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List of works by Pierre Hainaut

(18)F-FDG PET-CT for Surveillance of Brazilian Patients with Li-Fraumeni Syndrome

scientific article

20 years into the Gambia Hepatitis Intervention Study: assessment of initial hypotheses and prospects for evaluation of protective effectiveness against liver cancer.

scientific article published in November 2008

20-years of population-based cancer registration in hepatitis B and liver cancer prevention in the Gambia, West Africa

scientific article

249(ser) TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma.

scientific article

4-Aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European Prospective Investigation into Cancer and Nutrition prospective study

scientific article published in September 2005

A TP53 founder mutation, p.R337H, is associated with phyllodes breast tumors in Brazil

article

A common molecular mechanism underlies two phenotypically distinct 17p13.1 microdeletion syndromes

scientific article

A global view of hepatocellular carcinoma: trends, risk, prevention and management

scientific article published on 22 August 2019

A meta-analysis of cancer risk associated with the TP53 intron 3 duplication polymorphism (rs17878362): geographic and tumor-specific effects.

scientific article published on 14 February 2013

A sample storage management system for biobanks.

scientific article published on 31 August 2010

A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database ⬇️

scientific article published on July 1, 1998

A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53.

scientific article published on April 1993

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

scientific article (publication date: 3 April 2008)

ALK fusion variants detection by targeted RNA-next generation sequencing and clinical responses to crizotinib in ALK-positive non-small cell lung cancer.

scientific article published on 8 December 2017

Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake

scientific article

Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer

scientific article

Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

scientific article published on 14 July 2011

Absence of association between HPV DNA, TP53 codon 72 polymorphism, and risk of oesophageal cancer in a high-risk area of China

scientific article

Abstract 1836: Distinct tumor spectrum and age of onset in a Brazilian cohort of p.R337HTP53mutation carriers

article

Abstract 4282: GermlineTP53p.R337H mutations and Li-Fraumeni syndrome: A new variant form of the disease

Abstract 5598: Germline TP53 mutation in very early onset breast cancer patients without BRCA1 and BRCA2 mutation in Brazilian population

article

Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity.

scientific article published in April 2003

Aetiological differences in demographical, clinical and pathological characteristics of hepatocellular carcinoma in The Gambia

scientific article published on 8 December 2010

Aflatoxin exposure and viral hepatitis in the etiology of liver cirrhosis in the Gambia, West Africa

scientific article published on 10 July 2008

Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis

scientific article

Age at cancer onset in germline TP53 mutation carriers: association with polymorphisms in predicted G-quadruplex structures

scientific article published on 11 December 2013

Air pollution and risk of lung cancer in a prospective study in Europe

scientific article published in July 2006

Amount of DNA in plasma and cancer risk: A prospective study

An apoptosis methylation prognostic signature for early lung cancer in the IFCT-0002 trial

scientific article published on 20 March 2012

Analysis of p53 quaternary structure in relation to sequence-specific DNA binding

scientific article published on 01 January 1994

Analysis of p53, p16MTS, p21WAF1 and H-ras in archived bladder tumours from workers exposed to aromatic amines

scientific article published on May 1998

Ancestry of the Brazilian TP53 c.1010G>A (p.Arg337His, R337H) Founder Mutation: Clues from Haplotyping of Short Tandem Repeats on Chromosome 17p.

scientific article published on 30 November 2015

Anthropometry, Silhouette Trajectory, and Risk of Breast Cancer in Mexican Women

Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus

scientific article published on 28 May 2008

Arrayed primer extension resequencing of mutations in the TP53 tumor suppressor gene: comparison with denaturing HPLC and direct sequencing

scientific article published on July 2005

Assessment of genetic damage in healthy and diseased tissue.

scientific article published on January 2011

Assessment of transformed properties in vitro and of tumorigenicity in vivo in primary keratinocytes cultured for epidermal sheet transplantation.

scientific article

Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand

scientific article

Association between TP53 R249S mutation and polymorphisms in TP53 intron 1 in hepatocellular carcinoma

scientific article published on 8 July 2013

Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study

scientific article (publication date: 21 January 2010)

Association of prediagnostic physical activity with survival following breast cancer diagnosis: influence of TP53 mutation status

scientific article published on 26 September 2013

BTG gene expression in the p53-dependent and -independent cellular response to DNA damage

scientific article published on 01 February 2000

Biobanking in a fast moving world: an international perspective

scientific article published on January 2011

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models.

scientific article published on 23 September 2011

Biomarkers Predict p53 Gene Therapy Efficacy in Recurrent Squamous Cell Carcinoma of the Head and Neck

scientific article published in December 2009

Biomarkers in cancer research and treatment: promises and challenges

Biospecimen Reporting for Improved Study Quality

scientific article

Biospecimen reporting for improved study quality (BRISQ)

scientific article

Biospecimen reporting for improved study quality (BRISQ)

Breast cancer in Latin America: global burden, patterns, and risk factors

scientific article

Breast cancer in pre-menopausal women in West Africa: analysis of temporal trends and evaluation of risk factors associated with reproductive life.

scientific article published on 13 March 2013

Breast-cancer stromal cells with TP53 mutations

scientific article published on 01 April 2008

CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression

scientific article

Cancer Diagnostic and Predictive Biomarkers 2015.

scientific article published on 12 October 2015

Cancer Diagnostic and Predictive Biomarkers 2016.

scientific article published on 18 June 2017

Cancer as a metabolic disease

Cancer diagnostic and predictive biomarkers

scientific article

Cancer prevention and control: hepatocellular carcinoma

scientific article published on 25 July 2019

Cancers of the upper gastro-intestinal tract: a review of somatic mutation distributions.

scientific article published on April 2014

Changes in the pattern of breast cancer burden among African American women: evidence based on 29 states and District of Columbia during 1998 to 2010.

scientific article published on 22 September 2014

Characterisation of human fibroblasts as keratinocyte feeder layer using p63 isoforms status

scientific article published on January 2009

Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

scientific article published on 23 June 2016

Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance

scientific article published on 25 January 2007

Clinical implications of p53 tumor suppressor gene mutation and protein expression in esophageal adenocarcinomas: results of a ten-year prospective study.

scientific article published on May 2003

Combination of AKT inhibitor ARQ 092 and sorafenib potentiates inhibition of tumor progression in cirrhotic rat model of hepatocellular carcinoma.

scientific article published on 23 January 2018

Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma

scientific article published on 24 June 2008

Computational approaches for predicting the biological effect of p53 missense mutations: a comparison of three sequence analysis based methods

scientific article

Control of hepatocellular carcinoma through hepatitis B vaccination in areas of high endemicity: perspectives for global liver cancer prevention

scientific article published on 15 October 2009

Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

scientific article published on 17 March 2016

Correction: Protein Profiling in Hepatocellular Carcinoma by Label-Free Quantitative Proteomics in Two West African Populations.

scientific article

Cost-effectiveness of early cancer surveillance for patients with Li-Fraumeni syndrome

scientific article published on 04 February 2019

Cross-Validation Study for Epidermal Growth Factor Receptor and KRAS Mutation Detection in 74 Blinded Non-small Cell Lung Carcinoma Samples: A Total of 5550 Exons Sequenced by 15 Molecular French Laboratories (Evaluation of the EGFR Mutation Status f

article

Cross-talks between cyclooxygenase-2 and tumor suppressor protein p53: Balancing life and death during inflammatory stress and carcinogenesis

scientific article published on September 2007

Curbing the liver cancer epidemic in Africa.

scientific article published on February 2008

Cytokeratin expression in adenocarcinomas of the esophagogastric junction: a comparative study of adenocarcinomas of the distal esophagus and of the proximal stomach

scientific article published on 01 September 2002

DNA adducts and lung cancer risk: a prospective study

scientific article published in September 2005

DNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract

scientific article published in March 2012

DNA methylation of hepatitis B virus (HBV) genome associated with the development of hepatocellular carcinoma and occult HBV infection

scientific article

Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

scientific article

DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.

scientific article published in October 2002

Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study

scientific article

Detailed haplotype analysis at the TP53 locus in p.R337H mutation carriers in the population of Southern Brazil: evidence for a founder effect.

scientific article published on February 2010

Detection of R337H, a germline TP53 mutation predisposing to multiple cancers, in asymptomatic women participating in a breast cancer screening program in Southern Brazil

article

Detection of p53 codon 249 mutation in Nigerian patients with hepatocellular carcinoma using a novel evaluation of cell-free DNA.

scientific article published in October 2008

Dietary Carbohydrate, Glycemic Index, Glycemic Load, and Breast Cancer Risk Among Mexican Women

scientific article published on 3 September 2015

Distinct pattern of TP53 mutations in squamous cell carcinoma of the esophagus in Iran

scientific article published in November 2001

Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture

scientific article

Downregulation of transcription factor E4F1 in hepatocarcinoma cells: HBV-dependent effects on autophagy, proliferation and metabolism.

scientific article published on 25 October 2013

Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation

scientific article

EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration

scientific article published on December 2009

Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers

scientific article published on May 2013

Editorial foreword special issue "hepatocellular carcinoma--a worldwide translational approach"

scientific article published on 07 April 2009

Editorial: from cancer genotypes to phenotypes: a never-ending complexity

scientific article published in January 2016

Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma

scientific article

Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein.

scientific article published on 10 June 2010

Effects of tobacco smoke and benzo[a]pyrene on human endothelial cell and monocyte stress responses.

scientific article

Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53.

scientific article

Efficient hepatitis C antigen immunohistological staining in sections of normal, cirrhotic and tumoral liver using a new monoclonal antibody directed against serum-derived HCV E2 glycoproteins

scientific article published on August 2006

Environmental tobacco smoke and risk of respiratory cancer and chronic obstructive pulmonary disease in former smokers and never smokers in the EPIC prospective study

scientific article

Epidermal growth factor receptor (EGFR) mutations and expression in squamous cell carcinoma of the esophagus in central Asia

scientific article published on 17 December 2012

Epigenetic silencing of sFRP1 activates the canonical Wnt pathway and contributes to increased cell growth and proliferation in hepatocellular carcinoma

scientific article published on 15 February 2012

Esophageal cancer: cases and causes (part I)

scientific article published on 01 June 2007

Estrogen levels act as a rheostat on p53 levels and modulate p53-dependent responses in breast cancer cell lines

scientific article published on 11 March 2010

Evaluating the arrayed primer extension resequencing assay of TP53 tumor suppressor gene

scientific article

Evaluation of tumorigenic risk of tissue-engineered oral mucosal epithelial cells by using combinational examinations

scientific article published on 14 June 2010

Exposure to hazardous substances in a standard molecular biology laboratory environment: evaluation of exposures in IARC laboratories.

scientific article published on 27 May 2009

Extremely high Tp53 mutation load in esophageal squamous cell carcinoma in Golestan Province, Iran

scientific article

First International p53 Isoforms Meeting: 'p53 isoforms through evolution: from identification to biological function'

scientific article published on 10 December 2010

Frequent occurrence of gastric cancer in Asian kindreds with Li-Fraumeni syndrome

scientific article published on 13 November 2014

Future perspectives on molecular epidemiology ⬇️

chapter published in 2012

G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms

scientific article published on 26 November 2010

Genetic alterations in esophageal cancer and their relevance to etiology and pathogenesis: a review

scientific article published on June 1996

Genetic and epigenetic alterations as biomarkers for cancer detection, diagnosis and prognosis

scientific article published on 14 March 2007

Genetics of lung-cancer susceptibility

scientific article published on 13 October 2010

Genotoxic and non-genotoxic pathways of p53 induction ⬇️

scientific article published on December 10, 2001

Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia

scientific article published on 31 October 2011

Hepatitis B surface antigenaemia and alpha-foetoprotein detection from dried blood spots: applications to field-based studies and to clinical care in hepatitis B virus endemic areas.

scientific article

Hepatitis B viral load and risk for liver cirrhosis and hepatocellular carcinoma in The Gambia, West Africa

scientific article

Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells.

scientific article

Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity

scientific article published in February 2005

Hepatocellular carcinoma: from gene to public health.

scientific article published in December 1997

Higher-than-expected population prevalence of potentially pathogenic germline TP53 variants in individuals unselected for cancer history.

scientific article published on September 2017

Highly prevalent TP53 mutation predisposing to many cancers in the Brazilian population: a case for newborn screening?

scientific article published in September 2009

Hormonal therapy and risk of breast cancer in mexican women

scientific article

Human papillomavirus infection among 100 oesophageal cancer cases in the People's Republic of China

article

Human papillomavirus type 16 and TP53 mutation in oral cancer: matched analysis of the IARC multicenter study

scientific article published in January 2004

Human tissue biobanks as instruments for drug discovery and development: impact on personalized medicine

article

IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools

scientific article published in January 1998

IARC p53 mutation database: a relational database to compile and analyze p53 mutations in human tumors and cell lines. International Agency for Research on Cancer

scientific article

Identification of osteopontin as a novel marker for early hepatocellular carcinoma

scientific article published on 19 December 2011

Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcripts

scientific article

Impact of delay to cryopreservation on RNA integrity and genome-wide expression profiles in resected tumor samples

scientific article (publication date: 2013)

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

scientific article (publication date: June 2007)

In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249.

scientific article published on 28 November 2007

In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.

scientific article published on 12 June 2009

Inactivation of the p53 protein in cell lines derived from human esophageal cancers

scientific article published on March 1997

Increase in female liver cancer in the Gambia, West Africa: evidence from 19 years of population-based cancer registration (1988-2006)

scientific article

Increased oxidative damage in carriers of the germline TP53 p.R337H mutation

scientific article

Increased salt concentration reversibly destabilizes p53 quaternary structure and sequence-specific DNA binding.

scientific article published on March 1994

Independent prognostic value of somatic TP53 gene mutations in 1794 breast cancer patients.

scientific article published on 17 June 2005

Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma

scientific article published on 01 April 2008

Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC).

scientific article published on 23 November 2010

Initiation of human astrocytoma by clonal evolution of cells with progressive loss of p53 functions in a patient with a 283H TP53 germ-line mutation: evidence for a precursor lesion.

scientific article

Integrating mutation data and structural analysis of the TP53 tumor-suppressor protein

scientific article

Interaction of heat-shock protein 70 with p53 translated in vitro: evidence for interaction with dimeric p53 and for a role in the regulation of p53 conformation ⬇️

scientific article published on October 1, 1992

Interactions between hepatitis B virus and aflatoxin B(1): effects on p53 induction in HepaRG cells

scientific article

Interferon-inducible guanylate binding protein (GBP)-2: a novel p53-regulated tumor marker in esophageal squamous cell carcinomas

scientific article

International efforts to develop biospecimen best practices.

scientific article published on 16 March 2010

Intraepithelial p63-dependent expression of distinct components of cell adhesion complexes in normal esophageal mucosa and squamous cell carcinoma

scientific article

KRAS mutation status in primary nonsmall cell lung cancer and matched metastases

scientific article published in June 2010

Lessons from TP53 mutations in breast cancers: from carcinogen fingerprints to clinical correlates

scientific article published on 12 March 2000

Li-Fraumeni and Li-Fraumeni-like syndrome among children diagnosed with pediatric cancer in Southern Brazil

scientific article

Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype

scientific article published in October 2003

Li-Fraumeni syndrome in a Malaysian kindred

scientific article

Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium

scientific article published on 29 August 2012

Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence

scientific article

Loss of TP53-DNA interaction induced by p.C135R in lung cancer.

scientific article

Low Prevalence of TP53 Mutations and MDM2 Amplifications in Pediatric Rhabdomyosarcoma

scientific article published on 7 March 2012

Low frequency of p16/CDKN2 gene mutations in esophageal carcinomas

scientific article published in May 1996

Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity

scientific article published on 4 September 2014

Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissions.

scientific article published in September 2001

Massively regulated genes: the example of TP53.

scientific article published on January 2010

Metal ions as regulators of the conformation and function of the tumour suppressor protein p53: implications for carcinogenesis.

scientific article

Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells

scientific article published on 01 November 2000

Methodology of laboratory measurements in prospective studies on gene-environment interactions: the experience of GenAir

scientific article

Methylation patterns in sentinel genes in peripheral blood cells of heavy smokers: Influence of cruciferous vegetables in an intervention study

scientific article

MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma

scientific article

Modulation by copper of p53 conformation and sequence-specific DNA binding: role for Cu(II)/Cu(I) redox mechanism

scientific article

Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc.

scientific article published in March 1998

Molecular and clinical differences between adenocarcinomas of the esophagus and of the gastric cardia

scientific article published on January 2001

Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali

scientific article

Molecular detection of early-stage laryngopharyngeal squamous cell carcinomas

scientific article

Molecular epidemiology: linking molecular scale insights to population impacts ⬇️

chapter published in 2012

Molecular etiopathogenesis of esophageal cancers

scientific article published on January 1996

More chinks in the armor of cancer: potential for new therapies.

scientific article published on 21 November 2016

Mutant p53 protein, master regulator of human malignancies: a report on the Fifth Mutant p53 Workshop

scientific article published on 18 November 2011

Mutant p53 rescue and modulation of p53 redox state.

scientific article published on 29 August 2009

Mutant p53 targeting by the low molecular weight compound STIMA-1

scientific article published on 7 March 2008

Mutant p53 targeting by the low molecular weight compound STIMA-1.

scientific article published on May 2017

Mutation of TP53 and alteration of p14(arf) expression in EGFR- and KRAS-mutated lung adenocarcinomas

scientific article published on 26 October 2013

Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand

scientific article

Mésothéliome : les dispositifs en place en France « le réseau mésothéliome » 1998–2013

article

Natural variations of copper and sulfur stable isotopes in blood of hepatocellular carcinoma patients

scientific article

Next-generation sequencing: emerging lessons on the origins of human cancer

scientific article published on January 2011

Nitric oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein.

scientific article

Nitric oxide nitrates tyrosine residues of tumor-suppressor p53 protein in MCF-7 cells

scientific article published on 01 January 2000

Nitric oxide prevents gamma-radiation-induced cell cycle arrest by impairing p53 function in MCF-7 cells.

scientific article

Obesity, inflammatory markers, and endometrial cancer risk: a prospective case-control study

scientific article

On the origin of G --> T transversions in lung cancer

scientific article

Osteopontin and latent-TGF β binding-protein 2 as potential diagnostic markers for HBV-related hepatocellular carcinoma

scientific article

Overweight, obesity and risk of premenopausal breast cancer according to ethnicity: a systematic review and dose-response meta-analysis

scientific article

P53 at the atomic scale: the multiple faces of a crystal

scientific article published on 01 July 1997

PD-L1 protein expression assessed by immunohistochemistry is neither prognostic nor predictive of benefit from adjuvant chemotherapy in resected non-small cell lung cancer.

scientific article published on 30 January 2017

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

scientific article published on May 2009

PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines

scientific article published on 20 May 2014

Papillomavirus infection in the conjunctiva of individuals with and without AIDS: an autopsy series from Uganda

scientific article published on 6 September 2005

Paradoxical Response to Tuberculosis Treatment in a Patient Receiving Tumor Necrosis Factor-Alpha Antagonist ⬇️

scientific article published on April 11, 2012

Pathology as the cornerstone of human tissue banking: European consensus expert group report

scientific article published on September 2009

Patterns of Benign and Malignant Lesions of the Thyroid in Two Wilayahs of Northeastern Algeria.

scientific article

Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history

scientific article published on 01 June 2007

Pharmacological rescue of p53 in cancer cells: the soloist meets the PRIMA donna

scientific article published on 15 March 2011

Plasma Circulating Tumor DNA Levels for the Monitoring of Melanoma Patients: Landscape of Available Technologies and Clinical Applications.

scientific article published on 6 April 2017

Polycyclic aromatic hydrocarbon exposure in oesophageal tissue and risk of oesophageal squamous cell carcinoma in north-eastern Iran

scientific article published on 28 June 2010

Pooled Analysis of the Prognostic and Predictive Effects of TP53 Comutation Status Combined With KRAS or EGFR Mutation in Early-Stage Resected Non-Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy

scientific article published on 28 April 2017

Pooled analysis of the prognostic and predictive effects of KRAS mutation status and KRAS mutation subtype in early-stage resected non-small-cell lung cancer in four trials of adjuvant chemotherapy

scientific article

Poor intercellular transport and absence of enhanced antiproliferative activity after non-viral gene transfer of VP22-P53 or P53-VP22 fusions into p53 null cell lines in vitro or in vivo

scientific article published on 01 July 2005

Population-based breast (female) and cervix cancer rates in the Gambia: evidence of ethnicity-related variations

scientific article published in November 2010

Predicting the transactivation activity of p53 missense mutants using a four-body potential score derived from Delaunay tessellations

scientific article

Premalignant lesions of the esophagogastric mucosa.

scientific article published in August 2004

Prevalence of the TP53 p.R337H mutation in breast cancer patients in Brazil

scientific article

Prognostic and Predictive Effect of TP53 Mutations in Patients with Non-Small Cell Lung Cancer from Adjuvant Cisplatin-Based Therapy Randomized Trials: A LACE-Bio Pooled Analysis

scientific article

Prognostic and predictive value of TP53 mutations in node-positive breast cancer patients treated with anthracycline- or anthracycline/taxane-based adjuvant therapy: results from the BIG 02-98 phase III trial

scientific article

Prognostic value ofTP53,KRASandEGFRmutations in nonsmall cell lung cancer: the EUELC cohort

article

Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with DeltaNp73.

scientific article published on 28 November 2007

Protein profiling in hepatocellular carcinoma by label-free quantitative proteomics in two west African populations

scientific article

Proteomics beyond proteomics: toward clinical applications

scientific article published on January 2011

Pulmonary embolism findings on chest radiographs and multislice spiral CT.

scientific article published on 17 February 2004

Quantitation of p53 nuclear relocation in response to stress using a yeast functional assay: effects of irradiation and modulation by heavy metal ions.

scientific article published in September 2005

Quantitative analysis of DNA methylation after whole bisulfitome amplification of a minute amount of DNA from body fluids.

scientific article

Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors

scientific article published on January 2009

Quantitative analysis of plasma TP53 249Ser-mutated DNA by electrospray ionization mass spectrometry.

scientific article published in December 2005

Rare germline variant (rs78378222) in the TP53 3' UTR: Evidence for a new mechanism of cancer predisposition in Li-Fraumeni syndrome

scientific article published on 07 January 2016

Recent advances in p53 research: an interdisciplinary perspective.

scientific article published on 19 September 2008

Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice

scientific article

Redox control and interplay between p53 isoforms: roles in the regulation of basal p53 levels, cell fate, and senescence

scientific article published on 04 May 2011

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

scientific article published on October 1993

Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper.

scientific article published on October 1997

Relationships between lung adenocarcinoma and gender, age, smoking and occupational risk factors: A case-case study

scientific article published on 7 July 2009

Response to “Germline TP53 R337H mutation is not sufficient to establish Li-Fraumeni or Li-Fraumeni-like syndrome”, by Ribeiro et al

Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1.

scientific article published on March 2002

Revisiting tumor patterns and penetrance in germline TP53 mutation carriers: temporal phases of Li-Fraumeni syndrome.

scientific article

Role of obesity in the risk of breast cancer: lessons from anthropometry

scientific article published on 3 February 2013

Role of p53 in the induction of cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung cancer cell lines.

scientific article

Sarcomas in TP53 germline mutation carriers: a review of the IARC TP53 database

scientific article

Screening for germline BRCA1, BRCA2, TP53 and CHEK2 mutations in families at-risk for hereditary breast cancer identified in a population-based study from Southern Brazil

scientific article published on 24 May 2016

Seasonal variation in TP53 R249S-mutated serum DNA with aflatoxin exposure and hepatitis B virus infection

scientific article published on 18 July 2011

Ser-249 TP53 and CTNNB1 mutations in circulating free DNA of Egyptian patients with hepatocellular carcinoma versus chronic liver diseases.

scientific article published on 3 March 2008

Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia

scientific article published in January 2000

Ser-249TP53 mutation in tumour and plasma DNA of hepatocellular carcinoma patients from a high incidence area in the Gambia, West Africa

scientific article published in June 2004

Significance of TP53 mutations as predictive markers of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer.

scientific article

Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73.

scientific article

Smoky coal exposure, NBS1 polymorphisms, p53 protein accumulation, and lung cancer risk in Xuan Wei, China

scientific article

Somatic TP53 Mutations in the Era of Genome Sequencing.

scientific article

Somatic mutation databases as tools for molecular epidemiology and molecular pathology of cancer: proposed guidelines for improving data collection, distribution, and integration

scientific article

Sources of bias in the detection and reporting of p53 mutations in human cancer: analysis of the IARC p53 mutation database

scientific article published on 01 February 1999

Sources of pre-analytical variations in yield of DNA extracted from blood samples: analysis of 50,000 DNA samples in EPIC.

scientific article

Surface functionalization of gold nanoclusters with arginine: a trade-off between microtumor uptake and radiotherapy enhancement

scientific article published on 01 April 2020

Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms.

scientific article published on 2 June 2018

TP53 Mutations and HBX Status Analysis in Hepatocellular Carcinomas from Iran: Evidence for Lack of Association between HBV Genotype D and TP53 R249S Mutations

scientific article

TP53 PIN3 and MDM2 SNP309 polymorphisms as genetic modifiers in the Li-Fraumeni syndrome: impact on age at first diagnosis.

scientific article published on 18 June 2009

TP53 PIN3 and PEX4 polymorphisms and infertility associated with endometriosis or with post-in vitro fertilization implantation failure.

scientific article

TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia

scientific article

TP53 R249S mutations, exposure to aflatoxin, and occurrence of hepatocellular carcinoma in a cohort of chronic hepatitis B virus carriers from Qidong, China

scientific article published on 14 April 2009

TP53 and EGFR mutations in combination with lifestyle risk factors in tumours of the upper aerodigestive tract from South America

scientific article published on 2 December 2009

TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers

scientific article published in June 2005

TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival

scientific article published on 01 January 1998

TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child: evidence for chimerism involving a common mutant founder haplotype: case report

scientific article

TP53 mutation patterns in breast cancers: searching for clues of environmental carcinogenesis.

scientific article

TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer

scientific article published on January 2004

TP53 mutation spectrum in lung cancers and mutagenic signature of components of tobacco smoke: lessons from the IARC TP53 mutation database

scientific article published on 01 November 2001

TP53 mutations and MDM2 gene amplification in squamous-cell carcinomas of the esophagus in south Thailand

scientific article published on 01 October 2000

TP53 mutations as biomarkers for cancer epidemiology in Latin America: current knowledge and perspectives

scientific article

TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes

scientific article published on April 2007

TP53 mutations in human cancers: origins, consequences, and clinical use

scientific article

TP53 mutations in squamous-cell carcinomas of the conjunctiva: evidence for UV-induced mutagenesis

scientific article published on September 2004

TP53 mutations, amplification of P63 and expression of cell cycle proteins in squamous cell carcinoma of the oesophagus from a low incidence area in Western Europe

scientific article published on September 2001

TP53 mutations, human papilloma virus DNA and inflammation markers in esophageal squamous cell carcinoma from the Rift Valley, a high-incidence area in Kenya

scientific article

TP53 p.R337H is a conditional cancer-predisposing mutation: further evidence from a homozygous patient

scientific article

TP53 polymorphism, HPV infection, and risk of cervical cancer.

scientific article

TP53, EGFR, and KRAS mutations in relation to VHL inactivation and lifestyle risk factors in renal-cell carcinoma from central and eastern Europe

TP53: a key gene in human cancer.

scientific article

TP53andKRAS2Mutations in Plasma DNA of Healthy Subjects and Subsequent Cancer Occurrence: A Prospective Study

article by Emmanuelle Gormally et al published 1 July 2006 in Cancer Research

TP63 P2 promoter functional analysis identifies β-catenin as a key regulator of ΔNp63 expression

scientific article published on 6 June 2011

Targeted deep sequencing of plasma circulating cell-free DNA reveals Vimentin and Fibulin 1 as potential epigenetic biomarkers for hepatocellular carcinoma

scientific article

Targeting the hallmarks of cancer: towards a rational approach to next-generation cancer therapy

scientific article published in January 2013

Temperature sensitivity for conformation is an intrinsic property of wild-type p53.

scientific article published on February 1995

The European Prospective Investigation into Cancer and Nutrition biobank

scientific article

The Evolution of Tumors in Mice and Humans with Germline p53 Mutations

scientific article

The Gambia Liver Cancer Study: Infection with hepatitis B and C and the risk of hepatocellular carcinoma in West Africa

scientific article published on January 2004

The IARC TP53 database: new online mutation analysis and recommendations to users

scientific article published in June 2002

The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation

scientific article published on 28 June 2016

The TP53 fertility network

scientific article published on 18 December 2012

The TP53 mutation, R337H, is associated with Li-Fraumeni and Li-Fraumeni-like syndromes in Brazilian families.

scientific article published on 21 February 2006

The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy

scientific article published on 18 April 2009

The associations of sequence variants in DNA-repair and cell-cycle genes with cancer risk: genotype-phenotype correlations.

scientific article

The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

scientific article

The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway.

scientific article

The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.

scientific article published on 16 January 2003

The expression of TA and DeltaNp63 are regulated by different mechanisms in liver cells.

scientific article

The genetic–metabolic duality of cancer

The profile and contribution of rare germline copy number variants to cancer risk in Li-Fraumeni patients negative for TP53 mutations.

scientific article

The role of the pathologist in tissue banking: European Consensus Expert Group Report

scientific article

The tumor suppressor gene TP53: implications for cancer management and therapy

scientific article

The tumor suppressor protein p53: a receptor to genotoxic stress that controls cell growth and survival

scientific article published on January 1, 1995

The use of biomarkers to study pathogenesis and mechanisms of cancer: oesophagus and skin cancer as models

scientific article published on January 1, 1997

Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers

scientific article

Toward a roadmap in global biobanking for health

scientific article (publication date: November 2012)

Training the Next Generation of Biobankers: A Two-Year Master's Course in the Management of Biobanks.

scientific article published on 18 September 2017

Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis.

scientific article

Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB.

scientific article published on 08 May 2006

Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53

scientific article published on 19 November 2012

Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk: the EPIC study

scientific article published on 8 March 2011

Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome.

scientific article published on January 2010

Tumor-cell-derived microvesicles as carriers of molecular information in cancer

scientific article published on January 2013

Tumor-specific mutations in p53: The acid test ⬇️

scientific article published on 01 January 2002

Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

scientific article published on 22 October 2010

Up-regulation of Fas (APO-1/CD95) ligand and down-regulation of Fas expression in human esophageal cancer ⬇️

scientific article published on May 15, 1998

Variable population prevalence estimates of germline TP53 variants: A gnomAD-based analysis

article

WITHDRAWN: Expression of p53, p63, and p73 isoforms in squamous cell carcinoma and adenocarcinoma of esophagus☆,☆☆

retracted scientific article

Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome

scientific article

Wnt/beta-catenin signaling pathway in hepatocellular carcinomas cases from Colombia

scientific article published on January 2015

Worldwide genetic diversity of HBV genotypes and risk of hepatocellular carcinoma

scientific article published on 14 August 2009

Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging.

scientific article published on 27 June 2017

Zinc binding and redox control of p53 structure and function.

scientific article

[Epidemiology, prevention, screening and diagnosis of hepatocellular carcinoma]

scientific article published on 01 January 2009

[TP53 tumor suppressor gene: 20 years (and ten thousand mutations) later]

scientific article published on 01 January 2000

p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations

scientific article published in January 2005

p53 Protocols: the Original Soundtrack of 25 Years of p53 Research. Methods in Molecular Biology. Vol. 234.

scientific article published in December 2004

p53 and human cancer: the first ten thousand mutations.

scientific article

p53 as a sensor of carcinogenic exposures: mechanisms of p53 protein induction and lessons from p53 gene mutations.

scientific article

p53 in metabolism, aging and cancer

scientific article published on 29 October 2014

p53 regulates the transcription of its Delta133p53 isoform through specific response elements contained within the TP53 P2 internal promoter

scientific article

p53 status influences response to tamoxifen but not to fulvestrant in breast cancer cell lines

scientific article published on April 2011

p53, stem cell biology and childhood blastomas

scientific article published on 01 March 2019

p53-Dependent repression of focal adhesion kinase in response to estradiol in breast cancer cell-lines

scientific article published on 10 November 2010

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