX in the urothelium: an in vitro approach

Ossification pattern in forelimbs of the Siamese crocodile (Crocodylus siamensis): Similarity in ontogeny of carpus among crocodylian species

Pacing redistributes glycogen within the developing myocardium.

Pacing-induced ventricular remodeling in the chick embryonic heart

Partial deficiency of HIF-1α stimulates pathological cardiac changes in streptozotocin-induced diabetic mice.

Pathways to embryonic heart failure.

Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardium

Preclinical alternative model for analysis of porous scaffold biocompatibility in bone tissue engineering

Pressure overload alters stress-strain properties of the developing chick heart

Proteomic analysis of cardiac ventricles: baso-apical differences.

Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2.

Quantitative volumetric analysis of cardiac morphogenesis assessed through micro-computed tomography.

Relative position of the atrioventricular canal determines the electrical activation of developing reptile ventricles.

Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system.

Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease　- Comparison With Targeted Left Ventricular Myocardial Biopsy